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List of works by Ian M. Adcock

"Education is the passport to the future": enabling today's medical teachers to prepare tomorrow's respiratory health practitioners

scientific article published in September 2014

"T2-high" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin

scientific article published on 03 January 2019

13th European Respiratory Society Annual congress

scientific article published in December 2003

2nd cross company respiratory symposium

5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene

scientific article

A Preliminary Study of microRNA-208b after Acute Myocardial Infarction: Impact on 6-Month Survival.

scientific article

A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U-BIOPRED Cohorts

scientific article published on 01 May 2017

A Topological Data Analysis Network Model of Asthma Based on Blood Gene Expression Profiles

article

A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED

scientific article published on 15 February 2017

A bioinformatics analysis of exosomal microRNAs released following mycobacterial infection

scientific article published on 01 July 2019

A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model

scientific article published on 01 March 2014

A computational framework for complex disease stratification from multiple large-scale datasets.

scientific article published on 29 May 2018

A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice

scientific article

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.

scientific article

A new ataxia-telangiectasia mutation in an 11-year-old female

scientific article

A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease.

scientific article published on 9 April 2010

Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma

scientific article

Abnormal histone acetylase and deacetylase expression and function in lung inflammation.

scientific article published on August 2006

Activation of NF-kappaB transcription factor in asthma death

scientific article published in March 2009

Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice

scientific article

Agonist-induced up-regulation of platelet-activating factor receptor messenger RNA in human monocytes

scientific article published on 01 July 1994

Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma

scientific article published on January 2014

Airways diseases: insights from the European Respiratory Society Annual Congress 2017.

scientific article published in November 2017

Albuterol Does Not Antagonize the Inhibitory Effect of Dexamethasone on Monocyte Cytokine Release ⬇️

scientific article published on 01 March 1998

Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase

scientific article

Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease.

scientific article published in December 2005

An adult autosomal recessive chronic granulomatous disease patient with pulmonary Aspergillus terreus infection

scientific article published on 08 November 2018

An improved and rapid procedure for isolating RNA-Free Escherichia coli plasmid DNA

scientific article published on 01 May 1991

An integrative systems biology approach to understanding pulmonary diseases

scientific article published in June 2010

An unusual case of congenital short trachea with very long bronchi mimicking bronchial asthma

scientific article published on April 2002

Animal models of COPD: What do they tell us?

scientific article

Anti-Inflammatory Effects of Lactobacillus Rahmnosus and Bifidobacterium Breve on Cigarette Smoke Activated Human Macrophages

scientific article published on 28 August 2015

Anti-inflammatory actions of steroids: molecular mechanisms

scientific article published on December 1993

Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD.

scientific article

Anti-inflammatory mechanisms of glucocorticoids targeting granulocytes.

scientific article

Application of 'omics technologies to biomarker discovery in inflammatory lung diseases

scientific article published on 08 February 2013

Are There Any Epigenetic Similarities Between Treatment Unresponsive Sarcoidosis, COPD and Severe Asthma?

scientific article

Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

scientific article published on 01 April 2018

Association of endopeptidases, involved in SARS-CoV-2 infection, with microbial aggravation in sputum of severe asthma

scientific article published on 07 January 2021

Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD.

scientific article published on 23 August 2009

Association of serum TNF-α, IL-8 and free light chain with HLA-DR B alleles expression in pulmonary and extra-pulmonary sarcoidosis

scientific article

Asthma phenotypes and T-bet protein expression in cells treated with Fluticasone Furoate/Vilanterol

scientific article published on 07 January 2020

Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status

scientific article published on 26 November 2019

AsthmaMap: An expert-driven computational representation of disease mechanisms

scholarly article by Alexander Mazein et al published 30 July 2018 in Clinical & Experimental Allergy

AsthmaMap: an interactive knowledge repository for mechanisms of asthma

scientific article published on 09 December 2020

Attenuated production of intracellular IL-10 and IL-12 in monocytes from patients with severe asthma

scientific article published in March 2002

Attenuation of Ozone-Induced Airway Inflammation and Hyper-Responsiveness by c-Jun NH2 Terminal Kinase Inhibitor SP600125

scientific article published on 25 April 2007

Autoimmunity and COPD: Clinical Implications

scientific article published on 7 November 2017

B cells contribute to the antitumor activity of CpG-oligodeoxynucleotide in a mouse model of metastatic lung carcinoma.

scientific article

BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle

scientific article published on 19 February 2015

BET proteins are a key component of immunoglobulin gene expression.

scientific article

BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production

scientific article

Bacterial load and inflammatory response in sputum of alpha-1 antitrypsin deficiency patients with COPD

scientific article published on 21 August 2019

Barnes and Adcock reply

Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma

scientific article published on 10 September 2019

Bovis Bacillus Calmette-Guerin (BCG) infection induces exosomal miRNA release by human macrophages

scientific article

Brd4 is essential for IL-1β-induced inflammation in human airway epithelial cells

scientific article

Breaking news: DNA damage and repair pathways in COPD and implications for pathogenesis and treatment

scientific article published on 04 October 2018

Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation

scientific article published on 18 April 2019

Bromodomain and extra-terminal protein mimic JQ1 decreases inflammation in human vascular endothelial cells: Implications for pulmonary arterial hypertension.

