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List of works by Ursula Fearon

A clinically based protein discovery strategy to identify potential biomarkers of response to anti-TNF-α treatment of psoriatic arthritis

scientific article published on 24 June 2015

A critical review of the origin and control of adrenal androgens

scientific journal article

A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A.

scientific article

Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse.

scientific article published on 20 July 2007

Acute Serum Amyloid A induces cell migration cytoskeletal rearrangement and Notch signalling in rheumatoid arthritis.

scientific article published on 9 February 2012

Acute serum amyloid A induces migration, angiogenesis, and inflammation in synovial cells in vitro and in a human rheumatoid arthritis/SCID mouse chimera model.

scientific article published on 30 April 2010

Acute serum amyloid A is an endogenous TLR2 ligand that mediates inflammatory and angiogenic mechanisms

scientific article published on 19 August 2015

Acute serum amyloid A regulates cytoskeletal rearrangement, cell matrix interactions and promotes cell migration in rheumatoid arthritis

scientific article published on 10 April 2011

Acute-phase serum amyloid A regulates tumor necrosis factor α and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy.

scientific article

Acute-phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment, and matrix degradation in rheumatoid arthritis through an NF-κB–dependent signal transduction pathway

scientific article published on 01 January 2006

Altered expression of microRNA-23a in psoriatic arthritis modulates synovial fibroblast pro-inflammatory mechanisms via phosphodiesterase 4B

scientific article published on 01 September 2018

Altered metabolic pathways regulate synovial inflammation in Rheumatoid Arthritis

scientific article published on 11 November 2018

Angiogenesis and blood vessel stability in inflammatory arthritis

scientific article published in March 2010

Angiogenesis in arthritis: methodological and analytical details

scientific article published in January 2007

Angiogenesis in psoriasis and psoriatic arthritis: clues to disease pathogenesis

scientific article

Angiopoietins, growth factors, and vascular morphology in early arthritis.

scientific article published in February 2003

Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis

scientific article published on 09 January 2019

Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis

scientific article published on 10 December 2018

Biomarkers for rheumatoid and psoriatic arthritis.

scientific article published on 28 April 2015

Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures

scientific article published on 23 February 2011

Brief Report: Genetic Variation of the α1 -Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis

scientific article published on 13 April 2017

C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis

scientific journal article

CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression.

scientific article published on 28 April 2017

COVID-19 and rheumatic musculoskeletal disease patients: infection rates, attitudes and medication adherence in an Irish population

scientific article published on 09 November 2020

Cell metabolism as a potentially targetable pathway in RA

scientific article published on 01 February 2019

Cellular and molecular perspectives in rheumatoid arthritis

scientific article

Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications

scientific article published in 2022

Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy--a single centre, open-label study

scientific article

Comparison of interferon {gamma} release assays and conventional screening tests before tumour necrosis factor {alpha} blockade in patients with inflammatory arthritis.

scientific article

Comparison of remission criteria in a tumour necrosis factor inhibitor treated rheumatoid arthritis longitudinal cohort: patient global health is a confounder

scientific article published on 24 December 2013

Decreased CD20 expression in rheumatoid arthritis synovium following 8 weeks of rituximab therapy

scientific article published on 01 July 2008

Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease.

scientific article

Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis

scientific article published on 3 September 2014

Downregulation of the inhibitor of apoptosis protein survivin in keratinocytes and endothelial cells in psoriasis skin following infliximab therapy

scientific article

Dysregulated bioenergetics: a key regulator of joint inflammation.

scientific article published on 24 March 2016

Early changes in serum type ii collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy

scientific article published on 01 September 2007

Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection

scientific article published on 3 August 2012

Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis

scientific article published on 06 December 2018

Enrichment of polyfunctional T cells in PsA synovial tissue. Response to: 'Polyfunctional TEM cells in psoriatic arthritis synovium skewed towards Th17 cells' by Raychaudhuri et al

scientific article published on 08 January 2020

Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials

scientific article published on 24 November 2010

Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells.

