List of works by Paul W. Armstrong

1-Year Survival in a Randomized Trial of Facilitated Reperfusion

article by Stephen G. Ellis et al published October 2009 in JACC: Cardiovascular Interventions

2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: developed in coll

scientific article published on 10 December 2007

27th Bethesda Conference: matching the intensity of risk factor management with the hazard for coronary disease events. Task Force 5. Stratification of patients into high, medium and low risk subgroups for purposes of risk factor management

scientific article published on April 1996

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Efficacy and Safety of the Oral Soluble Guanylate Cyclase Stimulator: The VICTORIA Trial

scientific article published on 4 October 2017

A comparative evaluation of hemodynamic and neurohumoral effects of nitroglycerin and nifedipine in congestive heart failure.

scientific article

A comparison of U.S. and Canadian cardiac catheterization practices in detecting severe coronary artery disease after myocardial infarction: efficiency, yield and long-term implications

article

A comparison of pharmacologic therapy with/without timely coronary intervention vs. primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial infarction Therapy) study

scientific article (publication date: July 2006)

A comparison of the clinical impact of bleeding measured by two different classifications among patients with acute coronary syndromes

scientific article published on 26 January 2006

A dynamic model forecasting myocardial infarct size before, during, and after reperfusion therapy: an ASSENT-2 ECG/VCG substudy

scientific article

A marriage of enhancement: fibrinolysis and conjunctive therapy

scientific article (publication date: December 2004)

A model for predicting mortality in acute ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: results from the Assessment of Pexelizumab in Acute Myocardial Infarction Trial

scientific article published on 21 September 2010

A new synthetic approach to 2,3-dideoxy-2-fluoro-β-d-threo-pentofuranose, the fluorofuranose unit of the anti-HIV-active nucleoside, β-FddA

article

A novel enoxaparin regime for ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: a WEST sub-study

scientific article published on September 2007

A rapid troponin I assay is not optimal for determination of troponin status and prediction of subsequent cardiac events at suspicion of unstable coronary syndromes

scientific article published in February 2004

A tale of two countries: Insights from the differences in Canadian/American patterns of care for patients with acute coronary syndromes.

scientific article

ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary

article published 3 August 2004 in Circulation

Aborted myocardial infarction after primary percutaneous coronary intervention: magnetic resonance imaging insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial.

scientific article published on 24 November 2012

Aborted myocardial infarction in ST-elevation myocardial infarction: insights from the STrategic Reperfusion Early After Myocardial infarction trial.

scientific article

Aborted myocardial infarction in patients with ST-segment elevation: insights from the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen-3 Trial Electrocardiographic Substudy

scientific article published in July 2004

Aborted myocardial infarction: a new target for reperfusion therapy

scientific article

Activation of the inflammation, coagulation, and fibrinolysis systems, without influence of abciximab infusion in patients with non-ST-elevation acute coronary syndromes treated with dalteparin: a GUSTO IV substudy

scientific article (publication date: February 2004)

Activation of the inflammation, coagulation, and fibrinolysis systems, without influence of abciximab infusion in patients with non-ST–elevation acute coronary syndromes treated with dalteparin: a GUSTO IV substudy11Guest Editor for this manuscript

article by Stefan K James et al published February 2004 in American Heart Journal

Acute Heart Failure and Atrial Fibrillation: Insights From the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) Trial

scientific article

Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Ger

scientific article published on May 2007

Acute heart failure in the emergency department: Short and long-term outcomes of elderly patients with heart failure

scientific article published on 15 February 2008

Acute heart failure: perspectives from a randomized trial and a simultaneous registry

scientific article published on 02 October 2012

Advancing interdisciplinary health research: a synergism not to be denied

scientific article

Adverse outcomes in fibrinolytic-based facilitated percutaneous coronary intervention: insights from the ASSENT-4 PCI electrocardiographic substudy

scientific article published on 04 March 2008

Aetiology, timing and clinical predictors of early vs. late readmission following index hospitalization for acute heart failure: insights from ASCEND-HF.

scientific article published on 29 October 2017

Age and Outcomes in ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

article

Age, outcomes, and treatment effects of fibrinolytic and antithrombotic combinations: Findings from Assessment of the Safety and Efficacy of a New Thrombolytic (ASSENT)-3 and ASSENT-3 PLUS

scientific article published on 01 October 2006

Age, treatment, and outcomes in high-risk non-ST-segment elevation acute coronary syndrome patients: insights from the EARLY ACS trial

scientific article published on 13 July 2012

Aggressive clinical pattern of angina at restenosis following coronary angioplasty in unstable angina

scientific article published on 01 November 1992

Albuminuria and cardiovascular events in patients with acute coronary syndromes: Results from the TRACER trial

scientific article published on 27 April 2016

Aldosterone Antagonists — Last Man Standing? ⬇️

scientific article published on November 14, 2010

Alignment of site versus adjudication committee-based diagnosis with patient outcomes: Insights from the Providing Rapid Out of Hospital Acute Cardiovascular Treatment 3 trial.

scientific article published on 19 August 2015

Alterations in serum sodium in relation to atrial natriuretic factor and other neuroendocrine variables in experimental pacing-induced heart failure

scientific article published on 01 January 1989

Ameliorating reperfusion injury in STEMI: dead or alive?

scientific article

An assessment of ST-segment measurement variability between two core electrocardiogram laboratories

scientific article published on 18 October 2013

An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry

scientific article published in November 2004

Anemia Is Common in Heart Failure and Is Associated With Poor Outcomes

scientific article published on 01 January 2003

Angiographic morphology in unstable angina pectoris

scientific article

Angiographic outcomes with early eptifibatide therapy in non-ST-segment elevation acute coronary syndrome (from the EARLY ACS Trial).

