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List of works by Helena Carén

A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation

scientific article

A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma tumours.

scientific article published on September 2004

Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas

scientific article published on 29 March 2015

Accumulation of DNA methylation alterations in paediatric glioma stem cells following fractionated dose irradiation

scientific article published on 11 February 2020

Alterations in Tumor DNA Are Related to Short Postoperative Survival in Patients Resected for Pancreatic Carcinoma Aimed at Cure

scientific article published in July 2016

Analysis of neuroblastoma tumour progression; loss of PHOX2B on 4p13 and 17q gain are early events in neuroblastoma tumourigenesis

scientific article published on 01 March 2008

Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy

scientific article published on 8 November 2010

COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

scientific article

Cell line-based xenograft mouse model of paediatric glioma stem cells mirrors the clinical course of the patient.

scientific article

Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue.

scientific article

Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary tumors

scientific article published on 07 September 2011

DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas

scientific article published on 03 May 2021

DNA microarray analysis of chromosomal susceptibility regions to identify candidate genes for allergic disease: a pilot study

scientific article published in September 2004

Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem Cells

scientific article published on 27 November 2017

Differentiation therapy for glioblastoma - too many obstacles?

scientific article published on 28 December 2015

Dynamic Enhancer Methylation--A Previously Unrecognized Switch for Tissue-Type Plasminogen Activator Expression.

scientific article published on 28 October 2015

Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours

scientific article

Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors

scientific article published on 19 January 2016

Germline mutation screening of the Saethre-Chotzen-associated genes TWIST1 and FGFR3 in families with BRCA1/2-negative breast cancer.

scientific article

Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest

scientific article published on 21 October 2015

HG-83STABILITY OF PATIENT-DERIVED IN VITRO CULTURES OF STEM-LIKE CELLS FROM HIGH-GRADE PAEDIATRIC BRAIN TUMOURS.

scientific article published on 30 May 2016

High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response

scientific article published on 14 December 2017

High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumours

article

High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene

scientific article

High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset

scientific article

Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma

scientific article

Integrated virus-host methylome analysis in head and neck squamous cell carcinoma.

scientific article published on 18 July 2013

Intratumor DNA methylation heterogeneity in glioblastoma: implications for DNA methylation-based classification

Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces cell death

scientific article

MethPed: a DNA methylation classifier tool for the identification of pediatric brain tumor subtypes.

scientific article published on 9 July 2015

MethPed: an R package for the identification of pediatric brain tumor subtypes

scientific article

Orthotopic Transplantation of Human Paediatric High-Grade Glioma in Zebrafish Larvae

scientific article published on 10 May 2022

P06.10 Dose-response relationship of ALECSAT immunotherapy in autologous patient-derived glioblastoma stem cell cultures.

scientific article published on 19 April 2017

Patient-derived cells modeling pediatric glioma

scientific article published on 8 May 2017

Pediatric brain tumor cells release exosomes with a miRNA repertoire that differs from exosomes secreted by normal cells

scientific article published on 6 October 2017

Preoperative systemic levels of VEGFA, IL-7, IL-17A, and TNF-β delineate two distinct groups of children with brain tumors

scientific article published on 29 July 2016

RADIATION ONCOLOGY

Rapid and specific hypomethylation of enhancers in endothelial cells during adaptation to cell culturing

scientific article published on 14 June 2016

Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

scientific article published in March 2018

Stem cell cultures derived from pediatric brain tumors accurately model the originating tumors.

scientific article published on 26 January 2017

TUMOUR BIOLOGY

The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma

scientific article

The dynamics of DNA methylation covariation patterns in carcinogenesis.

scientific article

The good, the bad and the ugly: epigenetic mechanisms in glioblastoma

scientific article published on 04 July 2012

The two human homologues of yeast UFD2 ubiquitination factor, UBE4A and UBE4B, are located in common neuroblastoma deletion regions and are subject to mutations in tumours

scientific article published on 4 January 2006

Validation of the MethylationEPIC BeadChip for fresh-frozen and formalin-fixed paraffin-embedded tumours

scientific article published on 4 April 2017

Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor genes

scientific article published on 17 August 2009

Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner

scientific article published on March 2013

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