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List of works by Paolo Ghia

A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study.

scientific article published on 7 December 2015

A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence

article

A look into the future: can minimal residual disease guide therapy and predict prognosis in chronic lymphocytic leukemia?

scientific article published on January 1, 2012

A new life for rituximab?

scientific article published on 01 March 2016

A novel Rag2-/-gammac-/--xenograft model of human CLL.

scientific article

A novel ex vivo high-throughput assay reveals antiproliferative effects of idelalisib and ibrutinib in chronic lymphocytic leukemia.

scientific article

A novel molecular complex expressed on immature B cells: a possible role in T cell-independent B cell development

scientific article

A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression.

scientific article published on 3 May 2018

A woman and her canary: a tale of chlamydiae and lymphomas

scientific article published on 11 September 2007

AEGLE: A big bio-data analytics framework for integrated health-care services

AIDS-related non-Hodgkin's lymphomas: molecular genetics, viral infection and cytokine deregulation.

scientific article published on January 1996

ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres

scientific article published on 16 June 2016

Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia

scientific article published on 7 December 2015

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia.

scientific article published on 8 August 2013

Age-dependent accumulation of monoclonal CD4+CD8+double positive T lymphocytes in the peripheral blood of the elderly

scientific article published in December 2007

Age-dependent changes in B lymphocyte development in man and mouse

scientific article

An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

scientific article published on 8 December 2015

Another piece of the puzzle: is there a "nodal" monoclonal B-cell lymphocytosis? ⬇️

scientific article published on August 1, 2011

Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia

scientific article published on 2 September 2015

Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity

scientific article published on 04 November 2011

Antigen receptor stereotypy in chronic lymphocytic leukemia.

scientific article published on 4 November 2016

Antigen selection in B-cell lymphomas--tracing the evidence

scientific article published on 08 August 2013

Automated shape-based clustering of 3D immunoglobulin protein structures in chronic lymphocytic leukemia

scientific article published on 20 November 2018

B Cell Anergy Modulated by TLR1/2 and the miR-17∼92 Cluster Underlies the Indolent Clinical Course of Chronic Lymphocytic Leukemia Stereotyped Subset #4.

scientific article published on 8 April 2016

B-cell clones as early markers for chronic lymphocytic leukemia

scientific article

B-cell development: a comparison between mouse and man.

scientific article published in October 1998

Bendamustine and subcutaneous alemtuzumab combination is an effective treatment in relapsed/refractory chronic lymphocytic leukemia patients

scientific article published on 27 June 2014

Bertilaccio MT, Simonetti G, Dagklis A, et al. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood. 2011;118(3):660-669

Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology?

scientific article published in November 2012

Bone marrow microenvironment and the progression of multiple myeloma

scientific article published on September 1992

CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes

scientific article (publication date: March 2003)

CD38 modifications in chronic lymphocytic leukemia: are they relevant?

article

CLL-like monoclonal B-cell lymphocytosis: are we all bound to have it?

scientific article published on 15 September 2010

COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

scientific article published on 01 November 2021

COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus

scientific article published on 09 July 2020

CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells

scientific article published on 01 November 2002

Calreticulin as a novel B-cell receptor antigen in chronic lymphocytic leukemia

scientific article published on 27 July 2017

Changes in the apoptotic gene expression profile in CLL patients treated with rituximab combined with cladribine and cyclophosphamide-preliminary results

article

Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials ⬇️

scientific article

Characterization of bone marrow stromal cells from multiple myeloma

scientific article published on 01 September 1994

Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells

scientific article (publication date: August 2001)

Chronic B cell malignancies and bone marrow microenvironment

scientific article

Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

scientific article published on 23 May 2017

Chronic lymphocytic leukaemia

scientific article

Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

scientific article published in September 2015

Chronic lymphocytic leukaemia: a model for investigating potential new targets for the therapy of indolent lymphomas

scientific article

Chronic lymphocytic leukemia

Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22

scientific article (publication date: May 2002)

Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study

scientific article

Clonal B-cell lymphocytosis: a new member?