scientific article

Anticoagulant therapy in unstable angina.

scientific article

Anticoagulation after subcutaneous enoxaparin is time sensitive in STEMI patients treated with tenecteplase.

scientific article published in July 2012

Antithrombotic therapy and outcomes of patients with atrial fibrillation following primary percutaneous coronary intervention: results from the APEX-AMI trial

scientific article published on 06 June 2009

Applying novel methods to assess clinical outcomes: insights from the TRILOGY ACS trial

scientific article published on 10 July 2014

Applying the new STEMI guidelines: 1. Reperfusion in acute ST-segment elevation myocardial infarction

scientific article

Applying the new STEMI guidelines: 2. Disturbances of cardiac rhythm after ST-segment elevation myocardial infarction

scientific article published on October 2004

Are international differences in the outcomes of acute coronary syndromes apparent or real? A multilevel analysis

scientific article

Arrival by ambulance in acute heart failure: insights into the mode of presentation from Acute Studies of Nesiritide in Decompensated Heart Failure (ASCEND-HF).

scientific article published on 17 March 2016

Arterial access site and outcomes in patients undergoing percutaneous coronary intervention with and without vorapaxar

scientific article published on 23 December 2015

Ascertainment, classification, and impact of neoplasm detection during prolonged treatment with dual antiplatelet therapy with prasugrel vs. clopidogrel following acute coronary syndrome

scientific article

Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure

scientific article (publication date: 6 June 2006)

Aspirin use post-acute coronary syndromes: intolerance, bleeding and discontinuation

scientific article (publication date: December 2003)

Assessing risk in FRISC

scientific article published on 08 December 2004

Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI): a multicenter, randomized, double-blind, parallel-group, placebo-controlled study of pexelizumab in patients with acute myocardial infarction undergoing primary percutaneous corona

scientific article

Assessment of dyspnea in acute decompensated heart failure: insights from ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) on the contributions of peak expiratory flow

scientific article

Assessment of ventricular function in coronary artery disease by means of atrial pacing and exercise

scientific article published on 01 August 1970

Association Between Very Low Levels of High-Density Lipoprotein Cholesterol and Long-term Outcomes of Patients With Acute Coronary Syndrome Treated Without Revascularization: Insights From the TRILOGY ACS Trial

scientific article

Association between bleeding and mortality among women and men with high-risk acute coronary syndromes: insights from the Early versus Delayed, Provisional Eptifibatide in Acute Coronary Syndromes (EARLY ACS) trial

scientific article published on 5 September 2013

Association of aspirin dose and vorapaxar safety and efficacy in patients with non-ST-segment elevation acute coronary syndrome (from the TRACER Trial).

scientific article published on 25 December 2013

Association of global weather changes with acute coronary syndromes: gaining insights from clinical trials data

scientific article

Association of metabolic syndrome and its individual components with outcomes among patients with high-risk non-ST-segment elevation acute coronary syndromes

scientific article published on 24 April 2014

Association of mortality with years of education in patients with ST-segment elevation myocardial infarction treated with fibrinolysis

scientific article published on January 2011

Association of revascularisation with low mortality in non-ST elevation acute coronary syndrome, a report from GUSTO IV-ACS

scientific article published on 01 September 2004

Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: the GUSTO-I experience

article

Balancing the cyclooxygenase portfolio

scientific article (publication date: 23 May 2006)

Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction: insights from the APEX-AMI trial

scientific article published in July 2012

Baseline Q waves and time from symptom onset to ST-segment elevation myocardial infarction: insights from PLATO on the influence of sex.

scientific article published on 26 March 2015

Baseline Q waves as a prognostic modulator in patients with ST-segment elevation: insights from the PLATO trial

scientific article

Baseline Q-wave surpasses time from symptom onset as a prognostic marker in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention

scientific article

Baseline clinical characteristics of patients recruited into the assessment of treatment with lisinopril and survival study

scientific article published on 01 March 1999

Baseline features of the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial

scientific article published on 09 December 2019

Benefit of Facilitated Percutaneous Coronary Intervention in High-Risk ST-Segment Elevation Myocardial Infarction Patients Presenting to Nonpercutaneous Coronary Intervention Hospitals

Benefit of angiographic spontaneous reperfusion in STEMI: does it extend to diabetic patients?

scientific article published on 15 May 2009

Better Outcomes for Patients Treated at Hospitals That Participate in Clinical Trials

scientific article published on 01 March 2008

Biomarker-Based Risk Model to Predict Cardiovascular Mortality in Patients With Stable Coronary Disease

scientific article published on August 2017

Bleeding events with abciximab in acute coronary syndromes without early revascularization: An analysis of GUSTO IV-ACS.

scientific article published in May 2004

Cardiac Troponin T Levels for Risk Stratification in Acute Myocardial Ischemia

article

Cardiac depression by intravenous disopyramide in patients with left ventricular dysfunction.

scientific article

Cardiac troponin after percutaneous coronary intervention and 1-year mortality in non-ST-segment elevation acute coronary syndrome using systematic evaluation of biomarker trends

scientific article published on 15 May 2013

Cardiogenic shock and heart failure post-percutaneous coronary intervention in ST-elevation myocardial infarction: observations from "Assessment of Pexelizumab in Acute Myocardial Infarction".