scientific article

Functional characterization of NF- B inhibitor-like protein 1 (NF BIL1), a candidate susceptibility gene for rheumatoid arthritis

article

High-dose cyclophosphamide with stem cell rescue for severe rheumatoid arthritis: Short-term efficacy correlates with reduction of macroscopic and histologic synovitis

article

Histamine contributes to increased RANKL to osteoprotegerin ratio through altered nuclear receptor 4A activity in human chondrocytes.

scientific article

Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies.

scientific article published on 23 July 2009

Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathway

scientific article published on September 2009

Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis.

scientific article published on 13 February 2014

Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis

scientific article published on 01 August 2011

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

scientific article published on 26 May 2016

Hypoxia, oxidative stress and inflammation

scientific article published on 27 March 2018

Hypoxia: how does the monocyte-macrophage system respond to changes in oxygen availability?

scientific article published on 29 October 2013

IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates

scientific article

Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.

scientific article published on 28 February 2018

Increased Expression of the Orphan Nuclear Receptor NURR1 in Psoriasis and Modulation following TNF-α Inhibition

scientific article published on 02 August 2007

Increased T Cell Plasticity With Dysregulation of Follicular Helper T, Peripheral Helper T, and Treg Cell Responses in Children With Juvenile Idiopathic Arthritis and Down Syndrome-Associated Arthritis

scientific article published on 12 March 2020

Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting.

scientific article published on October 2006

Insulin Resistant Pathways are associated with Disease Activity in Rheumatoid Arthritis and are Subject to Disease Modification through Metabolic Reprogramming; A Potential Novel Therapeutic Approach

scientific article published on 16 December 2019

Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus.

scientific article

Interleukin 12 and interleukin 23 play key pathogenic roles in inflammatory and proliferative pathways in giant cell arteritis

scientific article published on 10 August 2018

Interleukin-17A induction of angiogenesis, cell migration, and cytoskeletal rearrangement

scientific article published on 01 November 2011

Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia ⬇️

scientific article

Interleukin‐27: A master regulator in inflammation ⬇️

scientific article published on 01 August 2011

Intra-adrenal factors are not involved in the differential control of cortisol and adrenal androgens in human adrenals

scientific article published on May 1998

Is remission a more realistic goal in psoriatic arthritis?

scientific article

Is the serum amyloid A we use really serum amyloid A? Comment on the article by Connolly et al. Reply

scientific article published in January 2013

JAK/STAT Blockade Alters Synovial Bioenergetics, Mitochondrial Function, and Proinflammatory Mediators in Rheumatoid Arthritis

scientific article published on 27 October 2018

Key Challenges in Rheumatic and Musculoskeletal Disease Translational Research

scientific article published on 18 November 2014

Knee joint synovitis: study of correlations and diagnostic performances of ultrasonography compared with histopathology.

scientific article

Macrophages in synovial inflammation

scientific article published on 10 October 2011

Matrix metalloproteinase 9, apoptosis, and vascular morphology in early arthritis

scientific article published on 01 September 2001

Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis.

scientific article published on 25 November 2011

Non-ACTH POMC fragments stimulate aldosterone production by human adrenal cells in vitro

scientific article published on September 1998

Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2

scientific article published on 17 November 2012

Notch-1 mediates endothelial cell activation and invasion in psoriasis

scientific article published in February 2014

Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis

scientific article published on 01 July 2012

Novel gene targets for miRNA146a and miRNA155 in anterior uveitis

article

Oncostatin M in rheumatoid arthritis: a key cytokine acts synergistically with other proinflammatory cytokines to promote human cartilage loss.

scientific article published on 17 February 2005

Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures

scientific article published on 01 October 2006

Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription

scientific article published on 01 July 2012

Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint.

scientific article

Oxidative stress impairs energy metabolism in primary cells and synovial tissue of patients with rheumatoid arthritis.

