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List of works by Andrea Sottoriva

A Big Bang model of human colorectal tumor growth

scientific article

Analysis of tumour ecological balance reveals resource-dependent adaptive strategies of ovarian cancer

scientific article published on 21 October 2019

Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data

scientific article published on 01 September 2018

Author Correction: Resolving genetic heterogeneity in cancer

scientific article published on 01 January 2020

Between-region genetic divergence reflects the mode and tempo of tumor evolution

scientific article published on 05 June 2017

Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine

scientific article

Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity.

scientific article published in January 2010

Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer

scientific article

Catch my drift? Making sense of genomic intra-tumour heterogeneity

scientific article published on 6 January 2017

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

scientific article published on 01 August 2020

Defining stem cell dynamics in models of intestinal tumor initiation

scientific article published in November 2013

Detecting repeated cancer evolution from multi-region tumor sequencing data

scientific article published on 31 August 2018

Detecting truly clonal alterations from multi-region profiling of tumours

scientific article published on 27 March 2017

Evolutionary dynamics of neoantigens in growing tumors

scientific article published on 14 September 2020

Evolutionary dynamics of residual disease in human glioblastoma

scientific article published on 01 March 2019

Exploiting evolutionary steering to induce collateral drug sensitivity in cancer

scientific article published on 21 April 2020

Exploring cancer stem cell niche directed tumor growth.

scientific article published on 15 April 2010

Identification of neutral tumor evolution across cancer types.

scientific article published on 18 January 2016

Immunosuppressive niche engineering at the onset of human colorectal cancer

scientific article published in 2022

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.

scientific article published on 14 February 2013

Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial.

scientific article published on 30 August 2018

Many private mutations originate from the first few divisions of a human colorectal adenoma.

scientific article

Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

scientific article published on 27 March 2020

Measuring cancer evolution from the genome.

scientific article

Measuring single cell divisions in human tissues from multi-region sequencing data

scientific article published on 25 February 2020

Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

scientific article published on 30 March 2020

Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity

scientific article published in Nature Communications

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

scientific article

Phenotypic plasticity and genetic control in colorectal cancer evolution

scientific article published in 2022

Quantification of subclonal selection in cancer from bulk sequencing data

scientific article published on 28 May 2018

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

scientific article published on 01 July 2021

Reply to 'Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution'

article by Benjamin Werner et al published 29 October 2018 in Nature Genetics

Reply to ‘Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data’

scientific article published on 01 December 2018

Reply: Neutral tumor evolution?

Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

scientific article published in August 2017

Resolving genetic heterogeneity in cancer

scientific article published on 01 July 2019

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

scientific article published on 8 December 2017

Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data

scientific article published on 29 July 2019

Subclonal reconstruction of tumors by using machine learning and population genetics

scientific article published on 02 September 2020

The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories.

scientific article published on February 2016

The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer

scientific article published on 11 June 2018

The evolutionary landscape of colorectal tumorigenesis ⬇️

scientific article published on 31 August 2018

The shaping and functional consequences of the microRNA landscape in breast cancer

scientific article published on 5 May 2013

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