List of works - Takashi Nonaka

A cellular model to monitor proteasome dysfunction by alpha-synuclein

scientific article

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

scientific article published on 24 July 2008

Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS

scientific article published on 18 July 2012

Assembly of the type III secretion apparatus of enteropathogenic Escherichia coli

scientific article

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

scientific article

BopC is a novel type III effector secreted by Bordetella bronchiseptica and has a critical role in type III-dependent necrotic cell death

scientific article published on 4 January 2006

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

scientific article

Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies

scientific article published on 06 September 2007

Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding.

scientific article

Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP).

scientific article published on 5 July 2002

Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration

scientific article published on 4 April 2016

Cleavage at the carboxyl-terminus of Ku80 during apoptosis in human Jurkat T cells.

scientific article published in June 2005

Cleavage of nonmuscle myosin heavy chain-A during apoptosis in human Jurkat T cells

scientific article published on 01 February 2005

Conversion of wild-type alpha-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.

scientific article published on 21 January 2009

Cysteine misincorporation in bacterially expressed human alpha-synuclein

scientific article published on 24 February 2006

Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.

scientific article published on 31 October 2013

Distinct pathways leading to TDP-43-induced cellular dysfunctions.

scientific article published on 3 April 2014

Drug screening for ALS using patient-specific induced pluripotent stem cells

scientific article published on August 2012

Enolase, a cellular glycolytic enzyme, is required for efficient transcription of Sendai virus genome.

scientific article published in July 2001

Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

scientific article published on 22 November 2011

Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain.

scientific article published on 21 August 2013

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.

scientific article

Frontotemporal dementia with Pick-type histology associated with Q336R mutation in the tau gene.

scientific article published on 26 March 2004

Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation

scientific article published on 28 January 2016

Human tauopathy-derived tau strains determine the substrates recruited for templated amplification

scientific article published on 01 September 2021

Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration

scientific article

Identification of casein kinase-1 phosphorylation sites on TDP-43.

scientific article published on 13 March 2009

In vitro recapitulation of aberrant protein inclusions in neurodegenerative diseases: New cellular models of neurodegenerative diseases.

scientific article published on July 2011

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes

scientific article

Inhibition of alpha-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.

scientific article

Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation

scientific article published on 6 October 2015

Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

scientific article published on 12 January 2016

Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions

scientific article published on 28 October 2020

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

scientific article

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.

scientific article

Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice

scientific article

Molecular analysis and biochemical classification of TDP-43 proteinopathy

scientific article published on 3 October 2012

Molecular dissection of TDP-43 proteinopathies

scientific article published on 16 June 2011

Molecular mechanisms of the co-deposition of multiple pathological proteins in neurodegenerative diseases.

scientific article

Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.

scientific article published on 5 November 2015

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease

scientific article published on 17 October 2017

Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

scientific article published on 23 September 2019

Pathological alpha-synuclein propagates through neural networks

scientific article

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

scientific article published on July 2008

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

scientific article published on 10 October 2002

Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells

scientific article

Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.

scientific article published on 14 January 2016

Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders

scientific article published on December 2016

Prion-like properties of pathological TDP-43 aggregates from diseased brains

scientific article published on 3 July 2013

Prion-like spreading of pathological α-synuclein in brain

scientific article published on 6 March 2013

Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells

scientific article published on 9 January 2012

Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases

scientific article published on 30 August 2010

Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleus

scientific article published on 20 June 2001

Shigella-induced necrosis and apoptosis of U937 cells and J774 macrophages

scientific article published in September 2003

Small molecule inhibitors of alpha-synuclein filament assembly

scientific article published on May 2006

Supramolecular structure of the Shigella type III secretion machinery: the needle part is changeable in length and essential for delivery of effectors

scientific article

TDP-43 Prions

scientific article published on 20 January 2017

TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.

scientific article

Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils ⬇️

scientific article published on 17 February 2016

The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.

scientific article published on 5 July 2016

The Wnt/Ca2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes

scientific article published on 18 October 2019

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

scientific article

Ubiquitination of alpha-synuclein.

scientific article

α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly

scientific article published on 19 May 2016

α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

scientific article published on 20 July 2021

α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome

scientific article published on 22 July 2020

α-Synuclein: Experimental Pathology

scientific article

List of works by Takashi Nonaka

A cellular model to monitor proteasome dysfunction by alpha-synuclein

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS

Assembly of the type III secretion apparatus of enteropathogenic Escherichia coli

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

BopC is a novel type III effector secreted by Bordetella bronchiseptica and has a critical role in type III-dependent necrotic cell death

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies

Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding.

Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP).

Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration

Cleavage at the carboxyl-terminus of Ku80 during apoptosis in human Jurkat T cells.

Cleavage of nonmuscle myosin heavy chain-A during apoptosis in human Jurkat T cells

Conversion of wild-type alpha-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.

Cysteine misincorporation in bacterially expressed human alpha-synuclein

Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.

Distinct pathways leading to TDP-43-induced cellular dysfunctions.

Drug screening for ALS using patient-specific induced pluripotent stem cells

Enolase, a cellular glycolytic enzyme, is required for efficient transcription of Sendai virus genome.

Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain.

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.

Frontotemporal dementia with Pick-type histology associated with Q336R mutation in the tau gene.

Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation

Human tauopathy-derived tau strains determine the substrates recruited for templated amplification

Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration

Identification of casein kinase-1 phosphorylation sites on TDP-43.

In vitro recapitulation of aberrant protein inclusions in neurodegenerative diseases: New cellular models of neurodegenerative diseases.

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes

Inhibition of alpha-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.

Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation

Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.

Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice

Molecular analysis and biochemical classification of TDP-43 proteinopathy

Molecular dissection of TDP-43 proteinopathies

Molecular mechanisms of the co-deposition of multiple pathological proteins in neurodegenerative diseases.

Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease

Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

Pathological alpha-synuclein propagates through neural networks

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells

Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.

Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders

Prion-like properties of pathological TDP-43 aggregates from diseased brains

Prion-like spreading of pathological α-synuclein in brain

Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells

Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases

Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleus

Shigella-induced necrosis and apoptosis of U937 cells and J774 macrophages

Small molecule inhibitors of alpha-synuclein filament assembly

Supramolecular structure of the Shigella type III secretion machinery: the needle part is changeable in length and essential for delivery of effectors

TDP-43 Prions

TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.

Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils ⬇️

The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.

The Wnt/Ca2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

Ubiquitination of alpha-synuclein.

α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly

α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome

α-Synuclein: Experimental Pathology