List of works - Mahmoud A. Pouladi

A fully humanized transgenic mouse model of Huntington disease.

scientific article

A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.

scientific article

A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

scientific article published on 18 January 2017

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

scientific article

A thiol probe for measuring unfolded protein load and proteostasis in cells.

scientific article published on 7 September 2017

Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease

scientific article published on 25 September 2010

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease.

scientific article

Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo.

scientific article published in January 2012

Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes

scientific article

Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness.

scientific article published on 14 August 2003

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

scientific article

Concomitant airway expression of granulocyte-macrophage colony-stimulating factor and decorin, a natural inhibitor of transforming growth factor-beta, breaks established inhalation tolerance.

scientific article published in September 2004

Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis

scientific article

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

scientific article published on February 2009

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

scientific article

Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.

scientific article

Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment

scientific article published on 27 May 2020

Fragile X syndrome therapy: to respond or not to respond may be a matter of methylation ⬇️

scientific article published on April 20, 2011

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

scientific article

Generation of four H1 hESC sublines carrying a hemizygous knock-out/mutant MECP2

scientific article published on 09 August 2019

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in

scientific article published on 01 April 2019

Heritability of pain sensitivity and opioid analgesia

scientific article

Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells

scientific article published on 27 June 2016

House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation

scientific article

Impact of cigarette smoke on clearance and inflammation after Pseudomonas aeruginosa infection

scientific article published on 18 August 2004

Impaired Remyelination in a Mouse Model of Huntington Disease

scientific article published on 02 April 2019

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

scientific article published on 01 February 2020

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.

scientific article published on July 2017

Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.

scientific article

Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.

scientific article published on 9 September 2002

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.

scientific article published on 11 February 2016

Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice

scientific article published on 3 July 2003

Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease

scientific article published on 23 April 2019

Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease

scientific article published on 17 October 2018

Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.

scientific article

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse.

scientific article

Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitization

scientific article published on 01 September 2005

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice

scientific article

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

scientific article published on 4 May 2016

Mouse models of Huntington disease: variations on a theme.

scientific article

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

scientific article

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

scientific article

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease

scientific article published on 10 July 2012

Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle.

scientific article

Novel mutation in HTRA1 in a family with diffuse white matter lesions and inflammatory features

scientific article published on 08 July 2019

PS: pain and sodium channels

scientific article published on 30 August 2012

Painful gains: missense mutations in SCN9A and idiopathic small nerve fibre neuropathy ⬇️

scientific article published on August 30, 2012

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

scientific article

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

scientific article published on 04 March 2021

Polyglutamine diseases and the risk of cancer

scientific article published in June 2012

Preclinical models: needed in translation? A Pro/Con debate.

scientific article published on September 2014

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin

scientific article published on 18 February 2009

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells.

scientific article published on 21 February 2017

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

scientific article published on 28 April 2016

Taking a SUMO off a TRP for bad conduct

scientific article published on 20 January 2010

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

scientific article

Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease.

scientific article published on 26 January 2016

pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model

scientific article published on 25 September 2020

List of works by Mahmoud A. Pouladi

A fully humanized transgenic mouse model of Huntington disease.

A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.

A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

A thiol probe for measuring unfolded protein load and proteostasis in cells.

Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease.

Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo.

Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes

Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness.

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

Concomitant airway expression of granulocyte-macrophage colony-stimulating factor and decorin, a natural inhibitor of transforming growth factor-beta, breaks established inhalation tolerance.

Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.

Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment

Fragile X syndrome therapy: to respond or not to respond may be a matter of methylation ⬇️

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

Generation of four H1 hESC sublines carrying a hemizygous knock-out/mutant MECP2

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in

Heritability of pain sensitivity and opioid analgesia

Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells

House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation

Impact of cigarette smoke on clearance and inflammation after Pseudomonas aeruginosa infection

Impaired Remyelination in a Mouse Model of Huntington Disease

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.

Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.

Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.

Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice

Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease

Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease

Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse.

Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitization

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

Mouse models of Huntington disease: variations on a theme.

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease

Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle.

Novel mutation in HTRA1 in a family with diffuse white matter lesions and inflammatory features

PS: pain and sodium channels

Painful gains: missense mutations in SCN9A and idiopathic small nerve fibre neuropathy ⬇️

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

Polyglutamine diseases and the risk of cancer

Preclinical models: needed in translation? A Pro/Con debate.

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells.

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

Taking a SUMO off a TRP for bad conduct

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease.

pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model