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List of works by Piotr Widłak

2-Acetylaminofluorene--a model mutagen and hepatocarcinogen. Characterization of its interactions with DNA

scientific article published on 01 January 1992

32P-postlabelling of bulky human DNA adducts enriched by different methods including immunoaffinity chromatography

scientific article published on 01 January 1996

A Novel Divisive iK-Means Algorithm with Region-Driven Feature Selection as a Tool for Automated Detection of Tumour Heterogeneity in MALDI IMS Experiments

article published in 2016

A recombination silencer that specifies heterochromatin positioning and ikaros association in the immunoglobulin kappa locus

scientific article published on 01 April 2006

Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: cooperation with exonuclease and DNase I.

scientific article

Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1

scientific article (publication date: 14 May 1999)

Active heat shock transcription factor 1 supports migration of the melanoma cells via vinculin down-regulation.

scientific article

An Optimized Method of Metabolite Extraction from Formalin-Fixed Paraffin-Embedded Tissue for GC/MS Analysis

scientific article (publication date: 2015)

Analyze of Maldi-TOF Proteomic Spectra with Usage of Mixture of Gaussian Distributions

Application of metabolomics in thyroid cancer research.

scientific article published on 20 April 2015

Association between plasma proteome profiles analysed by mass spectrometry, a lymphocyte-based DNA-break repair assay and radiotherapy-induced acute mucosal reaction in head and neck cancer patients

scientific article

Bulky DNA adducts in human sperm: relationship with fertility, semen quality, smoking, and environmental factors

scientific article published in May 2003

Cardiac endothelial cells isolated from mouse heart - a novel model for radiobiology

scientific article published on 31 August 2011

Changes in activity and structure of lysosomes from liver of mouse irradiated in vivo

scientific article published on 03 April 2018

Changes of protein glycosylation in the course of radiotherapy

scientific article published on 14 November 2015

Characterization of DNA sequences localized 11 to 17.5 kb upstream of the chicken embryonic pi-globin gene.

scientific article

Characterization of a novel protein that specifically binds to DNA modified by N-acetoxy-acetylaminofluorene and cis-diamminedichloroplatinum

scientific article

Circulating HPV16 DNA may complement imaging assessment of early treatment efficacy in patients with HPV-positive oropharyngeal cancer

scientific article published on 15 April 2020

Classification of Thyroid Tumors Based on Mass Spectrometry Imaging of Tissue Microarrays; a Single-Pixel Approach

scientific article published on 31 August 2020

Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: Association with tumor progression

scientific article published on 05 September 2011

Cross talk between cytokine and hyperthermia-induced pathways: identification of different subsets of NF-κB-dependent genes regulated by TNFα and heat shock.

scientific article published on 6 May 2015

Crosstalk between HSF1 and HSF2 during the heat shock response in mouse testes

scientific article published on 19 October 2014

Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells

scientific article published on 01 April 2006

DNA adducts caused by tamoxifen and toremifene in human microsomal system and lymphocytes in vitro

scientific article published on 01 July 1995

DNA adducts in environmental, occupational and life-style studies in human biomonitoring

scientific article published on January 1996

DNA and proteins of the nuclear matrix are the main targets of benzo[a]pyrene's action in rat hepatocytes

scientific article published on 01 January 1993

DNA microarrays, a novel approach in studies of chromatin structure.

scientific article published on January 2004

DNA repair is less efficient in the nuclear matrix than in non-matrix nuclear fractions in the liver of rats treated with 2-aminofluorene.

scientific article

Detection of metabolites discriminating subtypes of thyroid cancer: Molecular profiling of FFPE samples using the GC/MS approach

scientific article published on 28 September 2015

Detection of molecular signatures of oral squamous cell carcinoma and normal epithelium - application of a novel methodology for unsupervised segmentation of imaging mass spectrometry data

scientific article

Different Types of Cellular Stress Affect the Proteome Composition of Small Extracellular Vesicles: A Mini Review.

scientific article

Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours.

scientific article

Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G.

scientific article

Discrimination of normal oral mucosa from oral cancer by mass spectrometry imaging of proteins and lipids

scientific article published on 03 November 2018

Discrimination of papillary thyroid cancer from non-cancerous thyroid tissue based on lipid profiling by mass spectrometry imaging

scientific article published on 01 January 2018

Effects of the hepatocarcinogen 2-aminofluorene on RNA synthesis in rat liver

scientific article published on 01 January 1992

Engineered apoptotic nucleases for chromatin research

scientific article published on 10 July 2007

FDXR is a biomarker of radiation exposure in vivo.