scientific article published on July 2011

Cardiology and emergency medicine: United We Stand, divided we fall

scientific article published on 01 February 2002

Cardiovascular and Lifestyle Risk Factors and Cognitive Function in Patients With Stable Coronary Heart Disease

Cardiovascular clinical research in South America

scientific article published on 25 March 2013

Cardiovascular disease on a global scale: defining the path forward for research and practice

scientific article

Cardiovascular drug development: is it dead or just hibernating?

scientific article published on April 2015

Characterization of hemodynamically stable acute heart failure patients requiring a critical care unit admission: Derivation, validation, and refinement of a risk score

scientific article published on 25 March 2017

Charting the course of clinical research: From an inspired past to a promising future

scientific article published on 01 August 2004

Circulating Cardiac Troponin I Levels Measured by a Novel Highly Sensitive Assay in Acute Decompensated Heart Failure: Insights From the ASCEND-HF Trial

scientific article published on 01 August 2018

Circulating Kidney Injury Molecule-1 Levels in Acute Heart Failure: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).

scientific article

Clinical and prognostic implications of circulating pentraxin 3 levels in non ST-elevation acute coronary syndrome

scientific article published on 5 September 2013

Clinical features and outcomes of patients with type 2 myocardial infarction: Insights from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial

scientific article published on 16 October 2017

Clinical lessons learned from experimental heart failure

article

Clinical outcome endpoints in heart failure trials: a European Society of Cardiology Heart Failure Association consensus document

scientific article published on 19 June 2013

Clinical perspectives on reperfusion injury in acute myocardial infarction

scientific article published on 26 February 2014

Clopidogrel does not induce fibrinolysis in healthy subjects

scientific article

Collaborative angiographic patency trial of recombinant staphylokinase (CAPTORS II)

scientific article published on 01 September 2003

Combining baseline clinical descriptors and real-time response to therapy: the incremental prognostic value of continuous ST-segment monitoring in acute myocardial infarction

scientific article published in April 2004

Comparative assessment of short-term adverse events in acute heart failure with cystatin C and other estimates of renal function: results from the ASCEND-HF trial

scientific article published on 11 November 2014

Comparative effects of lidocaine and procainamide on acutely impaired hemodynamics.

scientific article published in August 1976

Comparison of Effectiveness of Enoxaparin Versus Unfractionated Heparin to Reduce Silent and Clinically Apparent Acute Myocardial Infarction in Patients Presenting With Non–ST-Segment Elevation Acute Coronary Syndrome

scientific article published on 15 November 2006

Comparison of benefits and complications of hirudin versus heparin for patients with acute coronary syndromes undergoing early percutaneous coronary intervention

Comparison of incidence of bleeding and mortality of men versus women with ST-elevation myocardial infarction treated with fibrinolysis

scientific article published on 10 November 2011

Comparison of outcomes of patients with myocardial infarction when living alone versus those not living alone

article

Comparison of six-month outcomes for primary percutaneous revascularization for acute myocardial infarction with drug-eluting versus bare metal stents (from the APEX-AMI study).

scientific article published on 7 November 2008

Comparison of the appropriateness of coronary angiography and coronary artery bypass graft surgery between Canada and New York State

scientific article published on September 1994

Comparison of the prognosis of spontaneous and percutaneous coronary intervention-related myocardial infarction.

scientific article

Composite End Points in Clinical Research: A Time for Reappraisal

scientific article published on June 2017

Compromised atrial coronary anatomy is associated with atrial arrhythmias and atrioventricular block complicating acute myocardial infarction

scientific article published on 01 July 2005

Concomitant proton-pump inhibitor use, platelet activity, and clinical outcomes in patients with acute coronary syndromes treated with prasugrel versus clopidogrel and managed without revascularization: insights from the Targeted Platelet Inhibition

scientific article published on 11 June 2015

Contemporary pharmacological reperfusion in ST elevation myocardial infarction

scientific article published on July 2012

Continuous 12-lead ST-segment recovery predicts outcome in acute myocardial infarction better than “snapshot” angiograms of TIMI flow

Coronary patency, infarct size and left ventricular function after thrombolytic therapy for acute myocardial infarction: results from the tissue plasminogen activator: Toronto (TPAT) placebo-controlled trial. TPAT Study Group

scientific article published in June 1991

Coronary reperfusion: numerators searching for denominators

scientific article published in The Lancet

Corrections needed to 2016 ESC guideline and AHA scientific statement on heart failure

scientific article published on 05 April 2017

Correlation between peak expiratory flow rate and NT-proBNP in patients with acute heart failure. An analysis from ASCEND-HF trial

scientific article published on 30 December 2014

Corrigendum to “Reduced dose tenecteplase and outcomes in elderly ST-segment elevation myocardial infarction patients: Insights from the Strategic Reperfusion Early After Myocardial infarction trial” [Am Heart J 169/6 (2015) 890–898]

scientific article published on 01 February 2017

Cost Effectiveness of Early Discharge after Uncomplicated Acute Myocardial Infarction

article

Cost effectiveness of thrombolytic therapy with tissue plasminogen activator as compared with streptokinase for acute myocardial infarction

scientific article published on May 1995

Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis

scientific article

Creatine kinase-MB elevation after percutaneous coronary intervention predicts adverse outcomes in patients with acute coronary syndromes

scientific article published in February 2004

Cycloaddition reactions of oximes; powerful new carbon–carbon bond forming methodology

article

Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease

article

Data and safety monitoring boards: academic credit where credit is due?

