List of works - Mohamed A. Ismail

A SiCl4–ZnCl2 induced general, mild and efficient one-pot, three-component synthesis of β-amido ketone libraries

A new convenient procedure for the thionation of carbonyl compounds utilizing tetrachlorosilane–sodium sulfide

Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes

scientific article published on June 2006

Adsorption of Cu(II), Cd(II), Hg(II), Pb(II) and Zn(II) from aqueous single metal solutions by guanyl-modified cellulose

scientific article

An efficient synthesis of 5,5′-diaryl-2,2′-bichalcophenes

Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines

scientific article published on 27 February 2019

Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

scientific article

Antiprotozoal agents as water soluble singlet oxygen photosensitizers: Imidazo[1,2-a]pyridine and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridine derivatives

Azaterphenyl diamidines as antileishmanial agents

scientific article published on 30 October 2007

Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruzi

scientific article

CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement

scientific article published on November 2013

Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug

scientific article published on 6 December 2012

DNA minor groove induced dimerization of heterocyclic cations: compound structure, binding affinity, and specificity for a TTAA site

scientific article published on 14 August 2010

Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif

scientific article published on 13 October 2007

Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

scientific article published in October 2004

Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents

scientific article published on 15 August 2005

Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents

scientific article

Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes

scientific article published on 21 May 2007

Discovery of new G-quadruplex binding chemotypes

scientific article published on January 2014

Effect of solvent and encapsulation in β-cyclodextrin on the photophysical properties of 4-[5-(thiophen-2-yl)furan-2-yl]benzamidine

Efficacy of two novel 2,2'-bifurans to inhibit methicillin-resistant Staphylococcus aureus infection in male mice in comparison to vancomycin

scientific article

Efficacy study of novel diamidine compounds in a Trypanosoma evansi goat model

scientific article

Evaluation of the biological activity of novel monocationic fluoroaryl-2,2'-bichalcophenes and their analogues

scientific article

Experimental and theoretical studies on corrosion inhibition of 4-amidinophenyl-2,2′-bifuran and its analogues in acidic media

scholarly article in RSC Advances, vol. 7 no. 73, 2017

Facile construction of substituted pyrimido[4,5-d]pyrimidones by transformation of enaminouracil

scientific article published on 16 May 2012

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

scientific article published on 7 November 2017

Green fluorescent diamidines as diagnostic probes for trypanosomes

scientific article published on 23 December 2013

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

scientific article published on 01 February 2019

Heterocyclic dications as a new class of telomeric G-quadruplex targeting agents

scientific article published on January 2012

In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.

scientific article published on 25 January 2010

In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness

scientific article

In vitro metabolism of an orally active O-methyl amidoxime prodrug for the treatment of CNS trypanosomiasis

scientific article published in March 2005

Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity

scientific article

Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures. ⬇️

scientific article

Microscopic rearrangement of bound minor groove binders detected by NMR.

scientific article

New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289

scientific article published on 20 July 2009

Novel 4-substituted phenyl-2,2'-bichalcophenes and aza-analogs as antibacterial agents: a structural activity relationship

scientific article published on 22 March 2013

Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents

scientific article

Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

scientific article published on 29 February 2008

Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove

scientific article published in November 2005

Peculiar reaction behaviour of barbituric acid derivatives towards aromatic amines

Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.

scientific article published on 14 June 2015

Progress in the chemistry of 4- thiazolidinones

SYNTHESIS OF NOVEL BITHIOPHENE-SUBSTITUTED HETEROCYCLES BEARING CARBONITRILE GROUPS.

scientific article

Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis

scientific article

Silicon-mediated Direct Conversion of Acyl Chlorides to Carbamoyl Azides or/and Tetrazolinones under Mild Conditions

Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and charge

article

Synthesis and CharacterizationviaMolecular Quantum Parameters of 2H-Thiazolo[3,2-a]pyrimidine-3,5,7(6H)-trione

Synthesis and Transformations of 2-Substituted Tetrahydro-4 H -benzo[4,5]thieno[2,3-d][1,3]oxazines and 2,3-Disubstituted Hexahydrobenzo[4,5]thieno[2,3-d]pyrimidines

Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum

scientific article published on 7 August 2009

Synthesis and antiproliferative activity of monocationic arylthiophene derivatives

scientific article published on 2 December 2016

Synthesis and antiprotozoal activity of aza-analogues of furamidine

scientific article published in October 2003

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives

scientific article published on 24 June 2013

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.

scientific article published on 18 October 2007

Synthesis and biological evaluation of some new Thiazolo[3,2-a][1,3,5]triazine derivatives

Synthesis and characterization of novel ion-imprinted guanyl-modified cellulose for selective extraction of copper ions from geological and municipality sample

scientific article published on 20 April 2018

Synthesis of Benzyloxybromobenzonitriles

Synthesis of deuterium and15N-labelled 2,5-Bis[5-amidino-2-pyridyl]furan and 2,5-Bis[5-(methoxyamidino)-2-pyridyl]furan

Synthesis of deuterium-labelled 6-[5-(4-amidinophenyl)furan-2-yl]nicotinamidine andN-alkoxy-6-{5-[4-(N-alkoxyamidino)phenyl]- furan-2-yl}-nicotinamidines

scholarly article by Mohamed A. Ismail & David W. Boykin published 30 March 2004 in Journal of Labelled Compounds and Radiopharmaceuticals

Synthesis, DNA Affinity, and Antiprotozoal Activity of Linear Dications: Terphenyl Diamidines and Analogues

scientific article published on 01 August 2006

Synthesis, DNA affinity, and antimicrobial activity of 4-substituted phenyl-2,2′-bichalcophenes and aza-analogues