scientific article published on 12 January 2018

Formation and removal of DNA adducts in liver of rats treated with hepatocarcinogens 2-aminofluorene or 2-acetylaminofluorene

scientific article published on 01 January 1991

Formation of DNA adducts in liver of rats treated with 2-aminofluorene. Differences between total and matrix attached DNA fractions

scientific article published on 01 January 1990

Formation of UV-photoadducts during DNA purification.

scientific article

Global survey of chromatin accessibility using DNA microarrays.

scientific article published on July 2004

Harmonization of exosome isolation from culture supernatants for optimized proteomics analysis

scientific article published in PLoS ONE

Heart irradiation reduces microvascular density and accumulation of HSPA1 in mice.

scientific article

Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-κB signalling

scientific article published on 24 May 2020

Heat shock transcription factor 1 down-regulates spermatocyte-specific 70 kDa heat shock protein expression prior to the induction of apoptosis in mouse testes.

scientific article published on April 2007

High levels of bulky DNA adducts in human sperm correlate with impaired fertility.

scientific article published in January 2003

High mobility group 1 and 2 proteins bind preferentially to DNA that contains bulky adducts induced by benzo[a]pyrene diol epoxide and N-acetoxy-acetylaminofluorene.

scientific article published on September 2000

High mobility group proteins stimulate DNA cleavage by apoptotic endonuclease DFF40/CAD due to HMG-box interactions with DNA

scientific journal article

Identification of novel putative regulators of the major apoptotic nuclease DNA Fragmentation Factor.

scientific article published on 10 December 2010

Identification of serum proteome components associated with progression of non-small cell lung cancer

scientific article published in 2014

Identification of serum proteome signatures of locally advanced and metastatic gastric cancer: a pilot study

scientific article published on 17 September 2015

In vitro chromatin assembly of the HIV-1 promoter. ATP-dependent polar repositioning of nucleosomes by Sp1 and NFkappaB.

scientific article published on July 1997

Influence of Confounding Factors on Radiation Dose Estimation Using In Vivo Validated Transcriptional Biomarkers

scientific article

Initializing the EM Algorithm for Univariate Gaussian, Multi-Component, Heteroscedastic Mixture Models by Dynamic Programming Partitions

Interaction of DNA with nuclear skeleton in rat hepatocytes

scientific article published on 01 January 1990

Interactions of rat repetitive sequence MspI8 with nuclear matrix proteins during spermatogenesis

scientific article published on 01 January 1996

Interactions of the matrix attachment region of DNA with the matrix proteins from the copper preincubated liver nuclei

scientific article published on 01 January 1995

Ionic and cofactor requirements for the activity of the apoptotic endonuclease DFF40/CAD

scientific article published on 01 February 2001

Ionizing radiation affects profile of serum metabolites: increased level of 3-hydroxybutyric acid in serum of cancer patients treated with radiotherapy

scientific article published on 4 November 2016

Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma

scientific article

Ionizing radiation affects the composition of the proteome of extracellular vesicles released by head-and-neck cancer cells in vitro

scientific article published on 01 May 2019

Irradiation with UV-C inhibits TNF-α-dependent activation of the NF-κB pathway in a mechanism potentially mediated by reactive oxygen species

scientific article

Isolation of Exosomes for the Purpose of Protein Cargo Analysis with the Use of Mass Spectrometry.

scientific article

Least Squares Estimators of Peptide Species Concentrations Based on Gaussian Mixture Decompositions of Protein Mass Spectra

article by Andrzej Polanski et al published 2015 in Springer Proceedings in Mathematics & Statistics

Long-term effects of low-dose mouse liver irradiation involve ultrastructural and biochemical changes in hepatocytes that depend on lipid metabolism

scientific article published on 22 February 2018

MALDI-MS-Based Profiling of Serum Proteome: Detection of Changes Related to Progression of Cancer and Response to Anticancer Treatment.

scientific article

MAR/SAR elements flank the rat hst70 gene transcription unit.

scientific article published in January 2004

MS-Based Proteomic Analysis of Serum and Plasma: Problem of High Abundant Components and Lights and Shadows of Albumin Removal.

scientific article published in January 2019

Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer.

scientific article

Mass spectrometry-based serum proteome pattern analysis in molecular diagnostics of early stage breast cancer

scientific article published on 13 July 2009

Metabolic Profiles of Whole Serum and Serum-Derived Exosomes Are Different in Head and Neck Cancer Patients Treated by Radiotherapy

scientific article published on 13 November 2020

Metabolome of Exosomes: Focus on Vesicles Released by Cancer Cells and Present in Human Body Fluids.