scientific article

Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: Experience from GUSTO-IIb

scientific article published on 01 January 1999

Declining in-hospital mortality and increasing heart failure incidence in elderly patients with first myocardial infarction

scientific article published in January 2009

Defining myocardial infarction: a work in progress: Ischaemic heart disease

scientific article published on August 2008

Detection of silent myocardial ischemia in diabetes mellitus

article

Determination of disopyramide and mono-N-desisopropyl-disopyramide in serum by gas-liquid chromatography with nitrogen-selective detection

scientific article published on 01 June 1983

Determining the cost economic "tipping point" for the addition of a regional percutaneous coronary intervention facility.

scientific article

Diabetes and heart failure in the crosshairs: where is the target?

scientific article

Diagnosing Acute Myocardial Infarction in Patients With Left Bundle Branch Block

article

Differences in admission rates and outcomes between men and women presenting to emergency departments with coronary syndromes

scientific article

Differences in treatment, outcomes, and quality of life among patients with heart failure in Canada and the United States

scientific article published on 23 October 2013

Differential occurrence, profile, and impact of first recurrent cardiovascular events after an acute coronary syndrome

scientific article

Differential treatment benefit of platelet glycoprotein IIb/IIIa inhibition with percutaneous coronary intervention versus medical therapy for acute coronary syndromes: exploration of methods

scientific article published in February 2004

Discharge timing and outcomes after uncomplicated non-ST-segment elevation acute myocardial infarction

scientific article published on 20 April 2018

Do baseline atrial electrocardiographic and infarction patterns predict new-onset atrial fibrillation after ST-elevation myocardial infarction? Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction Trial

scientific article published on 4 May 2010

Do countries or hospitals with longer hospital stays for acute heart failure have lower readmission rates?: Findings from ASCEND-HF.

scientific article published on 14 June 2013

Do evidence-based treatments provide incremental benefits to patients with congestive heart failure already receiving angiotensin-converting enzyme inhibitors? A secondary analysis of one-year outcomes from the Assessment of Treatment with Lisinopri

scientific article

Do the investigative sites that take part in a positive clinical trial translate that evidence into practice?

article

Does 24-hour ST-segment resolution postfibrinolysis add prognostic value to a Q wave? An ASSENT 2 electrocardiographic substudy

scientific article published on 01 October 2003

Does a hypertonic saline load predict fluid retention in pacing induced heart failure?

scientific article published on 01 January 1997

Does ambulatory monitoring contribute to exercise testing and myocardial perfusion scintigraphy in the prediction of the extent of coronary artery disease in stable angina?

scientific article published on 01 April 1994

Does chronic Chlamydia pneumoniae infection increase the risk of myocardial injury? Insights from patients with non-ST-elevation acute coronary syndromes

scientific article published on December 2002

Does eptifibatide confer a greater benefit to patients with unstable angina than with non-ST segment elevation myocardial infarction? Insights from the PURSUIT Trial

scientific article published in July 2002

Does silent myocardial infarction add prognostic value in ST-elevation myocardial infarction patients without a history of prior myocardial infarction? Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) Trial

scientific article

Does the discharge ECG provide additional prognostic insight(s) in non-ST elevation ACS patients from that acquired on admission?

scientific article published in March 2003

Drug Treatment of STEMI in the Elderly: Focus on Fibrinolytic Therapy and Insights from the STREAM Trial.

scientific article published on 5 February 2016

Dual Antiplatelet Therapy and Outcomes in Patients With Atrial Fibrillation and Acute Coronary Syndromes Managed Medically Without Revascularization: Insights From the TRILOGY ACS Trial.

scientific article published on 28 July 2016

Dual antiplatelet therapy in patients with diabetes and acute coronary syndromes managed without revascularization

scientific article

Dual natriuretic peptide system in experimental heart failure

article

Duration of eptifibatide infusion after percutaneous coronary intervention and outcomes among high-risk patients with non-ST-segment elevation acute coronary syndrome: insights from EARLY ACS.

scientific article published on September 2013

Duration of symptoms is the key modulator of the choice of reperfusion for ST-elevation myocardial infarction

scientific article published on March 2009

Dynamic modeling of 90-day mortality in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention

scientific article published on 15 January 2013

Dynamic prognostication in non-ST-elevation acute coronary syndromes: insights from GUSTO-IIb and PURSUIT.

scientific article

Early routine percutaneous coronary intervention after fibrinolysis vs. standard therapy in ST-segment elevation myocardial infarction: a meta-analysis

scientific article published on 02 July 2010

Early versus delayed, provisional eptifibatide in acute coronary syndromes

scientific article

Economic analysis of the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT-3) study: costs of reperfusion strategies in acute myocardial infarction

scientific article published in April 2005

Editorial independence for CMAJ: signposts along the road

scientific article published on 3 August 2006

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

scientific article

Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The VITALITY-HFpEF Randomized Clinical Trial

scientific article published on 01 October 2020

Effect of age on efficacy and safety of vorapaxar in patients with non-ST-segment elevation acute coronary syndrome: Insights from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial

scientific article published on 9 June 2016

Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: an observational study

scientific article published in April 2001

Effect of pexelizumab on mortality in patients with acute myocardial infarction or undergoing coronary artery bypass surgery: A systematic overview