scientific article

Pathways of cell activation in spondyloarthropathies.

scientific article

Performance characteristics and predictors of temporal artery ultrasound for the diagnosis of giant cell arteritis in routine clinical practice in a prospective cohort

scientific article published on 04 January 2019

Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity.

scientific article

Redox-mediated angiogenesis in the hypoxic joint of inflammatory arthritis

scientific article

Regulation of Inflammation and Angiogenesis in Giant Cell Arteritis by Acute-Phase Serum Amyloid A.

scientific article published on 27 May 2015

Remission in psoriatic arthritis: is it possible and how can it be predicted?

scientific article

Reply

scientific article published on 08 November 2017

Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis

scientific article published on 22 February 2017

Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy

scientific article published on 20 March 2006

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells

scientific article

Response to: 'Regulatory role of the JAK STAT kinase signalling system on the IL-23/IL-17 cytokine axis in psoriatic arthritis' by Raychaudhuri et al.

scientific article published on 8 February 2017

Response to: ustekinumab inhibits Th1 and Th17 polarisation in a giant-cell arteritis patient by Samson et al.

scientific article

Rheumatoid arthritis CD14<sup>+</sup> monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease

scientific article published on 19 January 2021

Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups

scientific article published on 03 December 2018

Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

scientific article

Synovial Immunophenotype and Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis Patients: Relationship to Treatment Response and Radiologic Prognosis

scientific article published on 21 July 2017

Synovial cytokine and growth factor regulation of MMPs/TIMPs: implications for erosions and angiogenesis in early rheumatoid and psoriatic arthritis patients

scientific article published in June 1999

Synovial tissue hypoxia and inflammation in vivo

scientific article

Synovial tissue research: a state-of-the-art review

scientific article

Synovial tissue research: a state-of-the-art review

scientific article published on 01 September 2017

Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers

scientific article

The Utility and Limitations of CRP, ESR and DAS28-CRP in Appraising Disease Activity in Rheumatoid Arthritis

scholarly article by Carl K Orr et al published 2018 in Frontiers in Medicine

The effects of alcohol consumption and its associations with disease activity among 979 patients with inflammatory arthritis

The pathogenesis of psoriatic arthritis

scientific article published in The Lancet

The pathogenic role of dendritic cells in non-infectious anterior uveitis

scientific article published on 25 May 2018

The pattern-recognition receptor nucleotide-binding oligomerization domain--containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts

scientific article

The role of metabolism in the pathogenesis of osteoarthritis

scientific article published on 06 April 2017

The steroidogenic effects of β-endorphin and joining peptide: a potential role in the modulation of adrenal androgen production

article

The value of serum type II collagen epitope measurement in assessing early clinical response to treatment with anti-tumour necrosis factor alpha therapy in rheumatoid arthritis

scholarly article by RH Mullan et al published 2005 in Arthritis Research and Therapy

Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors

scientific article

Toll-like receptor 2 (TLR2) induces migration and invasive mechanisms in rheumatoid arthritis.

scientific article published on 9 June 2015

Toll-like receptor 2 induced angiogenesis and invasion is mediated through the Tie2 signalling pathway in rheumatoid arthritis.

scientific article

Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia

scientific article published on 01 April 2011

Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity.

scientific article published on 6 August 2013

Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: Relationship to mediators of systemic and local inflammation

scientific article published on 01 November 2003

Ustekinumab for refractory giant cell arteritis: A prospective 52-week trial

scientific article published on 22 April 2018

Ustekinumab for the treatment of refractory giant cell arteritis

scientific article published on 03 May 2016

What makes psoriatic and rheumatoid arthritis so different?

scientific article

miR-17-5p reduces inflammation and bone erosions in collagen induced arthritis mice and directly targets the JAK-STAT pathway in rheumatoid arthritis fibroblast-like synoviocytes

scientific article published on 19 July 2020

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