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List of works by Maria Laura Bolognesi

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases

scientific article

A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation

scientific article

Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer’s Disease

scientific article published in 2021

Complementary medicinal chemistry-driven strategies toward new antitrypanosomal and antileishmanial lead drug candidates

scientific article

Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile

scientific article

Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.

scientific article published on 3 October 2017

Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment

scientific article

Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI)

scientific article

Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections.

scientific article published on 16 February 2018

Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei

scientific article published on 05 February 2019

Discovery of a class of diketopiperazines as antiprion compounds.

scientific article

From combinations to multitarget-directed ligands: A continuum in Alzheimer's disease polypharmacology

scientific article published on 19 June 2020

Harnessing Polypharmacology with Medicinal Chemistry

scientific article published on 15 February 2019

Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities

scientific article published on 26 June 2020

Medicinal Chemistry: Where Are All the Women?

scientific article published on 25 August 2017

Modulation of prion by small molecules: from monovalent to bivalent and multivalent ligands

scientific article

Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule.

scientific article

Multi-Target-Directed Ligands as Innovative Tools to Combat Trypanosomatid Diseases ⬇️

scientific article published on November 1, 2011

Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects

scientific article

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

scientific article published on 11 December 2014

Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's Disease

scientific article

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease

scientific article published on 16 February 2016

Parallel synthesis and cytotoxicity evaluation of a polyamine-quinone conjugates library.

scientific article

Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound

scientific article

Polypharmacology in a Single Drug: Multitarget Drugs ⬇️

scientific article published on January 1, 2013

Remembering Marie Curie's Legacy ⬇️

scientific article published on April 4, 2011

Repurposing of Drugs Targeting YAP-TEAD Functions

article published in 2018

Search for selective antagonists at α1-adrenoreceptors: neutral or negative antagonism? ⬇️

scientific article published on April 1, 1998

Small-molecule theranostic probes: a promising future in neurodegenerative diseases.

scientific article

Structure-activity relationships and mechanistic studies of novel mitochondria-targeted, leishmanicidal derivatives of the 4-aminostyrylquinoline scaffold

scientific article published on 14 March 2019

Synthesis and evaluation of a library of 2,5-bisdiamino-benzoquinone derivatives as probes to modulate protein-protein interactions in prions

scientific article

Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity

scientific article

Synthesis, muscarinic blocking activity and molecular modeling studies of 4-DAMP-related compounds ⬇️

scientific article published on 01 March 1995

Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

article

The concept of privileged structures in rational drug design: focus on acridine and quinoline scaffolds in neurodegenerative and protozoan diseases ⬇️

scientific article published on January 18, 2011

The modulatory role of M2 muscarinic receptor on apomorphine-induced yawning and genital grooming ⬇️

scientific article published on October 4, 2012

Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

scientific article published in February 2017

Universal Template Approach to Drug Design: Polyamines as Selective Muscarinic Receptor Antagonists ⬇️

scientific article published on October 8, 1998

Women in Medicinal Chemistry Special Issue Call for Papers

scientific article published on 05 April 2019

Women in Medicinal Chemistry: Ad Maiora!

scientific article published on 20 February 2020

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