Search filters

List of works by Michael Platten

A Suppressive Oligodeoxynucleotide Enhances the Efficacy of Myelin Cocktail/IL-4-Tolerizing DNA Vaccination and Treats Autoimmune Disease

scientific article published on 01 November 2005

A novel splice site associated polymorphism in the tuberous sclerosis 2 (TSC2) gene may predispose to the development of sporadic gangliogliomas

scientific article published in July 1997

A phase II, randomized, study of weekly APG101+reirradiation versus reirradiation in progressive glioblastoma

scientific article published on 22 October 2014

A vaccine targeting mutant IDH1 induces antitumour immunity

scientific article published on 25 June 2014

ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

scientific article published on 27 November 2014

Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers

scientific article published on 16 April 2015

Actively personalized vaccination trial for newly diagnosed glioblastoma

scientific article published on 19 December 2018

Acute Corticonuclear Tract Ischemic Stroke with Isolated Central Facial Palsy

scientific article published on 13 November 2018

Adding Papillomacular Bundle Measurements to Standard Optical Coherence Tomography Does Not Increase Sensitivity to Detect Prior Optic Neuritis in Patients with Multiple Sclerosis

scientific article

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

scientific article published on 19 June 2015

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

scientific article

Angiotensin II sustains brain inflammation in mice via TGF-beta

scientific article

Arterial hypertension and bevacizumab treatment in glioblastoma: no correlation with clinical outcome

scientific article published on 29 August 2009

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

scientific article

Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial

scientific article

Author Correction: Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies.

scientific article

Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma

scientific article published on 10 December 2019

Automated quantitative tumour response assessment of MRI in neuro-oncology with artificial neural networks: a multicentre, retrospective study

scientific article published on 02 April 2019

Bevacizumab does not increase the risk of remote relapse in malignant glioma.

scientific article

Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity.

scientific article published on 19 August 2009

Brain Atrophy in Natalizumab-treated Patients with Multiple Sclerosis: A 5-year Retrospective Study

scientific article published on 28 November 2018

Brain tumour cells interconnect to a functional and resistant network

scientific article published on 4 November 2015

Cancer immunotherapy: exploiting neoepitopes

scientific article published on 2 June 2015

Challenging cytomegalovirus data in glioblastoma

scientific article published on 18 December 2013

Changes in Demographic and Diagnostic Spectra of Patients with Neurological Symptoms Presenting to an Emergency Department During the COVID-19 Pandemic: A Retrospective Cohort Study

scientific article published on 30 September 2020

Characterization of Contrast-Enhancing and Non-contrast-enhancing Multiple Sclerosis Lesions Using Susceptibility-Weighted Imaging

scientific article published on 18 October 2019

Chorea as a paraneoplastic complication of Hodgkin's disease

scientific article published on 01 January 1998

Circulating and Tumor Myeloid-derived Suppressor Cells in Resectable Non-small-cell Lung Cancer

scientific article published on 4 April 2018

Comparative evaluation of T-cell receptors in experimental glioma-draining lymph nodes

scientific article published on 01 January 2021

Comparing Expert and Non-Expert Assessment of Patients Presenting with Neurological Symptoms to the Emergency Department: A Retrospective Observational Study

scientific article published on 13 February 2020

Comprehensive allelotype and genetic anaysis of 466 human nervous system tumors

scientific article

Concepts in glioma immunotherapy

scientific article

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.

scientific article

Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis

scientific article published on 2 February 2016

Costimulatory protein 4IgB7H3 drives the malignant phenotype of glioblastoma by mediating immune escape and invasiveness

scientific article

Current status and future directions of anti-angiogenic therapy for gliomas

scientific article published on 12 October 2015

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

scientific article published on 14 March 2017

Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology

scientific article published on 25 October 2019

Diffusion-weighted MRI in transient global amnesia and its diagnostic implications

scientific article published on 12 June 2020

Diffusion-weighted imaging of the dentate nucleus after repeated application of gadolinium-based contrast agents in multiple sclerosis

scientific article published on 07 January 2019

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

scientific article published on 24 October 2013

Does age matter? - A MRI study on peritumoral edema in newly diagnosed primary glioblastoma ⬇️

scientific article published on April 12, 2011

Driving mesenchymal transition in glioblastoma

scientific article published on 01 January 2020

EGFRvIII vaccine in glioblastoma-InACT-IVe or not ReACTive enough?