Effect of pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to fibrinolysis in acute myocardial infarction: the COMPlement inhibition in myocardial infarction treated with thromboLYtics (COMPLY) trial

scientific article published on 18 August 2003

Effect of prior clopidogrel use on outcomes in medically managed acute coronary syndrome patients

scientific article

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial

scientific article

Effect of vorapaxar on myocardial infarction in the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome (TRA·CER) trial

scientific article published on 25 March 2013

Effects of Socioeconomic Status on Mortality after Acute Myocardial Infarction

scientific article published on 01 January 2007

Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial

scientific article published on 21 July 2018

Effects of hemoperfusion during percutaneous transluminal coronary angioplasty on left ventricular function

scientific article published in June 1991

Effects of platelet glycoprotein IIb/IIIa receptor blockers in non-ST segment elevation acute coronary syndromes: benefit and harm in different age subgroups

scientific article published on 25 October 2006

Effects of propranolol on the hemodynamic, coronary sinus blood flow and myocardial metabolic response to atrial pacing

scientific article published in July 1977

Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial.

scientific article published on 21 June 2006

Efficacy and Safety of Vorapaxar in Non-ST-Segment Elevation Acute Coronary Syndrome Patients Undergoing Noncardiac Surgery

scientific article published on 15 December 2015

Efficacy and safety of tenecteplase in combination with the low-molecular-weight heparin enoxaparin or unfractionated heparin in the prehospital setting: the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 PLUS randomi

scientific article published on 7 July 2003

Efficacy and safety of two unfractionated heparin dosing strategies with tenecteplase in acute myocardial infarction (results from Assessment of the Safety and Efficacy of a New Thrombolytic Regimens 2 and 3)

Efficacy and safety of unfractionated heparin versus enoxaparin: a pooled analysis of ASSENT-3 and -3 PLUS data

scientific article

Efficacy of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: one-year follow-up results of the Assessment of the Safety of a New Thrombolytic-3 (ASSENT-3) randomized trial in acute myocardial infarction

scientific article (publication date: June 2004)

Elderly patients with acute coronary syndromes managed without revascularization: insights into the safety of long-term dual antiplatelet therapy with reduced-dose prasugrel versus standard-dose clopidogrel

scientific article published on 12 July 2013

Electrocardiographic left ventricular hypertrophy in GUSTO IV ACS: an important risk marker of mortality in women

scientific article published on 28 June 2007

Elevated creatine kinase-MB with normal creatine kinase predicts worse outcomes in patients with acute coronary syndromes: results from 4 large clinical trials

scientific article published in January 2006

Elevated left atrial pressure does not cause left-to-right shunting after mitral balloon valvuloplasty

scientific article published on 01 November 1991

Enoxaparin in primary and facilitated percutaneous coronary intervention A formal prospective nonrandomized substudy of the FINESSE trial (Facilitated INtervention with Enhanced Reperfusion Speed to Stop Events).

scientific article published in February 2010

Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial

scientific article

Estimating the length of waits: a description of the period lifetable method and comparison with census and event based methods

article

Etiology and differential diagnosis of acute mitral regurgitation

scientific article

Evaluating Research in Cardiovascular Medicine

scientific article published on 01 March 2011

Evaluation of Cardiac Magnetic Resonance as a Surrogate in ST-Segment Elevation Myocardial Infarction

scientific article published on 13 March 2015

Evaluation of early percutaneous coronary intervention vs. standard therapy after fibrinolysis for ST-segment elevation myocardial infarction: contribution of weighting the composite endpoint

scientific article published on 19 December 2012

Evaluation of paradoxic beneficial effects of smoking in patients receiving thrombolytic therapy for acute myocardial infarction: mechanism of the "smoker's paradox" from the GUSTO-I trial, with angiographic insights. Global Utilization of Streptoki

scientific article

Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction

scientific article published in November 2014

Facilitated PCI in patients with ST-elevation myocardial infarction

scientific article published in May 2008

Facilitated percutaneous coronary intervention versus primary percutaneous coronary intervention: design and rationale of the Facilitated Intervention with Enhanced Reperfusion Speed to Stop Events (FINESSE) trial

scientific article published in April 2004

Facilitated versus primary PCI for acute myocardial infarction – Authors' reply

scientific article published in The Lancet

Failure of investigator adherence to electrocardiographic entry criteria is frequent and influences clinical outcomes: lessons from APEX-AMI.

scientific article published on 29 October 2007

Feasibility and applicability of paramedic-based prehospital fibrinolysis in a large North American center

article

Fibrinolysis for acute myocardial infarction: the future is here and now.

scientific article

Fibrinolysis or primary PCI in myocardial infarction

scientific article

First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation

scientific article (publication date: 21 May 2002)

First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS Trial

scientific article published in March 2005

Forecasting mortality: dynamic assessment of risk in ST-segment elevation acute myocardial infarction

scientific article published on 11 January 2006

Frailty is associated with worse outcomes in non-ST-segment elevation acute coronary syndromes: Insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial

scientific article published on 20 April 2015

Frequency and clinical outcome of cardiogenic shock during acute myocardial infarction among patients receiving reteplase or alteplase. Results from GUSTO-III. Global Use of Strategies to Open Occluded Coronary Arteries.

scientific article

Frequency of transient reductions in left ventricular ejection fraction at rest in coronary artery disease

scientific article published on 01 July 1994

From controlled trials to clinical practice: monitoring transmyocardial revascularization use and outcomes

scientific article published in November 2003

Geographic Differences in Patients in a Global Acute Heart Failure Clinical Trial (from the ASCEND-HF Trial).

scientific article

Global variation in quality of care among patients hospitalized with acute heart failure in an international trial: findings from the acute study clinical effectiveness of nesiritide in decompensated heart failure trial (ASCEND-HF).

scientific article published on 30 July 2013

Glycoprotein IIb/IIIa Receptor Inhibitors in Combination With Vorapaxar, a Platelet Thrombin Receptor Antagonist, Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes (from the TRACER Trial).

