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List of works by Andrew C. Hooker

A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R.

scientific article

A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 - estimating occupancy in the absence of a reference region

scientific article published on 11 May 2013

Accelerating Monte Carlo power studies through parametric power estimation.

scientific article published on 2 March 2016

Adaptive Optimal Designs for Dose-Finding Studies with Time-to-Event Outcomes.

scientific article published on 28 December 2017

Adaptive-optimal design in PET occupancy studies

scientific article

Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014)

scientific article published on 19 July 2017

An evaluation of population D-optimal designs via pharmacokinetic simulations

scientific article

Application of the Optimal Design Approach to Improve a Pretransplant Drug Dose Finding Design for Ciclosporin

scientific article published on 04 May 2011

Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models.

scientific article published on 24 October 2017

Automated identification of axonal growth cones in time-lapse image sequences.

scientific article published on 19 September 2005

Chain length of dietary alkylresorcinols affects their in vivo elimination kinetics in rats

scientific article published on 14 August 2013

Classical examination of the Stark effect in hydrogen

article

Conditional weighted residuals (CWRES): a model diagnostic for the FOCE method.

scientific article published on 6 July 2007

Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology

scientific article published on 27 March 2018

Current Use and Developments Needed for Optimal Design in Pharmacometrics: A Study Performed Among DDMoRe's European Federation of Pharmaceutical Industries and Associations Members

scientific article published on 5 June 2013

Estimation of drug receptor occupancy when non-displaceable binding differs between brain regions – extending the simplified reference tissue model

scientific article published on June 2015

Ethically Attractive Dose-Finding Designs for Drugs With a Narrow Therapeutic Index

scientific article published on 12 January 2011

Evaluation of bias, precision, robustness and runtime for estimation methods in NONMEM 7.

scientific article

Improved precision of exposure-response relationships by optimal dose-selection. Examples from studies of receptor occupancy using PET and dose finding for neuropathic pain treatment

scientific article published on 20 March 2015

Improved utilization of ADAS-cog assessment data through item response theory based pharmacometric modeling

scientific article

Joint modeling of efficacy, dropout, and tolerability in flexible-dose trials: a case study in depression

scientific article published in May 2012

Maturation of Oxycodone Pharmacokinetics in Neonates and Infants: a Population Pharmacokinetic Model of Three Clinical Trials

scientific article published on 15 February 2017

Methodological comparison of in vitro binding parameter estimation: sequential vs. simultaneous non-linear regression

scientific article

Methods and software tools for design evaluation in population pharmacokinetics-pharmacodynamics studies.

scientific article published on January 2015

Model Description Language (MDL): A Standard for Modeling and Simulation

scientific article published on 23 June 2017

Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

scientific article

Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection

scientific article published on 4 November 2017

Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.

scientific article published on 7 March 2018

Model-Informed Drug Development and Review for Generic Products: Summary of FDA Public Workshop

article

Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

scientific article published on 26 June 2013

Multinomial logistic functions in markov chain models of sleep architecture: internal and external validation and covariate analysis.

scientific article

Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers.

scientific article

Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model

scientific article published on 12 October 2014

Optimal design in population kinetic experiments by set-valued methods

scientific article published on 15 July 2011

Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment.

scientific article published on 2 February 2011

Optimization of the intravenous glucose tolerance test in T2DM patients using optimal experimental design.

scientific article published on 25 June 2009

Optimizing disease progression study designs for drug effect discrimination.

scientific article published on 27 August 2013

POPED, a software for optimal experiment design in population kinetics.

scientific article published in April 2004

Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier

scientific article published in December 2008

Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development.

scientific article published on 15 June 2015

Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children

scientific article

Plasma and cerebrospinal fluid pharmacokinetics of naproxen in children

scientific article published on 8 November 2011

PopED lite: An optimal design software for preclinical pharmacokinetic and pharmacodynamic studies.

scientific article published on 8 February 2016

PopED: an extended, parallelized, nonlinear mixed effects models optimal design tool.

scientific article published on 27 May 2012

Population pharmacokinetic model for docetaxel in patients with varying degrees of liver function: incorporating cytochrome P4503A activity measurements

scientific article

Population pharmacometrics in support of analgesics studies.

scientific article published on 02 January 2014

Preconditioning of Nonlinear Mixed Effects Models for Stabilisation of Variance-Covariance Matrix Computations

scientific article published on 08 February 2016

Prediction-corrected visual predictive checks for diagnosing nonlinear mixed-effects models

scientific article

Quantitative Magnetic Resonance Imaging Analysis of Neovasculature Volume in Carotid Atherosclerotic Plaque

scientific article published on 01 February 2003

Robust Population Pharmacokinetic Experiment Design

scientific article published on 01 February 2005

Serial correlation in optimal design for nonlinear mixed effects models

scientific article published on 14 March 2012

Simultaneous optimal experimental design for in vitro binding parameter estimation

scientific article published on 13 August 2013

Simultaneous optimal experimental design on dose and sample times

scientific article published on 25 March 2009

Simultaneous pharmacokinetic modeling of alkylresorcinols and their main metabolites indicates dual absorption mechanisms and enterohepatic elimination in humans

scientific article published on 10 September 2014

The Standard Output: A Tool-Agnostic Modeling Storage Format

article

The effect of Fisher information matrix approximation methods in population optimal design calculations

scientific article published on November 2016

The effect of using a robust optimality criterion in model based adaptive optimization

scientific article published on 6 April 2017

Trial Treatment Length Optimization With an Emphasis on Disease Progression Studies

scientific article published on 01 March 2009

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