List of works - Camillo Rosano

(6-bromo-1,4-dimethyl-9H-carbazol-3-yl-methylene)-hydrazine (carbhydraz) acts as a GPER agonist in breast cancer cells.

scientific article

A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation

scientific article

A Bodipy as a luminescent probe for detection of the G protein estrogen receptor (GPER)

scientific article published on 24 September 2015

A Methanol Extract of Scabiosa atropurpurea Enhances Doxorubicin Cytotoxicity against Resistant Colorectal Cancer Cells In Vitro

scientific article published on 12 November 2020

A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models

scientific article

A novel calix[4]pyrrole derivative as a potential anticancer agent that forms genotoxic adducts with DNA

scientific article published on 23 July 2018

ABCB1 Structural Models, Molecular Docking, and Synthesis of New Oxadiazolothiazin-3-one Inhibitors.

scientific article published on 13 May 2013

Analysis of 18 novel mutations in the factor VIII gene

scientific article published in September 2003

Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control

scientific article

Biochemical characterization and crystal structure of a recombinant hen avidin and its acidic mutant expressed in Escherichia coli

scientific article

Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts.

scientific article

C6: A Monoclonal Antibody Specific for a Fibronectin Epitope Situated at the Interface between the Oncofoetal Extra-Domain B and the Repeat III8.

scientific article published on 11 February 2016

Crystal structure and anion binding in the prokaryotic hydrogenase maturation factor HypF acylphosphatase-like domain

scientific article

Crystallization and preliminary X-ray characterization of the acylphosphatase-like domain from the Escherichia coli hydrogenase maturation factor HypF.

scientific article published on 21 February 2002

Crystals of the hydrogenase maturation factor HypF N-terminal domain grown in microgravity, display improved internal order

Cyanide binding to Lucina pectinata hemoglobin I and to sperm whale myoglobin: an x-ray crystallographic study.

scientific article

Drug delivery with a calixpyrrole--trans-Pt(II) complex

scientific article

Ectopic mRNA analysis and molecular modelling substantiate severe haemophilia in a patient with a FVIII gene splice mutation

scientific article published on 01 February 2005

Effects on Energy Metabolism of Two Guanidine Molecules, (Boc)2 -Creatine and Metformin

scientific article published on 27 January 2017

Endocrine disruptor agent nonyl phenol exerts an estrogen-like transcriptional activity on estrogen receptor positive breast cancer cells.

scientific article published on January 2014

Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells.

scientific article

Evolutionary constraints for dimer formation in prokaryotic Cu,Zn superoxide dismutase

scientific article

Exogenous hormonal regulation in breast cancer cells by phytoestrogens and endocrine disruptors

scientific article

Exon skipping partially restores factor VIII coagulant activity in patients with mild hemophilia A with exon 13 duplication.

scientific article

Expanded spectrum of Pelizaeus-Merzbacher-like disease: literature revision and description of a novel GJC2 mutation in an unusually severe form

scientific article

Expression, purification and preliminary crystallographic studies on the catalytic region of the nonreceptor tyrosine kinase Fes

scientific article published on 16 December 2006

First pilot newborn screening for four lysosomal storage diseases in an Italian region: identification and analysis of a putative causative mutation in the GBA gene

scientific article published on 20 July 2012

From coins to cancer therapy: Gold, silver and copper complexes targeting human topoisomerases

scientific article published on 17 December 2019

Functional analysis of 11 novel GBA alleles

scientific article

Genetic analysis in FXI deficient patients from northwestern Italy: three novel and one recurrent mutation

scientific article

Host-guest chemistry of a bis-calix[4]pyrrole derivative containing a trans/cis-switchable azobenzene unit with several aliphatic bis-carboxylates

scientific article published on 24 February 2015

Host-guest chemistry of aromatic-amide-linked bis- and tris-calix[4]pyrroles with bis-carboxylates and citrate anion.

scientific article published on 8 January 2014

Human sirtuins: an overview of an emerging drug target in age-related diseases and cancer.