scientific article published on 18 August 2016

Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression

scientific article

Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease?

scientific article published on 13 April 2015

Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression.

scientific article

Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD

scientific article published on 10 April 2020

Bronchodilatory effect of the PPAR-gamma agonist rosiglitazone in smokers with asthma

scientific article

Budesonide facilitates weaning from mechanical ventilation in difficult-to-wean very severe COPD patients: Association with inflammatory mediators and cells.

scientific article published on 31 October 2017

CCL11 as a potential diagnostic marker for asthma?

scientific article published on 13 May 2014

COPD immunopathology

scientific article

CSF3R/CD114 mediates infection-dependent transition to severe asthma

scientific article published on 09 October 2018

Cancers Related to Immunodeficiencies: Update and Perspectives

scientific article

Cellular and molecular mechanisms in chronic obstructive pulmonary disease: an overview.

scientific article published in August 2004

Cellular endotoxin desensitization in patients with severe chronic heart failure.

scientific article

Cellular mechanisms underlying steroid-resistant asthma

scientific article published on 01 September 2019

Characteristics and treatment regimens across ERS SHARP severe asthma registries

scientific article published on 09 January 2020

Chemokine receptor inhibitors as a novel option in treatment of asthma.

scientific article published in September 2004

Chemokines and chemokine receptors blockers as new drugs for the treatment of chronic obstructive pulmonary disease.

scientific article

Chromosome 17q21 SNP and severe asthma.

scientific article

Chronic Airway Diseases Early Stratification (CADSET): a new ERS Clinical Research Collaboration

scientific article published on 18 March 2019

Chronic Obstructive Pulmonary Disease and Lung Cancer: A Lethal Association ⬇️

scientific article published on October 15, 2011

Chronic obstructive pulmonary disease and lung cancer: new molecular insights

scientific article published on 24 March 2011

Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function

scientific article

Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance

scientific article

Cigarette smoke induced airway inflammation is independent of NF-κB signalling

scientific article

Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor.

scientific article published on 19 October 2009

Circulating leptin concentrations in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

scientific article published on 19 October 2013

Clinical Definition of COPD Exacerbations and Classification of Their Severity

scientific article published on 01 March 2009

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

scientific article published on 10 September 2015

Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort

scientific article published on 01 April 2022

Clinical characteristics of re-positive COVID-19 patients in Huangshi, China: A retrospective cohort study

scientific article published on 04 November 2020

Clinical phenotypes of asthma should link up with disease mechanisms

scientific article

Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma.

scientific article

Common Infections and Target Organs Associated with Chronic Granulomatous Disease in Iran

scientific article published on 22 March 2019

Common features of tuberculosis and sarcoidosis

scientific article

Comparing biologicals and small molecule drug therapies for chronic respiratory diseases

scientific article published on 08 January 2019

Con: Genome-Wide Association Studies Have Not Been Useful in Understanding Asthma ⬇️

scientific article published on September 15, 2011

Concomitant patterns of tuberculosis and sarcoidosis

scientific article

Conjugated Alpha-Alumina nanoparticle with vasoactive intestinal peptide as a Nano-drug in treatment of allergic asthma in mice

scientific article

Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP-10 and MET

scientific article published on 11 February 2019

Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping

scientific article published on 27 December 2011

Correction to: Exhaled nitric oxide is not a biomarker for idiopathic pulmonary arterial hypertension or for treatment efficacy

scientific article published on 05 November 2019

Correction to: Silent hypoxia: higher NO in red blood cells of COVID-19 patients

scientific article published on 10 November 2020

Correction to: Water-pipe smoke condensate increases the internalization of Mycobacterium Bovis of type II alveolar epithelial cells (A549)

scientific article published on 22 September 2020

Correction: BMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production

scientific article published in PLoS ONE

Correction: Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling

scholarly article by Joseph M. D. Rastrick et al published 16 October 2013 in PLOS ONE

Correction: Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

scientific article published on 07 September 2018

Corrigendum to “Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation” [European Journal of Pharmacology 600 (2008) 117-122]

scholarly article by Alison S. Williams et al published May 2009 in European Journal of Pharmacology

Corticosteroid inhibition of growth-related oncogene protein-alpha via mitogen-activated kinase phosphatase-1 in airway smooth muscle cells

scientific article published on 01 June 2007

Corticosteroid modulation of immunoglobulin expression and B-cell function in COPD.

scientific article published on 17 February 2016

Corticosteroid resistance and novel anti-inflammatory therapies in chronic obstructive pulmonary disease: current evidence and future direction.

scientific article published on July 2012

Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase.

scientific article published on February 2004

Corticosteroid-insensitive asthma: molecular mechanisms.

scientific article

CpG-ODN increases the release of VEGF in a mouse model of lung carcinoma

scientific article published on 08 October 2010

Cross-talk between pro-inflammatory transcription factors and glucocorticoids.

scientific article

Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma

scientific article published on 17 March 2020

Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells

scientific article published on January 1997

Cytokine inhibition in the treatment of COPD.

scientific article

Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease

article

DNA methylation modules in airway smooth muscle are associated with asthma severity.

