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List of works by Alistair N Hume

A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes.

scientific article published on 16 August 2006

A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases

scientific article

A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes

scientific article

A role for Rab27 in neutrophil chemotaxis and lung recruitment.

scientific article

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes

scientific article published on 13 September 2016

Correction: A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes

scientific article published on 3 February 2016

Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux

scientific article

Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion

scientific article published on 02 January 2013

Exosome signaling in mammary gland development and cancer ⬇️

scientific article published on January 1, 2011

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome

scientific article

Inefficient recruitment of kinesin-1 to melanosomes precludes it from facilitating their transport

scientific article published on 10 May 2017

Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise

scientific article published on 18 September 2014

Melanosomes at a glance.

scientific article

Melanosomes on the move: a model to understand organelle dynamics.

scientific article published on October 2011

Membrane targeting of Rab GTPases is influenced by the prenylation motif

scientific article

Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases

scientific article

Myosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro.

scientific article

Myosin--a monarch of pigment transport?

scientific article published on 29 December 2014

Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport

scientific article published on 24 July 2014

Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.

scientific article published on 21 March 2009

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a.

scientific article

Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.

scientific article published in June 2001

Rab GTPases, intracellular traffic and disease.

scientific article

Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis

scientific article published on 18 October 2013

Rab27a Targeting to Melanosomes Requires Nucleotide Exchange but Not Effector Binding ⬇️

scientific article published on June 15, 2011

Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.

scientific article published on 06 March 2009

Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes

scientific article published on 14 August 2007

Rab27a and Rab27b control different steps of the exosome secretion pathway

scientific article

Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs.

scientific article published on December 2012

Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins

scientific article published on 13 July 2020

Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment

scientific article

Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland.

scientific article

Retention in the endoplasmic reticulum is the underlying mechanism of some hereditary haemorrhagic telangiectasia type 2 ALK1 missense mutations

scientific article published on 4 November 2012

Semi-automated analysis of organelle movement and membrane content: understanding rab-motor complex transport function

scientific article published on 11 October 2011

Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.

scientific article

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes

scientific journal article

Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type

scientific article published on 19 August 2003

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