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List of works by Kirsi Rilla

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.

scientific article published on 13 March 2009

Activated hyaluronan metabolism in the tumor matrix — Causes and consequences

scientific article published on 27 April 2018

Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation

scientific article published on 20 May 2013

Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells

scientific article

Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia

scientific article

Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes

scientific journal article

Chloropicrin-induced toxic responses in human lung epithelial cells

scientific article published on 15 February 2014

Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions

scientific article published on 14 December 2014

Chronic UVR causes increased immunostaining of CD44 and accumulation of hyaluronan in mouse epidermis

scientific article

Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles

scientific article published on 10 September 2015

Correlative light and electron microscopy is a powerful tool to study interactions of extracellular vesicles with recipient cells

scientific article published on 11 February 2019

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

scientific article published on 6 November 2008

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

scientific article published on 7 November 2017

Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function

scientific article

EGF REGULATES HAS2 EXPRESSION, CONTROLS EPIDERMAL THICKNESS AND STIMULATES KERATINOCYTE MIGRATION

EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells

scientific article published on 30 December 2016

Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)

scientific article published on 27 October 2018

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas.

scientific article

Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan

scientific article published on 21 March 2001

Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content

scientific article

Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3

scientific article published in 2014

Extracellular vesicles are integral and functional components of the extracellular matrix

scientific article

First in vivo detection and characterization of hyaluronan-coated extracellular vesicles in human synovial fluid

scientific article

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium.

scientific article

HYALURONAN STIMULATES KERATINOCYTE MIGRATION AND ACTIVATES THE TRANSCRIPTION FACTOR AP-1 IN KERATINOCYTES THROUGH THE JNK PATHWAY

HYALURONAN SYNTHASE 2 (HAS2) REGULATES MIGRATION OF EPIDERMAL KERATINOCYTES

High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome

scientific article published on 28 September 2016

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.

scientific article published on 27 April 2015

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

scientific article

Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles.

scientific article published on 5 May 2017

Hyaluronan enters keratinocytes by a novel endocytic route for catabolism

scientific article published on 12 July 2001

Hyaluronan histochemistry-a potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma

scientific article published on 01 April 2019

Hyaluronan in cytosol--microinjection-based probing of its existence and suggested functions

scientific article

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

scientific article published on June 2013

Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat

scientific article published on 4 October 2013

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

scientific article published on 9 January 2013

Hyaluronan synthase 1: a mysterious enzyme with unexpected functions

scientific article

Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion

scientific article published on 26 July 2015

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

scientific article

Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival

scientific article published on 14 December 2013

Hyaluronan synthesis induces microvillus-like cell surface protrusions

scientific article published on 4 April 2006

Hyaluronan-coated extracellular vesicles--a novel link between hyaluronan and cancer

scientific article published on January 2014

Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo

scientific article published on 28 January 2016

Induction of hyaluronan cables and monocyte adherence in epidermal keratinocytes

scientific article

Interleukin-1β-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats

scientific article published on 25 March 2015

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding

scientific article published in March 2013

Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling

scientific article

Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas

scientific article published on 25 February 2016

Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles.

scientific article

Methyl-beta-cyclodextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt.

scientific article

Molecular targets of chloropicrin in human airway epithelial cells

scientific article published on 2 May 2017

Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions

scientific article

Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity

scientific article

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

scientific article published on 18 December 2018

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ

scientific article published on 15 November 2020

Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen

scientific article published on 07 February 2014

Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells

scientific article published on 7 August 2013

Role of CD44 in the organization of keratinocyte pericellular hyaluronan

scientific article published on 10 November 2011

The Density and Length of Filopodia Associate with the Activity of Hyaluronan Synthesis in Tumor Cells

scientific article published on 15 July 2020

The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor

scientific article published on October 2004

Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes

scientific journal article

Transcriptional and post-translational regulation of hyaluronan synthesis.

scientific article published on 25 March 2011

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

scientific article published on 16 February 2016

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells

scientific article published on 27 July 2010

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