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List of works by Klaus Olkkola

A semiphysiological population pharmacokinetic model for dynamic inhibition of liver and gut wall cytochrome P450 3A by voriconazole

scientific article published in September 2013

Acute hormonal findings after aneurysmal subarachnoid hemorrhage - report from a single center.

scientific article published on 18 October 2016

Aetiology of in-hospital cardiac arrest on general wards

scientific article published in August 2016

Association of arterial blood pressure and CPR quality in a child using three different compression techniques, a case report

scientific article published on 02 July 2013

Azole antimycotics and drug interactions in the perioperative period

scientific article published on August 2010

Bioavailability of dexmedetomidine after intranasal administration

scientific article published on 12 February 2011

Blood pressure during resuscitation in man—The effect of pause during rhythm analysis revisited

scientific article published on 17 June 2011

Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics.

scientific article published on 21 April 2017

Cardiac arrest teams and medical emergency teams in Finland: a nationwide cross-sectional postal survey

scientific article published on 19 February 2014

Clinical practice guideline on atraumatic (pencil-point) vs conventional needles for lumbar puncture: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine

scientific article published on 17 January 2019

Clinical practice guideline on prevention of rhabdomyolysis induced acute kidney injury: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine

scientific article published on 09 September 2019

Comparison of four pain scales in patients with hip fracture or other lower limb trauma

scientific article published on 2 February 2011

Covariates of intravenous paracetamol pharmacokinetics in adults

scientific article

Deeper chest compression - more complications for cardiac arrest patients?

scientific article published on 5 March 2013

Diclofenac pharmacokinetic meta-analysis and dose recommendations for surgical pain in children aged 1-12 years

scientific article published on 30 January 2011

Does the pharmacology of oxycodone justify its increasing use as an analgesic?

scientific article published on 04 March 2013

Drowning in children: Utstein style reporting and outcome

scientific article published on 3 March 2014

Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial

scientific article

Effect of Terbinafine and Voriconazole on the Pharmacokinetics of the Antidepressant Venlafaxine

scientific article published on 08 August 2007

Effect of ciprofloxin on the pharmacokinetics of intravenous lidocaine

scientific article

Effect of mattress and bed frame deflection on real chest compression depth measured with two CPR sensors

scientific article

Effect of nitrous oxide on cisatracurium infusion demands: a randomized controlled trial

scientific article

Effect of timing and route of methylprednisolone administration during pediatric cardiac surgical procedures

scientific article published on 18 November 2014

Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl

scientific article published on 7 November 2007

Effect of voriconazole on the pharmacokinetics of diclofenac

scientific article published in December 2007

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

scientific article published on 06 January 2015

Effects of the antifungals voriconazole and fluconazole on the pharmacokinetics of s-(+)- and R-(-)-Ibuprofen

scientific article published on June 2006

Efficacy of oral paracetamol and ketoprofen for pain management after major orthopedic surgery

scientific article published in November 2008

Endorsement of clinical practice guidelines by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine

scientific article published on 03 December 2018

Enhancement of GABAergic activity: neuropharmacological effects of benzodiazepines and therapeutic use in anesthesiology

scientific article

Epidemiology and aetiology of impaired level of consciousness in prehospital nontrauma patients in an urban setting

scientific article published on 29 September 2015

Ethically justified treatment limitations in emergency situations

scientific article published on 22 January 2015

Factors associated with delayed activation of medical emergency team and excess mortality: an Utstein-style analysis

scientific article published on 23 September 2012

Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest

scientific article published in September 2013

Fentanyl for breakthrough cancer pain--what's new?

scientific article published on December 2010

Good quality of life before cardiac arrest predicts good quality of life after resuscitation.

scientific article published on 7 January 2018

High-Dose Methylprednisolone Has No Benefit Over Moderate Dose for the Correction of Tetralogy of Fallot

scientific article published on 3 May 2016

Interaction of oxycodone and voriconazole—a case series of patients with cancer pain supports the findings of randomised controlled studies with healthy subjects

scientific article published on 11 January 2011

Is the effect of non-invasive ventilation on survival in amyotrophic lateral sclerosis age-dependent?

scientific article

Isobaric bupivacaine via spinal catheter for hip replacement surgery: ED50 and ED95 dose determination

scientific article published in February 2006

Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy

scientific article published on 30 March 2016

Marked variation in oxycodone pharmacokinetics in infants

scientific article published in July 2005

Maturation of Oxycodone Pharmacokinetics in Neonates and Infants: a Population Pharmacokinetic Model of Three Clinical Trials

scientific article published on 15 February 2017

Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects.

