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List of works by Hitoshi Hashimoto

15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells.

scientific article published on 16 April 2010

A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells

scientific article

A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth.

scientific article

A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells.

scientific article

Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes.

scientific article published on 4 July 2018

Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission

scientific article published on 13 April 2011

Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice

scientific article published on 9 November 2017

Altered Notch Signaling in Developing Molar Teeth of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Deficient Mice

scientific article published on 10 August 2018

An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice

scientific article

An enriched environment ameliorates memory impairments in PACAP-deficient mice

scientific article

Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. ⬇️

scientific article published on 17 December 2016

Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test.

scientific article published on 31 May 2007

Anxiolytic-like effects of restraint during the dark cycle in adolescent mice.

scientific article

Association of Serotonin Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia

scientific article published on 15 February 2019

Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide

scientific article

Backup Mechanisms Maintain PACAP/VIP-Induced Arterial Relaxations in Pituitary Adenylate Cyclase-Activating Polypeptide-Deficient Mice

scientific article published on 11 May 2017

CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice

scientific article published on 16 February 2015

Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice

scientific article published on 6 April 2010

Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner

scientific article published on 27 February 2013

Cerulein-induced acute pancreatitis in PACAP knockout mice

scientific article published on 22 June 2010

Changes in light-induced phase shift of circadian rhythm in mice lacking PACAP.

scientific article published in October 2003

Characterization of the thermoregulatory response to pituitary adenylate cyclase-activating polypeptide in rodents.

scientific article published on 4 July 2014

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

scientific article published on 18 September 2014

Comparative examination of inner ear in wild type and pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice

scientific article published on 28 December 2011

Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice.

scientific article published on 24 June 2015

Comparative protein composition of the brains of PACAP-deficient mice using mass spectrometry-based proteomic analysis.

scientific article

Comparison of intestinal cold preservation injury on pituitary adenylate cyclase-activating polypeptide in knockout and wild-type mice

scientific article published on July 2010

Compensatory recovery of blood glucose levels in KKA(y) mice fed a high-fat diet: insulin-sparing effects of PACAP overexpression in β cells

scientific article published on 03 April 2012

Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice

scientific article

Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background

scientific article

Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice.

scientific article published on 25 October 2016

Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior

scientific article

Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice.

scientific article published on 5 June 2015

Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse

scientific article

Differential expression of mRNAs for PACAP and its receptors during neural differentiation of embryonic stem cells.

scientific article published on March 2005

Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model.

scientific article

Distribution of secretin receptors in the rat central nervous system: an in situ hybridization study

scientific article published on 11 October 2012

Disturbed spermatogenic signaling in pituitary adenylate cyclase activating polypeptide-deficient mice.

scientific article published on 3 November 2017

Double In situ Hybridization for MicroRNAs and mRNAs in Brain Tissues.

scientific article

Early Neurobehavioral Development of Mice Lacking Endogenous PACAP.

scientific article

Effects of pituitary adenylate cyclase activating polypeptide on human sperm motility.

scientific article

Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.

scientific article

Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain

scientific article published in January 2010

Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice

scientific article

Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice.

scientific article published on 6 February 2010

Examination of calcium-binding protein expression in the inner ear of wild-type, heterozygous and homozygous pituitary adenylate cyclase-activating polypeptide (PACAP)-knockout mice in kanamycin-induced ototoxicity

scientific article published on 24 October 2013

Functional roles of the neuropeptide PACAP in brain and pancreas.

scientific article

Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice.

scientific article published on 3 October 2007

GnRH-induced PACAP and PAC1 receptor expression in pituitary gonadotrophs: a possible role in the regulation of gonadotropin subunit gene expression

scientific article published on 27 May 2010

Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice

scientific article published on 10 October 2019

High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance

scientific article published on December 2016

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.

scientific article

Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP).

scientific article

Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro.

scientific article published on 23 January 2015

Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice.