Commentary: Comparison of current flow cytometry methods for monoclonal B cell lymphocytosis detection

scientific article

Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy

scientific article

Correction: Establishment and Characterization of PCL12, a Novel CD5+ Chronic Lymphocytic Leukaemia Cell Line.

scientific article published on 29 July 2015

Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact

scientific article published on 02 January 2019

DNA methylation profiles in chronic lymphocytic leukemia patients treated with chemoimmunotherapy

scientific article published on 02 December 2019

Determination of IGHV gene mutational status in chronic lymphocytic leukemia: bioinformatics advances meet clinical needs

article

Diagnostic criteria for monoclonal B-cell lymphocytosis

scientific article

Dichotomous Toll-like receptor responses in chronic lymphocytic leukemia patients under ibrutinib treatment

scientific article published on 03 January 2019

Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL).

scientific article published on January 2010

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors

scientific article published on 19 May 2016

Different time-dependent changes of risk for evolution in chronic lymphocytic leukemia with mutated or unmutated antigen B cell receptors

scientific article published on 24 January 2019

Differential microRNA profiles and their functional implications in different immunogenetic subsets of chronic lymphocytic leukemia

scientific article published on 20 May 2013

Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations

scientific article published on 30 January 2019

Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

scientific article

Distinct innate immunity pathways to activation and tolerance in subgroups of chronic lymphocytic leukemia with distinct immunoglobulin receptors

scientific article

Distinct molecular genetics of chronic lymphocytic leukemia in Taiwan: clinical and pathogenetic implications.

scientific article

Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2.

scientific article

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.

scientific article published on 28 November 2016

EHA evaluation of the ESMO-Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS v1.1) for haematological malignancies

scientific article published on 01 January 2020

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-update on methodological approaches and results interpretation

scientific article published on 2 February 2018

ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia

article

ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia

scientific article published on 02 February 2012

Early stages in the ontogeny of small B-cell lymphomas: genetics and microenvironment.

scientific article published on 10 April 2017

Efficacy and Safety of Duvelisib Following Disease Progression on Ofatumumab in Patients with Relapsed/Refractory CLL or SLL in the DUO Crossover Extension Study

scientific article published on 21 January 2020

Efficacy and safety of dinaciclib vs ofatumumab in patients with relapsed/refractory chronic lymphocytic leukemia.

scientific article

Efficacy of bendamustine and rituximab as first salvage treatment in chronic lymphocytic leukemia and indirect comparison with ibrutinib: a GIMEMA, ERIC and UK CLL FORUM study.

scientific article published on 19 April 2018

Erratum: The functional in vitro response to CD40 ligation reflects a different clinical outcome in patients with chronic lymphocytic leukemia

scholarly article published in Leukemia

Establishment and characterization of PCL12, a novel CD5+ chronic lymphocytic leukaemia cell line

scientific article published on 25 June 2015

Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: A multicentric international harmonization process

scientific article published on 01 July 2006

Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia

scientific article

Evidence of serum immunoglobulin abnormalities up to 9.8 years before diagnosis of chronic lymphocytic leukemia: a prospective study

scientific article published on 14 October 2009

Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8.

scientific article published on 21 April 2015

Exploiting B Cell Receptor Stereotypy to design Tailored Immunotherapy in Chronic Lymphocytic Leukemia

scientific article published on 13 October 2020

Exposure to animals and increased risk of marginal zone B-cell lymphomas of the ocular adnexae

scientific article published on 24 January 2012

Expression and function of toll like receptors in chronic lymphocytic leukaemia cells.

scientific article

Final Results of a Randomized, Phase III Study of Rituximab With or Without Idelalisib Followed by Open-Label Idelalisib in Patients With Relapsed Chronic Lymphocytic Leukemia

scientific article published on 17 April 2019

Final results of EFC6663: a multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chronic lymphocytic leukemia

scientific article

From Mice to Men: How B Cell Immunology Helped the Understanding of Leukemia Development

article

From a 2DE-gel spot to protein function: lesson learned from HS1 in chronic lymphocytic leukemia

scientific article

From normal to clonal B cells: Chronic lymphocytic leukemia (CLL) at the crossroad between neoplasia and autoimmunity

scientific article published on 22 March 2007

Functional Differences between IgM and IgD Signaling in Chronic Lymphocytic Leukemia

scientific article published on 17 August 2016

Functional effects of TNF and lymphotoxin alpha1beta2 on FDC-like cells.

