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List of works by Jonathan D. Mosley

A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin

scientific article published on 14 July 2016

A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough

scientific article

A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record

scientific article

A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers

scientific article published in Nature Communications

Association of Thyroid Function Genetic Predictors With Atrial Fibrillation: A Phenome-Wide Association Study and Inverse-Variance Weighted Average Meta-analysis

scientific article published on 01 February 2019

Benefit of pre-emptive pharmacogenetic information on clinical outcome

scientific article published on 29 January 2018

Biobanks and electronic medical records: enabling cost-effective research

scientific article

Cardiovascular risk factors in normotensive and hypertensive Egyptians.

scientific article published on November 2001

Clinical Features Associated With Nascent Left Ventricular Diastolic Dysfunction in a Population Aged 40 to 55 Years

scientific article published on 13 March 2018

Comparison of HLA allelic imputation programs.

scientific article

Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data

scientific article

Evaluating statistical approaches to leverage large clinical datasets for uncovering therapeutic and adverse medication effects

scientific article published on 01 September 2018

Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome

scientific article

FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis

scientific article

Finding a Needle in a QT Interval Big Data Haystack

scientific article

Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease

scientific article published on 03 December 2019

Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.

scientific article

Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk

scientific article published on 05 March 2013

Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults.

scientific article published on 24 May 2017

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

scientific article published on 31 January 2017

Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease

scientific article

Identifying genetically driven clinical phenotypes using linear mixed models

scientific article published on 25 April 2016

Influence of human leukocyte antigen (HLA) alleles and killer cell immunoglobulin-like receptors (KIR) types on heparin-induced thrombocytopenia (HIT).

scientific article

Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations

scientific article (publication date: 2014)

Intrinsic bias in breast cancer gene expression data sets

scientific article published on 29 June 2009

Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes

scientific article published on April 2017

LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins

Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica

article

Letter by Mosley Regarding Article, "Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat".

scientific article published in August 2015

Linkage analysis of alpha 1-antitrypsin deficiency: lessons for complex diseases

scientific article published in January 2001

Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data

scientific article

Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation

scientific article published on 01 April 2018

Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

scientific article

Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants.

scientific article published on May 2017

Phenotype risk scores identify patients with unrecognized Mendelian disease patterns

scientific article published in Science

QT variability during initial exposure to sotalol: experience based on a large electronic medical record.

scientific article published on 19 June 2013

Rapamycin inhibits multiple stages of c-Neu/ErbB2 induced tumor progression in a transgenic mouse model of HER2-positive breast cancer

scientific article published on August 2007

Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational study using electronic health records

scientific article published on 28 August 2018

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

scientific article

Splice variants of mIAP1 have an enhanced ability to inhibit apoptosis

scientific article

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

scientific article

The polygenic architecture of left ventricular mass mirrors the clinical epidemiology

scientific article published on 05 May 2020

Using systems approaches to address challenges for clinical implementation of pharmacogenomics

Using systems approaches to address challenges for clinical implementation of pharmacogenomics.

scientific article published on 06 December 2013

Validation and enhancement of a computable medication indication resource (MEDI) using a large practice-based dataset

scientific article (publication date: 2013)

Whole-exome sequencing in familial atrial fibrillation.

scientific article