Synthesis, antimicrobial activity and molecular modeling study of substituted 5-aryl-pyrimido[5,4-c]quinoline-2,4-diones

scientific article

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines.

scientific article published on 11 March 2016

Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines

scientific journal article

The adaptive potential of a survival artist: characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures.

scientific article

The position of imidazopyridine and metabolic activation are pivotal factors in the antimutagenic activity of novel imidazo[1,2-a]pyridine derivatives

scientific article published on 6 June 2013

The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA

scientific article

The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine

scientific article published on 13 February 2014

Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi ⬇️

scientific article published on November 11, 2010

Water-mediated binding of agents that target the DNA minor groove

scientific article

List of works by Mohamed A. Ismail

A SiCl4–ZnCl2 induced general, mild and efficient one-pot, three-component synthesis of β-amido ketone libraries

A new convenient procedure for the thionation of carbonyl compounds utilizing tetrachlorosilane–sodium sulfide

Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes

Adsorption of Cu(II), Cd(II), Hg(II), Pb(II) and Zn(II) from aqueous single metal solutions by guanyl-modified cellulose

An efficient synthesis of 5,5′-diaryl-2,2′-bichalcophenes

Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines

Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

Antiprotozoal agents as water soluble singlet oxygen photosensitizers: Imidazo[1,2-a]pyridine and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridine derivatives

Azaterphenyl diamidines as antileishmanial agents

Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruzi

CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement

Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug

DNA minor groove induced dimerization of heterocyclic cations: compound structure, binding affinity, and specificity for a TTAA site

Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif

Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents

Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents

Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes

Discovery of new G-quadruplex binding chemotypes

Effect of solvent and encapsulation in β-cyclodextrin on the photophysical properties of 4-[5-(thiophen-2-yl)furan-2-yl]benzamidine

Efficacy of two novel 2,2'-bifurans to inhibit methicillin-resistant Staphylococcus aureus infection in male mice in comparison to vancomycin

Efficacy study of novel diamidine compounds in a Trypanosoma evansi goat model

Evaluation of the biological activity of novel monocationic fluoroaryl-2,2'-bichalcophenes and their analogues

Experimental and theoretical studies on corrosion inhibition of 4-amidinophenyl-2,2′-bifuran and its analogues in acidic media

Facile construction of substituted pyrimido[4,5-d]pyrimidones by transformation of enaminouracil

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Green fluorescent diamidines as diagnostic probes for trypanosomes

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

Heterocyclic dications as a new class of telomeric G-quadruplex targeting agents

In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.

In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness

In vitro metabolism of an orally active O-methyl amidoxime prodrug for the treatment of CNS trypanosomiasis

Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity

Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures. ⬇️

Microscopic rearrangement of bound minor groove binders detected by NMR.

New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289

Novel 4-substituted phenyl-2,2'-bichalcophenes and aza-analogs as antibacterial agents: a structural activity relationship

Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents

Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove

Peculiar reaction behaviour of barbituric acid derivatives towards aromatic amines

Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.

Progress in the chemistry of 4- thiazolidinones

SYNTHESIS OF NOVEL BITHIOPHENE-SUBSTITUTED HETEROCYCLES BEARING CARBONITRILE GROUPS.

Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis

Silicon-mediated Direct Conversion of Acyl Chlorides to Carbamoyl Azides or/and Tetrazolinones under Mild Conditions

Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and charge

Synthesis and CharacterizationviaMolecular Quantum Parameters of 2H-Thiazolo[3,2-a]pyrimidine-3,5,7(6H)-trione

Synthesis and Transformations of 2-Substituted Tetrahydro-4 H -benzo[4,5]thieno[2,3-d][1,3]oxazines and 2,3-Disubstituted Hexahydrobenzo[4,5]thieno[2,3-d]pyrimidines

Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum

Synthesis and antiproliferative activity of monocationic arylthiophene derivatives

Synthesis and antiprotozoal activity of aza-analogues of furamidine

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.

Synthesis and biological evaluation of some new Thiazolo[3,2-a][1,3,5]triazine derivatives

Synthesis and characterization of novel ion-imprinted guanyl-modified cellulose for selective extraction of copper ions from geological and municipality sample

Synthesis of Benzyloxybromobenzonitriles

Synthesis of deuterium and15N-labelled 2,5-Bis[5-amidino-2-pyridyl]furan and 2,5-Bis[5-(methoxyamidino)-2-pyridyl]furan

Synthesis of deuterium-labelled 6-[5-(4-amidinophenyl)furan-2-yl]nicotinamidine andN-alkoxy-6-{5-[4-(N-alkoxyamidino)phenyl]- furan-2-yl}-nicotinamidines

Synthesis, DNA Affinity, and Antiprotozoal Activity of Linear Dications: Terphenyl Diamidines and Analogues

Synthesis, DNA affinity, and antimicrobial activity of 4-substituted phenyl-2,2′-bichalcophenes and aza-analogues

Synthesis, antimicrobial activity and molecular modeling study of substituted 5-aryl-pyrimido[5,4-c]quinoline-2,4-diones

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines.

Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines

The adaptive potential of a survival artist: characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures.

The position of imidazopyridine and metabolic activation are pivotal factors in the antimutagenic activity of novel imidazo[1,2-a]pyridine derivatives

The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA

The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine

Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi ⬇️

Water-mediated binding of agents that target the DNA minor groove