List of works - Alexander A. Shtil

3-Aminomethyl derivatives of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione for circumvention of anticancer drug resistance.

scientific article published on March 2005

60-Hz electric fields inhibit protein kinase C activity and multidrug resistance gene (MDR1) up-regulation

scientific article published on 01 March 1997

A novel acyclic oligomycin A derivative formed via retro-aldol rearrangement of oligomycin A.

scientific article published on 23 May 2012

Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis

scientific article published on 01 October 1996

Altered transcription and replication are the mechanisms of cytotoxicity of antitumor antibiotic olivomycin A

scientific article published on 01 November 2010

Bacterial eukaryotic type serine-threonine protein kinases: from structural biology to targeted anti-infective drug design

scientific article

Boronated protohaemins: synthesis and in vivo antitumour efficacy

scientific article

Carboranylporphyrins for boron neutron capture therapy of cancer

scientific article published on November 2003

Coherent phase microscopy, a novel approach to study the physiological state of the nucleolus

scientific article published on November 2005

Conjugates of phosphorylated zalcitabine and lamivudine with SiO2 nanoparticles: Synthesis by CuAAC click chemistry and preliminary assessment of anti-HIV and antiproliferative activity

scientific article published on 25 January 2017

Crystallization and preliminary X-ray diffraction analysis of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil

scientific article published on 22 May 2009

Developing Antitumor Magnetic Hyperthermia: Principles, Materials and Devices

scientific article

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

scientific article

Differential binding preference of methylpheophorbide a and its diboronated derivatives to albumin and low density lipoproteins

scientific article

Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells

scientific article published on January 1999

Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties

scientific article published on 04 February 2016

Disordering of human telomeric G-quadruplex with novel antiproliferative anthrathiophenedione

scientific article

Dissecting eukaryotic cells by coherent phase microscopy: quantitative analysis of quiescent and activated T lymphocytes

scientific article

Effects of isoprenoid analogues of SDB-ethylenediamine on multidrug resistant tumor cells alone and in combination with chemotherapeutic drugs

scientific article published on November 2002

Emergence of multidrug resistance in leukemia cells during chemotherapy: mechanisms and prevention

scientific article

Erratum: Modification of the antibiotic olivomycin I at the 2′-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity

scholarly article published in The Journal of Antibiotics

Ether lipids as anticancer agents: focus on non-phosphorus cationic glycerolipids.

scientific article

Expression of genes of glutathione transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in tumor cells during the formation of drug resistance to cisplatin.

scientific article

Expression, purification, crystallization and preliminary X-ray structure analysis of Vibrio cholerae uridine phosphorylase in complex with thymidine

scientific article published on 30 October 2012

Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors

scientific article

Identification of phosphorylation sites in aminoglycoside phosphotransferase VIII from Streptomyces rimosus

scientific article published on 01 November 2012

Immunosuppressive factor from liver induces apoptosis in thymoma EL-4 cells but not normal MHC class II-specific T lymphocytes.

scientific article published in February 1995

In silico design of protein kinase inhibitors: successes and failures.

scientific article published on March 2007

Inhibition of cytarabine-induced MDR1 (P-glycoprotein) gene activation in human tumor cells by fatty acid-polyethylene glycol-fatty acid diesters, novel inhibitors of P-glycoprotein function

scientific article published on 01 October 1996

Mechanisms of apoptosis are retained in cells with P glycoprotein-mediated drug resistance

scientific article published on 01 March 2006

Modification of olivomycin A at the side chain of the aglycon yields the derivative with perspective antitumor characteristics

scientific article

Modification of the antibiotic olivomycin I at the 2'-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity

scientific article

Morphological manifestations for the protective effect of miliacin in organs of immunogenesis after treatment with methotrexate

scientific article published on 01 October 2007

Multidrug-resistant tumor cells with decreased malignancy: a role for integrin alphavbeta3.