scientific article published on June 2013

Hydrophilic and amphiphilic water-soluble dendrimer prodrugs suitable for parenteral administration of a non-soluble non-nucleoside HIV-1 reverse transcriptase inhibitor thiocarbamate derivative

scientific article published on 28 August 2018

IDUA mutational profiling of a cohort of 102 European patients with mucopolysaccharidosis type I: identification and characterization of 35 novel α-L-iduronidase (IDUA) alleles.

scientific article

Identification and molecular characterization of six novel mutations in the UDP-N-acetylglucosamine-1-phosphotransferase gamma subunit (GNPTG) gene in patients with mucolipidosis III gamma

scientific article

Identification of two benzopyrroloxazines acting as selective GPER antagonists in breast cancer cells and cancer-associated fibroblasts

scientific article

Inhibition of MDR1 activity and induction of apoptosis by analogues of nifedipine and diltiazem: an in vitro analysis.

scientific article

Inhibition of human Topoisomerase II by new N,N,N-trimethylethanammonium iodide alkylcarbazole derivatives

scientific article published on 30 November 2018

Insight into molecular changes of the FIX protein in a series of Italian patients with haemophilia B.

scientific article

Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach.

scientific article

Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase

scientific article

Localization-controlled two-color luminescence imaging via environmental modulation of energy transfer in a multichromophoric species

scientific article published on 01 March 2018

MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells.

scientific article

Macromolecular Modelling and Docking Simulations for the Discovery of Selective GPER Ligands.

scientific article

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

scientific article published on 28 June 2020

Molecular analysis and characterization of nine novel CTSK mutations in twelve patients affected by pycnodysostosis. Mutation in brief #961. Online

scientific article published on 01 May 2007

Molecular analysis of ARSA and PSAP genes in twenty-one Italian patients with metachromatic leukodystrophy: identification and functional characterization of 11 novel ARSA alleles

scientific article published in November 2008

Molecular analysis of NPC1 and NPC2 gene in 34 Niemann-Pick C Italian patients: identification and structural modeling of novel mutations

scientific article published on 28 February 2009

Molecular and functional characterization of eight novel GAA mutations in Italian infants with Pompe disease.

scientific article published in June 2008

Molecular characterization of 22 novel UDP-N-acetylglucosamine-1-phosphate transferase alpha- and beta-subunit (GNPTAB) gene mutations causing mucolipidosis types IIalpha/beta and IIIalpha/beta in 46 patients.

scientific article

Molecular model of hexokinase binding to the outer mitochondrial membrane porin (VDAC1): Implication for the design of new cancer therapies ⬇️

scientific article published on February 20, 2011

Monitoring the process of HypF fibrillization and liposome permeabilization by protofibrils

scientific article published in May 2004

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies

scientific article published on 19 January 2022

Multifaceted properties of 1,4-dimethylcarbazoles: Focus on trimethoxybenzamide and trimethoxyphenylurea derivatives as novel human topoisomerase II inhibitors

scientific article published in January 2017

N-acylated and N,N'-diacylated imidazolidine-2-thione derivatives and N,N'-diacylated tetrahydropyrimidine-2(1H)-thione analogues: synthesis and antiproliferative activity.

scientific article

N-alkyl carbazole derivatives as new tools for Alzheimer's disease: preliminary studies.

scientific article

N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression.

scientific article published on 22 November 2016

N-thioalkylcarbazoles derivatives as new anti-proliferative agents: synthesis, characterisation and molecular mechanism evaluation. ⬇️

scientific article published in December 2018

Nanotechnology: going small for a giant leap in cancer diagnostics and therapeutics

scientific article

Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots

scientific article

New insights for the use of quercetin analogs in cancer treatment.

scientific article published on 27 October 2017

Newly Synthesized Imino-Derivatives Analogues of Resveratrol Exert Inhibitory Effects in Breast Tumor Cells

scientific article published on 21 October 2020

Niacin activates the G protein estrogen receptor (GPER)-mediated signalling.

scientific article

Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells.