scientific article published on August 2000

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

scientific article published on 18 May 2015

GLASS: assisted and standardized assessment of gene variations from Sanger sequence trace data.

scientific article published on 13 July 2017

Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia

scientific article published on November 2005

General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing

scientific article published on 16 March 2015

Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study

scientific article published on 23 January 2020

Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene

article

HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment

scientific article published on 29 January 2016

HS1 complexes with cytoskeleton adapters in normal and malignant chronic lymphocytic leukemia B cells

scientific article published on 17 May 2007

HS1 has a central role in the trafficking and homing of leukemic B cells

scientific article

HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses

scientific article

Heterogeneous Functional Effects of Concomitant B Cell Receptor and TLR Stimulation in Chronic Lymphocytic Leukemia with Mutated versus Unmutated Ig Genes

article

High-risk chronic lymphocytic leukemia in the era of pathway inhibitors: integrating molecular and cellular therapies

scientific article published on 11 July 2018

Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations.

scientific article published on 15 February 2018

How the microenvironment shapes chronic lymphocytic leukemia: the cytoskeleton connection

IGF1R as druggable target mediating PI3K-δ inhibitor resistance in a murine model of chronic lymphocytic leukemia

scientific article published on 22 April 2019

IGHV gene insertions and deletions in chronic lymphocytic leukemia: "CLL-biased" deletions in a subset of cases with stereotyped receptors

scientific article published on July 2006

Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia ⬇️

scientific article

Ibrutinib holds promise for patients with 17p deletion CLL.

scientific article published on 13 September 2016

Ibrutinib in the real world patient: many lights and some shades.

scientific article published on December 2016

Ibrutinib: better combined with other drugs?

scientific article published on 20 August 2014

Idelalisib and rituximab in relapsed chronic lymphocytic leukemia

scientific article

Idelalisib or placebo in combination with bendamustine and rituximab in patients with relapsed or refractory chronic lymphocytic leukaemia: interim results from a phase 3, randomised, double-blind, placebo-controlled trial

scientific article

IgG-switched CLL has a distinct immunogenetic signature from the common MD variant: ontogenetic implications

scientific article published on 15 November 2013

Immature B cells from human and mouse bone marrow can change their surface light chain expression

article

Immunogenetic studies of chronic lymphocytic leukemia: revelations and speculations about ontogeny and clinical evolution

scientific article

Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL.

scientific article published on 17 April 2013

Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia

article

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

scientific article published on 26 November 2018

Immunoglobulin gene analysis in chronic lymphocytic leukemia in the era of next generation sequencing

scientific article published on 19 June 2020

Immunoglobulin gene repertoire in ocular adnexal lymphomas: hints on the nature of the antigenic stimulation

scientific article published on 25 October 2011

Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations

scientific article published on 25 April 2017

Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia

scientific article

Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases

scientific article published on April 2011

Impact of B-cell count and imaging screening in cMBL: any need to revise the current guidelines?

scientific article published on 30 January 2012

Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL.

scientific article published on 31 July 2012

In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor

scientific article

In vitro sensitivity of CLL cells to fludarabine may be modulated by the stimulation of Toll-like receptors

scientific article published on 5 December 2012

In-vitro analyses of mechanisms of B-cell development

scientific article

Incidence of and risk factors for major haemorrhage in patients treated with ibrutinib: An integrated analysis

scientific article published on 02 December 2018

Inherited genetic susceptibility to monoclonal B-cell lymphocytosis

scientific article

Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia

scientific article published on 01 June 2019

Inhibition of chronic lymphocytic leukemia progression by full-length chromogranin A and its N-terminal fragment in mouse models

scientific article published on 17 May 2016

Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?

scientific article published on March 2016

Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia

scientific article published on 15 January 2019

International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia

scientific article published on 15 March 2007

Introduction to Chronic Lymphocytic Leukemia Young Investigator's Meeting

Iron induces cell death and strengthens the efficacy of anti-androgen therapy in prostate cancer models

scientific article published on 14 September 2020

Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases

scientific article published on 26 July 2011

KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function.