scientific article published on 2 August 2015

Medical emergency team activation: performance of conventional dichotomised criteria versus national early warning score

scientific article published on 12 February 2014

Methylprednisolone in neonatal cardiac surgery: reduced inflammation without improved clinical outcome

scientific article published on 18 April 2013

Miconazole oral gel increases exposure to oral oxycodone by inhibition of CYP2D6 and CYP3A4.

scientific article

Midazolam and other benzodiazepines

scientific article

Minimum effective local anaesthetic dose of isobaric levobupivacaine and ropivacaine administered via a spinal catheter for hip replacement surgery.

scientific article published on 29 October 2004

Neurocognitive long term follow-up study on drowned children

scientific article

Oral voriconazole and miconazole oral gel produce comparable effects on the pharmacokinetics and pharmacodynamics of etoricoxib

scientific article

Oxycodone clearance is markedly reduced with advancing age: a population pharmacokinetic study

scientific article published on 26 December 2011

Oxycodone: new 'old' drug

scientific article published on August 2009

Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration

scientific article published in July 2005

Pharmacokinetic-pharmacodynamic relationship of dobutamine and heart rate, stroke volume and cardiac output in healthy volunteers

scientific article published in January 2008

Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients

scientific article published on 26 October 2011

Plasma levels of bupivacaine and its metabolites after subacromial infusions in concentrations 2.5 or 5.0 mg/ml

scientific article published on 29 October 2010

Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability

article

Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients

scientific article published on 25 January 2012

Predictive equations over-estimate the resting energy expenditure in amyotrophic lateral sclerosis patients who are dependent on invasive ventilation support

scientific article

Prehospital National Early Warning Score predicts early mortality.

scientific article published on 8 January 2019

Quality controlled manual chest compressions and cerebral oxygenation during in-hospital cardiac arrest

scientific article published on 28 September 2011

Randomised controlled study comparing general and spinal anaesthesia with and without a tourniquet on the outcomes of total knee arthroplasty: study protocol

Re: Pergolizzi et al. 2011: Exposure to potential CYP450 pharmacokinetic drug-drug interactions

scientific article published on 01 January 2012

Real-time audiovisual feedback system in a physician-staffed helicopter emergency medical service in Finland: the quality results and barriers to implementation

scientific article published in July 2013

Response to Value of indirect calorimetry in non-invasive ventilation

scientific article published in February 2013

Reversal of neuromuscular blockade by sugammadex does not affect EEG derived indices of depth of anesthesia

scientific article published on 24 August 2010

Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects

scientific article

Rifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine

scientific article

Rifampicin markedly decreases the exposure to oral and intravenous tramadol

scientific article published on 15 December 2012

S-ketamine concentrations are greatly increased by grapefruit juice

scientific article

S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial

scientific article published on 07 June 2021

Semimechanistic Population Pharmacokinetic Model to Predict the Drug-Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers

scientific article published on 10 September 2018

Simultaneous beat-to-beat assessment of arterial blood pressure and quality of cardiopulmonary resuscitation in out-of-hospital and in-hospital settings

scientific article published on 23 August 2015

St John's wort greatly decreases the plasma concentrations of oral S-ketamine

scientific article

The duration of residual neuromuscular block after administration of neostigmine or sugammadex at two visible twitches during train-of-four monitoring

scientific article published on 26 October 2010

The effect of tepid amino acid-enriched induction cardioplegia on the outcome of infants undergoing cardiac surgery

scientific article published on 21 March 2012

The quality of manual chest compressions during transport--effect of the mattress assessed by dual accelerometers

scientific article

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction

scientific article published on 26 October 2012

Using respiratory rate and thoracic movement to assess respiratory insufficiency in amyotrophic lateral sclerosis: a preliminary study

scientific article

Validation of indirect calorimetry for measurement of energy expenditure in healthy volunteers undergoing pressure controlled non-invasive ventilation support

scientific article published on 30 December 2011

Vital dysfunctions after intensive care discharge: prevalence and impact on patient outcome

scientific article published on 21 November 2012

Voriconazole and fluconazole increase the exposure to oral diazepam

scientific article

Voriconazole drastically increases exposure to oral oxycodone

scientific article published on 3 October 2008

Voriconazole greatly increases the exposure to oral buprenorphine

scientific article published on 30 August 2018

Voriconazole increases while itraconazole decreases plasma meloxicam concentrations

scientific article

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

scientific article published on 10 August 2016

Voriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-life

scientific article published in November 2006

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