scientific article

Metabolome-based biomarkers: their potential role in the early detection of lung cancer

scientific article published on 30 September 2018

Metabolomic Signature Discriminates Normal Human Cornea from Keratoconus-A Pilot GC/MS Study

scientific article published on 25 June 2020

MicroRNA Profile of Exosomes and Parental Cells is Differently Affected by Ionizing Radiation

scientific article published on 08 May 2020

Mitochondrial transcription factor A is the major protein in rodent hepatocytes that recognizes DNA lesions induced by N-acetoxy-acetylaminofluorene

scientific article published on 04 December 2006

Modeling apoptotic chromatin condensation in normal cell nuclei. Requirement for intranuclear mobility and actin involvement

scientific article

Modeling of Imaging Mass Spectrometry Data and Testing by Permutation for Biomarkers Discovery in Tissues

Molecular Heterogeneity of Papillary Thyroid Cancer: Comparison of Primary Tumors and Synchronous Metastases in Regional Lymph Nodes by Mass Spectrometry Imaging.

scientific article

Molecular profiles of thyroid cancer subtypes: Classification based on features of tissue revealed by mass spectrometry imaging.

scientific article published on 16 October 2016

N-Nitrosodimethylamine and 7-methylguanine DNA adducts in tissues of rats fed Chinese salted fish

article

NF-κB signaling pathway is inhibited by heat shock independently of active transcription factor HSF1 and increased levels of inducible heat shock proteins

scientific article

Nucleosomes and regulation of gene expression. Structure of the HIV-1 5'LTR

scientific article published on January 1, 1998

OC-0265: Whole body response to radiation in head and neck and prostate cancer patient; the serum proteome comparative analysis

scholarly article by M. Pietrowska et al published April 2015 in Radiotherapy and Oncology

PHLDA1 Does Not Contribute Directly to Heat Shock-Induced Apoptosis of Spermatocytes.

scientific article

Panel of serum metabolites discriminates cancer patients and healthy participants of lung cancer screening - a pilot study.

scientific article published on 12 August 2017

Partial-Body Irradiation in Patients with Prostate Cancer Treated with IMRT Has Little Effect on the Composition of Serum Proteome.

scientific article published on 30 June 2015

Power of Proteomics and Progress in Precision Medicine - 13th Central and Eastern European Proteomic Conference (CEEPC), Ustroń, Poland

scientific article published on 08 June 2020

Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells.

scientific article

Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the expression of NF-kappaB-dependent genes.

scientific article published on 21 February 2018

Prognostic significance of Epstein-Barr virus viral load in patients with T1-T2 nasopharyngeal cancer

scientific article published on 22 October 2019

Proteome Profiling of Exosomes Purified from a Small Amount of Human Serum: The Problem of Co-Purified Serum Components.

scientific article

Proteome profiles of different types of thyroid cancers.

scientific article published on 25 November 2017

Proteomes of exosomes from HPV(+) or HPV(-) head and neck cancer cells: differential enrichment in immunoregulatory proteins

scientific article published on 15 April 2019

Proteomic analysis of exosomal cargo: the challenge of high purity vesicle isolation.

scientific article published on 31 March 2016

Proteomic landscape in Central and Eastern Europe: the 9th Central and Eastern European Proteomic Conference, Poznań, Poland.

scientific article published on 11 November 2015

Proteomic profile of melanoma cell‐derived small extracellular vesicles in patients’ plasma: a potential correlate of melanoma progression

scientific article published in February 2021

RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation

article

Radiation Therapy–Related Changes in Serum Proteome and Lipidome Are Primarily Associated With a Type of Acute Toxicity: Comparison of Radiation-Induced Effects in Patients Treated Because of Head and Neck Cancer or Prostate Cancer

article

Radiation-induced changes in serum lipidome of head and neck cancer patients

scientific article

Radiation-related changes in serum proteome profiles detected by mass spectrometry in blood of patients treated with radiotherapy due to larynx cancer.

scientific article

Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients

scientific article published on 06 September 2019

Radiotherapy-related changes in serum proteome patterns of head and neck cancer patients; the effect of low and medium doses of radiation delivered to large volumes of normal tissue

scientific article

Reconstitution of UV-damaged DNA into chromatin using Xenopus oocyte extracts.