scientific article published on 18 February 2015

Guideline adjudicated fibrinolytic failure: incidence, findings, and management in a contemporary clinical trial

scientific article

Health-related quality of life outcomes with prasugrel among medically managed non-ST-segment elevation acute coronary syndrome patients: Insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Corona

scientific article

Heart failure complicating non-ST-segment elevation acute coronary syndrome: timing, predictors, and clinical outcomes

scientific article

Heparin in Acute Coronary Disease — Requiem for a Heavyweight? ⬇️

scientific article published on August 14, 1997

High-degree atrioventricular block, asystole, and electro-mechanical dissociation complicating non-ST-segment elevation myocardial infarction

scientific article

Higher T-Wave Amplitude Associated With Better Prognosis in Patients Receiving Thrombolytic Therapy for Acute Myocardial Infarction (a GUSTO-I Substudy) 11This study was funded by grants from Bayer, New York, New York; CIBA-Corning, Medfield, Massach

scientific article published on 01 May 1998

Highlights from the III International Symposium of Thrombosis and Anticoagulation (ISTA), October 14-16, 2010, São Paulo, Brazil

scientific article published in August 2011

Hospital variation in treatment and outcomes in acute coronary syndromes: Insights from the Alberta Contemporary Acute Coronary Syndrome Patients Invasive Treatment Strategies (COAPT) study.

scientific article

Hospitalization for Recently Diagnosed Versus Worsening Chronic Heart Failure: From the ASCEND-HF Trial

scientific article published on June 2017

How does intermittent pacing modify the response to rapid ventricular pacing in experimental heart failure?

scientific article published on 01 June 1995

How many patients with heart failure are eligible for cardiac resynchronization? Insights from two prospective cohorts

scientific article published on 16 August 2005

Hypertension Control in Adults With Diabetes Mellitus and Recurrent Cardiovascular Events: Global Results From the Trial Evaluating Cardiovascular Outcomes With Sitagliptin

scientific article published on 28 August 2017

Hypotension during hospitalization for acute heart failure is independently associated with 30-day mortality: findings from ASCEND-HF

scientific article published on 3 October 2014

Identifying Low-risk Patients for Early Discharge From Emergency Department Without Using Subjective Descriptions of Chest Pain: Insights From Providing Rapid Out of Hospital Acute Cardiovascular Treatment (PROACT) 3 and 4 Trials.

scientific article published on 6 March 2017

Impact of CYP2C19 Metabolizer Status on Patients With ACS Treated With Prasugrel Versus Clopidogrel

scientific article

Impact of Human Development Index on the profile and outcomes of patients with acute coronary syndrome

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Impact of smoking status on platelet function and clinical outcomes with prasugrel vs. clopidogrel in patients with acute coronary syndromes managed without revascularization: Insights from the TRILOGY ACS trial

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Influence of Patient Goals of Care on Performance Measures in Patients Hospitalized for Heart Failure: An Analysis of the Enhanced Feedback For Effective Cardiac Treatment (EFFECT) Registry.

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Insufficient reduction in heart rate during hospitalization despite beta-blocker treatment in acute decompensated heart failure: insights from the ASCEND-HF trial

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Interprovincial Differences in Canadian Coronary Care Unit Resource Use and Outcomes.

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Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease

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Long-Term Results After the Glycoprotein IIb/IIIa Inhibitor Abciximab in Unstable Angina: One-Year Survival in the GUSTO IV-ACS (Global Use of Strategies To Open Occluded Coronary Arteries IV--Acute Coronary Syndrome) Trial

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Low doses vs. high doses of the angiotensin converting-enzyme inhibitor lisinopril in chronic heart failure: a cost-effectiveness analysis based on the Assessment of Treatment with Lisinopril and Survival (ATLAS) study

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Predictors of clinical outcomes in acute decompensated heart failure: Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure outcome models

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Predictors of stroke within 30 days in patients with non-ST-segment elevation acute coronary syndromes

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Prehospital management of acute ST-elevation myocardial infarction: a time for reappraisal in North America

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Prognostic usefulness of white blood cell count and temperature in acute myocardial infarction (from the CARDINAL Trial).

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Proportion of patients followed in a specialized heart failure clinic needing an implantable cardioverter defibrillator as determined by applying different trial eligibility criteria

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Providing Rapid Out of Hospital Acute Cardiovascular Treatment 4 (PROACT-4).

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Public sensationalism and clinical trials: how to address the challenges of science?

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Race, Bleeding, and Outcomes in STEMI Patients Treated with Fibrinolytic Therapy

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Randomized trial of warfarin, aspirin, and clopidogrel in patients with chronic heart failure: the Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) trial

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Reactivation of ischemic events in acute coronary syndromes: results from GUSTO-IIb. Gobal Use of Strategies To Open occluded arteries in acute coronary syndromes

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Renal failure in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention: Predictors, clinical and angiographic features, and outcomes

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Reperfusion before percutaneous coronary intervention in ST-elevation myocardial infarction patients is associated with lower N-terminal pro-brain natriuretic peptide levels during follow-up, irrespective of pre-treatment with full-dose fibrinolysis

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Response to letter "associations of inflammatory biomarkers to body mass index among patients with acute coronary syndrome".

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Secondary Prevention of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus: International Insights From the TECOS Trial (Trial Evaluating Cardiovascular Outcomes With Sitagliptin).

