List of works - Trevor A Graham

A Big Bang model of human colorectal tumor growth

scientific article

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia

scientific article published on 01 August 2018

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

scientific article (publication date: 2013)

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables

scientific article published on July 2011

A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence

scientific article published in April 2008

A novel use of random priming-based single-strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples

scientific article published on 16 December 2019

AI-powered pan-species computational pathology: bridging clinic and wildlife care

preprint

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

scientific article

Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data

scientific article published on 01 September 2018

Author Correction: Resolving genetic heterogeneity in cancer

scientific article published on 01 January 2020

Author Correction: The effects of mutational processes and selection on driver mutations across cancer types

scientific article published on 20 April 2020

Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor.

scientific article

Between-region genetic divergence reflects the mode and tempo of tumor evolution

scientific article published on 05 June 2017

Breast cancer dormancy can be maintained by small numbers of micrometastases.

scientific article

Bridging clinic and wildlife care with AI-powered pan-species computational pathology

scholarly article

Cancer associated fibroblast FAK regulates malignant cell metabolism

scientific article published on 10 March 2020

Cancer: Resolving the stem-cell debate

scientific article published in August 2012

Catch my drift? Making sense of genomic intra-tumour heterogeneity

scientific article published on 6 January 2017

Cell migration leads to spatially distinct but clonally related airway cancer precursors.

scientific article published on 18 February 2014

Characterization of LGR5 stem cells in colorectal adenomas and carcinomas

scientific article

Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation.

scientific article

Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas

scientific article published on 25 January 2010

Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia

scientific article published on 07 November 2008

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

scientific article published on 01 August 2020

Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma

scientific article published on 01 June 2019

Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells.

scientific article

Crypt fusion as a homeostatic mechanism in the human colon

scientific article published on 14 March 2019

Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study

scientific article published on 17 November 2017

Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study.

scientific article published on 23 June 2015

Detecting repeated cancer evolution from multi-region tumor sequencing data

scientific article published on 31 August 2018

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

scientific article published on 5 April 2016

Evolution of Barrett's esophagus through space and time at single-crypt and whole-biopsy levels.

scientific article published on 23 February 2018

Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus

scientific article published on 23 December 2015

Evolutionary dynamics of neoantigens in growing tumors

scientific article published on 14 September 2020

Evolutionary history of human colitis-associated colorectal cancer

article

Field cancerization in Barrett's esophagus

scientific article

Field cancerization in the GI tract.

scientific article published on August 2011

Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis.

scientific article

Field defects in DNA repair: is loss of MGMT an initial event in colorectal carcinogenesis?

scientific article published in November 2010

Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview.

scientific article published on 31 March 2015

Genetic diversity during the development of Barrett's oesophagus-associated adenocarcinoma: how, when and why?

scientific article published on April 2010

Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

scientific article published on 09 November 2020

Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma.

scientific article published on 8 February 2018

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

scientific article

Identification of neutral tumor evolution across cancer types.

scientific article published on 18 January 2016

Immunosuppressive niche engineering at the onset of human colorectal cancer

scientific article published in 2022

Insights Into the Pathophysiology of Esophageal Adenocarcinoma.

scientific article published on 13 October 2017

Investigating the fixation and spread of mutations in the gastrointestinal epithelium.

scientific article published on December 2008

Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

scientific article published on June 2015

LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.

scientific article published on March 2013

Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.

scientific article published on 13 June 2013

Location, location, location! The reality of life for an intestinal stem cell in the crypt

scientific article

Long-term proton pump induced hypergastrinaemia does induce lineage-specific restitution but not clonal expansion in benign Barrett's oesophagus in vivo.

scientific article

Low-grade dysplasia in ulcerative colitis: risk factors for developing high-grade dysplasia or colorectal cancer

scientific article

Measuring cancer evolution from the genome.

scientific article

Measuring single cell divisions in human tissues from multi-region sequencing data

scientific article published on 25 February 2020

Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

scientific article published on 30 March 2020

Modelling the evolution of genetic instability during tumour progression

scientific article published on 26 November 2012

Most low-level microsatellite instability in colorectal cancers can be explained without an elevated slippage rate

scientific article published in June 2008

Multiregion human bladder cancer sequencing reveals tumour evolution, bladder cancer phenotypes and implications for targeted therapy

scientific article published on 18 March 2019

Navigating the path to distant metastasis

scientific article published on 01 July 2020

New paradigms in clonal evolution: punctuated equilibrium in cancer.

scientific article

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.

scientific article published on 30 November 2015

Phenotypic plasticity and genetic control in colorectal cancer evolution

scientific article published in 2022

Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development.

scientific article published on March 2013

Quantification of crypt and stem cell evolution in the normal and neoplastic human colon

scientific article (publication date: 21 August 2014)

Quantification of subclonal selection in cancer from bulk sequencing data

scientific article published on 28 May 2018

Quantification of within-sample genetic heterogeneity from SNP-array data.

scientific article

Quantifying human intestinal stem cell and crypt dynamics: the implications for cancer screening and prevention

scientific article published on 20 January 2016

Re: Mitochondria and tumor progression in ulcerative colitis.

scientific article

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

scientific article published on 01 July 2021

Reply to ‘Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data’

scientific article published on 01 December 2018

Reply: Neutral tumor evolution?

Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

scientific article published in August 2017

Resolving genetic heterogeneity in cancer

scientific article published on 01 July 2019

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

scientific article published on 8 December 2017

Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis

scientific article

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

scientific article published on 31 March 2018

Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data

scientific article published on 29 July 2019

Stem cells and inflammation in the intestine.

scientific article published on January 2011

Stem cells and solid cancers

scientific article published on 05 June 2009

Stem cells and their implications for colorectal cancer.

scientific article published on February 2011

Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

scientific article published on 22 October 2013

Subclonal reconstruction of tumors by using machine learning and population genetics

scientific article published on 02 September 2020

The clonal origins of dysplasia from intestinal metaplasia in the human stomach.

scientific article

The effects of mutational processes and selection on driver mutations across cancer types.

scientific article

The evolutionary landscape of colorectal tumorigenesis ⬇️

scientific article published on 31 August 2018

The human urothelium consists of multiple clonal units, each maintained by a stem cell

scientific article

The mutational signatures of formalin fixation on the human genome

scientific article published in 2022

Tumour Cell Heterogeneity

scientific article

Use of methylation patterns to determine expansion of stem cell clones in human colon tissue.

scientific article published on 28 December 2010

Utilizing DNA mutations to trace epithelial cell lineages in human tissues

scientific article published in January 2012

What Can Be Learnt about Disease Progression in Breast Cancer Dormancy from Relapse Data? ⬇️

scientific article published on May 6, 2013

List of works by Trevor A Graham

A Big Bang model of human colorectal tumor growth

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables

A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence

A novel use of random priming-based single-strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples

AI-powered pan-species computational pathology: bridging clinic and wildlife care

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data

Author Correction: Resolving genetic heterogeneity in cancer

Author Correction: The effects of mutational processes and selection on driver mutations across cancer types

Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor.

Between-region genetic divergence reflects the mode and tempo of tumor evolution

Breast cancer dormancy can be maintained by small numbers of micrometastases.

Bridging clinic and wildlife care with AI-powered pan-species computational pathology

Cancer associated fibroblast FAK regulates malignant cell metabolism

Cancer: Resolving the stem-cell debate

Catch my drift? Making sense of genomic intra-tumour heterogeneity

Cell migration leads to spatially distinct but clonally related airway cancer precursors.

Characterization of LGR5 stem cells in colorectal adenomas and carcinomas

Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation.

Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas

Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma

Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells.

Crypt fusion as a homeostatic mechanism in the human colon

Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study

Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study.

Detecting repeated cancer evolution from multi-region tumor sequencing data

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

Evolution of Barrett's esophagus through space and time at single-crypt and whole-biopsy levels.

Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus

Evolutionary dynamics of neoantigens in growing tumors

Evolutionary history of human colitis-associated colorectal cancer

Field cancerization in Barrett's esophagus

Field cancerization in the GI tract.

Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis.

Field defects in DNA repair: is loss of MGMT an initial event in colorectal carcinogenesis?

Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview.

Genetic diversity during the development of Barrett's oesophagus-associated adenocarcinoma: how, when and why?

Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma.

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

Identification of neutral tumor evolution across cancer types.

Immunosuppressive niche engineering at the onset of human colorectal cancer

Insights Into the Pathophysiology of Esophageal Adenocarcinoma.

Investigating the fixation and spread of mutations in the gastrointestinal epithelium.

Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.

Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.

Location, location, location! The reality of life for an intestinal stem cell in the crypt

Long-term proton pump induced hypergastrinaemia does induce lineage-specific restitution but not clonal expansion in benign Barrett's oesophagus in vivo.

Low-grade dysplasia in ulcerative colitis: risk factors for developing high-grade dysplasia or colorectal cancer

Measuring cancer evolution from the genome.

Measuring single cell divisions in human tissues from multi-region sequencing data

Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

Modelling the evolution of genetic instability during tumour progression

Most low-level microsatellite instability in colorectal cancers can be explained without an elevated slippage rate

Multiregion human bladder cancer sequencing reveals tumour evolution, bladder cancer phenotypes and implications for targeted therapy

Navigating the path to distant metastasis

New paradigms in clonal evolution: punctuated equilibrium in cancer.

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.

Phenotypic plasticity and genetic control in colorectal cancer evolution

Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development.

Quantification of crypt and stem cell evolution in the normal and neoplastic human colon

Quantification of subclonal selection in cancer from bulk sequencing data

Quantification of within-sample genetic heterogeneity from SNP-array data.

Quantifying human intestinal stem cell and crypt dynamics: the implications for cancer screening and prevention

Re: Mitochondria and tumor progression in ulcerative colitis.

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Reply to ‘Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data’

Reply: Neutral tumor evolution?

Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

Resolving genetic heterogeneity in cancer

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data