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List of works by Jennifer P. Morton

A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis

scientific article published on 15 January 2011

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

scientific article published in October 2017

A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression

scientific article published on 05 March 2019

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

scientific article

AKT regulates NPM dependent ARF localization and p53mut stability in tumors

scientific article

Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis.

scientific article published on 31 May 2017

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

scientific article

Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

scientific article published on 02 November 2018

Activation of the IL-6R/Jak/stat pathway is associated with a poor outcome in resected pancreatic ductal adenocarcinoma.

scientific article published on 23 February 2013

Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis

scientific article

Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue

scientific article published on 28 June 2013

An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

scientific article published on 12 March 2021

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

scientific article published on 04 December 2011

BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues

scientific article

Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

scientific article published on 11 March 2019

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

scientific article published on 12 August 2019

CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells

scientific article

CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

scientific article published in May 2018

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

scientific article

CXCR2 inhibition in pancreatic cancer: opportunities for immunotherapy?

CXCR2 inhibition suppresses acute and chronic pancreatic inflammation

scientific article published on 4 June 2015

Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine

scientific article published on 05 November 2018

Dasatinib inhibits mammary tumour development in a genetically engineered mouse model

scientific article published on August 2013

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma

scientific article published on 17 March 2010

Deregulation of RNA polymerase III transcription in cervical epithelium in response to high-risk human papillomavirus

article

Exploiting inflammation for therapeutic gain in pancreatic cancer

scientific article

Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel

scientific article

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

scientific article

Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene

scientific article published on 01 January 2000

Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes

scientific article

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

scientific article published on August 2010

Functions of TAp63 and p53 in restraining the development of metastatic cancer.

scientific article published on 22 July 2013

GEMMs as preclinical models for testing pancreatic cancer therapies

scientific article

Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer

scientific article published on 01 December 2021

Genomic analyses identify molecular subtypes of pancreatic cancer

scientific article published on 24 February 2016

Hypermutation In Pancreatic Cancer

scientific article

Increased formate overflow is a hallmark of oxidative cancer.

scientific article

Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling.

scientific article published on 24 October 2015

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

scientific article published on 7 June 2013

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

scientific article published on 22 December 2015

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer.

scientific article

LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

scientific article published on 06 May 2010

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.

scientific article

MYC‐y mice: From tumour initiation to therapeutic targeting of endogenous MYC ⬇️

scientific article published on 08 March 2013

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

scientific article published on 28 February 2019

Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

scientific article published on 3 July 2017

MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.

scientific article

MicroRNA Molecular Profiles Associated with Diagnosis, Clinicopathologic Criteria, and Overall Survival in Patients with Resectable Pancreatic Ductal Adenocarcinoma

scientific article published on 23 November 2011

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

scientific article

Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging

scientific article

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

scientific article

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

scientific article

Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.

scientific article

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma.

scientific article published on 25 January 2018

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ⬇️

scientific article published in Nature Communications

Neutrophils: Homing in on the myeloid mechanisms of metastasis.

scientific article published on 18 December 2017

Notch3 drives development and progression of cholangiocarcinoma.

scientific article published on 10 October 2016

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

scientific article

PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy

scientific article

Pancreatic Cancer: From Genome Discovery to PRECISION-Panc

scientific article published on 12 September 2019

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

scientific article

RNA polymerase III transcription is repressed in response to the tumour suppressor ARF.

scientific article published on 16 April 2007

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

scientific article published on 28 December 2016

Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

scientific article

Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy.

scientific article published on September 2011

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis

scientific article published on 25 July 2016

Removing physiological motion from intravital and clinical functional imaging data

scientific article published on 09 July 2018

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer.

scientific article published on 26 December 2017

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.

scientific article published on 27 March 2017

Shh signaling and pancreatic cancer: implications for therapy?

scientific article

Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

scholarly article

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

scientific article

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

scientific article published on 28 October 2017

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

scientific article published on 08 October 2020

Targeting mTOR dependency in pancreatic cancer

scientific article

Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.

scientific article published on 22 January 2018

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

scientific article published on 15 June 2015

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

scientific article (publication date: December 2009)

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues

scientific article published on 13 March 2014

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

scientific article published on 05 June 2019

The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

scientific article published on 30 July 2019

The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model? ⬇️

scientific article published on February 2012

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

scientific article published on 31 January 2017

Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment.

scientific article

Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology.

scientific article published on 4 December 2017

Timing Is Everything: Brca2 and p53 Mutations in Pancreatic Cancer

scientific article published on 23 February 2011

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

scientific article published in April 2017

Trp53 deletion stimulates the formation of metastatic pancreatic tumors

scientific article published on 29 February 2008

mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer

scientific article published on 6 October 2016

p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma

scientific article published in October 2010

p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB.

scientific article

p53 status determines the role of autophagy in pancreatic tumour development

scientific article published on 4 December 2013

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.

scientific article

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