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Sex differences in mortality following acute coronary syndromes

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Sex-Stratified Trends in Enrollment, Patient Characteristics, Treatment, and Outcomes Among Non-ST-Segment Elevation Acute Coronary Syndrome Patients: Insights From Clinical Trials Over 17 Years

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Sharing Data from Cardiovascular Clinical Trials--A Proposal

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Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial

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Sitagliptin and risk of fractures in type 2 diabetes: Results from the TECOS trial.

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Spontaneous MI After Non-ST-Segment Elevation Acute Coronary Syndrome Managed Without Revascularization: The TRILOGY ACS Trial

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Stereoselective synthesis of (8R,8aS)-8-methylhexahydroindolizin-5-one

Strategic lessons from the clinical event classification process for the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial

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Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes: Insights From the TRACER Trial

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Stroke after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction: timing, characteristics, and clinical outcomes

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Sudden Cardiac Death After Non-ST-Segment Elevation Acute Coronary Syndrome

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Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND-HF.

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Sustained ventricular arrhythmias among patients with acute coronary syndromes with no ST-segment elevation: incidence, predictors, and outcomes

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Sustained ventricular arrhythmias and mortality among patients with acute myocardial infarction: results from the GUSTO-III trial

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Synthesis of the putative structures of homopumiliotoxins 235C and 233F

Tandem intramolecular Michael addition and 1,3-dipolar cycloaddition reactions of oximes; versatile new carbon–carbon bond forming methodology

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Temporal Biomarker Profiling Reveals Longitudinal Changes in Risk of Death or Myocardial Infarction in Non-ST-Segment Elevation Acute Coronary Syndrome

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Temporal and Provincial Variation in Ambulance Use Among Patients Who Present to Acute Care Hospitals With ST-Elevation Myocardial Infarction.

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Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction

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Temporal trends in patient and treatment delay among men and women presenting with ST-elevation myocardial infarction.

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Testosterone supplementation in heart failure: a meta-analysis

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Testosterone therapy in women with heart failure "why can't a woman be more like a man?".

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The 49th parallel: How much latitude?

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The Canadian Academy of Health Sciences: coming of age at the right time

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The Choice Is Reperfusion Therapy

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The Early Glycoprotein IIb/IIIa Inhibition in Non–ST-Segment Elevation Acute Coronary Syndrome (EARLY ACS) trial: A randomized placebo-controlled trial evaluating the clinical benefits of early front-loaded eptifibatide in the treatment of patients

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The Effects of Climate Change on Cardiac Health

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The Power of More Than One

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The Strategic Reperfusion Early After Myocardial Infarction (STREAM) study

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The Warfarin and Antiplatelet Therapy in Heart Failure trial (WATCH): rationale, design, and baseline patient characteristics

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The association between meteorological events and acute heart failure: new insights from ASCEND-HF.

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The burden of non-cardiac comorbidities and association with clinical outcomes in an acute heart failure trial - insights from ASCEND-HF

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The clinical course of health status and association with outcomes in patients hospitalized for heart failure: insights from ASCEND-HF

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The ebb and flow of the NHS waiting list: how do recruitment and admission affect event-based measures of the length of 'time-to-admission'?

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The failure of orally administered glycoprotein IIb/IIIa inhibitors to prevent recurrent cardiac events

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The forgotten lead: does aVR ST-deviation add insight into the outcomes of ST-elevation myocardial infarction patients?

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The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations

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The future of clinical trials in secondary prevention after acute coronary syndromes ⬇️

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The impact of anthropomorphic indices on clinical outcomes in patients with acute ST-elevation myocardial infarction

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The impact of gender on the treatment and outcomes of patients with early reinfarction after fibrinolysis: insights from ASSENT-2⋆

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The impact of place of enrollment and delay to reperfusion on 90-day post-infarction mortality in the ASSENT-4 PCI trial: assessment of the safety and efficacy of a new treatment strategy with percutaneous coronary intervention

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The influence of time from symptom onset and reperfusion strategy on 1-year survival in ST-elevation myocardial infarction: A pooled analysis of an early fibrinolytic strategy versus primary percutaneous coronary intervention from CAPTIM and WEST

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The long-term effects of dietary sodium restriction on clinical outcomes in patients with heart failure. The SODIUM-HF (Study of Dietary Intervention Under 100 mmol in Heart Failure): a pilot study.

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The organization, function, and outcomes of ST-elevation myocardial infarction networks worldwide: current state, unmet needs and future directions

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The prognostic value of creatine kinase elevations extends across the whole spectrum of acute coronary syndromes

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The prognostic value of the admission and predischarge electrocardiogram in acute coronary syndromes: The GUSTO-IIb ECG Core Laboratory experience

The relationship between baseline risk and mortality in ST-elevation acute myocardial infarction treated with pharmacological reperfusion: Insights from the Global Utilization of Strategies To open Occluded arteries (GUSTO) V trial

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The relationship between left ventricular ejection fraction and mortality in patients with acute heart failure: insights from the ASCEND-HF Trial

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The relationship between meteorological conditions and index acute coronary events in a global clinical trial

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The spectrum of unstable angina: Prognostic role of serum creatine kinase determination

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The typing of fetal antigen 2 in human amniotic fluid

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The use of beta-blockers in a tertiary care heart failure clinic: dosing, tolerance, and outcomes

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Third Universal Definition of Myocardial Infarction

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Thrombin-receptor antagonist vorapaxar in acute coronary syndromes

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Time from symptom onset to treatment and outcomes after thrombolytic therapy. GUSTO-1 Investigators.