scientific article published on April 2004

Multifactorial drug resistance: P-glycoprotein on the apex of the pyramid

scientific article

N-benzoxazol-2-yl-N'-1-(isoquinolin-3-yl-ethylidene)-hydrazine, a novel compound with antitumor activity, induces radicals and dissipation of mitochondrial membrane potential.

scientific article

Naphtho[2,3-f]indole-5,10-dione aminoalkyl derivatives: a new class of topoisomerase I inhibitors

scientific article published in March 2008

Naphthoindole-based analogues of tryptophan and tryptamine: synthesis and cytotoxic properties.

scientific article published on 23 January 2007

New conjugates of polyene macrolide amphotericin B with benzoxaboroles: synthesis and properties

scientific article published on 23 March 2016

Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand.

scientific article

Novel Photosensitizers Trigger Rapid Death of Malignant Human Cells and Rodent Tumor Transplants via Lipid Photodamage and Membrane Permeabilization ⬇️

scientific article published on September 15, 2010

Novel antitumor L-arabinose derivative of indolocarbazole with high affinity to DNA.

scientific article

Novel boronated chlorin e6-based photosensitizers: synthesis, binding to albumin and antitumour efficacy

scientific article

Novel boronated derivatives of 5,10,15,20-tetraphenylporphyrin: synthesis and toxicity for drug-resistant tumor cells.

scientific article published on 26 September 2005

Novel derivatives of bacteriochlorophyll a: complex formation with albumin and the mechanism of tumor cell photodamage

scientific article published on 01 January 2014

Novel fluorescent pyrimidine nucleosides containing 2,1,3-benzoxadiazole and naphtho-[1,2,3-CD] Indole-6 (2H)-one fragments

scientific article

Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties

scientific article published on 8 August 2014

Olivomycin induces tumor cell apoptosis and suppresses p53-induced transcription

scientific article published on April 2005

Partial restoration of the actin cytoskeleton in transformed Syrian hamster fibroblasts selected for low levels of 'typical' multidrug resistance

scientific article published on March 1994

Preferential DNA photocleavage potency of Zn(II) over Ni(II) derivatives of carboxymethyl tetracationic porphyrin: the role of the mode of binding to DNA.

scientific article

Quantitative phase imaging of living cells: application of the phase volume and area functions to the analysis of "nucleolar stress".

scientific article published on November 2013

Quantitative real-time analysis of nucleolar stress by coherent phase microscopy

scientific article

Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.

scientific article

Redundancy of biological regulation as the basis of emergence of multidrug resistance.

scientific article

Role of phosphatidylinositol-3 kinase in regulation of differential sensitivity of melanoma cells to antitumor agents. A model for hormone resistance development in tumor cells.

scientific article published on March 2004

Role of the acyl groups in carbohydrate chains in cytotoxic properties of olivomycin A.

scientific article published on 22 May 2013

Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles

scientific article published in December 2008

Signal transduction pathways and transcriptional mechanisms as targets for prevention of emergence of multidrug resistance in human cancer cells

scientific article

Studies of complex formation of olivomycin A and its derivatives with DNA

scientific article published on 01 November 2010

Study on retroaldol degradation products of antibiotic oligomycin A.

scientific article published on 2 October 2013

Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.

scientific article published on 3 December 2015

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

scientific article published on 18 May 2016

Synthesis and cytotoxic potency of novel tris(1-alkylindol-3-yl)methylium salts: role of N-alkyl substituents.

scientific article published on 23 July 2010

Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones

scientific article

Synthesis and cytotoxicity of oligomycin A derivatives modified in the side chain

scientific article published on 6 April 2013

Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones

scientific article published on 8 September 2014

Synthesis and properties of a novel brominated oligomycin A derivative

scientific article published on 08 February 2012

Synthesis and structure-activity relationship studies of 4,11-diaminonaphtho[2,3-f]indole-5,10-diones

scientific article published on 2 May 2006

The Modified Heparin-Binding L-Asparaginase of Wolinella succinogenes.

