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List of works by Iñaki F. Trocóniz

A different kinetic profile of ochratoxin A in mature male rats

scientific article published on 13 May 2009

A pooled analysis of CD4 response to zidovudine and zalcitabine treatment in patients with AIDS and AIDS-related complex

scientific article

A population pharmacodynamic model for lactate dehydrogenase and neuron specific enolase to predict tumor progression in small cell lung cancer patients

scientific article

A review of mixed-effects models of tumor growth and effects of anticancer drug treatment used in population analysis.

scientific article

A semi-physiological-based pharmacokinetic/pharmacodynamic model to describe the effects of topotecan on b-lymphocyte lineage cells

scientific article published on 26 January 2010

A systems pharmacology model for inflammatory bowel disease

scientific article published on 7 March 2018

Application of different methods to formulate PEG-liposomes of oxaliplatin: evaluation in vitro and in vivo

scientific article

Assessment of Clinical Response to <scp>V937</scp> Oncolytic Virus After Intravenous or Intratumoral Administration Using Physiologically‐Based Modeling

scientific article published in 2023

Biopharmaceutic and pharmacodynamic modeling of the in vitro antiproliferative effect of new controlled delivery systems of cisplatin

scientific article

Bringing Model-Based Prediction to Oncology Clinical Practice: A Review of Pharmacometrics Principles and Applications.

scientific article

Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans?

scientific article published on 22 November 2014

Characterizing Gemcitabine Effects Administered as Single Agent or Combined with Carboplatin in Mice Pancreatic and Ovarian Cancer Xenografts: A Semimechanistic Pharmacokinetic/Pharmacodynamics Tumor Growth-Response Model

scientific article published on 27 December 2016

Commentary on Pharmacometrics for Immunotherapy

scientific article published on 20 December 2016

Comparative pharmacokinetics, tissue distributions, and effects on renal function of novel polymeric formulations of amphotericin B and amphotericin B-deoxycholate in rats

scientific article published on April 2000

Comparison of different semi-mechanistic models for chemotherapy-related neutropenia: application to BI 2536 a Plk-1 inhibitor

scientific article

Comparison of manual versus ambulatory blood pressure measurements with pharmacokinetic-pharmacodynamic modeling of antihypertensive compounds: application to moxonidine

scientific article published on 01 July 2000

Correlation between anti-PD-L1 tumor concentrations and tumor-specific and nonspecific biomarkers in a melanoma mouse model

scientific article published on 18 October 2016

Dealing with Time-Dependent Pharmacokinetics during the Early Clinical Development of a New Leukotriene B4 Synthesis Inhibitor

article

Drug Exposure to Establish Pharmacokinetic-Response Relationships in Oncology

scientific article published on 01 February 2020

EGF-liposomes promote efficient EGFR targeting in xenograft colocarcinoma model

scientific article published on 19 February 2016

Early Prediction of Disease Progression in Small Cell Lung Cancer: Toward Model-Based Personalized Medicine in Oncology

scientific article published on 4 May 2015

Effects of fasting and gender on ochratoxin A toxicokinetics in F344 rats

scientific article

Enantiomeric separation of tramadol and its active metabolite in human plasma by chiral high-performance liquid chromatography: application to pharmacokinetic studies

scientific article published on 01 January 1999

Establishing the Quantitative Relationship Between Lanreotide Autogel®, Chromogranin A, and Progression-Free Survival in Patients with Nonfunctioning Gastroenteropancreatic Neuroendocrine Tumors.

scientific article published on 23 February 2016

Feasibility of microdialysis to determine interstitial rocuronium concentration in the muscle tissue of anesthetized neurosurgical patients.

scientific article published in April 2010

Finding the Dose for Ceftolozane-Tazobactam in Critically Ill Children with and without Acute Kidney Injury

scientific article published on 10 December 2020

Gene therapy: a pharmacokinetic/pharmacodynamic modelling overview.

scientific article published on 13 April 2010

Hematological response of topotecan in tumor-bearing rats: modeling of the time course of different cellular populations.

scientific article published on April 2004

Intestinal absorption of penclomedine from lipid vehicles in the conscious rat: contribution of emulsification versus digestibility

scientific article

Intrahepatic injection of recombinant adeno-associated virus serotype 2 overcomes gender-related differences in liver transduction

scientific article published on June 2006

Joint population pharmacokinetic/pharmacodynamic model for the heart rate effects at rest and at the end of exercise for cilobradine

scientific article published on 11 December 2012

Kinetic and Dynamic Computational Model-Based Characterization of New Proteins in Mice: Application to Interferon Alpha Linked to Apolipoprotein A-I ⬇️

scientific article published on July 27, 2012

Mathematical model approach to describe tumour response in mice after vaccine administration and its applicability to immune-stimulatory cytokine-based strategies

scientific article published on 19 April 2013

Mechanism-based modeling of the clinical effects of bevacizumab and everolimus on vestibular schwannomas of patients with neurofibromatosis type 2.