scientific article published on 15 February 2018

Dealing with Stress: Defective Metabolic Adaptation in Chronic Obstructive Pulmonary Disease Pathogenesis.

scientific article published in November 2017

Decreased T lymphocyte infiltration in bronchial biopsies of subjects with severe chronic obstructive pulmonary disease

scientific article published in June 2001

Decreased breath excretion of redox active iron in COPD: a protective failure?

scientific article published on 23 December 2015

Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

scientific article

Decreased percentage of CD4(+)Foxp3(+)TGF-β(+) and increased percentage of CD4(+)IL-17(+) cells in bronchoalveolar lavage of asthmatics

scientific article

Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients

scientific article

Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways

scientific article published on 02 September 2020

Developing a novel integrated model of p38 MAPK and glucocorticoid signalling pathways

Dexamethasone and RU24858 Induce Survival and Growth Factor Receptor Bound Protein 2, Leukotriene B4 Receptor 1 and Annexin-1 Expression in Primary Human Neutrophils

scientific article

Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells

scientific article published on 18 September 2015

Dexamethasone inhibits ozone-induced gene expression of macrophage inflammatory protein-2 in rat lung

scientific article published on April 1995

Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats

scientific article published on 06 August 2010

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

scientific article published in Journal of Biological Chemistry

Differential expression of IL-10 receptor by epithelial cells and alveolar macrophages

scientific article published in May 2004

Differential patterns of histone acetylation in inflammatory bowel diseases

scientific article

Differential regulation and function of 5'-untranslated GR-exon 1 transcripts.

scientific article

Differential regulation of the constitutive and inducible nitric oxide synthase mRNA by lipopolysacchride treatment in vivo in the rat

scientific article published on 01 July 1996

Discordant use of short-acting β2 agonists in children and adults with severe, uncontrolled asthma from the U-BIOPRED cohort

scientific article published on 24 November 2020

Dissociated Glucocorticoids

Dissociation of DNA damage and mitochondrial injury caused by hydrogen peroxide in SV-40 transformed lung epithelial cells

scientific article

Divergent effect of mometasone on human eosinophil and neutrophil apoptosis

scientific article published in August 2002

Does Neutrophil Phenotype Predict the Survival of Trauma Patients?

scientific article published on 06 September 2019

ERS International Congress, Madrid, 2019: highlights from the Airway Diseases, Asthma and COPD Assembly

scientific article published on 01 January 2020

ERS Lung Science Conference 2016 report.

scientific article

Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats

scientific article

Effect of cigarette smoking on haem-oxygenase expression in alveolar macrophages

scientific article published in June 2004

Effect of interleukin-10 on the production of tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with chronic heart failure

scientific article published on 01 August 2002

Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study

scientific article published on 5 February 2009

Effect of mesenchymal stem cell-derived exosomes on the induction of mouse tolerogenic dendritic cells

scientific article published on 11 February 2020

Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors

scientific article

Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model.

scientific article

Effects of cigarette smoke extract on human airway smooth muscle cells in COPD.

scientific article

Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung

article

Effects of glucocorticoids on gene transcription

scientific article

Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays.

scientific article published in August 2004

Effects of the polyunsaturated fatty acids, EPA and DHA, on hematological malignancies: a systematic review

scientific article published on 5 February 2018

Elevated CXCL-8 expression in bronchoalveolar lavage correlates with disease severity in patients with acute respiratory distress syndrome resulting from tuberculosis.

scientific article

Endotoxin and steroid effects on nitric oxide synthase mRNA expression in rat lung and other tissues ⬇️

scientific article published on May 1, 1994

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort

scientific article published in PLoS ONE

Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs.

scientific article published on November 1994

Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung

scientific article published on 19 February 2019

Epigenetic regulation of airway inflammation.

scientific article published on 27 August 2007

Epigenetics and airways disease

scientific article

Epigenetics and chromatin remodeling play a role in lung disease

scientific article

Epigenetics in asthma and COPD.

scientific article published on 31 July 2012

Epigenetics in asthma and other inflammatory lung diseases

scientific article published on August 2010

Epigenetics of asthma ⬇️

scientific article published on March 21, 2011

Epigenome-modifying tools in asthma

scientific article

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

scholarly article by Zala Jevnikar et al published June 2018 in The Journal of Allergy and Clinical Immunology

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

scientific article published on 27 June 2019

Epithelial expression and role of secreted STC1 on asthma airway hyperresponsiveness through calcium channel modulation

scientific article published on 30 December 2020

Erratum to “Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness” [Eur. J. Pharmacol. 452 (2002) 123–133]

scholarly article published in European Journal of Pharmacology

Erratum to “The role of PDE4 in pulmonary inflammation and goblet cell hyperplasia in allergic rats” [Biochem. Biophys. Acta 1762 (2006) 525–532]

scholarly article by Hui-Fang Tang et al published August 2006 in BBA: Molecular Basis of Disease

Evaluation of Innate Immune Mediators Related to Respiratory Viruses in the Lung of Stable COPD Patients

scientific article published on 10 June 2020

Evidence for M2 macrophages in granulomas from pulmonary sarcoidosis: A new aspect of macrophage heterogeneity

scientific article published on 26 October 2017

Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta

scientific article published on August 1997

Exhaled carbon monoxide in asthmatics: a meta-analysis

scientific article

Exhaled nitric oxide is not a biomarker for idiopathic pulmonary arterial hypertension or for treatment efficacy

scientific article published on 29 October 2019

Exosomes and Exosomal miRNA in Respiratory Diseases

scientific article

Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy.