scientific article

Impaired long-term potentiation in vivo in the dentate gyrus of pituitary adenylate cyclase-activating polypeptide (PACAP) or PACAP type 1 receptor-mutant mice ⬇️

scientific article published on November 14, 2003

Impaired nocifensive behaviours and mechanical hyperalgesia, but enhanced thermal allodynia in pituitary adenylate cyclase-activating polypeptide deficient mice

scientific article published on October 2010

Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse

scientific article published on 9 November 2012

Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism

scientific article published on 30 December 2015

Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with 11C-labeled 20-HETE synthase-specific inhibitor

scientific article published on 6 June 2012

Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice

scientific article

Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.

scientific article published on 21 October 2010

Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice.

scientific article published on 26 November 2009

Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations

scientific article

Inhibition of self-renewal and induction of neural differentiation by PACAP in neural progenitor cells

scientific article published on 01 July 2006

Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity

scientific article published on 12 May 2010

Intranasal application of secretin, similarly to intracerebroventricular administration, influences the motor behavior of mice probably through specific receptors

scientific article published in July 2012

Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency

scientific article published on 23 June 2016

Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus

scientific article published on 5 June 2008

KB-R7943 inhibits store-operated Ca(2+) entry in cultured neurons and astrocytes

scientific article published in December 2000

Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism

scientific article published on 25 January 2018

Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice

scientific article published on 15 August 2008

Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice

scientific article published on 01 July 2006

Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice

scientific article published on 08 October 2020

Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: Possible role of activation of the central amygdala.

scientific article published on 24 December 2011

Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats

scientific article published on 30 October 2018

Markedly reduced white adipose tissue and increased insulin sensitivity in adcyap1-deficient mice

scientific article published on 29 April 2008

Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice.

scientific article published on 25 September 2012

Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice

scientific article published on 19 June 2007

Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo

scientific article published on 30 June 2011

Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) show increased susceptibility to in vivo renal ischemia/reperfusion injury

scientific article published on 05 January 2011

Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro

scientific article published on 22 November 2009

Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice

scientific article published in December 2006

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

scientific article published on 03 November 2022

Monoaminergic neuronal development is not affected in PACAP-gene-deficient mice

scientific article published in March 2005

Neuroprotective action of endogenous PACAP in cultured rat cortical neurons.

scientific article published in March 2005

Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse

scientific article published on 12 August 2010

Neuroprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on spinal cord injury

scientific article

New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice

scientific article published in July 2006

Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice

scientific article published in August 2009

Overexpression of PACAP in the pancreas failed to rescue early postnatal mortality in PACAP-null mice.

scientific article published on December 2004

Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice.

scientific article published on 23 January 2004

Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism.

scientific article

PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density

scientific article published on 11 March 2013

PACAP activates Rac1 and synergizes with NGF to activate ERK1/2, thereby inducing neurite outgrowth in PC12 cells.

scientific article published in April 2004

PACAP centrally mediates emotional stress-induced corticosterone responses in mice.

scientific article published on 27 March 2011

PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus.

scientific article published in November 2004

PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF.

scientific article published on 25 March 2015

PACAP is an endogenous protective factor-insights from PACAP-deficient mice.

scientific article published on 14 April 2012

PACAP is transiently expressed in anterior pituitary gland of rats: in situ hybridization and cell immunoblot assay studies

scientific article

PACAP provides colonic protection against dextran sodium sulfate induced colitis

scientific article

PACAP suppresses dry eye signs by stimulating tear secretion

scientific article

PACAP- and PHI-mediated sustained relaxation in circular muscle of gastric fundus: findings obtained in PACAP knockout mice.

scientific article published on 17 October 2005

PACAP-deficient mice exhibit light parameter-dependent abnormalities on nonvisual photoreception and early activity onset

scientific article

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes

scientific article published on 26 February 2020

Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice.

