List of works by Bernhard K. Keppler

(Aminoethanol)dichloroplatinum(II) complexes: influence of the hydroxyethyl moiety on 5'-GMP and DNA binding, intramolecular stability, the partition coefficient and anticancer activity

scientific article

1,1,3,3-Tetramethyl-1,3-disila-2-oxa[3]ferrocenophane: improved synthesis and new crystal structure

18F fluoroethylations: different strategies for the rapid translation of 11C-methylated radiotracers.

scientific article published on 21 September 2007

3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru(II)(arene) anticancer complexes with biologically active ligands

scientific article published on May 2013

5-Hydr-oxy-2-methyl-4H-pyran-4-one

scientific article

A Dogma in Doubt: Hydrolysis of Equatorial Ligands of PtIV Complexes under Physiological Conditions

scientific article published on 25 April 2019

A SAR study of novel antiproliferative ruthenium and osmium complexes with quinoxalinone ligands in human cancer cell lines

scientific article

A bioinformatics approach to the identification, classification, and analysis of hydroxyproline-rich glycoproteins

scientific article published on 15 April 2010

A comparative study of adduct formation between the anticancer ruthenium(III) compound HInd trans-[RuCl4(Ind)2] and serum proteins.

scientific article

A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin?

scientific article

A high-throughput assay for a human telomerase protein-human telomerase RNA interaction.

scientific article

A novel class of bis- and tris-chelate diam(m)inebis(dicarboxylato)platinum(IV) complexes as potential anticancer prodrugs.

scientific article

A novel cytotoxic cerium complex: aquatrichloridobis(1,10-phenanthroline)cerium(III) (KP776). Synthesis, characterization, behavior in H2O, binding towards biomolecules, and antiproliferative activity

scientific article

A one step/one pot synthesis of N,N-bis(phosphonomethyl)amino acids and their effects on adipogenic and osteogenic differentiation of human mesenchymal stem cells

scientific article

A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography

scientific article

A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process

scientific article

A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2'-deoxyguanosine 5'-monophosphate (dGMP).

scientific article

Activity of two platinum-linked phosphonic acids against autochthonous rat colorectal cancer as well as in two human colon-cancer cell lines

scientific article published in January 1992

Albumin-based nanoparticles as magnetic resonance contrast agents: I. Concept, first syntheses and characterisation

scientific article published on 20 February 2010

Am(m)ines make the difference: organoruthenium am(m)ine complexes and their chemistry in anticancer drug development

scientific article published on 22 January 2013

Amidines derived from Pt(IV)-mediated nitrile-amino alcohol coupling and their Zn(II)-catalyzed conversion into oxazolines.

scientific article published in April 2003

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin.

scientific article published on 26 May 2017

An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent alpha-N-heterocyclic chalcogensemicarbazones

scientific article

Analysis of anticancer platinum(II)-complexes by microemulsion electrokinetic chromatography: separation of diastereomers and estimation of octanol-water partition coefficients

scientific article published in February 2005

Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: indications of guanosine 5'-monophosphate O6-N7 chelation

scientific article published in November 2004

Analysis of quaternary ammonium and phosphonium ionic liquids by reversed-phase high-performance liquid chromatography with charged aerosol detection and unified calibration

scientific article published on 11 September 2008

Analytical instrumentation in toxicology

scientific article published on 01 September 1980

Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes

scientific article

Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma.

scientific article

Anticancer activity of metal complexes: involvement of redox processes

scientific article published on 11 May 2011

Anticancer activity of methyl-substituted oxaliplatin analogs

scientific article published on 13 February 2012

Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24).

scientific article published on 15 December 2005

Anticancer metal drugs and immunogenic cell death.

scientific article published on 16 June 2016

Anticancer-agent-linked phosphonates with antiosteolytic and antineoplastic properties: a promising perspective in the treatment of bone-related malignancies?

scientific article published on 01 January 1990

Antineoplastic activity of three ruthenium derivatives against chemically induced colorectal carcinoma in rats

scientific article published on 01 January 1992

Antitumor activity of 1.3-diketonato zirconium (IV) and hafnium (IV) complexes

scientific article published in January 1985

Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato) titanium(IV) compounds against Walker 256 carcinosarcoma. A new class of antineoplastic agents

scientific article published on 01 January 1982

Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium (IV) compounds. A new class of antineoplastic agents

scientific article published on 01 January 1983

Antitumor activity of imidazolium-bisimidazole-tetrachlororuthenate (III). A representative of a new class of inorganic antitumor agents

scientific article published on 01 January 1986

Antitumor activity of phenyl substituted dihalogenobis (1-phenyl-1,3-butanedionato)titanium (IV) compounds

scientific article published in January 1985

Antitumor activity of some ruthenium derivatives in human colon cancer cell lines in vitro

scientific article published on 01 June 1992

Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: synthesis, solution speciation and bioactivity

scientific article published on 3 February 2014

Antitumour Organometallics. III. In Vivo Activity of Diphenylantimony(III) and Diorganotin(IV) Dithiophosphorus Derivatives Against P388 Leukemia.

scientific article published on January 1994

Antitumour metal compounds: more than theme and variations

scientific article

Application of capillary electrophoresis-inductively coupled plasma mass spectrometry to comparative studying of the reactivity of antitumor ruthenium(III) complexes differing in the nature of counter-ion toward human serum proteins.

scientific article published on 11 April 2008

Application of capillary electrophoresis-mass spectrometry for the investigation of the binding behavior of oxaliplatin to 5'-GMP in the presence of the sulfur-containing amino acid L-methionine

scientific article published in January 2002

Application of ionic liquids for the removal of heavy metals from wastewater and activated sludge

scientific article

Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance

scientific article published on 01 February 2007

Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent.

scientific article

Assessment of the preclinical activity of budotitane in three different transplantable tumor systems, its lack of mutagenicity, and first results of clinical phase I studies

scientific article published in June 1989

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis

scientific article published on 16 February 2018

Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation

scientific article published on 10 February 2016

Binding of Antitumor Ruthenium(III) Complexes to Plasma Proteins

scientific article published in January 2000

Bioanalysis young investigator: Michael Groessl

scientific article published in May 2012

Biodistribution of anti-diabetic Zn(II) complexes in human serum andin vitroprotein-binding studies by means of CZEâ ICP-MS

scientific article published on 01 December 2009

Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action

scientific article published on 3 March 2016

Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS.

scientific article published on 7 March 2018

Bioinformatic Identification and Analysis of Hydroxyproline-Rich Glycoproteins in Populus trichocarpa

scientific article

Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells.

scientific article

Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors

scientific article published on 19 March 2020

Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles

scientific article

Biomolecule binding vs. anticancer activity: Reactions of Ru(arene)[(thio)pyr-(id)one] compounds with amino acids and proteins

scientific article published on 26 August 2011

Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media

scientific article published in April 2001

Bis- and Tetrakis(carboxylato)platinum(IV) complexes with mixed axial ligands - synthesis, characterization, and cytotoxicity

scientific article

Bulky N(,N)-(di)alkylethane-1,2-diamineplatinum(II) compounds as precursors for generating unsymmetrically substituted platinum(IV) complexes.

scientific article published on 21 June 2013

CE in anticancer metallodrug research--an update

scientific article published on October 2007

CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP.

scientific article published on 14 December 2007

Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46.

scientific article

Can neutral analytes be concentrated by transient isotachophoresis in micellar electrokinetic chromatography and how much?

scientific article published on 15 April 2014

Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: a novel approach for the analysis of anticancer metallodrugs in human serum and plasma

scientific article published on May 2008

Capillary electrophoresis in anti-cancer metallodrug research: advances and future challenges

scientific article published on June 2003

Capillary electrophoresis of metal-based drugs.

scientific article published on 10 May 2007

Capillary electrophoresis of platinum-group elements. Analytical, speciation and biochemical studies.

scientific article

Capillary electrophoretic assay for the stability of tris(8-quinolinolato)gallium(III) in tablet formulations

scientific article published on 21 May 2008

Capillary electrophoretic study of carboplatin and analogues with nucleoside monophosphates, di- and trinucleotides

scientific article

Capillary electrophoretic study of cisplatin interaction with nucleoside monophosphates, di- and trinucleotides

scientific article published on 01 August 1999

Capillary zone electrophoresis and capillary zone electrophoresis–electrospray ionization mass spectrometry studies on the behavior of anticancer cis- and trans-[dihalidobis(2-propanone oxime)platinum(II)] complexes in aqueous solutions

scientific article published on 28 July 2012

Carbohydrate-metal complexes and their potential as anticancer agents

scientific article published on January 2008

Carboxylation of Dihydroxoplatinum(IV) Complexes via a New Synthetic Pathway

scientific article published on 01 March 1996

Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds

scientific article published on 7 January 2012

Central European Society for Anticancer Drug Research

scientific article published on 01 October 2000

Characterization of interactions between human serum albumin and tumor-inhibiting amino alcohol platinum(II) complexes using capillary electrophoresis.

scientific article published on 11 January 2007

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies

scientific article published on 18 October 2012

Chemoresistance in rat ovarian tumours

scientific article published on January 1991

Chromatin-modifying enzymes as therapeutic targets--Part 1

scientific article published on 01 October 2008

Chromatin-modifying enzymes as therapeutic targets--Part 2

scientific article published on 01 November 2008

Cisplatin damage: are DNA repair proteins saviors or traitors to the cell?

scientific article

Cisplatin-linked phosphonates in the treatment of the transplantable osteosarcoma in vitro and in vivo

scientific article published on September 1990

Combination of cadmium and high cholesterol levels as a risk factor for heart fibrosis.

scientific article

Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats

scientific article published on 01 January 1987

Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis

scientific article published in June 2005

Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application.

scientific article

Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands.

scientific article

Comparative solution equilibrium studies on pentamethylcyclopentadienyl rhodium complexes of 2,2'-bipyridine and ethylenediamine and their interaction with human serum albumin.

scientific article published on 2 September 2015

Compared effects of ruthenium red and cis [Ru(NH3)4Cl2]Cl on the isolated ischaemic-reperfused rat heart

scientific article published in January 1995

Comparison of the Antiproliferative Activity of Two Antitumour Ruthenium(III) Complexes With Their Apotransferrin and Transferrin-Bound Forms in a Human Colon Cancer Cell Line.

scientific article

Comparison of the binding behavior of oxaliplatin, cisplatin and analogues to 5'-GMP in the presence of sulfur-containing molecules by means of capillary electrophoresis and electrospray mass spectrometry

scientific article

Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium-Synthesis, structure and bioactivity of the vanadium complex

scientific article published on 11 April 2015

Computational Electrochemistry of Ruthenium Anticancer Agents. Unprecedented Benchmarking of Implicit Solvation Methods

scientific article published on 01 March 2008

Conjugation of organoruthenium(II) 3-(1H-benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance cytotoxicity in cancer cells

scientific article published on 23 November 2011

Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics.

scientific article

Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics.

scientific article published on 2 December 2015

DNA Interactions of pH-Sensitive, Antitumor Bis(aminoalcohol)dichloroplatinum(II) Complexes†,‡

scientific article published on 01 December 2006

DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media

scientific article published on 28 October 2008

DNA or protein? Capillary zone electrophoresis-mass spectrometry rapidly elucidates metallodrug binding selectivity

scientific article

Design, synthesis, physical and chemical characterisation, and biological interactions of lectin-targeted latex nanoparticles bearing Gd-DTPA chelates: an exploration of magnetic resonance molecular imaging (MRMI).

scientific article published in March 2005

Determination of binding constants and stoichiometries for platinum anticancer drugs and serum transport proteins by capillary electrophoresis using the Hummel-Dreyer method.

scientific article

Determination of cisplatin and its hydrolytic metabolite in human serum by capillary electrophoresis techniques

scientific article published on 3 October 2005

Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells

scientific article

Diamminetetrakis(carboxylato)platinum(IV) complexes--synthesis, characterization, and cytotoxicity

scientific article published on September 2012

Differences in protein binding and excretion of Triapine and its Fe(III) complex

scientific article published on 19 October 2015

Early results from a phase I study on orally administered tris(8-quinolinolato)gallium(III) (FFC11, KP46) in patients with solid tumors--a CESAR study (Central European Society for Anticancer Drug Research--EWIV).

scientific article published in December 2005

Effect of cis-, trans-diamminedichloroplatinum(II) and DBP on human serum albumin

scientific article published on 01 November 1999

Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones.

scientific article published on 31 July 2007

Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues.

scientific article

Efficacy of beta-diketonato complexes of titanium, zirconium, and hafnium against chemically induced autochthonous colonic tumors in rats

scientific article published on 01 January 1987

Efficacy of new ruthenium complexes against chemically induced autochthonous colorectal carcinoma in rats

scientific article published on 01 May 1989

Efficiently Detecting Metallodrug-Protein Adducts: Ion Trap versus Time-of-Flight Mass Analyzers

scientific article published on 18 March 2014

Electron microscopic visualization of telomerase from Euplotes aediculatus bound to a model telomere DNA.

scientific article published on August 2006

Electronic State of Sodium trans-[Tetrachloridobis(1H-indazole)ruthenate(III)] (NKP-1339) in Tumor, Liver and Kidney Tissue of a SW480-bearing Mouse.

scientific article published on 23 January 2017

Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry. Short communication

scientific article published in August 2008

Emerging roles of the 26S proteasome in nuclear hormone receptor-regulated transcription.

scientific article

En route to osmium analogues of KP1019: synthesis, structure, spectroscopic properties and antiproliferative activity of trans-[Os(IV)Cl4(Hazole)2]

scientific article published on 8 July 2011

Enhancing lipophilicity as a strategy to overcome resistance against platinum complexes?

scientific article published on 19 February 2011

Extraction of natural radionuclides from aqueous solutions by novel maltolate-based task-specific ionic liquids

scientific article published on 27 November 2014

Extravasation of Pt-based chemotherapeutics - bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS).

scientific article published on March 2015

First example of the solid-state thermal cyclometalation of ligated benzophenone imine giving novel luminescent platinum(II) species.

scientific article

Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex

scientific article

Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites

scientific article published on 08 November 2011

From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A).

scientific article

From hydrolytically labile to hydrolytically stable Ru(II)-arene anticancer complexes with carbohydrate-derived co-ligands.

scientific article published on 14 October 2010

Front Cover: Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity (Chem. Biodiversity 10/2022)

scientific article published in 2022

G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes.

scientific article

Gallium and other main group metal compounds as antitumor agents.

scientific article published on January 2004

Gallium compound GaQ(3) -induced Ca(2+) signalling triggers p53-dependent and -independent apoptosis in cancer cells

scientific article

Gallium in cancer treatment

scientific article published on 01 January 2004

Gallium in cancer treatment.

scientific article

Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase.

scientific article published on 22 February 2007

Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of action

scientific article published on 28 November 2007

Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions.

scientific article published on 22 December 2013

HPIC-UV-ICP-SFMS study of the interaction of cisplatin with guanosine monophosphate

scientific article

Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells

scientific article

Heavy metals in the mallard Anas platyrhynchos from eastern Austria.

scientific article published on 10 December 2016

Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells.

scientific article published on 16 October 2004

High resolution mass spectrometry for studying the interactions of cisplatin with oligonucleotides

scientific article

Highly cytotoxic copper(II) complexes with modified paullone ligands

scientific article

Hydrolysis and cytotoxic properties of osmium(II)/(III)-DMSO-azole complexes. Short communication

scientific article published in August 2008

Hydrolysis of the tumor-inhibiting ruthenium(III) complexes HIm trans-[RuCl4(im)2] and HInd trans-[RuCl4(ind)2] investigated by means of HPCE and HPLC-MS.

scientific article published in March 2001

Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)]

scientific article published on 21 May 2008

IRX14 and IRX14-LIKE, two glycosyl transferases involved in glucuronoxylan biosynthesis and drought tolerance in Arabidopsis

scientific article published on 30 June 2010

Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate

scientific article published on 27 May 2013

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention

scientific article published on 23 June 2016

Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.

scientific article published in August 2009

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

scientific article published on 15 March 2012

Improved reaction conditions for the synthesis of new NKP-1339 derivatives and preliminary investigations on their anticancer potential

scientific article

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

scientific article

Inductively coupled plasma mass spectrometry for metallodrug development: albumin binding and serum distribution of cytotoxic cis- and trans-isomeric platinum(II) complexes

scientific article published on 22 April 2014

Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019.

scientific article published on 26 June 2011

Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes

scientific article published on 26 January 2013

Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines.

scientific article published on July 2015

Influence of the Arene Ligand and the Leaving Group on the Anticancer Activity of (Thio)maltol Ruthenium(II)–(η6-Arene) Complexes

Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin.

scientific article

Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes

scientific article

Inhibition of Escherichia coli DNA polymerase I catalysed DNA polymerization by trans-imidazolium-bisimidazoletetrachlororuthenate(III)

scientific article published on 01 October 1991

Inhibition of telomerase activity by preventing proper assemblage.

scientific article published on January 2004

Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion.

scientific article published on 17 September 2009

Inhibitory effects of gallium chloride and tris (8-quinolinolato) gallium III on A549 human malignant cell line

scientific article

Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study.

scientific article

Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins

scientific article published on 15 November 2014

Interactions of a novel ruthenium-based anticancer drug (KP1019 or FFC14a) with serum proteins--significance for the patient

scientific article published on 01 December 2005

Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology.

scientific article published on June 2006

Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies

scientific article published on 21 June 2011

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339.

scientific article published on 11 March 2010

Intrinsic and Acquired Forms of Resistance against the Anticancer Ruthenium Compound KP1019 [Indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A)

scientific article published on 26 August 2004

Introducing N-, P-, and S-donor leaving groups: an investigation of the chemical and biological properties of ruthenium, rhodium and iridium thiopyridone piano stool complexes

scientific article published on 02 November 2020

Introducing the 4-Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates

scientific article published on 20 December 2016

Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects

scientific article published on 6 August 2009

Investigations into the interaction between tumor-inhibiting ruthenium(III) complexes and nucleotides by capillary electrophoresis.

scientific article

Ionic liquids for extraction of metals and metal containing compounds from communal and industrial waste water.

scientific article published on 21 June 2011

Is the reactivity of M(II)-arene complexes of 3-hydroxy-2(1H)-pyridones to biomolecules the anticancer activity determining parameter?

scientific article published on September 2010

Isomeric [RuCl2(dmso)2(indazole)2] complexes: ruthenium(II)-mediated coupling reaction of acetonitrile with 1H-indazole

scientific article published on 15 June 2005

KP1019 (FFC14A) from bench to bedside: preclinical and early clinical development--an overview.

scientific article published on December 2005

KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients

scientific article published on October 2008

Kinetics of binding properties of 5'-GMP with cisplatin under simulated physiological conditions by capillary electrophoresis

scientific article published on 01 August 2000

L- and D-proline thiosemicarbazone conjugates: coordination behavior in solution and the effect of copper(II) coordination on their antiproliferative activity.

scientific article published on 13 August 2012

LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs.

scientific article published on 25 January 2016

LC– and CZE–ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(iii)] (KP1339) in mouse plasma

scientific article published on 21 September 2011

Lectin conjugates as biospecific contrast agents for MRI. Coupling of Lycopersicon esculentum agglutinin to linear water-soluble DTPA-loaded oligomers.

scientific article

Lectin-Gd-loaded chitosan hydrogel nanoparticles: a new biospecific contrast agent for MRI

scientific article published on 01 February 2011

Loss of CUL4A expression is underlying cisplatin hypersensitivity in colorectal carcinoma cells with acquired trabectedin resistance

scientific article published on 17 January 2017

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

scientific article published on 02 September 2016

Macromolecular Pt(IV) Prodrugs from Poly(organo)phosphazenes.

scientific article

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

scientific article published on 14 October 2011

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.

scientific article published on March 2013

Maltol-derived ruthenium-cymene complexes with tumor inhibiting properties: the impact of ligand-metal bond stability on anticancer activity in vitro

scientific article published on November 2009

Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects.

scientific article published on 11 February 2016

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

scientific article

Metabolite sensitivity in the methaqualone radioimmunoassay.

scientific article

Metal Ions and Metal Complexes in Alzheimer's Disease.

scientific article published on 20 May 2016

Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents.

scientific article published on 20 December 2016

Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation

scientific article published on 17 January 2013

Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy

scientific article published on 13 November 2007

Microfluidic preparation of [18F]FE@SUPPY and [18F]FE@SUPPY:2 — comparison with conventional radiosyntheses

scientific article published on 03 December 2010

Modulation of activity of known cytotoxic ruthenium(III) compound (KP418) with hampered transmembrane transport in electrochemotherapy in vitro and in vivo

scientific article

Molecular mode of action of NKP-1339 - a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines

scientific article published on 18 March 2016

Mono-carboxylated diaminedichloridoplatinum(IV) complexes--selective synthesis, characterization, and cytotoxicity

scientific article published on 11 July 2011

Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney

scientific article published on 03 February 2016

Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).

scientific article

NCA nucleophilic radiofluorination on substituted benzaldehydes for the preparation of [18F]fluorinated aromatic amino acids

scientific article published on 23 November 2005

NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer.

scientific article published on 17 September 2012

Nanoformulation improves activity of the (pre)clinical anticancer ruthenium complex KP1019.

scientific article published on May 2014

Nanoscalic silver possesses broad-spectrum antimicrobial activities and exhibits fewer toxicological side effects than silver sulfadiazine

scholarly article by Oliver Brandt et al published May 2012 in Nanomedicine: Nanotechnology, Biology and Medicine

Natural organic matter and iron export from the Tanner Moor, Austria

scientific article (publication date: June 2013)

New method for the speciation of ruthenium-based chemotherapeutics in human serum by conjoint liquid chromatography on affinity and anion-exchange monolithic disks

scientific article published on 24 October 2014

New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro

scientific article published on 27 March 2010

New tumor-inhibiting metal complexes

scientific article published on September 1990

New tumor-inhibiting metal complexes. Chemistry and antitumor properties

scientific article published on January 1994

Novel bis(carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV) complexes with exceptionally high cytotoxicity

scientific article published on 23 July 2008

Novel cis- and trans-configured bis(oxime)platinum(II) complexes: synthesis, characterization, and cytotoxic activity

scientific article

Novel di- and tetracarboxylatoplatinum(IV) complexes. Synthesis, characterization, cytotoxic activity, and DNA platination.

scientific article published on 22 November 2007

Novel endothall-containing platinum(IV) complexes: synthesis, characterization, and cytotoxic activity

scientific article

Novel oximato-bridged platinum(II) di- and trimer(s): synthetic, structural, and in vitro anticancer activity studies

scientific article

Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy.

scientific article published on 26 October 2015

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour

scientific article published on 01 February 2020

Novel tetracarboxylatoplatinum(IV) complexes as carboplatin prodrugs.

scientific article

Novel thiosalicylate-based ionic liquids for heavy metal extractions.

scientific article published on 19 April 2016

Organometallic 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines as potential anticancer agents

scientific article

Organometallic Ruthenium and Osmium Compounds of Pyridin-2- and -4-ones as Potential Anticancer Agents

scientific article published on 01 September 2012

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

scientific article published on April 2013

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy

scientific article

Osmium NAMI-A analogues: synthesis, structural and spectroscopic characterization, and antiproliferative properties.

scientific article published on 12 May 2007

Osmium(II)--versus ruthenium(II)--arene carbohydrate-based anticancer compounds: similarities and differences.

scientific article published on 2 July 2010

Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity

scientific article

PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses.

scientific article published on 7 May 2015

Paradoxical effect of dichlorobis(1-phenylbutane-1,3-dionato)molybdenum (IV), (Mo(bzac)2Cl2 on the growth of autochthonous chemically induced colorectal tumors in SD rats

scientific article published on 01 March 1987

Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study

scientific article

Pharmacological properties of cerium compounds.

scientific article

Phosphite-Derivatized Ruthenium-Carbohydrate Complexes in the Catalytic Hydration of Nitriles. Short Communication

scientific article published on 01 August 2008

Photoreduction of Terrigenous Fe-Humic Substances Leads to Bioavailable Iron in Oceans

scientific article

Photoreduction of Terrigenous Fe-Humic Substances Leads to Bioavailable Iron in Oceans.

scientific article published on 21 April 2016

Physicochemical Studies and Anticancer Potency of Ruthenium η-p-Cymene Complexes Containing Antibacterial Quinolones

scientific article published on 6 April 2011

Platinum group metallodrug-protein binding studies by capillary electrophoresis - inductively coupled plasma-mass spectrometry: a further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins

scientific article published in March 2006

Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: characterization of interactions between Pt(II) complexes and human serum albumin.

scientific article published in July 2004

Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation

scientific article published on 29 October 2013

Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue

scientific article published on 01 June 2017

Preclinical activity of trans-indazolium[tetrachlorobisindazoleruthenate(III)] (NSC 666158; IndCR; KP 1019) against tumour colony-forming units and haematopoietic progenitor cells

scientific article published on 01 December 1997

Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins

scientific article published on 25 July 2006

Preclinical evaluation of dichlorobis(1-phenylbutane-1,3-dionato)titanium (IV) and budotitane. Two representatives of the new class of antitumor-active bis-beta-diketonato metal complexes

scientific article published on 01 December 1986

Preclinical evaluation of diethoxy-(1-phenyl-1,3-butanedionato) titanium (IV) in human tumour xenografts

scientific article published on 01 January 1984

Preclinical toxicology and tissue gallium distribution of a novel antitumour gallium compound: tris (8-quinolinolato) gallium (III).

scientific article published in March 1996

Preparation and characterization of immobilized [A336][MTBA] in PVA-alginate gel beads as novel solid-phase extractants for an efficient recovery of Hg (II) from aqueous solutions.

scientific article

Preparation and first evaluation of [(18)F]FE@SUPPY: a new PET tracer for the adenosine A(3) receptor.

scientific article published in January 2008

Probing the stability of serum protein–ruthenium(III) drug adducts in the presence of extracellular reductants using CE

scientific article published on 01 July 2007

Protein-binding Properties of two Antitumour Ru(III) Complexes to Human Apotransferrin and Apolactoferrin

scientific article published in January 1994

Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice.

scientific article

Rational development of oxaliplatin analogues --synthesis and preliminary structure-activity relationships

scientific article published on December 2005

Reaction monitoring of platinum(II) complex--5'-guanosine monophosphate adduct formation by ion exchange liquid chromatography/electrospray ionization mass spectrometry

scientific article published in July 2001

Recent developments in the field of tumor-inhibiting metal complexes.

scientific article

Redox behavior of tumor-inhibiting ruthenium(iii) complexes and effects of physiological reductants on their binding to GMP

scientific article published on 11 January 2006

Redox-active antineoplastic ruthenium complexes with indazole: correlation of in vitro potency and reduction potential

scientific article

Relevance of peat-draining rivers for the riverine input of dissolved iron into the ocean.

scientific article published on 5 March 2010

Resistance against novel anticancer metal compounds: differences and similarities

scientific article published on February 2008

Response Profiling Using Shotgun Proteomics Enables Global Metallodrug Mechanisms of Action To Be Established.

scientific article published on 7 November 2016

Reversion of Structure-Activity Relationships of Antitumor Platinum Complexes by Acetoxime but Not Hydroxylamine Ligands

scientific article published on 18 October 2006

Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling

scientific article published on 23 November 2015

Ribonucleotide reductase as one important target of [Tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772).

scientific article

River-derived humic substances as iron chelators in seawater

scientific article published in August 2015

Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry

scientific article published on 07 March 2010

Ruthenium(II)-arene complexes with functionalized pyridines: synthesis, characterization and cytotoxic activity.

scientific article

Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs.

scientific article

RutheniumII(η6-arene) complexes of thiourea derivatives: synthesis, characterization and urease inhibition

scientific article published on 16 June 2014

Searching for the magic bullet: anticancer platinum drugs which can be accumulated or activated in the tumor tissue

scientific article published on January 2007

Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

scientific article

Sensitivity of rodent osteosarcoma clones to platinum-containing phosphonic acid complexes in vitro.

scientific article published in January 1990

Solid-phase synthesis of oxaliplatin-TAT peptide bioconjugates.

scientific article published on 27 January 2012

Solution equilibria and antitumor activities of pentamethylcyclopentadienyl rhodium complexes of picolinic acid and deferiprone

scholarly article by Éva A. Enyedy et al published April 2015 in Journal of Coordination Chemistry

Solution equilibria of anticancer ruthenium(II)-(η(6)-p-cymene)-hydroxy(thio)pyr(id)one complexes: impact of sulfur vs. oxygen donor systems on the speciation and bioactivity

scientific article

Solvolysis of the Tumor-Inhibiting Ru(III)-Complex trans-Tetrachlorobis(Indazole)Ruthenate(III).

scientific article

Speciation of metal-based nanomaterials in human serum characterized by capillary electrophoresis coupled to ICP-MS: a case study of gold nanoparticles.

scientific article

Sphagnum-dominated bog systems are highly effective yet variable sources of bio-available iron to marine waters

scientific article published on 10 March 2016

Strategies for the covalent conjugation of a bifunctional chelating agent to albumin: synthesis and characterization of potential MRI contrast agents

scientific article published on 05 November 2010

Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and anti

scientific article published on 3 April 2007

Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development

scientific article published on 24 November 2017

Structure-activity relationships of highly cytotoxic copper(II) complexes with modified indolo[3,2-c]quinoline ligands.

scientific article published on 27 October 2010

Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands

scientific article

Studies of KP46 and KP1019 and the Hydrolysis Product of KP1019 in Lipiodol Emulsions: Preparation and Initial Characterizations as Potential Theragnostic Agents

scientific article published on 20 December 2016

Studies on the interactions between human serum albumin and imidazolium [trans-tetrachlorobis(imidazol)ruthenate(III)].

scientific article

Studies on the interactions between human serum albumin and trans-indazolium (bisindazole) tetrachlororuthenate(III).

scientific article

Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds

scientific article

Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle

scientific article published on 08 May 2019

Synergistic antitumor interactions between newly synthesized ruthenium complexes and cytokines in human colon carcinoma cell lines

scientific article published in April 1992

Synthesis and Characterization of New Ethylenediamine Platinum(IV) Complexes Containing Lipophilic Carboxylate Ligands

scientific article published in January 1995

Synthesis and antitumor activity of triazolium-bis(triazole)-tetrachlororuthenate (III) and bistriazolium-triazolepentachlororuthenate (III). Two representatives of a new class of inorganic antitumor agents

scientific article published on 01 July 1987

Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes

scientific article

Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin

scientific article

Synthesis and in vitro antitumor potency of (cyclohexane-1,2-diamine)platinum(II) complexes with aminotris(methylenephosphonic acid) as bone-seeking ligand

scientific article

Synthesis and reactivity of the aquation product of the antitumor complex trans-[Ru(III)Cl4(indazole)2]-.

scientific article published on 14 June 2008

Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives

scientific article published on 22 July 2005

Synthesis and structures of novel 1-methylcytosinato-bridged (ethylenediamine)platinum(II) and platinum(III) dinuclear complexes

scientific article published on 4 March 2010

Synthesis of (N,N'-Bis(2-Hydroxyethyl)Ethane-1,2-Diamine)Malonatoplatinum(II) and X-Ray Crystal Structure of the Cis-R,S-Isomer

scientific article published on January 2000

Synthesis of ferrocenylglucose phosphonite and bisphosphinite: Pd(II) and Pt(II) complexes, Pd-catalyzed allylic alkylation

Synthesis, Characterization and Molecular Structures of some Bismuth(III) Complexes with Thiosemicarbazones and Dithiocarbazonic Acid Methylester Derivatives with Activity against Helicobacter Pylori

scientific article published in January 1995

Synthesis, Characterization and Solution Chemistry of trans-Indazoliumtetrachlorobis(Indazole)Ruthenate(III), a New Anticancer Ruthenium Complex. IR, UV, NMR, HPLC Investigations and Antitumor Activity. Crystal Structures of trans-1-Methyl-Indazoliu

scientific article

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes and Their Unexpected (Biological) Behavior

scientific article published on 20 January 2020

Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin.

scientific article published on 12 March 2009

Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2,4-triazole)Ru(III) complexes.

scientific article published on September 2003

Synthesis, characterization, and cytotoxic activity of novel potentially pH-sensitive nonclassical platinum(II) complexes featuring 1,3-dihydroxyacetone oxime ligands.

scientific article published on 27 September 2011

Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand

scientific article published on November 2003

Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible.

scientific article published on August 2004

Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine (4)N-dimethylthiosemicarbazone.

scientific article

Synthesis, structure, spectroscopic properties, and antiproliferative activity in vitro of novel osmium(III) complexes with azole heterocycles.

scientific article

Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates

scientific article published on 31 August 2010

Synthesis, structures and in vitro cytotoxicity of some platinum(II) complexes containing thiocarbamate esters

scientific article

Synthetic iron complexes as models for natural iron-humic compounds: Synthesis, characterization and algal growth experiments

scientific article published on 31 October 2016

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

scientific article published on 9 February 2015

Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs.

scientific article published on 5 October 2016

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder.

scientific article published on 12 April 2012

Task-specific thioglycolate ionic liquids for heavy metal extraction: Synthesis, extraction efficacies and recycling properties.

scientific article

Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy

scientific article published on 28 August 2015

The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo-A Comparison of O,O-, S,O-, and N,N-Chelate Effects

scientific article published on 19 November 2019

The biochemical role of the heat shock protein 90 chaperone complex in establishing human telomerase activity.

scientific article published on 19 May 2006

The effect of cytoprotective agents in platinum anticancer therapy.

scientific article published on January 2004

The effect of formaldehyde solution in the gas chromatographic determination of morphine

scientific article published on 01 September 1980

The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes

scientific article published on April 2010

The first metal-based paullone derivative with high antiproliferative activity in vitro.

scientific article published in March 2006

The first ruthenium-based paullones: syntheses, X-ray diffraction structures, and spectroscopic and antiproliferative properties in vitro

scientific article published on 3 April 2007

The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines

scientific article

The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells.

scientific article

The hydration of chloroacetonitriles catalyzed by mono- and dinuclear Ru(II)- and Os(II)-arene complexes.

scientific article published in October 2008

The influence of electroporation on cytotoxicity of anticancer ruthenium(III) complex KP1339 in vitro and in vivo.

scientific article published in June 2010

The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs.

scientific article published on 17 March 2016

The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo

scientific article published on 18 June 2013

Theoretical investigations and density functional theory based quantitative structure-activity relationships model for novel cytotoxic platinum(IV) complexes

scientific article published on 27 December 2012

Therapeutic efficacy of two different cytostatic-linked phosphonates in combination with razoxane in the transplantable osteosarcoma of the rat

scientific article published on 01 July 1990

Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior.

scientific article published on 19 October 2016

Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs.

scientific article

Time-dependent interactions of platinum(II) complexes with 5'-GMP under simulated physiological conditions studies by capillary electrophoresis.

scientific article

Total mercury in sediments, macrophytes, and fish from a shallow steppe lake in eastern Austria

scientific article

Toward high-throughput monitoring of metallodrug-protein interaction using capillary electrophoresis in chemically modified capillaries

scientific article published on 01 May 2008

Towards targeting anticancer drugs: ruthenium(ii)-arene complexes with biologically active naphthoquinone-derived ligand systems.

scientific article

Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity

scientific article

Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells.

scientific article published on 30 December 2013

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.

scientific article

Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents.

scientific article published on 9 April 2015

Tumor-inhibiting platinum(II) complexes with aminoalcohol ligands: comparison of the mode of action by capillary electrophoresis and electrospray ionization-mass spectrometry

scientific article

Tumorhemmende Metallverbindungen: Entwicklung, Bedeutung und Perspektiven

scientific article published on 01 January 2006

Tumour-inhibiting platinum complexes--state of the art and future perspectives.

scientific article

Tumour-inhibiting platinum(II) complexes with aminoalcohol ligands: biologically important transformations studied by micellar electrokinetic chromatography, nuclear magnetic resonance spectroscopy and mass spectrometry

scientific article published on 23 August 2005

Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes

scientific article published on October 2010

Tuning of redox potentials for the design of ruthenium anticancer drugs -- an electrochemical study of [trans-RuCl(4)L(DMSO)](-) and [trans-RuCl(4)L(2)](-) complexes, where L = imidazole, 1,2,4-triazole, indazole.

scientific article

Tuning of redox properties for the design of ruthenium anticancer drugs: part 2. Syntheses, crystal structures, and electrochemistry of potentially antitumor [Ru III/II Cl6-n(Azole)n]z(n = 3, 4, 6) complexes.

scientific article

Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy

scientific article published on 26 September 2007

Two new "onium" fluorosilicates, the products of interaction of fluorosilicic acid with 12-membered macrocycles: structures and spectroscopic properties

scientific article

Unprecedented twofold intramolecular hydroamination in diam(m)ine-dicarboxylatodichloridoplatinum(IV) complexes - ethane-1,2-diamine vs. ammine ligands.

scientific article

Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity

scientific article published on 17 December 2012

Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches

scientific article

Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity

scientific article

Water-soluble cationic derivatives of indirubin, the active anticancer component from Indigo naturalis

scientific article

X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism.

scientific article

X-ray absorption near edge structure spectroscopy to resolve the in vivo chemistry of the redox-active indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019).

scientific article published on 31 January 2013

X-ray absorption spectroscopy of an investigational anticancer gallium(III) drug: interaction with serum proteins, elemental distribution pattern, and coordination of the compound in tissue

scientific article published on 5 June 2012

[Os(IV)Cl(5)(Hazole)](-) complexes: synthesis, structure, spectroscopic properties, and antiproliferative activity

scientific article

ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide

scientific article

p53 increases intra-cellular calcium release by transcriptional regulation of calcium channel TRPC6 in GaQ3-treated cancer cells

scientific article (publication date: 2013)

{(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): a novel enantiomerically pure oxaliplatin derivative showing improved anticancer activity in vivo

scientific article

α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation.

scientific article

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