scientific article

On the Coordination and Oxidation States of the Active-Site Copper Ion in Prokaryotic Cu,Zn Superoxide Dismutases

scientific article published on 01 August 1998

Playing with opening and closing of heterocycles: using the cusmano-ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and P-glycoprotein inhibitors.

scientific article published on 14 October 2014

Preliminary characterization of two different crystal forms of acylphosphatase from the hyperthermophile archaeon Sulfolobus solfataricus

scientific article

Preliminary crystallographic characterization of the human β2 microglobulin His31Tyr mutant in a tetrameric assembly

scientific article published on 27 June 2003

Probing the catalytic mechanism of GDP-4-keto-6-deoxy-d-mannose Epimerase/Reductase by kinetic and crystallographic characterization of site-specific mutants

scientific article

Quaternary assembly and crystal structure of GDP-D-mannose 4,6 dehydratase from Paramecium bursaria Chlorella virus

scientific article

Recent Advances on the Role of G Protein-Coupled Receptors in Hypoxia-Mediated Signaling.

scientific article published on 10 February 2016

Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators

scientific article

Role of the non-receptor tyrosine kinase fes in cancer

scientific article published on January 2011

Segregation analysis in a family at risk for the Maroteaux-Lamy syndrome conclusively reveals c.1151G>A (p.S384N) as to be a polymorphism.

scientific article

Self-assembly of triton X-100 in water solutions: a multiscale simulation study linking mesoscale to atomistic models.

scientific article published on 28 August 2015

Severe congenital neutropenia: a negative synergistic effect of multiple mutations ofELANE(ELA2) gene

article

Single mutations at the subunit interface modulate copper reactivity in Photobacterium leiognathi Cu,Zn superoxide dismutase

scientific article

Single mutations at the subunit interface modulate copper reactivity in Photobacterium leiognathi Cu,Zn superoxide dismutase

Single mutations at the subunit interface modulate copper reactivity in photobacterium leiognathi Cu, Zn superoxide dismutase

Sirtuins as drug targets

scientific article published in June 2013

Small FVIII gene rearrangements in 18 hemophilia A patients: five novel mutations

scientific article

Solution properties of full-length integrin alpha(IIb)beta3 refined models suggest environment-dependent induction of alternative bent /extended resting states

scientific article published on 24 June 2010

Structural Comparison of the Interaction of Tubulin with Various Ligands Affecting Microtubule Dynamics ⬇️

scientific article published on July 1, 2012

Structural characterization of the nonameric assembly of an Archaeal alpha-L-fucosidase by synchrotron small angle X-ray scattering

scientific article published in July 2004

Structure, conformational stability, and enzymatic properties of acylphosphatase from the hyperthermophile Sulfolobus solfataricus

scientific article

Structure-activity relationships of resveratrol and derivatives in breast cancer cells.

scientific article

Synthesis and antitumor activity of some substituted indazole derivatives.

scientific article published on 19 February 2014

Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity

scientific article published on 31 August 2011

Synthesis of short retinoidal amides related to fenretinide: antioxidant activities and differentiation-inducing ability.

scientific article

Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents

scientific article

The Discovery of Highly Potent THP Derivatives as OCTN2 Inhibitors: From Structure-Based Virtual Screening to In Vivo Biological Activity

scientific article published on 08 October 2020

The implementation of SOMO (SOlution MOdeller) in the UltraScan analytical ultracentrifugation data analysis suite: enhanced capabilities allow the reliable hydrodynamic modeling of virtually any kind of biomacromolecule

scientific article

The three-dimensional structure of beta2 microglobulin: results from X-ray crystallography

scientific article

Three-dimensional structural characterization of a novel Drosophila melanogaster acylphosphatase.

scientific article

Tracking protons from respiratory chain complexes to ATP synthase c-subunit: The critical role of serine and threonine residues

scientific article published on 24 November 2016

Two novel GPER agonists induce gene expression changes and growth effects in cancer cells

scientific article

Uncommon EGFR Exon 19 Mutations Confer Gefitinib Resistance in Advanced Lung Adenocarcinoma.

scientific article

beta2-microglobulin H31Y variant 3D structure highlights the protein natural propensity towards intermolecular aggregation

scientific article

List of works by Camillo Rosano

(6-bromo-1,4-dimethyl-9H-carbazol-3-yl-methylene)-hydrazine (carbhydraz) acts as a GPER agonist in breast cancer cells.