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Time to treatment and the impact of a physician on prehospital management of acute ST elevation myocardial infarction: insights from the ASSENT-3 PLUS trial

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Time-Varying Effects of Prasugrel Versus Clopidogrel on the Long-Term Risks of Stroke After Acute Coronary Syndromes: Results From the TRILOGY ACS Trial

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Time-based risk assessment after myocardial infarction. Implications for timing of discharge and applications to medical decision-making

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Timing of death and myocardial infarction in patients with non-ST elevation acute coronary syndromes: insights from randomized clinical trials

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Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction

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To transfer or not to transfer: acute myocardial infarction reperfusion

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Torsemide Versus Furosemide in Patients With Acute Heart Failure (from the ASCEND-HF Trial)

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Towards a new order in cardiovascular medicine: re-engineering through global collaboration

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Trade-off of myocardial infarction vs. bleeding types on mortality after acute coronary syndrome: lessons from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) randomized trial

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Transatlantic Comparison of ST-Segment Elevation Myocardial Infarction Guidelines: Insights From the United States and Europe

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Transfer times and outcomes in patients with ST-segment-elevation myocardial infarction undergoing interhospital transfer for primary percutaneous coronary intervention: APEX-AMI insights

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Transfusion and mortality in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention

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Transition From Meeting Abstract to Full-length Journal Article for Randomized Controlled Trials

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Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment-Elevation Acute Coronary Syndromes Clinical Trials

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Trends in clinical trials of non-ST-segment elevation acute coronary syndromes over 15 years

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Troponin I in acute decompensated heart failure: insights from the ASCEND-HF study

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Troponin T and quantitative ST-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients

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Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome: prospective verification in the GUSTO-IV trial

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Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome: a GUSTO-IV substudy

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Troponin-T and N-terminal pro-B-type natriuretic peptide predict mortality benefit from coronary revascularization in acute coronary syndromes: a GUSTO-IV substudy

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Two hard lessons ⬇️

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Unexplained international differences in clinical outcomes after acute myocardial infarction and fibrinolytic therapy: lessons from the Hirulog and Early Reperfusion or Occlusion (HERO)-2 trial

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Universal definition of myocardial infarction

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Unraveling the spectrum of left bundle branch block in acute myocardial infarction: insights from the Assessment of the Safety and Efficacy of a New Thrombolytic (ASSENT 2 and 3) trials

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Upstream Clopidogrel Use and the Efficacy and Safety of Early Eptifibatide Treatment in Patients With Acute Coronary Syndrome

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Upstream use of small-molecule glycoprotein iib/iiia inhibitors in patients with non-ST-segment elevation acute coronary syndromes: a systematic overview of randomized clinical trials

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Use of electrocardiogram indices of myocardial ischemia for risk stratification and decision making of reperfusion strategies

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Use of evidence-based medicine for acute coronary syndromes in the elderly and very elderly: insights from the Sibrafiban vs aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes trials

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Use of glycoprotein IIb/IIIa inhibitors in primary percutaneous coronary intervention: insights from the APEX-AMI trial

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Use of renin-angiotensin system blockers in acute coronary syndromes: findings from Get With the Guidelines-Coronary Artery Disease Program

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Use of resources, quality of life, and clinical outcomes in patients with and without new Q waves after thrombolytic therapy for acute myocardial infarction (from the GUSTO-I trial).

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Use of thienopyridine prior to presentation with non-ST-segment elevation acute coronary syndrome and association with safety and efficacy of vorapaxar: insights from the TRACER trial

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Usefulness and safety of vorapaxar in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention (from the TRACER Trial).

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Usefulness of biomarkers for predicting long-term mortality in patients with diabetes mellitus and non-ST-elevation acute coronary syndromes (a GUSTO IV substudy).

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Usefulness of exercise electrocardiography and thallium scintigraphy in unstable angina pectoris in predicting the extent and severity of coronary artery disease

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Usefulness of ischemic response to mental stress in predicting silent myocardial ischemia during ambulatory monitoring

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Usefulness of spironolactone in a specialized heart failure clinic

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Validation of BARC Bleeding Criteria in Patients With Acute Coronary Syndromes: The TRACER Trial

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Variation in the use of stress testing and outcomes in patients with non-ST-elevation acute coronary syndromes: insights from GUSTO IIb.

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Variations in practice and outcomes in patients undergoing primary percutaneous coronary intervention in the United States and Canada: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI) trial

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Variations in pre-hospital fibrinolysis process of care: insights from the Assessment of the Safety and Efficacy of a New Thrombolytic 3 Plus international acute myocardial infarction pre-hospital care survey

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Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction

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Vorapaxar in acute coronary syndrome patients undergoing coronary artery bypass graft surgery: subgroup analysis from the TRACER trial (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome).

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Vorapaxar in patients with peripheral artery disease and acute coronary syndrome: insights from Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER).

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Vorapaxar with or without clopidogrel after non-ST-segment elevation acute coronary syndromes: results from the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome trial

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Vorapaxar, a platelet thrombin-receptor antagonist, in medically managed patients with non-ST-segment elevation acute coronary syndrome: results from the TRACER trial.

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Warfarin use and outcomes in patients with atrial fibrillation complicating acute coronary syndromes

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What do we know? Limitations of the two methods most commonly used to estimate the length of the prospective wait

scientific article published on February 2009

What is the frequency and functional and clinical significance of complex lesions in non–infarct-related arteries after fibrinolysis for acute ST-elevation myocardial infarction?

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Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome

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Worsening heart failure during hospitalization for acute heart failure: Insights from the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF)

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X=y-zh systems as potential 1,3-dipoles—5

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