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List of works by Corrado Santocanale

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

scientific article

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

scientific article (publication date: 8 October 1998)

A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization.

scientific article published on January 2013

A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response

scientific article (publication date: 2014)

Activation of dormant origins of DNA replication in budding yeast

scientific article

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

scientific article

CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage

scientific article published on 04 June 2020

Cdc7 is an active kinase in human cancer cells undergoing replication stress.

scientific article published on 24 October 2006

Cdc7 kinase - a new target for drug development.

scientific article published on January 2010

Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.

scientific article published on October 2010

Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships

scientific article published on 18 January 2008

Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint

scientific article published on 17 April 2013

Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage

scientific article

Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships

scientific article

Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models

scientific article published on 24 July 2013

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast.

scientific article

DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach

scientific article (publication date: 14 October 2016)

DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors

scientific article published on 31 May 2017

DNA mediated chromatin pull-down for the study of chromatin replication.

scientific article published on 19 September 2011

Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex

scientific article

Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha.

scientific article

First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery

First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery

scientific article

Genomic footprinting of budding yeast replication origins during the cell cycle

scientific article published on 01 January 1997

Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation

scientific article

Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.

scientific article

Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.

scientific article published on 18 July 2011

MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells

scientific article published on 22 July 2013

Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitylase

scientific article published on 12 February 2020

Overproduction and functional analysis of DNA primase subunits from yeast and mouse

scientific article published on 01 April 1992

Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML

scientific article published in Scientific Reports

Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

scientific article published on 18 December 2015

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring

scientific article published on 5 November 2015

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring

scientific article published on 04 November 2015

The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase.

scientific article published on 26 February 2016

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies

scientific article

The yeast DNA polymerase-primase complex: genes and proteins

scientific article

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