scientific article published on 8 May 2018

Expression and activity of histone deacetylases in human asthmatic airways

scientific article published in August 2002

Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies

scientific article published on 01 September 2001

Expression of honeybee prepromelittin as a fusion protein in Escherichia coli

scientific article published in October 1991

Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma

scientific article published on 25 September 2006

Ezrin, a Membrane Cytoskeleton Cross Linker Protein, as a Marker of Epithelial Damage in Asthma

scientific article published on 01 February 2019

FN3K expression in COPD: a potential comorbidity factor for cardiovascular disease

scientific article published on 01 November 2020

First report of occurrence of Mycobacterium tuberculosis and Non-tuberculous mycobacteria in a heterozygous carrier of chronic granulomatous patient

scholarly article by Dina Soroush et al published March 2015 in International journal of mycobacteriology

Flow cytometry applications in the study of immunological lung disorders

scientific article

Fluticasone furoate and vilanterol for the treatment of chronic obstructive pulmonary disease

scientific article

Formoterol attenuates neutrophilic airway inflammation in asthma

scientific article published in October 2005

Functional effects of the microbiota in chronic respiratory disease

scientific article published on 08 April 2019

Gene-environment interactions in the development of chronic obstructive pulmonary disease.

scientific article published on October 2006

Glucocorticoid Actions on Airway Smooth Muscle

Glucocorticoid Receptor Nuclear Translocation in CD4 T Cells from Severe and Moderate Asthmatic Patients Treated with Fluticasone/Vilanterol

scientific article published in February 2018

Glucocorticoid pathways in chronic obstructive pulmonary disease therapy.

scientific article

Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands

scientific article published in September 2003

Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy.

scientific article

Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.

scientific article

Glucocorticoid resistance in inflammatory diseases.

scientific article published on May 2009

Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation

scientific article published in October 2001

Glucocorticoid-regulated transcription factors.

scientific article

Glucocorticoids

scientific article published on 01 January 2017

Glucocorticoids: effects on gene transcription

scientific article

Glucocorticoids: new mechanisms and future agents

scientific article

Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD.

scientific article

Health effects of air pollution: what we need to know and to do in the next decade

scientific article published on 01 April 2019

Heightened response to e-cigarettes in COPD

High concentrations of B-adrenergic agonists inhibit DNA binding of glucocorticoids in human lung in vitro ⬇️

scientific article published on May 1, 1995

High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report

scientific article published on 01 January 2019

Histological Evidence for Therapeutic Induction of Angiogenesis Using Mast Cells and Platelet-Rich Plasma within A Bioengineered Scaffold following Rat Hindlimb Ischemia

scientific article published on 29 July 2019

Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma

scientific article published on 15 April 2004

Histone acetylation and deacetylation: importance in inflammatory lung diseases

scientific article (publication date: March 2005)

Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression

scientific article

Histone deacetylase inhibitors as novel anti-inflammatory agents

scientific article published on November 2006

Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils.

scientific article

Histone deacetylation: an important mechanism in inflammatory lung diseases

scientific article published on December 2005

Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease

scientific article published on 19 May 2020

How can we minimise the use of regular oral corticosteroids in asthma?

scientific article published on 05 February 2020

How do corticosteroids work in asthma?

scientific article

How variability in clinical phenotypes should guide research into disease mechanisms in asthma

scientific article (publication date: December 2013)

Hydrogen Sulfide Inhibits Proliferation and Release of IL-8 from Human Airway Smooth Muscle Cells

Hydrogen peroxide in exhaled breath condensate in patients with asthma: a promising biomarker?

scientific article published on 24 March 2011

Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

scientific article published on 12 May 2008

Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells

scientific article published on 4 February 2011

Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription.

scientific article published on 30 October 2009

IL-17-high asthma with features of a psoriasis immunophenotype

scientific article published on 15 April 2019

IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis

scientific article published on 18 July 2019

IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive anti-viral immunity

scientific article published on 12 October 2018

I_MDS: an inflammatory bowel disease molecular activity score to classify patients with differing disease-driving pathways and therapeutic response to anti-TNF treatment

scientific article published on 30 April 2019

Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level

scientific article published on 01 July 1997

Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy

scientific article published on 28 July 2011

Immunoglobulin Free Light Chains in the Pathogenesis of Lung Disorders

scientific article published on August 2017

Immunologic finding of disseminated granuloma reaction in patients with Mycobacterium tuberculosis and sarcoidosis

scholarly article by Maryam A. Dizaj et al published March 2015 in International journal of mycobacteriology

Immunological Features of Chronic Obstructive Pulmonary Disease (COPD) Induced by Indoor Pollution and Cigarette Smoke

scientific article

Immunopathology of sarcoidosis

scientific article

Impact of protein acetylation in inflammatory lung diseases

scientific article published on 24 July 2007

Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD

scientific article published on 13 February 2014

Impaired innate immune gene profiling in airway smooth muscle cells from chronic cough patients

scientific article

Importin-7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity

scientific article published on 9 August 2013

In vitro effects of water-pipe smoke condensate on the endocytic activity of Type II alveolar epithelial cells (A549) with bacillus Calmette-Guérin

scientific article published on 11 November 2016

Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD.