scientific article

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Is Involved in Adult Mouse Hippocampal Neurogenesis After Stroke

scientific article

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Regulates the Hypothalamo-Pituitary-Thyroid (HPT) Axis via Type 2 Deiodinase in Male Mice

scientific article published on 5 April 2016

Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema

scientific article

Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation

scientific article published on 18 March 2019

Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice

scientific article published on 11 January 2020

Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor.

scientific article

Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.

scholarly article

Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery.

scientific article

Pituitary adenylate cyclase-activating polypeptide deficiency enhances oxazolone-induced allergic contact dermatitis in mice

scientific article published on 23 April 2010

Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain.

scientific article

Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice.

scientific article

Pituitary adenylate cyclase-activating polypeptide plays an anti-inflammatory role in endotoxin-induced airway inflammation: in vivo study with gene-deleted mice

scientific article published on 14 May 2011

Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion

scientific article published on 25 July 2016

Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

scientific article published on 13 November 2009

Possible involvement of a cyclic AMP-dependent mechanism in PACAP-induced proliferation and ERK activation in astrocytes

scientific article published in November 2003

Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation.

scientific article published on 14 June 2016

Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain

scientific article

Presence of endogenous PACAP-38 ameliorated intestinal cold preservation tissue injury.

scientific article published on 9 April 2010

Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction.

scientific article published on 29 July 2016

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome

scientific article published on 19 June 2019

Psychopharmacology of combined activation of the serotonin1A and σ1 receptors

scientific article

Reduced hypothermic and hypnotic responses to ethanol in PACAP-deficient mice

scientific article published on December 2004

Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model

scientific article

Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers

scientific article published on 6 June 2016

Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist.

scientific article

Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide

scientific article published on 19 February 2010

Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor.

scientific article published on 13 April 2010

Retardation of retinal vascular development in apelin-deficient mice

scientific article

Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice

scientific article

Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice.

scientific article published in September 2007

Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice.

scientific article published on 31 October 2015

Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions.

scientific article

Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice.

scientific article

Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination of the rodent brain: lessons from PACAP-deficient mice

scientific article

Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis

scientific article published on 23 October 2010

Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice.

scientific article

Roles of PACAP and PHI as inhibitory neurotransmitters in the circular muscle of mouse antrum

scientific article

Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-).

scientific article published in July 2006

Serotonin 5-HT(7) receptor blockade reverses behavioral abnormalities in PACAP-deficient mice and receptor activation promotes neurite extension in primary embryonic hippocampal neurons: therapeutic implications for psychiatric disorders.

scientific article published on 29 July 2012

Simultaneous neuron- and astrocyte-specific fluorescent marking.

scientific article published on 24 February 2015

Structural and Morphometric Comparison of Lower Incisors in PACAP-Deficient and Wild-Type Mice.

scientific article published on 6 May 2016

Structural and morphometric comparison of the molar teeth in pre-eruptive developmental stage of PACAP-deficient and wild-type mice

scientific article

Structured line illumination Raman microscopy

scientific article

The Female Encounter Test: A Novel Method for Evaluating Reward-Seeking Behavior or Motivation in Mice

scientific article published on 29 May 2015

The behavioral phenotype of pituitary adenylate-cyclase activating polypeptide-deficient mice in anxiety and depression tests is accompanied by blunted c-Fos expression in the bed nucleus of the stria terminalis, central projecting Edinger-Westphal

scientific article published on 09 December 2011

The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide

scientific article published on 01 February 2011

The pituitary adenylate cyclase–activating polypeptide is a physiological inhibitor of platelet activation

article published in 2004

The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice

scientific article published on 27 January 2012

The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide.

scientific article published in February 2013

Trophic effects of PACAP on pancreatic islets: a mini-review.

scientific article published on 20 July 2010

Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response.

scientific article published on 24 November 2017

VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice

scientific article published in PLoS ONE

Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST

scientific article published on 08 April 2019

Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder.

scientific article published on 19 November 2015

mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model

scientific article published on 09 November 2018

p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice

scientific journal article

β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.

scientific article

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