scientific article published on 4 May 2016

Mechanistic Multiscale Pharmacokinetic Model for the Anticancer Drug 2',2'-difluorodeoxycytidine (Gemcitabine) in Pancreatic Cancer

scientific article published on 10 February 2020

Mechanistic modelling of enzyme‐restoration effects of new recombinant liver‐targeted proteins in acute intermittent porphyria

scientific article published on 16 February 2022

Methadone: a review of its pharmacokinetic/pharmacodynamic properties.

scientific article

Modeling Respiratory Depression Induced by Remifentanil and Propofol during Sedation and Analgesia Using a Continuous Noninvasive Measurement of pCO2.

scientific article published on 11 December 2015

Modeling of the sedative and airway obstruction effects of propofol in patients with Parkinson disease undergoing stereotactic surgery.

scientific article published in December 2002

Modeling the effect of propofol and remifentanil combinations for sedation-analgesia in endoscopic procedures using an Adaptive Neuro Fuzzy Inference System (ANFIS).

scientific article

Modeling the influence of the A118G polymorphism in the OPRM1 gene and of noxious stimulation on the synergistic relation between propofol and remifentanil: sedation and analgesia in endoscopic procedures.

scientific article

Modeling tumor response after combined administration of different immune-stimulatory agents.

scientific article published on 11 July 2013

Modelling and simulation in the development and use of anti-cancer agents: an underused tool?

scientific article

Modelling overdispersion and Markovian features in count data

scientific article

Modelling the genesis and treatment of cancer: the potential role of physiologically based pharmacodynamics.

scientific article

Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1

scientific article published on 03 February 2021

Obesity does not influence the onset and offset of sevoflurane effect as measured by the hysteresis between sevoflurane concentration and bispectral index

scientific article published on 19 May 2011

Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer.

scientific article published on 19 April 2018

Optimizing oncology therapeutics through quantitative translational and clinical pharmacology: challenges and opportunities.

scientific article

Performance in population models for count data, part I: maximum likelihood approximations

scientific article

Pharmacodynamic modeling of the effects of lanreotide Autogel on growth hormone and insulin-like growth factor 1.

scientific article published on 6 May 2011

Pharmacokinetic profiles determine optimal combination treatment schedules in computational models of drug resistance

scientific article published on 19 June 2020

Pharmacokinetic-Pharmacodynamic Modelling of the antipyretic effect of two oral formulations of ibuprofen

scientific article published on June 2000

Pharmacokinetic-pharmacodynamic modeling of the influence of chronic phenytoin therapy on the rocuronium bromide response in patients undergoing brain surgery.

scientific article published on 3 June 2008

Pharmacokinetic-pharmacodynamic modelling in anaesthesia

scientific article published on January 2015

Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase-2, in rats.

scientific article

Pharmacokinetic/pharmacodynamic evaluation of amoxicillin, amoxicillin/clavulanate and ceftriaxone in the treatment of paediatric acute otitis media in Spain

scientific article published on 22 February 2011

Pharmacokinetic/pharmacodynamic model of the testosterone effects of triptorelin administered in sustained release formulations in patients with prostate cancer

scientific article published on 12 June 2012

Pharmacokinetic/pharmacodynamic modeling of the antinociceptive effects of (+)-tramadol in the rat: role of cytochrome P450 2D activity.

scientific article published on 11 February 2003

Pharmacokinetics and population pharmacodynamic analysis of lanreotide Autogel

scientific article

Pharmacokinetic–Pharmacodynamic Modeling of Mivacurium in Rats

scientific article published on 01 February 1997

Pharmacological profiles of acute myeloid leukemia treatments in patient samples by automated flow cytometry: a bridge to individualized medicine.

scientific article

Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development.

scientific article published on 15 June 2015

Phase I dose-finding study and a pharmacokinetic/pharmacodynamic analysis of the neutropenic response of intravenous diflomotecan in patients with advanced malignant tumours

scientific article published on 28 October 2005

Population Pharmacokinetic Analysis of Lanreotide Autogel/Depot in the Treatment of Neuroendocrine Tumors: Pooled Analysis of Four Clinical Trials

scientific article

Population Pharmacokinetics of Volasertib Administered in Patients with Acute Myeloid Leukaemia as a Single Agent or in Combination with Cytarabine

scientific article published on 19 June 2017

Population dose-response model for tadalafil in the treatment of male erectile dysfunction

scientific article published in August 2004

Population in vitro-in vivo correlation model for pramipexole slow-release oral formulations

scientific article

Population pharmacokinetic analysis of lanreotide Autogel in healthy subjects : evidence for injection interval of up to 2 months

scientific article published on January 2009

Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation.