scientific article published in September 2002

Increased neutrophil gelatinase-associated lipocalin (NGAL) promotes airway remodelling in chronic obstructive pulmonary disease.

scientific article published on 5 April 2017

Increased p21CIP1/WAF1and B Cell Lymphoma Leukemia-xLExpression and Reduced Apoptosis in Alveolar Macrophages from Smokers

scientific article published on 01 September 2002

Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung

scientific article

Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation.

scientific article published on February 1994

Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells

scientific article

Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization

scientific article

Inferring cell-scale signalling networks via compressive sensing

scientific article

Inflammasome signaling in pathogenesis of lung diseases.

scientific article published on January 2012

Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism.

scientific article published on 10 April 2015

Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future.

scientific article published on 26 June 2009

Inhaled long-acting β2 agonists enhance glucocorticoid receptor nuclear translocation and efficacy in sputum macrophages in COPD.

scientific article published on 23 September 2013

Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma

scientific article

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice

scientific article published on 22 January 2009

Inhibition of ozone-induced lung neutrophilia and nuclear factor-κB binding activity by vitamin A in rat

scientific article

Inhibitory effect of hydrogen sulfide on ozone-induced airway inflammation, oxidative stress, and bronchial hyperresponsiveness.

scientific article published in January 2015

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD.

scientific article

Instability of sputum molecular phenotypes in U-BIOPRED severe asthma

scientific article published on 02 October 2020

Integrated analysis reveals lung fibrinogen gamma chain as a biomarker for chronic obstructive pulmonary disease

scientific article published on 01 December 2021

Integrated care pathways for airway diseases (AIRWAYS-ICPs).

scientific article published on 12 June 2014

Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis

scientific article

Interactions of glucocorticoids and beta 2-agonists

scientific article published on January 1996

Interleukin-4 and Lipopolysaccharide Synergize to Induce Vascular Cell Adhesion Molecule-1 Expression in Human Lung Microvascular Endothelial Cells ⬇️

scientific article published on 01 May 1998

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

scientific article published on 12 December 2013

Investigation of urine lipoarabinomannan in human immunodeficiency virus patients with or without coinfection with Tuberculosis in Iran.

scientific article

Is mitochondrial dysfunction a driving mechanism linking COPD to nonsmall cell lung carcinoma?

scientific article published on 25 October 2017

Kinase inhibitors and airway inflammation.

scientific article

Kinase targets and inhibitors for the treatment of airway inflammatory diseases: the next generation of drugs for severe asthma and COPD?

scientific article published on January 2004

Klotho expression is reduced in COPD airway epithelial cells: effects on inflammation and oxidant injury

scientific article

LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling.

scientific article published on 12 January 2012

Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome

scientific article published on 8 May 2018

Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement.

scientific article

Limitation of COPD Studies in Animal Modeling

scientific article

Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA.

scientific article published in November 1993

Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells

scientific article published on 2 September 2011

Longitudinally Stable, Clinically Defined Clusters of Patients with Asthma Independently Identified in the ADEPT and U-BIOPRED Asthma Studies

scientific article published in March 2016

Loss of Control of Asthma Following Inhaled Corticosteroid Withdrawal Is Associated With Increased Sputum Interleukin-8 and Neutrophils

scientific article published on 05 June 2007

Low-dose theophylline does not exert its anti-inflammatory effects in mild asthma through upregulation of interleukin-10 in alveolar macrophages

scientific article published in November 2001

MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.

scientific article published in September 2009

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

scientific article published on 02 January 2020

Manipulation of Dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma

scientific article published on 28 December 2017

Mecanismos moleculares de los glucocorticoides

scientific article published on 01 January 2005

Mechanisms involved in lung cancer development in COPD.

scientific article published on 14 October 2010

Mechanisms of corticosteroid resistance in severe asthma and chronic obstructive pulmonary disease (COPD).

scientific article

Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways

scientific article

Metabolic re-patterning in COPD airway smooth muscle cells

scientific article published on 30 November 2017

MiRNAs in tuberculosis: Their decisive role in the fate of TB

scientific article published on 10 September 2020

MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy

scientific article

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2.

scientific article published on 10 June 2016

Microarray analysis of long non-coding RNAs in COPD lung tissue.

scientific article published on 27 December 2014

Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness

scientific article published on 27 June 2019

Mitochondrial dysfunction in airways and quadriceps muscle of patients with chronic obstructive pulmonary disease

scientific article published on 12 October 2020

Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages

scientific article published on 18 July 2003

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

scientific article published on 11 December 2018

Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCepsilon and JAK2 in RAW macrophages.

scientific article published on 24 November 2007

Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13.

scientific article published on 16 April 2008

Molecular Mechanisms of Glucocorticoid Receptor Action

Molecular interactions between glucocorticoids and long-acting beta2-agonists.

scientific article

Molecular links between COPD and lung cancer: new targets for drug discovery?

scientific article published on 11 May 2019

Molecular mechanisms of corticosteroid resistance.

