List of works - Marco J Herold

A non-canonical function of Ezh2 preserves immune homeostasis.

scientific article published on 21 February 2017

A point mutation in the signal peptide impairs the development of innate lymphoid cell subsets

scientific article published on 15 August 2018

A1/Bfl-1 in leukocyte development and cell death

scientific article

Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death

scientific article published on 23 September 2011

Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.

scientific article published on 3 May 2007

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo

scientific article

An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles

scientific article

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells

scientific article published on 16 January 2018

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

scientific article published on January 2012

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

scientific article published on 31 March 2017

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

scientific article

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

scientific article published in December 2014

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

scientific article published on 24 April 2019

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

scientific article published on 25 November 2020

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

scientific article published on 08 March 2016

CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats

scientific article published on 7 May 2013

CRISPR/Cas9-The ultimate weapon to battle infectious diseases?

scientific article

CRISPR/Cas9: A tool for immunological research

scientific article published on 7 February 2018

Characterisation of a novel A1-specific monoclonal antibody.

scientific article published on 4 December 2014

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

scientific article published on 13 January 2017

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

scientific article published on 28 August 2018

Characterization of a novel human BFL-1-specific monoclonal antibody

scientific article published on 12 November 2019

Clearance of measles virus from persistently infected cells by short hairpin RNA.

scientific article

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

scientific article published on 20 January 2017

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

scientific article

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

scientific article published on 09 October 2015

Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis

scientific article published on 20 October 2020

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

scientific article published on 29 September 2017

Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy

scientific article published on 17 November 2020

DNA repair processes are critical mediators of p53-dependent tumor suppression

scientific article published on 11 June 2018

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

scientific article published on 18 October 2017

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

scientific article published on 14 April 2017

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer

scientific article published on 03 April 2020

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

scientific article published on 23 October 2019

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

scientific article published in 2022

Erratum: Corrigendum: The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

article

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA.

scientific article published on 31 July 2014

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

scientific article

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

scientific article published on 25 October 2018

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

scientific article published on 28 August 2018

Glucocorticoid-induced apoptosis in animal models of multiple sclerosis.

scientific article published on January 2013

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

scientific article published on 23 April 2007

HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells

scientific article published on 30 January 2020

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

scientific article published on 30 September 2016

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.

scientific article

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

scientific article published on 17 November 2017

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

scientific article published on 19 July 2013

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

scientific article published on 23 August 2018

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

scientific article published on 9 October 2014

It's not over until the FAT lady sings

scientific article published on 17 January 2014

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

scientific article published in March 2018

Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

scientific article published in 2022

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

scientific article published on 01 April 2019

MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway

scientific article published on 12 July 2018

MDM4 is a rational target for treating breast cancers with mutant p53.

scientific article published on 18 January 2017

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability.

scientific article published on December 2016

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

scientific article

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins

scientific article published on 24 July 2018

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids

scientific article published on 07 October 2019

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

scientific article published on 11 December 2019

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

scientific article published on January 2013

Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.

scientific article published on 11 December 2014

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

scientific article published on 14 July 2015

PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.

scientific article

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

scientific article published on 14 April 2021

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

scientific article published on 26 November 2019

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3.

scientific article

Proliferation arrest in B-Raf mutant melanoma cell lines upon MAPK pathway activation

scientific article

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

scientific article

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.

scientific article published on 12 September 2016

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

scientific article published on 01 May 2019

Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells

scientific article

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP.

scientific article published on 19 September 2016

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells

scientific article published on 01 June 2019

Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNA: insight into neuroinflammatory disease

scientific article published in September 2009

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

scientific article published in August 2017

Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells.

scientific article published on 30 March 2017

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

scientific article published on 05 October 2020

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

scientific article published on 24 July 2018

Targeting Mdmx to treat breast cancers with wild-type p53.

scientific article

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice ⬇️

scientific article published on May 11, 2012

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

scientific article published on January 2014

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.

scientific article published on 13 January 2017

The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens

scientific article

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

scientific article published on 19 October 2016

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

scientific article published on 24 August 2020

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice

scientific article published on 11 August 2017

The new editor-targeted genome engineering in the absence of homology-directed repair

scientific article published on 13 June 2016

The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils

scientific article published on 18 June 2020

The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

scientific article published on 04 November 2020

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

scientific article

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

scientific article published on 11 May 2021

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

scientific article published on 18 February 2016

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

scientific article published on 02 January 2019

Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

scientific article published on 11 April 2022

Using CRISPR/Cas9 Technology for Manipulating Cell Death Regulators

scientific article published in January 2016

VDAC2 enables BAX to mediate apoptosis and limit tumor development

scientific article published in Nature Communications

miR17~92 is essential for the survival of hematopoietic stem and progenitor cells by restraining pro-apoptotic BIM

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells

scientific article published on 07 October 2019

List of works by Marco J Herold

A non-canonical function of Ezh2 preserves immune homeostasis.

A point mutation in the signal peptide impairs the development of innate lymphoid cell subsets

A1/Bfl-1 in leukocyte development and cell death

Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death

Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo

An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats

CRISPR/Cas9-The ultimate weapon to battle infectious diseases?

CRISPR/Cas9: A tool for immunological research

Characterisation of a novel A1-specific monoclonal antibody.

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis

Characterization of a novel human BFL-1-specific monoclonal antibody

Clearance of measles virus from persistently infected cells by short hairpin RNA.

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy

DNA repair processes are critical mediators of p53-dependent tumor suppression

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

Erratum: Corrigendum: The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA.

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

Glucocorticoid-induced apoptosis in animal models of multiple sclerosis.

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

It's not over until the FAT lady sings

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway

MDM4 is a rational target for treating breast cancers with mutant p53.

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability.

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3.

Proliferation arrest in B-Raf mutant melanoma cell lines upon MAPK pathway activation

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP.

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells

Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNA: insight into neuroinflammatory disease

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells.

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1