scientific article published in October 2017

Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma

scientific article published in August 2007

Enzastaurin before and concomitant with radiation therapy, followed by enzastaurin maintenance therapy, in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation

scientific article published on August 2013

Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2.

scientific article published in May 2001

First-line therapy with temozolomide induces regression of primary CNS lymphoma.

scientific article published in May 2002

Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies.

scientific article published on 10 January 2018

Fulminant Cytotoxic Edema in a Patient with Pneumococcal Meningoencephalitis

scientific article published on 01 October 2019

Functional MHC Class II Is Upregulated in Neurofibromin-Deficient Schwann Cells

scientific article published on 10 January 2013

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

scientific article published on 20 December 2016

General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation

scientific article published on 20 May 2016

Geriatric neuro-oncology: from mythology to biology

scientific article published on December 2011

Glioblastoma in elderly patients: solid conclusions built on shifting sand?

scientific article published on 18 July 2017

Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma

scientific article published on 13 January 2015

Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta

scientific article published on June 1, 2001

Good maths is needed to understand CMV data in glioblastoma

scientific article

HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report.

scientific article published on 16 May 2017

Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis

scientific article published on 12 October 2020

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

scientific article published on 18 February 2020

High-throughput discovery of cancer-targeting TCRs

scientific article published on 06 November 2019

Highlights in Central Nervous System Tumors.

scientific article

How to integrate immunotherapy into standard of care in glioblastoma

scientific article published on 01 June 2019

Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production

scientific article published on 19 February 2021

IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO.

scientific article published on 12 May 2015

Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma

scientific article published on 02 August 2018

Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma

scientific article published on 01 June 2019

Imaging necrosis during treatment is associated with worse survival in EORTC 26101 study

scientific article published on 10 May 2019

Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma

scientific article published on 20 September 2013

Immunmodulation durch Tryptophanstoffwechsel

scientific article published on 02 July 2013

Immunoadsorption therapy for paraneoplastic syndromes

scientific article

Impact of tapering and discontinuation of bevacizumab in patients with progressive glioblastoma

scientific article published on 15 July 2016

In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.

scientific article published on 31 October 2016

Increasing the sensitivity of MRI for the detection of multiple sclerosis lesions by long axial coverage of the spinal cord: a prospective study in 119 patients

scientific article published in December 2016

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

scientific article published on 10 July 2014

Interaction between heart and brain in sudden cardiac death

scientific article published on 28 February 2017

Interaction between the heart and the brain in transient global amnesia

scientific article published on 10 September 2019

Intrathecal activation of CD8<sup>+</sup> memory T cells in IgG4-related disease of the brain parenchyma

scientific article published on 13 July 2021

Involvement of protein kinase Cdelta and extracellular signal-regulated kinase-2 in the suppression of microglial inducible nitric oxide synthase expression by N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast).

scientific article published in October 2003

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages.

scientific article published on 8 November 2017

Lack of T1 hyperintensity in the dentate nucleus after 15 administrations of a macrocyclic contrast agent in multiple sclerosis.

scientific article

Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide

scientific article published on July 2016

MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial

scientific article published on 5 February 2015

MICA/NKG2D-mediated immunogene therapy of experimental gliomas.