scientific article published on August 2008

Molecular mechanisms of glucocorticosteroid actions.

scientific article published in January 2000

Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumonia.

scientific article published on January 2006

Molecular pathogenesis of cigarette smoking-induced stable COPD.

scientific article

Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity.

scientific article published on 5 March 2008

Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease

scientific article published in November 2004

Multidimensional endotyping using nasal proteomics predicts molecular phenotypes in the asthmatic airways

scientific article published in 2022

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction.

scientific article published on June 2008

NF-kB: a pivotal role in asthma and a new target for therapy

scholarly article by Peter J. Barnes & Ian M. Adcock published February 1997 in Trends in Pharmacological Sciences

NF-kappa B: a pivotal role in asthma and a new target for therapy

scientific article published on February 1997

NF-κB Function in Inflammation, Cellular Stress and Disease

scholarly article by Neil R. Chapman et al published 2002 in Cell and Molecular Response to Stress

NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model.

scientific article

Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study

scientific article published on 04 August 2016

Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor

scientific article

Neutrophilic Asthma

scientific article published on 01 February 2018

New drugs for asthma

New drugs targeting Th2 lymphocytes in asthma

scientific article

New drugs under development for COPD

scientific article published on 03 September 2020

New insights into the molecular mechanisms of corticosteroids actions.

scientific article published on June 2006

New targets for drug development in asthma

scientific article published on September 2008

New treatments for COPD

scientific article published on 18 April 2013

Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.

scientific article published on 3 May 2009

Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis

scientific article published on 12 October 2017

Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease

scientific article published on 28 September 2005

Novel Anti-Inflammatory Treatments for Asthma and COPD

scholarly article published 29 February 2012

Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic pulmonary arterial hypertension

scientific article (publication date: 15 August 2014)

Nuclear factor κ-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension.

scientific article published on 04 October 2013

Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations.

scientific article published on April 2003

Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk

scientific article published in 2023

Overcoming reduced glucocorticoid sensitivity in airway disease: molecular mechanisms and therapeutic approaches.

scientific article published on May 2010

Overcoming steroid insensitivity in smoking asthmatics.

scientific article published on May 2008

Overcoming steroid unresponsiveness in airways disease.

scientific article published on August 2009

Overview: why are corticosteroids ineffective in COPD?

scientific article

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD.

scientific article

Oxidative stress and redox regulation of lung inflammation in COPD.

scientific article published on July 2006

Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy

scientific article published on June 2007

Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in human epithelial cells.

scientific article published on March 1994

Oxidative stress induces NFkB DNA binding and inducible NOS mRNA in the human epithelial cell line A549 ⬇️

scientific article published on May 1, 1994

Oxidative stress modulates theophylline effects on steroid responsiveness

scientific article published on 23 October 2008

Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration

scientific article published on February 2004

Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease

scientific article

Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

scientific article

Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease.

scientific article published on 14 December 2009

Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-kappa b in rat lung: inhibition by corticosteroids.

scientific article published on February 1996

PHF11 and DPP10: A Tale of Two Genes in Asthma

article

Paecilomyces formosus Infection in an Adult Patient with Undiagnosed Chronic Granulomatous Disease

scientific article published on 20 April 2017

Pathophysiological mechanisms of asthma. Application of cell and molecular biology techniques.

scientific article

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

scientific article

Pattern recognitions receptors in immunodeficiency disorders

scientific article published on 14 January 2017

Pharmacogenomics and targeted therapy of cancer: Focusing on non-small cell lung cancer.

scientific article published on 25 February 2015

Pharmacology of airway inflammation in asthma and COPD.

scientific article

Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease.

scientific article published on 05 January 2010

Phospho-p38 MAPK expression in COPD patients and asthmatics and in challenged bronchial epithelium

scientific article

Phosphodiesterase expression in human epithelial cells ⬇️

scientific article published on October 1, 1998

Plasmacytoid Dendritic Cells Alter the Antitumor Activity of CpG-Oligodeoxynucleotides in a Mouse Model of Lung Carcinoma

scientific article published on 20 September 2010

Plasmapheresis reduces cytokine and immune cell levels in COVID-19 patients with acute respiratory distress syndrome (ARDS)

scientific article published on 04 December 2020

Positional cloning of a novel gene influencing asthma from chromosome 2q14.

scientific article

Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma

scientific article

Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125.

scientific article published on 15 December 2004

Precision medicine for the discovery of treatable mechanisms in severe asthma

scientific article published on 15 April 2019

Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study

scientific article published in 2022

Probiotics in the management of lung diseases

scientific article published on 8 May 2013

Profile of fluticasone furoate/vilanterol dry powder inhaler combination therapy as a potential treatment for COPD

scientific article published on 24 February 2014

Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness

scientific article published on 09 November 2018

Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response.

scientific article

Reduced Phagocytic Capacity of Blood Monocyte/Macrophages in Tuberculosis Patients Is Further Reduced by Smoking

scientific article published on June 2016

Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3.

scientific article published on February 2007

Regulation of Wnt4 in chronic obstructive pulmonary disease

scientific article published on 5 March 2013

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

scientific article published on 20 May 2008

Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma

scientific article published on 13 April 2006

Rescue treatment in asthma. More than as-needed bronchodilation

scientific article published on June 2009

Research highlights from the 2017 ERS International Congress: airway diseases in focus

scientific article published in January 2018

Research highlights from the 2018 European Respiratory Society International Congress: airway disease

article

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

scientific article (publication date: February 2016)