scientific article

Population pharmacokinetic analysis of the new oral thrombin inhibitor dabigatran etexilate (BIBR 1048) in patients undergoing primary elective total hip replacement surgery

scientific article published in March 2007

Population pharmacokinetic model of lithium and drug compliance assessment

scientific article published on 16 November 2016

Population pharmacokinetic modelling of BIBN 4096 BS, the first compound of the new class of calcitonin gene-related peptide receptor antagonists

scientific article published in July 2004

Population pharmacokinetic modelling of irosustat in postmenopausal women with oestrogen-receptor positive breast cancer incorporating non-linear red blood cell uptake.

scientific article published on 30 October 2014

Population pharmacokinetic models for cefuroxime and metronidazole used in combination as prophylactic agents in colorectal surgery: Model-based evaluation of standard dosing regimens

scientific article published on 16 February 2015

Population pharmacokinetic/pharmacodynamic model for the sedative effects of flibanserin in healthy volunteers

scientific article published on 5 January 2012

Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors

scientific article

Population pharmacokinetic/pharmacodynamic modelling of the analgesic effects of tramadol in pediatrics

scientific article published on 9 August 2006

Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects

scientific article published on 29 February 2016

Population pharmacokinetics of ganciclovir after intravenous ganciclovir and oral valganciclovir administration in solid organ transplant patients infected with cytomegalovirus.

scientific article published on 08 September 2009

Population pharmacokinetics of meropenem in critically ill patients undergoing continuous renal replacement therapy

scientific article

Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis.

scientific article published in August 2013

Population pharmacokinetics of prophylactic cefoxitin in patients undergoing colorectal surgery

scientific article published on 15 January 2012

Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer

scientific article published on 01 March 2019

Predicting relapsing-remitting dynamics in multiple sclerosis using discrete distribution models: a population approach

scientific article

Prediction of neutropenia-related effects of a new combination therapy with the anticancer drugs BI 2536 (a Plk1 inhibitor) and pemetrexed

scientific article published on 6 October 2010

Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies.

scientific article

Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome.

scientific article

Review on modeling anti-antibody responses to monoclonal antibodies.

scientific article published on 16 July 2014

SEMI-MECHANISTIC PHARMACOKINETIC MODELING OF LIPID CORE NANOCAPSULES: UNDERSTANDING QUETIAPINE PLASMA AND BRAIN DISPOSITION IN A NEURODEVELOPMENTAL ANIMAL MODEL OF SCHIZOPHRENIA

scientific article published on 27 July 2020

Sedation-analgesia with propofol and remifentanil: concentrations required to avoid gag reflex in upper gastrointestinal endoscopy.

scientific article published on July 2015

Semi-mechanistic description of the in-vitro antiproliferative effect of different antitumour agents

scientific article published on January 2008

Semi-mechanistic modeling of the interaction between the central and peripheral effects in the antinociceptive response to lumiracoxib in rats.

scientific article

Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain

scientific article published on 05 October 2013

Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice

scientific article published on 26 November 2007

Semi-mechanistic pharmacodynamic modelling of gene expression and silencing processes

scientific article

Semi-mechanistic pharmacokinetic/pharmacodynamic modelling of the antinociceptive response in the presence of competitive antagonism: the interaction between tramadol and its active metabolite on micro-opioid agonism and monoamine reuptake inhibitio

scientific article

Semi-mechanistic population pharmacokinetic/pharmacodynamic model for neutropenia following therapy with the Plk-1 inhibitor BI 2536 and its application in clinical development

scientific article published on 9 January 2010

Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid.

scientific article

Semimechanistic cell-cycle type-based pharmacokinetic/pharmacodynamic model of chemotherapy-induced neutropenic effects of diflomotecan under different dosing schedules.

scientific article published on 6 May 2015

Serum protein binding of lerisetron, a novel specific 5HT3 antagonist, in patients with cancer

scientific article published on 01 January 1998

Systematic modelling and design evaluation of unperturbed tumour dynamics in xenografts

scientific article published on 24 April 2018

Tadalafil population pharmacokinetics in patients with erectile dysfunction

scientific article published on 13 April 2007

Target-mediated disposition model describing the dynamics of IL12 and IFNγ after administration of a mifepristone-inducible adenoviral vector for IL-12 expression in mice.

scientific article published on 8 November 2012

Tenoxicam pharmacokinetics in rats: a population model

scientific article published on 01 December 1995

The influence of age on the dynamic relationship between end-tidal sevoflurane concentrations and bispectral index

scientific article

Towards patient stratification and treatment in the autoimmune disease lupus erythematosus using a systems pharmacology approach.

scientific article published on 11 April 2016

Tramadol and o-desmethyl tramadol clearance maturation and disposition in humans: a pooled pharmacokinetic study

scientific article published on 01 February 2015

Validation of a semi-physiological model for caffeine in healthy subjects and cirrhotic patients.

scientific article published on 2 April 2015

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