scientific article

The X-ray structure of Salmonella typhimurium uridine nucleoside phosphorylase complexed with 2,2'-anhydrouridine, phosphate and potassium ions at 1.86 A resolution

scientific article

The copper-containing monocarboranylporphyrin: a prototype of new DNA-binding cytotoxic compounds

scientific article published on 01 July 2005

The first series of 4,11-bis[(2-aminoethyl)amino]anthra[2,3-b]furan-5,10-diones: Synthesis and anti-proliferative characteristics

scientific article published on 19 November 2010

The role of beta1 integrin subfamily in anchorage-dependent apoptosis of breast carcinoma cells differing in multidrug resistance.

scientific article

The role of carboxymethyl substituents in the interaction of tetracationic porphyrins with DNA.

scientific article

The water channels, new druggable targets to combat cancer cell survival, invasiveness and metastasis.

scientific article published on October 2007

Virtual screening of chemical compounds active against breast cancer cell lines based on cell cycle modelling, prediction of cytotoxicity and interaction with targets

scientific article published on 11 September 2015

X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae

scientific article

List of works by Alexander A. Shtil

3-Aminomethyl derivatives of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione for circumvention of anticancer drug resistance.

60-Hz electric fields inhibit protein kinase C activity and multidrug resistance gene (MDR1) up-regulation

A novel acyclic oligomycin A derivative formed via retro-aldol rearrangement of oligomycin A.

Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis

Altered transcription and replication are the mechanisms of cytotoxicity of antitumor antibiotic olivomycin A

Bacterial eukaryotic type serine-threonine protein kinases: from structural biology to targeted anti-infective drug design

Boronated protohaemins: synthesis and in vivo antitumour efficacy

Carboranylporphyrins for boron neutron capture therapy of cancer

Coherent phase microscopy, a novel approach to study the physiological state of the nucleolus

Conjugates of phosphorylated zalcitabine and lamivudine with SiO2 nanoparticles: Synthesis by CuAAC click chemistry and preliminary assessment of anti-HIV and antiproliferative activity

Crystallization and preliminary X-ray diffraction analysis of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil

Developing Antitumor Magnetic Hyperthermia: Principles, Materials and Devices

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

Differential binding preference of methylpheophorbide a and its diboronated derivatives to albumin and low density lipoproteins

Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells

Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties

Disordering of human telomeric G-quadruplex with novel antiproliferative anthrathiophenedione

Dissecting eukaryotic cells by coherent phase microscopy: quantitative analysis of quiescent and activated T lymphocytes

Effects of isoprenoid analogues of SDB-ethylenediamine on multidrug resistant tumor cells alone and in combination with chemotherapeutic drugs

Emergence of multidrug resistance in leukemia cells during chemotherapy: mechanisms and prevention

Erratum: Modification of the antibiotic olivomycin I at the 2′-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity

Ether lipids as anticancer agents: focus on non-phosphorus cationic glycerolipids.

Expression of genes of glutathione transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in tumor cells during the formation of drug resistance to cisplatin.

Expression, purification, crystallization and preliminary X-ray structure analysis of Vibrio cholerae uridine phosphorylase in complex with thymidine

Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors

Identification of phosphorylation sites in aminoglycoside phosphotransferase VIII from Streptomyces rimosus

Immunosuppressive factor from liver induces apoptosis in thymoma EL-4 cells but not normal MHC class II-specific T lymphocytes.

In silico design of protein kinase inhibitors: successes and failures.

Inhibition of cytarabine-induced MDR1 (P-glycoprotein) gene activation in human tumor cells by fatty acid-polyethylene glycol-fatty acid diesters, novel inhibitors of P-glycoprotein function

Mechanisms of apoptosis are retained in cells with P glycoprotein-mediated drug resistance

Modification of olivomycin A at the side chain of the aglycon yields the derivative with perspective antitumor characteristics

Modification of the antibiotic olivomycin I at the 2'-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity

Morphological manifestations for the protective effect of miliacin in organs of immunogenesis after treatment with methotrexate

Multidrug-resistant tumor cells with decreased malignancy: a role for integrin alphavbeta3.