Resolution of Inflammatory Responses: a brief introduction

article

Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium

scientific article published on 25 February 2020

Response

Retraction notice to Kinase inhibitors and airway inflammation [Eur. J. Pharmacol 533/1-3 (2006) 118 – 132 of Kinase inhibitors and airway inflammation] ⬇️

scientific article published on May 15, 2012

Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation.

scientific article published on 18 July 2013

Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease

scientific article

Role of Atypical Chemokines and Chemokine Receptors Pathways In the Pathogenesis of Copd

scientific article published on 19 August 2020

Role of CBP in glucocorticoid-induced gene repression ⬇️

scientific article published on 01 August 1998

Role of Epigenetics in the Pathogenesis of Asthma

scientific article

Role of Innate Lymphoid Cells in Lung Disease

scientific article

Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation

scientific article published on 30 October 2018

Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases

scientific article published on 29 November 2019

Role of P2X7 Receptors in Release of IL-1β: A Possible Mediator of Pulmonary Inflammation

scientific article published on January 2012

Role of Stem Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease and Pulmonary Emphysema

scientific article published on 01 October 2018

Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia

scientific article published on 12 July 2007

Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease.

scientific article published on 13 December 2017

Role of cathepsin S in ozone-induced airway hyperresponsiveness and inflammation

scientific article published on 14 November 2008

Role of inflammatory cells in airway remodeling in COPD

scholarly article by Yujie Wang et al published 12 October 2018 in International Journal of Chronic Obstructive Pulmonary Disease

Role of microRNAs in allergic asthma: present and future.

scientific article published on April 2015

Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness

scientific article published in September 2002

Role of non-coding RNAs in maintaining primary airway smooth muscle cells

scientific article

Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation.

scientific article

Role of the mucins in pathogenesis of COPD: implications for therapy

scientific article published on 19 March 2020

Role of transcription factors in the pathogenesis of asthma and COPD.

scientific article published on February 2013

Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model

scientific article published on 09 January 2019

Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema

scientific article published on 22 November 2018

STAT4 activation in smokers and patients with chronic obstructive pulmonary disease

scientific article published in July 2004

STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects.

scientific article

Sarcoidosis: Role of non-tuberculosis mycobacteria and Mycobacterium tuberculosis

scientific article

Serum Exosomal miRNAs Are Associated with Active Pulmonary Tuberculosis

scientific article published on 11 February 2019

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study

scientific article published on 6 October 2016

Signalling and transcriptional regulation in inflammatory and immune cells: importance in lung biology and disease

scientific article published on 01 November 2005

Silent hypoxia: higher NO in red blood cells of COVID-19 patients

scientific article published on 16 October 2020

Simvastatin Suppresses Airway IL-17 and Upregulates IL-10 in Patients With Stable COPD.

scientific article

Single-nucleotide polymorphisms associated with symptomatic infection and differential human gene expression in healthy seropositive persons each implicate the cytoskeleton, integrin signaling, and oncosuppression in the pathogenesis of human parvov

scientific article published on 3 June 2005

Smads as intracellular mediators of airway inflammation

scientific article published on April 2004

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma

scientific article published on 07 January 2021

Sputum macrophage diversity and activation in asthma: role of severity and inflammatory phenotype

scientific article published on 01 August 2020

Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12-18 months

scientific article published on 27 April 2020

Sputum myeloperoxidase in chronic obstructive pulmonary disease.

scientific article

Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.

scientific article published on 12 April 2018

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.

scientific article published on 17 May 2017

Statins as potential therapeutic drug for asthma?

scientific article

Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue?

scientific article published on June 2004

Steroid resistance in asthma: mechanisms and treatment options

scientific article published on April 2008

Steroid resistance in severe asthma: current mechanisms and future treatment.

scientific article published on January 2011

Steroid responsiveness of renal epithelial cells. Dissociation of transrepression and transactivation

scientific article published on 31 October 2002

Strategies for improving the efficacy and therapeutic ratio of glucocorticoids.

scientific article published on 23 March 2012

Stratification of asthma phenotypes by airway proteomic signatures

scientific article published on 28 March 2019

Subtypes of eosinophilic asthma with discrete gene pathway phenotypes

scientific article published on 28 September 2019

Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation

scientific article

Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease

scientific article

Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation.

scientific article published on 17 August 2007

Susceptibility to influenza virus infection of bronchial biopsies in asthma.

scientific article published on March 2017

Susceptibility to mycobacterial disease due to mutations in IL-12Rβ1 in three Iranian patients.

scientific article published on 18 December 2017

Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites

scientific article published on 10 July 2009

Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies

scientific article

Systems medicine and integrated care to combat chronic noncommunicable diseases

scientific article

T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients.

scientific article published in August 2009

T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED.

scientific article

TGF-β Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD.

scientific article published on 28 December 2017

TGFbeta1 allele association with asthma severity

scientific article published on 27 October 2001

TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM2.5)

scientific article published on 02 June 2019

Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease

scientific article

Targeting Th2 cells in asthmatic airways

scientific article published in September 2004

Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.

scientific article

The BET Bromodomain Inhibitor I-BET-151 Induces Structural and Functional Alterations of the Heart Mitochondria in Healthy Male Mice and Rats ⬇️

scientific article published on 27 March 2019

The Detrimental Health Effects of Traffic-related Air Pollution

article

The ERS Research Agency: the beginning

scientific article published in April 2016

The IRONy of Iron-overload and Iron-deficiency in Chronic Obstructive Pulmonary Disease.

scientific article

The Immune Response and Immunopathology of COVID-19

scientific article published on 26 August 2020

The Journal of Inflammation.

scientific article

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD.

scientific article published on 11 January 2016

The Potential Biomarkers and Immunological Effects of Tumor-Derived Exosomes in Lung Cancer.

scientific article published on 18 April 2018

The Role of Mast Cells in IgE-Independent Lung Diseases

scientific article published on 21 February 2020

The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis

scientific article published on August 2016

The Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) ERS Clinical Research Collaboration: a new dawn in asthma research

scientific article published on 29 November 2018

The analysis of exosomal micro-RNAs in peripheral blood mononuclear cell-derived macrophages after infection with bacillus Calmette-Guérin by RNA sequencing

scientific article

The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide.

scientific article published on 9 May 2018

The developmental origins of asthma: does epigenetics hold the key?

scientific article published in October 2009

The discovAIR project: a roadmap towards the Human Lung Cell Atlas

scientific article published on 27 January 2022

The effect of oxidative stress on histone acetylation and IL-8 release

scientific article published on February 2003

The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung

scientific article published on 01 January 1994

The first U-BIOPRED sputum handprint of severe asthma

scientific article published in September 2015

The future of asthma research and development: a roadmap from the European Asthma Research and Innovation Partnership (EARIP).

scientific article published in May 2017

The glucocorticoid RU24858 does not distinguish between transrepression and transactivation in primary human eosinophils.

scientific article

The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population

scientific article published on 20 November 2020

The relationship between COPD and lung cancer

scientific article

The role of histone deacetylases in asthma and allergic diseases

scientific article published on 30 January 2008

The role of pattern recognition receptors in lung sarcoidosis.

scientific article published on 17 January 2017

The roles of miRNAs as potential biomarkers in lung diseases

scientific article

The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity

scientific journal article

Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

scientific article

Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease.

scientific article

Toll-like receptor 2 and 4 have Opposing Roles in the Pathogenesis of Cigarette Smoke-induced Chronic Obstructive Pulmonary Disease

scientific article

Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA

Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations.

scientific article published on 28 October 2016

Transcription Factors

Transcription factors and asthma

scientific article

Transcription factors in asthma and COPD.

scientific article published in August 2004

Transcription inhibitors and inflammatory cell activity

scientific article published on 14 June 2019

Transcriptional Effects of Ozone and Impact on Airway Inflammation

scientific article published on 10 July 2019

Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle.

scientific article published on 02 July 2016

Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma.

scientific article

Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations

scientific article published on 18 October 2021

Translational models of lung disease

scientific article

Treatable Traits in the European U-BIOPRED Adult Asthma Cohorts

scientific article published on 12 November 2018

Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD.

scientific article

Tumour necrosis factor alpha causes retention of activated glucocorticoid receptor within the cytoplasm of A549 cells

scientific article published on August 1996

Tumour necrosis factor-α regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-κB and AP-1.

scientific article

Type 2-low asthma phenotypes by integration of sputum transcriptomics and serum proteomics

scientific article published on 31 August 2020

U-BIOPRED accessible handprint: combining omics platforms to identify stable asthma subphenotypes

scientific article published on 15 September 2018

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

scientific article

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer.

scientific article

Up-regulation of blood arachidonate (20:4) levels in patients with chronic obstructive pulmonary disease

scientific article published on 30 May 2012

Update on Neutrophil Function in Severe Inflammation

Update on glucocorticoid action and resistance

scientific article published on 01 March 2006

Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation

scientific article published on 15 July 2020

Vitamin D Metabolism is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease

scientific article published on 18 March 2020

Water-pipe smoke condensate increases the internalization of Mycobacterium Bovis of type II alveolar epithelial cells (A549).

scientific article

What Immunological Defects Predispose to Non-tuberculosis Mycobacterial Infections?

scholarly article by Esmaeil Mortaz et al published April 2018 in Iranian Journal of Allergy, Asthma and Immunology

Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins

scientific article published in June 2005

Zymosan attenuates melanoma growth progression, increases splenocyte proliferation and induces TLR-2/4 and TNF-α expression in mice.

scientific article published on 22 March 2018

eNose breathprints as a surrogate biomarker for classifying asthma patients by atopy

scientific article published on 09 June 2020

miR-1224 Expression Is Increased in Human Macrophages after Infection with Bacillus Calmette-Guérin (BCG)

scientific article published in June 2018

p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma

scientific article

p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma

scientific article published on 14 September 2011

p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex

scientific article published on 6 June 2001

β-adrenoceptor agonists interfere with glucocorticoid receptor DNA binding in rat lung

scientific article published on 01 April 1995

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