A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation

A Bodipy as a luminescent probe for detection of the G protein estrogen receptor (GPER)

A Methanol Extract of Scabiosa atropurpurea Enhances Doxorubicin Cytotoxicity against Resistant Colorectal Cancer Cells In Vitro

A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models

A novel calix[4]pyrrole derivative as a potential anticancer agent that forms genotoxic adducts with DNA

ABCB1 Structural Models, Molecular Docking, and Synthesis of New Oxadiazolothiazin-3-one Inhibitors.

Analysis of 18 novel mutations in the factor VIII gene

Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control

Biochemical characterization and crystal structure of a recombinant hen avidin and its acidic mutant expressed in Escherichia coli

Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts.

C6: A Monoclonal Antibody Specific for a Fibronectin Epitope Situated at the Interface between the Oncofoetal Extra-Domain B and the Repeat III8.

Crystal structure and anion binding in the prokaryotic hydrogenase maturation factor HypF acylphosphatase-like domain

Crystallization and preliminary X-ray characterization of the acylphosphatase-like domain from the Escherichia coli hydrogenase maturation factor HypF.

Crystals of the hydrogenase maturation factor HypF N-terminal domain grown in microgravity, display improved internal order

Cyanide binding to Lucina pectinata hemoglobin I and to sperm whale myoglobin: an x-ray crystallographic study.

Drug delivery with a calixpyrrole--trans-Pt(II) complex

Ectopic mRNA analysis and molecular modelling substantiate severe haemophilia in a patient with a FVIII gene splice mutation

Effects on Energy Metabolism of Two Guanidine Molecules, (Boc)2 -Creatine and Metformin

Endocrine disruptor agent nonyl phenol exerts an estrogen-like transcriptional activity on estrogen receptor positive breast cancer cells.

Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells.

Evolutionary constraints for dimer formation in prokaryotic Cu,Zn superoxide dismutase

Exogenous hormonal regulation in breast cancer cells by phytoestrogens and endocrine disruptors

Exon skipping partially restores factor VIII coagulant activity in patients with mild hemophilia A with exon 13 duplication.

Expanded spectrum of Pelizaeus-Merzbacher-like disease: literature revision and description of a novel GJC2 mutation in an unusually severe form

Expression, purification and preliminary crystallographic studies on the catalytic region of the nonreceptor tyrosine kinase Fes

First pilot newborn screening for four lysosomal storage diseases in an Italian region: identification and analysis of a putative causative mutation in the GBA gene

From coins to cancer therapy: Gold, silver and copper complexes targeting human topoisomerases

Functional analysis of 11 novel GBA alleles

Genetic analysis in FXI deficient patients from northwestern Italy: three novel and one recurrent mutation

Host-guest chemistry of a bis-calix[4]pyrrole derivative containing a trans/cis-switchable azobenzene unit with several aliphatic bis-carboxylates

Host-guest chemistry of aromatic-amide-linked bis- and tris-calix[4]pyrroles with bis-carboxylates and citrate anion.

Human sirtuins: an overview of an emerging drug target in age-related diseases and cancer.

Hydrophilic and amphiphilic water-soluble dendrimer prodrugs suitable for parenteral administration of a non-soluble non-nucleoside HIV-1 reverse transcriptase inhibitor thiocarbamate derivative

IDUA mutational profiling of a cohort of 102 European patients with mucopolysaccharidosis type I: identification and characterization of 35 novel α-L-iduronidase (IDUA) alleles.

Identification and molecular characterization of six novel mutations in the UDP-N-acetylglucosamine-1-phosphotransferase gamma subunit (GNPTG) gene in patients with mucolipidosis III gamma

Identification of two benzopyrroloxazines acting as selective GPER antagonists in breast cancer cells and cancer-associated fibroblasts

Inhibition of MDR1 activity and induction of apoptosis by analogues of nifedipine and diltiazem: an in vitro analysis.

