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List of works by Holger Gerhardt

A new method for large scale isolation of kidney glomeruli from mice

scientific article

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.

scientific article published on 27 September 2017

A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.

scientific article

ATTRACT

scientific article published on 18 July 2019

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers.

scientific article published on 27 October 2017

Agent-based simulation of notch-mediated tip cell selection in angiogenic sprout initialisation

scientific article published in January 2008

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.

scientific article

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

scientific article published on 30 April 2008

Angiogenesis: a team effort coordinated by notch.

scientific article published on February 2009

Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine-tuning

scientific article published on 27 August 2019

Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks

scientific article published on 23 June 2021

Basic and Therapeutic Aspects of Angiogenesis ⬇️

scientific article (publication date: 16 September 2011)

Blood flow boosts BMP signaling to keep vessels in shape.

scientific article published on September 2016

Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo

scientific article published on 29 February 2016

Computer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesis

scientific article

Coordinating cell behaviour during blood vessel formation.

scientific article published on 28 September 2011

Correction: Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

scientific article published on 27 April 2020

Correction: dynamic endothelial cell rearrangements drive developmental vessel regression.

scientific article published on 14 May 2015

Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling

scientific article published in October 2003

Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.

scientific article published on 18 December 2013

Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.

scientific article published on December 2009

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

scientific article published on February 2007

Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins

scientific article

Dendritic cell expression of the Notch ligandjagged2 is not essential for Th2 response inductionin vivo

article

Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of glioblastoma multiforme via intranasal administration.

scientific article published on 19 February 2016

Differential expression of endothelial beta-catenin and plakoglobin during development and maturation of the blood-brain and blood-retina barrier in the chicken

scientific article published in January 2000

Differentiation of a unique macroglial cell type in the pecten oculi of the chicken

scientific article published on 01 December 1999

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

scientific article (publication date: 15 February 2007)

Dynamic endothelial cell rearrangements drive developmental vessel regression

scientific article

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth

scientific article published on 16 October 2017

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

scientific article published on 01 January 2019

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

scientific article published on 03 October 2019

Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions

scientific article published on 29 April 2015

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

scientific article published on 28 October 2011

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

scientific article

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility

scientific article published in Nature Communications

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

scientific article published on 26 September 2010

Endothelial-pericyte interactions in angiogenesis.

scientific article

Erratum: Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells

scientific article published in Nature

FOXO1 couples metabolic activity and growth state in the vascular endothelium

scientific article published on 06 January 2016

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

scientific article published on April 2015

Filopodia are dispensable for endothelial tip cell guidance

scientific article

Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization

scientific article published in January 2015

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients.

scientific article published on 6 June 2019

Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity.

scientific article published on 4 September 2013

Glycolytic regulation of cell rearrangement in angiogenesis.

scientific article

Growth factor gradients in vascular patterning.

scientific article

Hold Me, but Not Too Tight-Endothelial Cell-Cell Junctions in Angiogenesis.

scientific article published on 29 August 2017

How do endothelial cells orientate?

scientific article

Imaging Glioma Progression by Intravital Microscopy

scientific article published on 01 January 2019

Imaging of Endothelial Cell Dynamic Behavior in Zebrafish

scientific article published on 01 January 2018

Imaging transient blood vessel fusion events in zebrafish by correlative volume electron microscopy

scientific article (publication date: 2009)

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

scientific article published on 16 September 2013

Integrin signalling regulates YAP and TAZ to control skin homeostasis

scientific article published on 17 March 2016

Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis.

scientific article

Introduction to the ECR special angiogenesis issue

scientific article published on 15 March 2013

Intron with transgenic marker (InTraM) facilitates high-throughput screening of endogenous gene reporter lines

scientific article published on 11 August 2020

Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems.

scientific article published on 3 November 2011

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

scientific article published on 6 January 2016

Lack of CCM1 induces hypersprouting and impairs response to flow

scientific article

Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial Cells

scientific article published on 8 July 2011

Localization of Legionella bacteria within ribosome-studded phagosomes is not restricted to Legionella pneumophila

scientific article

Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways

scientific article published on 13 January 2020

Maturation of the blood-retina barrier in the developing pecten oculi of the chicken

scientific article published in June 1997

Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks

scientific article published in June 2017

Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes

scientific article published on 4 October 2017

Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs

scientific article published on 06 September 2018

N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy

scientific article (publication date: 2011)

N-cadherin expression in endothelial cells during early angiogenesis in the eye and brain of the chicken: relation to blood-retina and blood-brain barrier development.

scientific article

NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes

scientific article published on 15 September 2018

Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system

scientific journal article

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

scientific article published on 4 February 2016

Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis

scientific article

PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow

scientific article published on 17 July 2018

PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.

scientific article

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

scientific article

Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis

scientific article published on 12 December 2013

Pericytes or Mesenchymal Stem Cells: Is That the Question?

scientific article published in March 2017

Pericytes: gatekeepers in tumour cell metastasis?

scientific article published on 22 September 2007

Peripheral mural cell recruitment requires cell-autonomous heparan sulfate.

scientific article published on 27 April 2009

PolNet: A Tool to Quantify Network-Level Cell Polarity and Blood Flow in Vascular Remodeling

scientific article published on 01 May 2018

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.

scientific article published on 2 March 2018

Quantitative assessment of angiogenesis, perfused blood vessels and endothelial tip cells in the postnatal mouse brain.

scientific article published on 11 December 2014

Remodeling of an <i>in vitro</i> microvessel exposed to cyclic mechanical stretch

scientific article published on 02 April 2021

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

scientific article

Role of PFKFB3-driven glycolysis in vessel sprouting

scientific article

Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.

scientific article published on 13 May 2010

Role of pericytes in vascular morphogenesis.

scientific article

Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice.

scientific article published on January 2004

SRF selectively controls tip cell invasive behavior in angiogenesis.

scientific article published in June 2013

Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

scientific article

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

scientific article published on October 2002

Svep1 stabilises developmental vascular anastomosis in reduced flow conditions

scientific article published on 24 March 2022

Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

scientific article published on 13 April 2016

The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability

scientific article

The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling

scientific article

The pecten oculi of the chicken as a new in vivo model of the blood-brain barrier

scientific article published on 01 July 1996

The peripapillary glia of the optic nerve head in the chicken retina.

scientific article published in July 2000

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

scientific article

Tipping the balance: robustness of tip cell selection, migration and fusion in angiogenesis

scientific article

Tissue engineering: Blood vessels on a chip

scientific article published in August 2012

Tissue guidance without filopodia.

scientific article

Tumor vessel normalization by chloroquine independent of autophagy.

scientific article published on August 2014

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.

scientific article published on 26 April 2017

Ultrastructural localization of adhesion molecules in the healthy and inflamed choroid plexus of the mouse.

scientific article

Unique vascular phenotypes following over-expression of individual VEGFA isoforms from the developing lens

scientific article published on 16 November 2006

VEGF and Notch in tip and stalk cell selection

scientific article published on January 2013

VEGF and endothelial guidance in angiogenic sprouting

scientific article

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

scientific article (publication date: 23 June 2003)

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

scientific article published on 11 September 2011

Vascular morphogenesis: a Wnt for every vessel?

scientific article published on 26 October 2009

Visualization of endothelial actin cytoskeleton in the mouse retina

scientific article

Wiring the Vascular Network with Neural Cues: A CNS Perspective

scientific article (publication date: 15 July 2015)

Wnt/beta-catenin signaling controls development of the blood-brain barrier

scientific article published on 27 October 2008

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

scientific article

cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner

scientific article

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