scientific article published on 27 March 2012

KIBRAgene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia

scientific article published on 01 March 2012

Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models

scientific article published on 7 June 2011

Lenalidomide maintenance after first-line therapy for high-risk chronic lymphocytic leukaemia (CLLM1): final results from a randomised, double-blind, phase 3 study

scientific article published on 12 September 2017

Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study

scientific article published on 18 October 2019

Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial

scientific article published on 20 October 2015

Long-term safety of single-agent ibrutinib in patients with chronic lymphocytic leukemia in 3 pivotal studies

scientific article published on 01 June 2019

Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis

scientific article published on 29 April 2013

MBL and MoBL - Response to Ziegler-Heitbrock

MBL versus CLL: how important is the distinction?

scientific article published on April 2013

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

scientific article

Management of adverse events associated with idelalisib treatment in chronic lymphocytic leukemia and follicular lymphoma: A multidisciplinary position paper

scientific article published on 05 September 2018

Management of chronic lymphocytic leukemia

scientific article

MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27.

scientific article

Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase

scientific article

Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation

scientific article published on December 2008

Minimal residual disease analysis in chronic lymphocytic leukemia: a way for achieving more personalized treatments

scientific article published on 26 March 2018

Molecular evidence for antigen drive in the natural history of mantle cell lymphoma

scientific article published on 2 April 2015

Monoclonal B cell lymphocytosis and "in situ" lymphoma

scientific article published on 30 August 2013

Monoclonal B cell lymphocytosis in hepatitis C virus infected individuals.

scientific article published in January 2010

Monoclonal B lymphocytosis in the general population

scientific article published in January 2009

Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management

scientific article published on 21 January 2010

Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding

scientific article published on 17 December 2013

Monoclonal B-cell lymphocytosis: Does the elderly patient need a specialistic approach?

article published in 2018

Monoclonal B-cell lymphocytosis: right track or red herring?

scientific article published on 14 March 2012

Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly.

scientific article

Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy

scientific article published on 8 July 2014

No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy

scientific article published on 21 December 2017

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

scientific article

Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease?

scientific article published on 28 July 2008

Numerous Ontogenetic Roads to Mantle Cell Lymphoma: Immunogenetic and Immunohistochemical Evidence.

scientific article published on 27 April 2017

Ofatumumab in poor-prognosis chronic lymphocytic leukemia: a phase IV, non-interventional, observational study from the European Research Initiative on Chronic Lymphocytic Leukemia

scientific article

Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia

scientific article published on 16 May 2019

Optimising outcomes for patients with chronic lymphocytic leukaemia on ibrutinib therapy: European recommendations for clinical practice.

scientific article published on 9 January 2018

Outcomes with ibrutinib by line of therapy and post-ibrutinib discontinuation in patients with chronic lymphocytic leukemia: Phase 3 analysis

scientific article published on 08 March 2019

Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations.

scientific article

Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications

scientific article

Overview of monoclonal B-cell lymphocytosis

scientific article

Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens

scientific article published on 12 September 2017

Patterns of cytokine expression in AIDS-related non-Hodgkin's lymphoma

article

Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase.

scientific article published on April 2015

Positive and negative selection events during B lymphopoiesis

scientific article published on April 1995

Prognostic relevance of MYD88 mutations in CLL: the jury is still out.

scientific article published on August 2015

Recurrent mutations refine prognosis in chronic lymphocytic leukemia.

scientific article

Relevance of Minimal Residual Disease in the Era of Targeted Agents

scientific article published on 01 November 2019

Reply to "CLL and COVID-19 at the Hospital Clinic of Barcelona: an interim report" Analysis of six hematological centers in Lombardy : On behalf of CLL commission of Lombardy Hematology Network (REL)

scientific article published on 04 August 2020

Reply to 'Male preponderance in chronic lymphocytic leukemia utilizing IGHV1-69.' When size of the sample matters

scientific article

Reproducible diagnosis of chronic lymphocytic leukemia by flow cytometry: An European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) Harmonisation project

scientific article

Reprogramming cell death: BCL2 family inhibition in hematological malignancies

scientific article

Role of the tumor microenvironment in mature B-cell lymphoid malignancies

scientific article

SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders

scientific article published on 23 May 2014

Selection of antigen receptors in splenic marginal-zone lymphoma: further support from the analysis of the immunoglobulin light-chain gene repertoire

article

Similar epidemiological trends of pre-neoplastic precursors and their respective lymphoid malignancies in Taiwan.