Inhibition of human Topoisomerase II by new N,N,N-trimethylethanammonium iodide alkylcarbazole derivatives

Insight into molecular changes of the FIX protein in a series of Italian patients with haemophilia B.

Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach.

Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase

Localization-controlled two-color luminescence imaging via environmental modulation of energy transfer in a multichromophoric species

MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells.

Macromolecular Modelling and Docking Simulations for the Discovery of Selective GPER Ligands.

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

Molecular analysis and characterization of nine novel CTSK mutations in twelve patients affected by pycnodysostosis. Mutation in brief #961. Online

Molecular analysis of ARSA and PSAP genes in twenty-one Italian patients with metachromatic leukodystrophy: identification and functional characterization of 11 novel ARSA alleles

Molecular analysis of NPC1 and NPC2 gene in 34 Niemann-Pick C Italian patients: identification and structural modeling of novel mutations

Molecular and functional characterization of eight novel GAA mutations in Italian infants with Pompe disease.

Molecular characterization of 22 novel UDP-N-acetylglucosamine-1-phosphate transferase alpha- and beta-subunit (GNPTAB) gene mutations causing mucolipidosis types IIalpha/beta and IIIalpha/beta in 46 patients.

Molecular model of hexokinase binding to the outer mitochondrial membrane porin (VDAC1): Implication for the design of new cancer therapies ⬇️

Monitoring the process of HypF fibrillization and liposome permeabilization by protofibrils

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies

Multifaceted properties of 1,4-dimethylcarbazoles: Focus on trimethoxybenzamide and trimethoxyphenylurea derivatives as novel human topoisomerase II inhibitors

N-acylated and N,N'-diacylated imidazolidine-2-thione derivatives and N,N'-diacylated tetrahydropyrimidine-2(1H)-thione analogues: synthesis and antiproliferative activity.

N-alkyl carbazole derivatives as new tools for Alzheimer's disease: preliminary studies.

N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression.

N-thioalkylcarbazoles derivatives as new anti-proliferative agents: synthesis, characterisation and molecular mechanism evaluation. ⬇️

Nanotechnology: going small for a giant leap in cancer diagnostics and therapeutics

Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots

New insights for the use of quercetin analogs in cancer treatment.

Newly Synthesized Imino-Derivatives Analogues of Resveratrol Exert Inhibitory Effects in Breast Tumor Cells

Niacin activates the G protein estrogen receptor (GPER)-mediated signalling.

Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells.

On the Coordination and Oxidation States of the Active-Site Copper Ion in Prokaryotic Cu,Zn Superoxide Dismutases

Playing with opening and closing of heterocycles: using the cusmano-ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and P-glycoprotein inhibitors.

Preliminary characterization of two different crystal forms of acylphosphatase from the hyperthermophile archaeon Sulfolobus solfataricus

Preliminary crystallographic characterization of the human β2 microglobulin His31Tyr mutant in a tetrameric assembly

Probing the catalytic mechanism of GDP-4-keto-6-deoxy-d-mannose Epimerase/Reductase by kinetic and crystallographic characterization of site-specific mutants

Quaternary assembly and crystal structure of GDP-D-mannose 4,6 dehydratase from Paramecium bursaria Chlorella virus

Recent Advances on the Role of G Protein-Coupled Receptors in Hypoxia-Mediated Signaling.

Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators

Role of the non-receptor tyrosine kinase fes in cancer

Segregation analysis in a family at risk for the Maroteaux-Lamy syndrome conclusively reveals c.1151G>A (p.S384N) as to be a polymorphism.

Self-assembly of triton X-100 in water solutions: a multiscale simulation study linking mesoscale to atomistic models.

Severe congenital neutropenia: a negative synergistic effect of multiple mutations ofELANE(ELA2) gene

Single mutations at the subunit interface modulate copper reactivity in Photobacterium leiognathi Cu,Zn superoxide dismutase

Single mutations at the subunit interface modulate copper reactivity in Photobacterium leiognathi Cu,Zn superoxide dismutase