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List of works by Jacob Giehm Mikkelsen

A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues

scientific article

A lentiviral vector-based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin

scientific article published on March 2013

Adeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo.

scientific article

Amelioration of psoriasis by anti-TNF-alpha RNAi in the xenograft transplantation model

scientific article

Anti-Apoptotic Effects of Lentiviral Vector Transduction Promote Increased Rituximab Tolerance in Cancerous B-Cells

scientific article

CRISPR-Cas9-directed gene tagging using a single integrase-defective lentiviral vector carrying a transposase-based Cas9 off switch

scientific article published in 2022

Cis-acting gene regulatory activities in the terminal regions of sleeping beauty DNA transposon-based vectors

scientific article published in December 2007

Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells

scientific article

Complementarity-directed RNA dimer-linkage promotes retroviral recombination in vivo

scientific article published on 9 January 2004

DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors

scientific article

DNA transposon-based gene vehicles - scenes from an evolutionary drive

scientific article (publication date: 9 December 2013)

Defective RNA sensing by RIG-I in severe influenza virus infection

scientific article published on 17 February 2018

Defects in <i>LC3B2</i> and <i>ATG4A</i> underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans

scientific article published on 01 December 2020

Delivering the Goods for Genome Engineering and Editing

scientific article published on 23 June 2015

Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin

scientific article (publication date: 2012)

Dominant negative SERPING1 variants cause intracellular retention of C1-inhibitor in hereditary angioedema

scientific article published on 10 December 2018

Driving DNA transposition by lentiviral protein transduction

scientific article

Efficient replication of full-length murine leukemia viruses modified at the dimer initiation site regions

scientific article published on January 2004

Efficient sleeping beauty DNA transposition from DNA minicircles

scientific article published on 26 February 2013

Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs

scientific article published on 21 September 2018

Epigenetic marking and repression of porcine endogenous retroviruses

scientific article published on 16 January 2013

Establishment of a pig fibroblast-derived cell line for locus-directed transgene expression in cell cultures and blastocysts.

scientific article published on 25 March 2010

Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant

scientific article

Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

scientific article

Fv1-like restriction of N-tropic replication-competent murine leukaemia viruses in mCAT-1-expressing human cells

scientific article published on February 2002

Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT).

scientific article published on 31 October 2012

Helper-Independent Sleeping Beauty transposon-transposase vectors for efficient nonviral gene delivery and persistent gene expression in vivo

scientific article published in October 2003

High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma

scientific article published on 5 February 2016

Human herpesvirus 6B U19 protein is a PML-regulated transcriptional activator that localizes to nuclear foci in a PML-independent manner

scientific article published on January 2008

Hybrid lentivirus-transposon vectors with a random integration profile in human cells.

scientific article

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

scientific article

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.

scientific article published on 23 October 2013

Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein

article

Improved microRNA suppression by WPRE-linked tough decoy microRNA sponges.

scientific article published on 9 May 2017

Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections

scientific article published on 07 August 2017

Induction of atherosclerosis in mice and hamsters without germline genetic engineering.

scientific article published on 27 March 2014

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

scientific article published on 19 February 2016

Integrase-defective lentiviral vectors--a stage for nonviral integration machineries.

scientific article published on October 2011

In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells.

scientific article published on 21 September 2017

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

scientific article published on 16 June 2016

Lentiviral Delivery of Proteins for Genome Engineering

scientific article published on 27 May 2016

Lentiviral vectors for cutaneous RNA managing

scientific article published on March 2012

Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic

scientific article published on 20 April 2022

Managing microRNAs with vector-encoded decoy-type inhibitors

scientific article published on 11 June 2013

Mobilization of DNA transposable elements from lentiviral vectors

scientific article

Modulation of homo- and heterodimerization of Harvey sarcoma virus RNA by GACG tetraloops and point mutations in palindromic sequences

scientific article published in November 2002

Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors

scientific article published on 28 January 2015

Mutational analysis of the N-terminal DNA-binding domain of sleeping beauty transposase: critical residues for DNA binding and hyperactivity in mammalian cells

scientific article

Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus

scientific article published on 9 June 2015

Pig transgenesis by Sleeping Beauty DNA transposition

scientific article

Postintegrative gene silencing within the Sleeping Beauty transposition system

scientific article (publication date: December 2007)

Potent microRNA suppression by RNA Pol II-transcribed 'Tough Decoy' inhibitors

scientific article published on 18 December 2012

Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1

scientific article published on July 2017

Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA.

scientific article

Regulated gene insertion by steroid-induced PhiC31 integrase

scientific article published on 22 May 2008

Regulation of pro-inflammatory cytokines TNFα and IL24 by microRNA-203 in primary keratinocytes

scientific article published on 20 August 2012

Robust Lentiviral Gene Delivery But Limited Transduction Capacity of Commonly Used Adeno-Associated Viral Serotypes in Xenotransplanted Human Skin.

scientific article

Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy

article

Suppression of Choroidal Neovascularization in Mice by Subretinal Delivery of Multigenic Lentiviral Vectors Encoding Anti-Angiogenic MicroRNAs

scientific article

Suppression of choroidal neovascularization in mice by subretinal delivery of multigenic lentiviral vectors encoding anti-angiogenic microRNAs

scientific article published on 27 July 2017

Suppression of microRNAs by dual-targeting and clustered Tough Decoy inhibitors

scientific article published on 16 January 2013

Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE)

scientific article published on 09 November 2019

Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases

scientific article published on 24 April 2014

Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors.

scientific article published on 09 June 2016

Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin

scientific article

The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells

scientific article

Time-Restricted PiggyBac DNA Transposition by Transposase Protein Delivery Using Lentivirus-Derived Nanoparticles.

scientific article

Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo

scientific article published on 16 September 2002

U20 is responsible for human herpesvirus 6B inhibition of tumor necrosis factor receptor-dependent signaling and apoptosis

scientific article published on 15 August 2012

miRNA sponges: soaking up miRNAs for regulation of gene expression.

scientific article published on 23 December 2013

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