scientific article published on December 2003

MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria

scientific article published on 04 December 2018

Macrophage migration inhibitory factor (MIF) expression in human malignant gliomas contributes to immune escape and tumour progression

scientific article

Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes ⬇️

scientific article published on 29 September 2020

Microenvironmental clues for glioma immunotherapy

scientific article published on April 2014

Molecular profiling-based decision for targeted therapies in IDH wild-type glioblastoma

scientific article published on 22 January 2020

Monitoring innate immune cell dynamics in the glioma microenvironment by magnetic resonance imaging and multiphoton microscopy (MR-MPM)

scientific article published on 01 January 2020

Multiple sclerosis: trapped in deadly glue

scientific article published on 01 March 2005

Mutant IDH1: An immunotherapeutic target in tumors

scientific article published in December 2014

N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) inhibits transforming growth factor-beta relesase and reduces migration and invasiveness of human malignant glioma cells

scientific article published on July 2001

N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) suppresses microglial inducible nitric oxide synthase (iNOS) expression and activity induced by interferon-gamma (IFN-gamma)

scientific article

N2M2 (NOA20) phase I/II trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma

scientific article published on 01 January 2019

NDRG1 prognosticates the natural course of disease in WHO grade II glioma

scientific article published on 7 January 2014

Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle

scientific article

Neurological sequelae of cancer immunotherapies and targeted therapies

scientific article published on December 2016

Neuroradiological response criteria for malignant gliomas

scientific article

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

scientific article published on 15 December 2015

Noninvasive Characterization of Tumor Angiogenesis and Oxygenation in Bevacizumab-treated Recurrent Glioblastoma by Using Dynamic Susceptibility MRI: Secondary Analysis of the European Organization for Research and Treatment of Cancer 26101 Trial

scientific article published on 28 July 2020

Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients

scientific article published on 31 July 2018

Normal mast cell numbers in the tissues of AhR-deficient mice

scientific article published on 7 October 2015

O10.01PROGNOSTIC AND PREDICTIVE BIOMARKER-BASED SUBGROUPS IN THE NOA-04 TRIAL.

scientific article published in September 2014

O6.09PROSTAGLANDIN E RECEPTOR-4 ACTIVATION REGULATES TRYPTOPHAN METABOLISM IN HUMAN MALIGNANT GLIOMAS.

scientific article published in September 2014

Off-label use of IV t-PA in patients with intracranial neoplasm and cavernoma.

scientific article published on 5 February 2018

PROGNOSTIC AND PREDICTIVE BIOMARKER-BASED SUBGROUPS IN THE NOA-04 TRIAL.

scientific article published in July 2014

Painful neuropathy due to intraneural leukemic spread in a patient with acute myeloid leukemia

scientific article published on 01 August 2007

Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo

scientific article published on 25 January 2017

Personalized neurooncology

scientific article

Perspectives of immunotherapy in isocitrate dehydrogenase-mutant gliomas

scientific article published on 01 November 2018

Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082).

scientific article

Practice-changing developments in neuro-oncology: embracing heterogeneity

scientific article published on 08 February 2019

Primary cerebral non-Langerhans cell histiocytosis: MRI and differential diagnosis

scientific article published on 25 July 2002

Primary glioblastoma cultures: can profiling of stem cell markers predict radiotherapy sensitivity?

scientific article published on 18 July 2014

Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases

scientific article

Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation

scientific article published on 25 September 2013

Prognostic relevance of miRNA-155 methylation in anaplastic glioma

scientific article published on 18 November 2016

Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase

scientific article

Protein kinase Cβ as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis

scientific article published on 19 August 2013

Proximity ligation assay evaluates IDH1R132H presentation in gliomas

scientific article

Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma

scientific article published on 01 February 2019

Radiologic progression of glioblastoma under therapy - an exploratory analysis of AVAglio

scientific article published in September 2017

Recent developments and future directions in adult lower-grade gliomas: Society for Neuro-Oncology (SNO) and European Association of Neuro-Oncology (EANO) consensus

scientific article published on 01 July 2019

Role of TGF-beta in oncogenesis

scientific article published on 01 February 2001

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

scientific article

Sarcoma classification by DNA methylation profiling

scientific article published on 21 January 2021

Single-Cell High-Throughput Technologies in Cerebrospinal Fluid Research and Diagnostics

scientific article published on 11 June 2019

Slowing down glioblastoma progression in mice by running or the anti-malarial drug dihydroartemisinin? Induction of oxidative stress in murine glioblastoma therapy

scientific article published on 20 July 2016

Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis

scientific article published in March 2001

Spatiotemporal evolution of venous narrowing in acute MS lesions.

