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List of works by Helmut Butzkueven

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data.

scientific article

A case of serotonin syndrome induced by moclobemide during an extreme heatwave ⬇️

scientific article published on 01 October 1997

A double-blind, randomized, controlled study of botulinum toxin type A in MS-related tremor.

scientific article published in July 2012

A genetic basis for multiple sclerosis severity: Red herring or real?

scientific article published on 18 August 2016

A new era in the treatment of multiple sclerosis

scientific article (publication date: 3 August 2015)

A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis

scientific article (publication date: 26 October 2010)

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis

scientific article published in October 2011

A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis.

scientific article published on 17 July 2015

A role for galanin in human and experimental inflammatory demyelination

scholarly article

A tract-based diffusion study of cerebral white matter in neuromyelitis optica reveals widespread pathological alterations

scientific article

Altered thalamic functional connectivity in multiple sclerosis

scientific article published on 19 January 2015

Altered topological organization of white matter structural networks in patients with neuromyelitis optica

scientific article

Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels.

scientific article

Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients

scientific article published on 26 January 2007

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

scientific article published on 29 September 2013

Anti-aquaporin-4 antibody positivity in neuromyelitis optica is associated with lesion activity

scientific article published on 13 July 2013

Anti-inflammatory disease-modifying treatment and short-term disability progression in SPMS.

scientific article published on 9 August 2017

Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy

scientific article published in September 2009

Aspergillus arachnoiditis post intrathecal baclofen pump insertion.

scientific article published on 17 May 2013

Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation

scientific article

BREMSO: a simple score to predict early the natural course of multiple sclerosis.

scientific article published on 25 March 2015

Baseline brain activity changes in patients with clinically isolated syndrome revealed by resting-state functional MRI.

scientific article published on 21 September 2012

Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve

scientific article

Brain health: time matters in multiple sclerosis

scientific article

Brain plasticity in relapsing-remitting multiple sclerosis: evidence from resting-state fMRI.

scientific article published on 23 February 2011

Ceruloplasmin gene-deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution

scientific article

Cladribine followed by autologous stem-cell transplantation in progressive multiple sclerosis

scientific article published in January 2004

Cladribine versus fingolimod, natalizumab and interferon β for multiple sclerosis.

scientific article

Clinical isolated syndrome: a 3-year follow-up study in China

scientific article published on 16 June 2011

Combined peripheral nerve and central nervous system demyelination in a patient with chronic inflammatory demyelinating polyneuropathy

scientific article

Commentary on "Possible induction of acute disseminated encephalomyelitis (ADEM)-like demyelinating illness by intrathecal mesenchymal stem cell injection".

scientific article

Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status.

scientific article

Common variation in the MOG gene influences transcript splicing in humans.

scientific article published on 30 August 2010

Comparative effectiveness of glatiramer acetate and interferon beta formulations in relapsing-remitting multiple sclerosis

scientific article published on 5 December 2014

Comparative efficacy of first-line natalizumab vs IFN-β or glatiramer acetate in relapsing MS.

scientific article published on April 2016

Comparative efficacy of switching to natalizumab in active multiple sclerosis

scientific article

Comparison of switch to fingolimod or interferon beta/glatiramer acetate in active multiple sclerosis

scientific article published on April 2015

Continuing fingolimod after development of macular edema: A case report.

scientific article

Contribution of different relapse phenotypes to disability in multiple sclerosis.

scientific article published on 7 April 2016

Cortical thinning correlates with cognitive change in multiple sclerosis but not in neuromyelitis optica

scientific article

Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome

scientific article

Data quality evaluation for observational multiple sclerosis registries

scientific article

Defining reliable disability outcomes in multiple sclerosis

scientific article published on 10 September 2015

Defining secondary progressive multiple sclerosis

scientific article published on 7 July 2016

Different patterns of longitudinal brain and spinal cord changes and their associations with disability progression in NMO and MS.

scientific article published on 30 June 2017

Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis.

scientific article published on 21 February 2012

Diffusion tensor imaging of acute inflammatory lesion evolution in multiple sclerosis.

scientific article published on 16 October 2012

Diffusion tensor imaging of the optic radiations after optic neuritis

scientific article published on 13 September 2011

Discontinuing disease-modifying therapy in MS after a prolonged relapse-free period: a propensity score-matched study

scientific article published on 13 June 2016

Dopamine agonist-induced pathological gambling in restless legs syndrome due to multiple sclerosis

scientific article published on 01 March 2007

Dysequilibrium of the PTH-FGF23-vitamin D axis in relapsing remitting multiple sclerosis; a longitudinal study.

scientific article

Efficacy and safety of natalizumab in multiple sclerosis: interim observational programme results.

scientific article

Endogenous leukemia inhibitory factor production limits autoimmune demyelination and oligodendrocyte loss

article

Endogenously regulated Dab2 worsens inflammatory injury in experimental autoimmune encephalomyelitis

scientific article published on 09 July 2013

EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE)

scientific article

Epoch Analysis of On-Treatment Disability Progression Events over Time in the Tysabri Observational Program (TOP)

scientific article published on 15 January 2016

Extended haplotype analysis in the HLA complex reveals an increased frequency of the HFE-C282Y mutation in individuals with multiple sclerosis

scientific article published on 11 March 2004

Familial recurrence risks for multiple sclerosis in Australia

scientific article published on 7 May 2011

Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus.

scientific article

Fingolimod after natalizumab and the risk of short-term relapse

scientific article published on 07 March 2014

Fluctuations of MS births and UV-light exposure.

scientific article

Gait and balance deterioration over a 12-month period in multiple sclerosis patients with EDSS scores ≤ 3.0.

scientific article published on 6 February 2017

Gait and balance impairment in early multiple sclerosis in the absence of clinical disability

scientific article published on 01 October 2006

Galanin in Glia: Expression and Potential Roles in the CNS ⬇️

scientific article published on January 1, 2010

Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor

scientific article published on 29 January 2015

Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.

scientific article published on May 2008

Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis

scientific article

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

scientific article

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

scientific article

Genotype and Phenotype in Multiple Sclerosis-Potential for Disease Course Prediction?

scientific article published on 24 April 2018

Geographical variations in sex ratio trends over time in multiple sclerosis.

scientific article

Greater sensitivity to multiple sclerosis disability worsening and progression events using a roving versus a fixed reference value in a prospective cohort study

scientific article published on May 2017

HLA-DRB1 associations with disease susceptibility and clinical course in Australians with multiple sclerosis.

scientific article published on 21 April 2009

Health-related quality of life as an independent predictor of long-term disability for patients with relapsing-remitting multiple sclerosis

scientific article published on 24 January 2013

Heterogeneity at the HLA-DRB1 allelic variation locus does not influence multiple sclerosis disease severity, brain atrophy or cognition

scientific article published on 13 December 2010

Higher latitude is significantly associated with an earlier age of disease onset in multiple sclerosis.

scientific article published on 3 November 2016

Highly active immunomodulatory therapy ameliorates accumulation of disability in moderately advanced and advanced multiple sclerosis

scientific article published on 28 September 2016

How to diagnose multiple sclerosis and what are the pitfalls

scientific article published on 08 October 2009

Immunosuppressive therapy is valuable in aggressive multiple sclerosis

scientific article published on 01 November 2000

Incidence and prevalence of NMOSD in Australia and New Zealand.

scientific article published on 26 May 2017

Increasing age at disability milestones among MS patients in the MSBase Registry

scientific article published on 14 April 2012

Interleukin-2 receptor-α proximal promoter hypomethylation is associated with multiple sclerosis

scientific article

Is my MS patient failing treatment?

scientific article published on 15 June 2016

LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival

scientific article published on 01 June 2002

LIF receptor signaling modulates neural stem cell renewal

scientific article published in November 2004

Leukemia inhibitory factor protects axons in experimental autoimmune encephalomyelitis via an oligodendrocyte-independent mechanism

scientific article

Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair

scientific article published on 01 April 2008

Long-term disability trajectories in primary progressive MS patients: A latent class growth analysis

scientific article published on April 2017

Lymphocyte count in peripheral blood is not associated with the level of clinical response to treatment with fingolimod

scientific article published on 22 November 2017

MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve

scientific article published on 13 July 2007

MSBase: an international, online registry and platform for collaborative outcomes research in multiple sclerosis

scientific article published on December 2006

Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

scientific article published on 5 June 2015

Microstructural abnormalities in the trigeminal nerves of patients with trigeminal neuralgia revealed by multiple diffusion metrics

scientific article published on 21 December 2012

Monoclonal antibodies in the treatment of multiple sclerosis: emergence of B-cell-targeted therapies

scientific article published on 20 March 2017

Multimodal characterization of gray matter alterations in neuromyelitis optica

scientific article

Multiple sclerosis in Latin America: A different disease course severity? A collaborative study from the MSBase Registry

scientific article

Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells

scientific article published on 09 June 2020

Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients

scientific article

Multiple sclerosis: a haplotype association study

scientific article published in January 2005

Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting

scientific article published on 02 May 2018

Neurodegeneration in MS and NMO: The Eye and the Blood.

scientific article

Neurofilament Proteins as Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis ⬇️

scientific article published on January 23, 2011

Neuroglial responses to CNS injury: prospects for novel therapeutics

scientific article

Neuroprotection in multiple sclerosis: a therapeutic challenge for the next decade

scientific article published on February 2010

Neurotrophin receptor expression and responsiveness by postnatal cerebral oligodendroglia

scientific article published in December 2001

Nitrous oxide myelopathy in an abuser of whipped cream bulbs

scientific article published in January 2000

Novel Functional MRI Task for Studying the Neural Correlates of Upper Limb Tremor

scientific article published on 02 July 2018

Observational data: Understanding the real MS world

scientific article

Oligodendrocytes exhibit selective expression of suppressor of cytokine signaling genes and signal transducer and activator of transcription 1 independent inhibition of interferon-gamma-induced toxicity in response to leukemia inhibitory factor

article

On the utility of data from the International HapMap Project for Australian association studies.

scientific article

Onset seizures independently predict poor outcome after subarachnoid hemorrhage

scientific article published on 01 November 2000

Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis

scientific article published on 07 January 2009

Optic nerve diffusion tensor imaging after acute optic neuritis predicts axonal and visual outcomes

scientific article

Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.

scientific article

PAST SUN EXPOSURE, SKIN PHENOTYPE AND RISK OF MULTIPLE SCLEROSIS

Parallel changes in structural and functional measures of optic nerve myelination after optic neuritis

scientific article published on 28 May 2015

Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study

scientific article

Persistence on therapy and propensity matched outcome comparison of two subcutaneous interferon beta 1a dosages for multiple sclerosis

scientific article

Predictors and dynamics of postpartum relapses in women with multiple sclerosis.

scientific article

Predictors of disability worsening in clinically isolated syndrome.

scientific article published on 27 March 2015

Predictors of long-term disability accrual in relapse-onset multiple sclerosis

scientific article published on 4 May 2016

Predictors of relapse and disability progression in MS patients who discontinue disease-modifying therapy

Prognostic indicators in pediatric clinically isolated syndrome

scientific article published on 25 April 2017

Prolonged interval between sentinel pseudotumoral demyelination and development of primary CNS lymphoma

scientific article

Prospects for stem cell transplantation in multiple sclerosis.

scientific article

Quantifying risk of early relapse in patients with first demyelinating events: Prediction in clinical practice.

scientific article published on 24 November 2016

Re: early relapses after the first dose of natalizumab in active multiple sclerosis

scientific article published in April 2009

Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians

scientific article published on 24 July 2008

Reply to: Comment on Y.D. Fragoso et al.: "Lymphocyte count in peripheral blood is not associated with the level of clinical response to treatment with fingolimod" [Mult. Scler. Relat. Disord. (2017)]

scientific article published on 24 February 2018

Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study

scientific article published on 29 July 2013

Risk of early relapse following the switch from injectables to oral agents for multiple sclerosis

scientific article published on 19 January 2016

Risk of relapse phenotype recurrence in multiple sclerosis.

scientific article

SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians

scientific article published on 30 October 2007

Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial

scientific article

Seasonal variation of relapse rate in multiple sclerosis is latitude dependent.

scientific article published on 20 October 2014

Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis.

scientific article published on 31 July 2016

Serial MRI in multiple sclerosis: a prospective pilot study of lesion load, whole brain volume and thalamic atrophy

scientific article published in February 2004

Serum phosphorylated neurofilament-heavy chain levels in multiple sclerosis patients

Sex as a determinant of relapse incidence and progressive course of multiple sclerosis

scientific article published on 18 October 2013

Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses

scientific article published on 21 June 2006

Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination

scholarly article

Switch to natalizumab versus fingolimod in active relapsing-remitting multiple sclerosis

scientific article published on 17 January 2015

Switching from natalizumab to fingolimod: A randomized, placebo-controlled study in RRMS

scientific article published on 29 May 2015

The Australian Multiple Sclerosis (MS) immunotherapy study: a prospective, multicentre study of drug utilisation using the MSBase platform

scientific article

The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results from the MSBase Registry

The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function

scientific article published on 11 June 2015

The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis

scientific article published on 21 July 2015

The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude

scientific article published on 20 December 2011

The importance of collecting structured clinical information on multiple sclerosis

scientific article

The occurrence of dystonia in upper-limb multiple sclerosis tremor

scientific article

The role of vitamin D and P2X7R in multiple sclerosis

scientific article published on 14 March 2019

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 1 historical and established therapies. MS Neurology Group of the Australian and New Zealand Association of Neurolo

scientific article published on 30 June 2014

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 2 new and emerging therapies and their efficacy. MS Neurology Group of the Australian and New Zealand Association o

scientific article

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 3 treatment practicalities and recommendations. MS Neurology Group of the Australian and New Zealand Association of

scientific article published on 30 June 2014

Timing of high-efficacy therapy in relapsing-remitting multiple sclerosis: A systematic review

scientific article

Towards personalized therapy for multiple sclerosis: prediction of individual treatment response.

scientific article published in September 2017

Treatment decisions in multiple sclerosis - insights from real-world observational studies.

scientific article published on 13 January 2017

Treatment effectiveness of alemtuzumab compared with natalizumab, fingolimod, and interferon beta in relapsing-remitting multiple sclerosis: a cohort study.

scientific article published on 10 February 2017

Treatment of experimental autoimmune encephalomyelitis with antisense oligonucleotides against the low affinity neurotrophin receptor

scientific article published in March 2000

Tremor in multiple sclerosis is associated with cerebello-thalamic pathology.

scientific article published on 2 November 2017

Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice

scientific article

Validation of a novel biomarker for acute axonal injury in experimental autoimmune encephalomyelitis.

scientific article

Validation of linear cerebral atrophy markers in multiple sclerosis

scientific article published on 01 February 2008

Vitamin D for the treatment of multiple sclerosis: a meta-analysis

scientific article published on 03 October 2018

Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia

scientific article published on 11 April 2007

What do effective treatments for multiple sclerosis tell us about the molecular mechanisms involved in pathogenesis?

scientific article

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