scientific article

Single-agent ibrutinib versus chemoimmunotherapy regimens for treatment-naïve patients with chronic lymphocytic leukemia: A cross-trial comparison of phase 3 studies

scientific article published on 09 October 2018

Splenic marginal zone lymphomas in acquired C1-inhibitor deficiency: clinical and molecular characterization

scientific article published on 02 August 2018

Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies

scientific article

Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis

scientific article published on 24 October 2007

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

scientific article published on 01 May 2001

Sustained efficacy and detailed clinical follow-up of first-line ibrutinib treatment in older patients with chronic lymphocytic leukemia: extended phase 3 results from RESONATE-2

scientific article published on 07 June 2018

Synthetic high-density lipoproteins as targeted monotherapy for chronic lymphocytic leukemia

scientific article published on 04 January 2017

T cell dynamics in chronic lymphocytic leukemia under different treatment modalities

scientific article published on 02 July 2020

TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics

scientific article published on 15 November 2018

Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia

scientific article published on 27 September 2018

Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting

scientific article

Targeting B-cell anergy in chronic lymphocytic leukemia.

scientific article published on 4 March 2013

Targeting Hedgehog in haematological malignancies

scientific article published on 26 July 2015

Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression

scientific article published on 10 February 2016

Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia

scientific article published on 16 January 2013

The characterization of chemokine production and chemokine receptor expression reveals possible functional cross-talks in AML blasts with monocytic differentiation

scientific article

The evolving treatment landscape of chronic lymphocytic leukemia

scientific article published on 01 November 2019

The frequency ofTP53gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors

article

The functional in vitro response to CD40 ligation reflects a different clinical outcome in patients with chronic lymphocytic leukemia

article

The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia.

scientific article published on 14 May 2016

The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring

article

The importance of B cell receptor isotypes and stereotypes in chronic lymphocytic leukemia

scientific article published on 16 December 2018

The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia.

scientific article published on 28 February 2017

The microenvironment in lymphomas--dissecting the complex crosstalk between tumor cells and 'by-stander' cells.

scientific article

The microenvironment in mature B-cell malignancies: a target for new treatment strategies

scientific article published on 27 July 2009

The nature and origin of the B-chronic lymphocytic leukemia cell: a tentative model

scientific article published in August 2004

The normal counterpart to the chronic lymphocytic leukemia B cell

scientific article published on September 2007

The origin of B-cell chronic lymphocytic leukemia

scientific article

The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression

scientific article

The phase 3 DUO trial: duvelisib versus ofatumumab in relapsed and refractory CLL/SLL ⬇️

scientific article published on 04 October 2018

The role of Bcl-2 in the pathogenesis of B chronic lymphocytic leukemia

scientific article

Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells.

scientific article

Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenic significance in specific subsets of patients

scientific article published on 12 July 2011

Toll-like receptor stimulation in splenic marginal zone lymphoma can modulate cell signaling, activation and proliferation

scientific article published on 20 August 2015

Toll-like receptors signaling: A complex network for NF-κB activation in B-cell lymphoid malignancies.

scientific article

Tumour debulking and reduction in predicted risk of tumour lysis syndrome with single-agent ibrutinib in patients with chronic lymphocytic leukaemia

scientific article published on 10 February 2019

Updated Efficacy and Safety from the Phase 3 Resonate-2 Study: Ibrutinib As First-Line Treatment Option in Patients 65 Years and Older with Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia

Scientific article published on 2 Dec 2016

Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid.

scientific article

What does it mean I have a monoclonal B-cell lymphocytosis?: Recent insights and new challenges

scientific article published on 6 February 2016

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

scientific article published on 16 December 2015

Xenograft models of chronic lymphocytic leukemia: problems, pitfalls and future directions

scientific article published on 13 September 2012

ZAP-70 expression is associated with increased risk of autoimmune cytopenias in CLL patients

scientific article

ZAP-70 expression, as detected by immunohistochemistry on bone marrow biopsies from early-phase CLL patients, is a strong adverse prognostic factor

scientific article published on 02 November 2006

ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage.

scientific article published on April 2006

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