scientific article published in January 1998

Resveratrol administration prevents radiation-related changes in metabolic profiles of hearts 20 weeks after irradiation of mice with a single 2 Gy dose

scientific article published on 01 December 2020

Roles of the major apoptotic nuclease-DNA fragmentation factor-in biology and disease.

scientific article published on January 2009

SPEN protein expression and interactions with chromatin in mouse testicular cells

scientific article published on 07 June 2018

Serum Proteome Signature of Radiation Response: Upregulation of Inflammation-Related Factors and Downregulation of Apolipoproteins and Coagulation Factors in Cancer Patients Treated With Radiation Therapy--A Pilot Study.

scientific article published on 07 April 2015

Serum lipid profile discriminates patients with early lung cancer from healthy controls

scientific article published in August 2017

Serum mass profile signature as a biomarker of early lung cancer.

scientific article published on 16 June 2016

Signal Partitioning Algorithm for Highly Efficient Gaussian Mixture Modeling in Mass Spectrometry

scientific article published on 31 July 2015

Signaling of Tumor-Derived sEV Impacts Melanoma Progression

scientific article published on 17 July 2020

Sperm DNA adducts impair fertilization during ICSI but not during IVF.

scientific article published in January 2007

Subunit structures and stoichiometries of human DNA fragmentation factor proteins before and after induction of apoptosis.

scientific article

Support Vector Machines in Biomedical and Biometrical Applications

Systemic Effects of Radiotherapy and Concurrent Chemo-Radiotherapy in Head and Neck Cancer Patients-Comparison of Serum Metabolome Profiles

scientific article published on 07 February 2020

Systemic effects of ionizing radiation at the proteome and metabolome levels in the blood of cancer patients treated with radiotherapy: the influence of inflammation and radiation toxicity

scientific article published on 10 March 2017

Systemic modulation of stress and immune parameters in patients treated for prostate adenocarcinoma by intensity-modulated radiation therapy or stereotactic ablative body radiotherapy

scientific article published on 09 June 2020

TNFalpha-induced activation of NFkappaB protects against UV-induced apoptosis specifically in p53-proficient cells.

scientific article

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

scientific article

The Influence of Ionizing Radiation on Exosome Composition, Secretion and Intercellular Communication

scientific article

The apoptotic endonuclease DFF40/CAD is inhibited by RNA, heparin and other polyanions

scientific article

The histone H1 C-terminal domain binds to the apoptotic nuclease, DNA fragmentation factor (DFF40/CAD) and stimulates DNA cleavage.

scientific article published in May 2005

The influence of DNA damage on cell cycle regulation

scientific article published on 01 January 1997

The major apoptotic endonuclease DFF40/CAD is a deoxyribose-specific and double-strand-specific enzyme

scientific article published in March 2008

The mutation profile of differentiated thyroid cancer coexisting with undifferentiated anaplastic cancer resembles that of anaplastic thyroid cancer but not that of archetypal differentiated thyroid cancer

scientific article published on 22 November 2020

The non-random distribution of UV-induced photoproducts in the nuclear matrix and non-matrix DNA fractions

scientific article published on 01 November 1996

The nuclear protein p30 specifically interacts with a nuclear matrix attachment region from the rat genome

scientific article published in January 2004

The role of chromatin proteins in DNA damage recognition and repair

scientific article

The truncation of Ku86 in human lymphocytes

scientific article published in March 2004

Therapy-Related Changes in the Serum Proteome Patterns of Early Stage Breast Cancer Patients with Different Outcomes.

scientific article published in January 2017

Tissue fixed with formalin and processed without paraffin embedding is suitable for imaging of both peptides and lipids by MALDI-IMS

scientific article published on 25 May 2016

Unique features of the apoptotic endonuclease DFF40/CAD relative to micrococcal nuclease as a structural probe for chromatin

scientific article published in August 2006

[Apoptosis: nuclease, caspases, cytochrome c]

scientific article published on 01 January 1998

[Interactions of proteins with damaged DNA]

scientific article published on 01 January 1995

[Proteins recognizing and binding damaged DNA; involvement in DNA repair and carcinogenesis]

scientific article published on 01 January 2000

[Proteins that recognize DNA strand breaks and their role in cellular stress response]

scientific article published on 01 January 2003

[Repair of ionizing radiation induced DNA double strand breaks]

scientific article published on 01 January 2000

[Site-specific formation and repair of mutagenic DNA damage of genetic material]

scientific article published on 01 January 1994

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