Multifactorial drug resistance: P-glycoprotein on the apex of the pyramid

N-benzoxazol-2-yl-N'-1-(isoquinolin-3-yl-ethylidene)-hydrazine, a novel compound with antitumor activity, induces radicals and dissipation of mitochondrial membrane potential.

Naphtho[2,3-f]indole-5,10-dione aminoalkyl derivatives: a new class of topoisomerase I inhibitors

Naphthoindole-based analogues of tryptophan and tryptamine: synthesis and cytotoxic properties.

New conjugates of polyene macrolide amphotericin B with benzoxaboroles: synthesis and properties

Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand.

Novel Photosensitizers Trigger Rapid Death of Malignant Human Cells and Rodent Tumor Transplants via Lipid Photodamage and Membrane Permeabilization ⬇️

Novel antitumor L-arabinose derivative of indolocarbazole with high affinity to DNA.

Novel boronated chlorin e6-based photosensitizers: synthesis, binding to albumin and antitumour efficacy

Novel boronated derivatives of 5,10,15,20-tetraphenylporphyrin: synthesis and toxicity for drug-resistant tumor cells.

Novel derivatives of bacteriochlorophyll a: complex formation with albumin and the mechanism of tumor cell photodamage

Novel fluorescent pyrimidine nucleosides containing 2,1,3-benzoxadiazole and naphtho-[1,2,3-CD] Indole-6 (2H)-one fragments

Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties

Olivomycin induces tumor cell apoptosis and suppresses p53-induced transcription

Partial restoration of the actin cytoskeleton in transformed Syrian hamster fibroblasts selected for low levels of 'typical' multidrug resistance

Preferential DNA photocleavage potency of Zn(II) over Ni(II) derivatives of carboxymethyl tetracationic porphyrin: the role of the mode of binding to DNA.

Quantitative phase imaging of living cells: application of the phase volume and area functions to the analysis of "nucleolar stress".

Quantitative real-time analysis of nucleolar stress by coherent phase microscopy

Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.

Redundancy of biological regulation as the basis of emergence of multidrug resistance.

Role of phosphatidylinositol-3 kinase in regulation of differential sensitivity of melanoma cells to antitumor agents. A model for hormone resistance development in tumor cells.

Role of the acyl groups in carbohydrate chains in cytotoxic properties of olivomycin A.

Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles

Signal transduction pathways and transcriptional mechanisms as targets for prevention of emergence of multidrug resistance in human cancer cells

Studies of complex formation of olivomycin A and its derivatives with DNA

Study on retroaldol degradation products of antibiotic oligomycin A.

Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

Synthesis and cytotoxic potency of novel tris(1-alkylindol-3-yl)methylium salts: role of N-alkyl substituents.

Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones

Synthesis and cytotoxicity of oligomycin A derivatives modified in the side chain

Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones

Synthesis and properties of a novel brominated oligomycin A derivative

Synthesis and structure-activity relationship studies of 4,11-diaminonaphtho[2,3-f]indole-5,10-diones

The Modified Heparin-Binding L-Asparaginase of Wolinella succinogenes.

The X-ray structure of Salmonella typhimurium uridine nucleoside phosphorylase complexed with 2,2'-anhydrouridine, phosphate and potassium ions at 1.86 A resolution

The copper-containing monocarboranylporphyrin: a prototype of new DNA-binding cytotoxic compounds

The first series of 4,11-bis[(2-aminoethyl)amino]anthra[2,3-b]furan-5,10-diones: Synthesis and anti-proliferative characteristics

The role of beta1 integrin subfamily in anchorage-dependent apoptosis of breast carcinoma cells differing in multidrug resistance.

The role of carboxymethyl substituents in the interaction of tetracationic porphyrins with DNA.

The water channels, new druggable targets to combat cancer cell survival, invasiveness and metastasis.

Virtual screening of chemical compounds active against breast cancer cell lines based on cell cycle modelling, prediction of cytotoxicity and interaction with targets

X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae