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List of works by Ke Ding

(2-Pyridyl)acetone-promoted Cu-catalyzed O-arylation of phenols with aryl iodides, bromides, and chlorides

scientific article published in September 2009

1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose

scientific article published on 9 April 2015

2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR(L⁸⁵⁸R/T⁷⁹⁰M).

scientific article published on 30 July 2015

2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy

scientific article published on 02 August 2019

2-Pyridinyl beta-ketones as new ligands for room-temperature CuI-catalysed C-N coupling reactions

scientific article published on 20 February 2009

2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells

scientific article published on 23 March 2020

3-aminopyrazolopyrazine derivatives as spleen tyrosine kinase inhibitors

scientific article published on 6 June 2016

4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New Axl Kinase Inhibitors

scientific article published on 5 July 2016

A CuAAC/Ullmann C-C coupling tandem reaction: copper-catalyzed reactions of organic azides with N-(2-iodoaryl)propiolamides or 2-iodo-N-(prop-2-ynyl)benzenamines

scientific article published on 22 June 2012

A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton ⬇️

scientific article published on November 16, 2010

A novel Bcl-2 small molecule inhibitor 4-(3-methoxy-phenylsulfannyl)-7-nitro-benzofurazan-3-oxide (MNB)-induced apoptosis in leukemia cells

scientific article

A novel reactive turn-on probe capable of selective profiling and no-wash imaging of Bruton's tyrosine kinase in live cells

scientific article published on 01 March 2019

A patent review of discoidin domain receptor 1 (DDR1) modulators (2014-present)

scientific article published on 26 February 2020

A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis and sensitizes lung cancer cells to chemotherapy

scientific article

A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties

scientific article published on 3 December 2016

Affinity-Based Protein Profiling Reveals Cellular Targets of Photoreactive Anticancer Inhibitors

scientific article published on 26 November 2019

Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/β-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia

scientific article published on 4 August 2016

Antitumor activity of 7RH, a discoidin domain receptor 1 inhibitor, alone or in combination with dasatinib exhibits antitumor effects in nasopharyngeal carcinoma cells

scientific article published on 05 September 2016

Antitumor activity of S116836, a novel tyrosine kinase inhibitor, against imatinib-resistant FIP1L1-PDGFRα-expressing cells

scientific article

Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process

scientific article published on 4 November 2009

Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents.

scientific article

BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone

scientific article

BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase

scientific article

Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease

scientific article published on 08 October 2011

Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors

scientific article published on 11 May 2020

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.

scientific article published on 8 February 2016

Copper-catalyzed desymmetric intramolecular Ullmann C-N coupling: an enantioselective preparation of indolines

scientific article

Copper-catalyzed tandem reaction of isocyanides with N-(2-haloaryl)propiolamides for the synthesis of pyrrolo[3,2-c]quinolin-4-ones

scientific article published on 02 June 2011

Copper-catalyzed tandem reactions of 1-(2-iodoary)-2-yn-1-ones with isocyanides for the synthesis of 4-oxo-indeno[1,2-b]pyrroles

scientific article published on 17 December 2010

Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells.

scientific article

DC120, a novel AKT inhibitor, preferentially suppresses nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2.

scientific article published on March 2015

DC120, a novel and potent inhibitor of AKT kinase, induces tumor cell apoptosis and suppresses tumor growth

scientific article published on 2 May 2012

Design and Optimization of 3'-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors

scientific article published on 06 January 2020

Design and synthesis of N-(4-aminopyridin-2-yl)amides as B-Raf(V600E) inhibitors

scientific article published on 26 April 2016

Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility.

scientific article

Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2

scientific article published on 20 August 2018

Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine790 → Methionine790 Mutant ⬇️

scientific article published on March 22, 2012

Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents

scientific article published on 11 June 2015

Design, Synthesis, and Structure-Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5- d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors.

scientific article published on 2 March 2018

Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors

scientific article published on 17 June 2019

Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands.

scientific article published in March 2005

Design, synthesis, and biological evaluation of 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives as new irreversible epidermal growth factor receptor inhibitors with improved pharmacokinetic properties.

scientific article published on 31 October 2013

Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant.

scientific article

Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation

scientific article

Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer

scientific article published on 18 February 2016

Discovery of new chemical entities as potential leads against Mycobacterium tuberculosis.

scientific article published on 2 November 2016

Discovery of pteridin-7(8H)-one-based irreversible inhibitors targeting the epidermal growth factor receptor (EGFR) kinase T790M/L858R mutant.

scientific article published on 9 October 2013

Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands

scientific article published in May 2005

Evaluation of aminohydantoins as a novel class of antimalarial agents.

scientific article

Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents

scientific article

Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer

scientific article published on 13 March 2014

Fibroblast Growth Factor Receptor 4 (FGFR4) Selective Inhibitors as Hepatocellular Carcinoma Therapy, Advances and Prospects

scientific article published on 16 November 2018

GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells

scientific article published on 20 April 2010

GZD2202, a novel TrkB inhibitor, suppresses BDNF-mediated proliferation and metastasis in neuroblastoma models

scientific article published on 30 October 2018

GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways

scientific article published on 28 July 2016

GZD856, a novel potent PDGFRα/β inhibitor, suppresses the growth and migration of lung cancer cells in vitro and in vivo

scientific article published on 29 February 2016

Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis

scientific article published on 2 November 2016

Hybrid compounds as new Bcr/Abl inhibitors

scientific article published on 13 February 2011

Hybrid pyrimidine alkynyls inhibit the clinically resistance related Bcr-Abl(T315I) mutant

scientific article published on 9 July 2015

Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea

scientific article published on 19 March 2020

Identification and optimization of new dual inhibitors of B-Raf and epidermal growth factor receptor kinases for overcoming resistance against vemurafenib

scientific article published on 18 March 2014

Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.

scientific article published on 28 January 2013

Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation

Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway

scientific article published on 7 September 2010

Identification of Pyrazolo[1,5-]pyridine-3-carboxamide Diaryl Derivatives as Drug Resistant Antituberculosis Agents

article published in 2019

Leucine-zipper and Sterile-α Motif Kinase (ZAK): A Potential Target for Drug Discovery

scientific article published on 20 September 2016

MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53.

scientific article

N-(3-Ethynyl-2,4-difluorophenyl)sulfonamide Derivatives as Selective Raf Inhibitors

scientific article published on 18 March 2015

New Promise and Opportunities for Allosteric Kinase Inhibitors

scientific article published on 30 December 2019

New benzimidazole-2-urea derivates as tubulin inhibitors

scientific article

New thiazole carboxamides as potent inhibitors of Akt kinases

scientific article

Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells

scientific article

Novel anaplastic lymphoma kinase inhibitors targeting clinically acquired resistance

scientific article

Novel hybrids of (phenylsulfonyl)furoxan and anilinopyrimidine as potent and selective epidermal growth factor receptor inhibitors for intervention of non-small-cell lung cancer.

scientific article published on 24 May 2013

Novel thiazole amine class tyrosine kinase inhibitors induce apoptosis in human mast cells expressing D816V KIT mutation.

scientific article

Palladium-catalyzed amidation of N-tosylhydrazones with isocyanides

scientific article published on 21 September 2011

Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin.

scientific article published on 28 January 2014

Ponatinib induces apoptosis in imatinib-resistant human mast cells by dephosphorylating mutant D816V KIT and silencing β-catenin signaling

scientific article published on 19 February 2014

Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis

scientific article published on 11 December 2018

Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity

scientific article published on 10 September 2016

Pyrimido[4,5‐d]pyrimidin‐4(1H)‐one Derivatives as Selective Inhibitors of EGFR Threonine790 to Methionine790 (T790M) Mutants ⬇️

scientific article published on June 26, 2013

Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor

scientific article published on 05 February 2020

Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice

scientific article published on 29 November 2016

Rational Design and Structure Validation of a Novel Peptide Inhibitor of the Adenomatous-Polyposis-Coli (APC)-Rho-Guanine-Nucleotide-Exchange-Factor-4 (Asef) Interaction

scientific article published on 20 August 2018

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

scientific article

Recent advance in the design of small molecular modulators of estrogen-related receptors.

scientific article

Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4

scientific article published on 03 July 2019

Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice

scientific article published on 16 November 2016

SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells.

scientific article

Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids

scientific article published in January 2006

Small molecule discoidin domain receptor kinase inhibitors and potential medical applications.

scientific article published on 21 January 2015

Small-Molecule CSF1R Inhibitors as Anticancer Agents

scientific article published on 18 June 2019

Small-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics

scientific article published on 23 November 2020

Small-molecule BET inhibitors in clinical and preclinical development and their therapeutic potential.

scientific article

Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.

scientific article published on 6 June 2017

Structure-Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4-Methylester-Rakicidin A.

scientific article published on 27 January 2016

Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S)

scientific article published on 23 July 2019

Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

scientific article published on 24 May 2016

Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC).

scientific article published on 22 March 2018

Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors

scientific article published on 16 June 2011

Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.

scientific article published on 7 June 2007

Structure-based design of potent non-peptide MDM2 inhibitors

scientific article published in July 2005

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

scientific article published on June 2006

Structure-based discovery of novel 4,5,6-trisubstituted pyrimidines as potent covalent Bruton's tyrosine kinase inhibitors

scientific article published on 7 May 2016

Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors

scientific article published on 14 February 2014

Synthesis of [1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-ones through copper-catalyzed tandem reactions of N-(2-haloaryl)propiolamides with sodium azide

scientific article published on 15 February 2012

Synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reactions

scientific article published on 01 April 2010

Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs)

scientific article published on 12 February 2019

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

scholarly article

The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation

scientific article published on 12 July 2016

Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases

scientific article published on 11 October 2019

Up-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1.

scientific article published on 7 September 2016

YL143, a novel mutant selective irreversible EGFR inhibitor, overcomes EGFRL858R, T790M -mutant resistance in vitro and in vivo

scientific article published on 13 March 2018

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