List of works - Manuela Bartolini

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies

scientific article

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents

scientific article published on 2 November 2012

3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy

scientific article published in June 2003

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases

scientific article

A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors

scientific article published on 17 July 2019

A small molecule targeting the multifactorial nature of Alzheimer's disease.

scientific article published in January 2007

Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives

Analysis of Amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis.

scientific article published on 7 February 2006

Analytical methods for the determination of folic acid in a polymeric micellar carrier

scientific article published in August 2003

Batchwise covalent immobilization of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies

scientific article published on 12 April 2005

Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity

scientific article

Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation

scientific article published on 22 February 2011

Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities

scientific article published in August 2010

Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease

scientific article published on 17 December 2015

Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor

Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease

scientific article published on 24 August 2011

Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones

scientific article published in 2007

Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation

scientific article published in June 2005

Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery.

scientific article published in February 2005

Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening

scientific article published on 31 March 2018

Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment

scientific article

Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors

scientific article

Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues

scientific article published in November 2004

Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease

scientific article published on November 2005

Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors

scientific article published on 8 March 2008

Determination of inhibitors' potency (IC50) by a direct high-performance liquid chromatographic method on an immobilised acetylcholinesterase column

scientific article

Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography.

scientific article

Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies

scientific article

Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies.

scientific article

Disclosure of a fundamental clue for the elucidation of the myricetin mechanism of action as amyloid aggregation inhibitor by mass spectrometry.

scientific article

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease

scientific article published on 10 March 2022

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

scientific article published on 28 December 2020

Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment

scientific article published on 31 May 2019

Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation.

scientific article

Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer's Disease

scientific article published on 30 July 2018

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease

scientific article published on 8 September 2011

Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives

Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase

scientific article

Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease

scientific article

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold

scholarly article by Angela Rampa published in July 2015

From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease

scientific article published on 24 March 2014

Heterocyclic inhibitors of AChE acylation and peripheral sites

scientific article

Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.

scientific article

Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases

scientific article

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy

scientific article published on 24 March 2016

Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease

scientific article published on 04 October 2008

Immobilized enzyme-based analytical tools in the -omics era: Recent advances

scientific article published on 31 July 2018

Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush

scientific article published on 8 July 2008

Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action

scientific article

Kinetic characterization of amyloid-beta 1-42 aggregation with a multimethodological approach.

scientific article

Monolithic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies.

scientific article published in March 2004

Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.

scientific article published on 8 July 2011

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

scientific article published on 4 October 2007

Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.

scientific article published on 30 November 2007

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation

scientific article

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

scientific article published on 30 March 2012

Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects

scientific article

Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity

article by Maria Laura Bolognesi et al published 1 May 2011 in Bioorganic & Medicinal Chemistry Letters

New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy

scientific article published on 12 September 2018

New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation

scientific article published on 18 September 2017

No G-Quadruplex Structures in the DNA of Parvovirus B19: Experimental Evidence versus Bioinformatic Predictions

scientific article published on 25 August 2020

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease

scientific article published on 16 February 2016

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease

scientific article published on 13 September 2007

Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

scientific article published on 3 June 2008

Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates

scientific article

Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids

scientific article published on 23 December 2014

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

scientific article published on 27 February 2019

Optimization of a trypsin-bioreactor coupled with high-performance liquid chromatography-electrospray ionization tandem mass spectrometry for quality control of biotechnological drugs.

scientific article published on 3 February 2006

Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation

scientific article published in January 2005

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds

scientific article published in September 2009

Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease

scientific article published on 5 October 2013

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy

scientific article published on 17 April 2019

Rational approach to discover multipotent anti-Alzheimer drugs.

scientific article

SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues

scientific article

Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection

scientific article published on 11 August 2020

Strategies for the inhibition of protein aggregation in human diseases

scientific article published on May 2010

Structural and functional integrity of human serum albumin: Analytical approaches and clinical relevance in patients with liver cirrhosis

scientific article published on 18 April 2017

Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine

scientific article published in April 2009

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine

scientific article published in March 2003

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties

scientific article published in December 2004

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer

Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.

scientific article

Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues

Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

scientific article

Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.

scientific article published on 23 November 2011

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.

scientific article published on 16 February 2010

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease

scientific article published on May 2009

Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.

scientific article

The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?

scientific article

The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon

scientific article

The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90 ⬇️

scientific article published on March 21, 2012

The role of Li+, Na+, and K+ in the ligand binding inside the human acetylcholinesterase gorge

Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks

scientific article published on December 2009

beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies

scientific article published in February 2003

List of works by Manuela Bartolini

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents

3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases

A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors

A small molecule targeting the multifactorial nature of Alzheimer's disease.

Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives

Analysis of Amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis.

Analytical methods for the determination of folic acid in a polymeric micellar carrier

Batchwise covalent immobilization of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies

Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity

Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation

Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities

Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease

Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor

Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease

Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones

Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation

Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery.

Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening

Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment

Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors

Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues

Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease

Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors

Determination of inhibitors' potency (IC50) by a direct high-performance liquid chromatographic method on an immobilised acetylcholinesterase column

Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography.

Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies

Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies.

Disclosure of a fundamental clue for the elucidation of the myricetin mechanism of action as amyloid aggregation inhibitor by mass spectrometry.

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment

Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation.

Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer's Disease

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease

Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives

Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase

Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold

From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease

Heterocyclic inhibitors of AChE acylation and peripheral sites

Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.

Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy

Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease

Immobilized enzyme-based analytical tools in the -omics era: Recent advances

Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush

Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action

Kinetic characterization of amyloid-beta 1-42 aggregation with a multimethodological approach.

Monolithic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies.

Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects

Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity

New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy

New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation

No G-Quadruplex Structures in the DNA of Parvovirus B19: Experimental Evidence versus Bioinformatic Predictions

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease

Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease

Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates

Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

Optimization of a trypsin-bioreactor coupled with high-performance liquid chromatography-electrospray ionization tandem mass spectrometry for quality control of biotechnological drugs.

Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds

Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy

Rational approach to discover multipotent anti-Alzheimer drugs.

SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues

Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection

Strategies for the inhibition of protein aggregation in human diseases

Structural and functional integrity of human serum albumin: Analytical approaches and clinical relevance in patients with liver cirrhosis

Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine