List of works - Alena Gros

A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses.

scientific article

Adenovirus i-leader truncation bioselected against cancer-associated fibroblasts to overcome tumor stromal barriers

scientific article published on 23 August 2011

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

scientific article

Bioselection of a gain of function mutation that enhances adenovirus 5 release and improves its antitumoral potency.

scientific article

Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer

scientific article published in Science

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

scientific article published on February 2013

Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.

scientific article

Construction of Capsid-Modified Adenoviruses by Recombination in Yeast and Purification by Iodixanol-Gradient ⬇️

scientific article published on January 1, 2012

Deletion of VAI and VAII RNA genes in the design of oncolytic adenoviruses

scientific article published on September 2006

Determinants for Neoantigen Identification

scientific article published on 24 June 2019

Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens

scientific article published on 16 June 2016

Durable complete response in a patient with metastatic melanoma following adoptive transfer of autologous T cells recognizing 10 mutated tumor antigens.

scientific article published on 4 November 2015

Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy

scientific article published on 04 October 2018

GALV expression enhances the therapeutic efficacy of an oncolytic adenovirus by inducing cell fusion and enhancing virus distribution

scientific article

Immunogenicity of somatic mutations in human gastrointestinal cancers.

scientific article published on 29 October 2015

Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells

scientific article published on 21 November 2019

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

scientific article published on 14 September 2016

Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.

scientific article published on 8 November 2016

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

scientific article published on 14 December 2015

Myeloid cells obtained from the blood but not from the tumor can suppress T-cell proliferation in patients with melanoma.

scientific article

Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy

scientific article published on 08 March 2023

PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors

scientific article published on 25 March 2014

Phenotype and function of T cells infiltrating visceral metastases from gastrointestinal cancers and melanoma: implications for adoptive cell transfer therapy

scientific article published on 31 July 2013

Positive selection of gene-modified cells increases the efficacy of pancreatic cancer suicide gene therapy.

scientific article

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

scientific article published on 22 February 2016

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

scientific article published on 01 November 2019

Role of the putative heparan sulfate glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated retargeting

scientific article published on September 2006

Selection of circulating PD-1+ lymphocytes from cancer patients enriches for tumor-reactive and mutation-specific lymphocytes.

scientific article

Syncytia formation affects the yield and cytotoxicity of an adenovirus expressing a fusogenic glycoprotein at a late stage of replication

scientific article

Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6

scientific article

The expanding role of immunotherapy.

scientific article published on 11 February 2017

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor

scientific article published on 28 June 2016

Tumor-reactive CD8+ T cells in metastatic gastrointestinal cancer refractory to chemotherapy.

scientific article

Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest

scientific article

Urokinase-type plasminogen activator receptor transcriptionally controlled adenoviruses eradicate pancreatic tumors and liver metastasis in mouse models

scientific article

Verapamil enhances the antitumoral efficacy of oncolytic adenoviruses

scientific article

List of works by Alena Gros

A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses.

Adenovirus i-leader truncation bioselected against cancer-associated fibroblasts to overcome tumor stromal barriers

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

Bioselection of a gain of function mutation that enhances adenovirus 5 release and improves its antitumoral potency.

Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.

Construction of Capsid-Modified Adenoviruses by Recombination in Yeast and Purification by Iodixanol-Gradient ⬇️

Deletion of VAI and VAII RNA genes in the design of oncolytic adenoviruses

Determinants for Neoantigen Identification

Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens

Durable complete response in a patient with metastatic melanoma following adoptive transfer of autologous T cells recognizing 10 mutated tumor antigens.

Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy

GALV expression enhances the therapeutic efficacy of an oncolytic adenovirus by inducing cell fusion and enhancing virus distribution

Immunogenicity of somatic mutations in human gastrointestinal cancers.

Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

Myeloid cells obtained from the blood but not from the tumor can suppress T-cell proliferation in patients with melanoma.

Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy

PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors

Phenotype and function of T cells infiltrating visceral metastases from gastrointestinal cancers and melanoma: implications for adoptive cell transfer therapy

Positive selection of gene-modified cells increases the efficacy of pancreatic cancer suicide gene therapy.

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

Role of the putative heparan sulfate glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated retargeting

Selection of circulating PD-1+ lymphocytes from cancer patients enriches for tumor-reactive and mutation-specific lymphocytes.

Syncytia formation affects the yield and cytotoxicity of an adenovirus expressing a fusogenic glycoprotein at a late stage of replication

Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6

The expanding role of immunotherapy.

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor

Tumor-reactive CD8+ T cells in metastatic gastrointestinal cancer refractory to chemotherapy.

Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest

Urokinase-type plasminogen activator receptor transcriptionally controlled adenoviruses eradicate pancreatic tumors and liver metastasis in mouse models

Verapamil enhances the antitumoral efficacy of oncolytic adenoviruses