scientific article

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.

scientific article published on 30 May 2017

Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter-methylated malignant astrocytoma

scientific article published on 17 February 2020

Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway

scientific article published on 5 August 2014

Suppression of Th1 differentiation by tryptophan supplementation in vivo

scientific article published on 18 April 2017

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

scientific article published on 09 July 2018

Suppression of human CD4+ T cell activation by 3,4-dimethoxycinnamonyl-anthranilic acid (tranilast) is mediated by CXCL9 and CXCL10

scientific article published on 14 June 2011

Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer

scientific article published on 3 January 2017

Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment

scientific article published on 7 May 2012

Susceptibility-weighted imaging in malignant melanoma brain metastasis

scientific article published on 21 February 2019

Synergy of vaccination and agonist OX40 treatment-toward a mechanism-driven combination of glioma immunotherapy

scientific article published on 28 October 2017

Synovial Fibroblasts Selectively Suppress Th1 Cell Responses through IDO1-Mediated Tryptophan Catabolism.

scientific article

T cells engineered to home in on brain cancer

scientific article published in Nature

TCR validation toward gene therapy for cancer

scientific article published on 06 November 2019

Targeting resistance against the MDM2 inhibitor RG7388 in glioblastoma cells by the MEK inhibitor trametinib

scientific article published on 01 October 2018

Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial

scientific article

Temporal evolution of acute multiple sclerosis lesions on serial sodium (23Na) MRI

scientific article published on 17 January 2019

The aryl hydrocarbon receptor as a promoter of malignant glioma

scientific article published in February 2012

The aryl hydrocarbon receptor in tumor immunity

scientific article published on May 2012

The aryl hydrocarbon receptor links integrin signaling to the TGF-β pathway

scientific article published on 26 October 2015

The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress

scientific article published on 2 April 2013

The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells

scientific article (publication date: 2011)

The promises of immunotherapy in gliomas.

scientific article published on 4 October 2017

The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.

scientific article published on 15 November 2016

The therapeutic potential of targeting tryptophan catabolism in cancer

scientific article published on 10 December 2019

Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-beta and protein kinase R.

scientific article published in April 2009

Towards optimizing the sequence of bevacizumab and nitrosoureas in recurrent malignant glioma.

scientific article

Toxicity of teriflunomide in aryl hydrocarbon receptor deficient mice

scientific article published on 2 September 2015

Transforming growth factors beta(1) (TGF-beta(1)) and TGF-beta(2) promote glioma cell migration via Up-regulation of alpha(V)beta(3) integrin expression.

scientific article published in February 2000

Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite

scientific article

Treatment of optic neuritis with erythropoietin (TONE): a randomised, double-blind, placebo-controlled trial-study protocol

scientific article published on March 2016

Tregs in gliomas - the jury is still out.

scientific article published on 9 March 2015

Trial watch: IDO inhibitors in cancer therapy

scientific article

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion ⬇️

scientific article published on October 22, 2012

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

scientific article published on 01 May 2019

Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma

scientific article published on 03 September 2021

Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis

scientific article published on 24 January 2017

Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4.

scientific article

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

scientific article published on 28 October 2019

Tweety-Homolog 1 Drives Brain Colonization of Gliomas.

scientific article published on 08 June 2017

Understanding and Treating Glioblastoma

scientific article published on 01 August 2018

Understanding and targeting alkylator resistance in glioblastoma

scientific article published in October 2014

Up-regulation of specific NF 1 gene transcripts in sporadic pilocytic astrocytomas.

scientific article published on August 1996

Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

scientific article published on 05 September 2018

Vaccine-based immunotherapeutic approaches to gliomas and beyond

scientific article published on 12 May 2017

What remains after transient global amnesia (TGA)? An ultra-high field 7 T magnetic resonance imaging study of the hippocampus

scientific article published on 29 October 2019

Withdrawal: Identification of tumor antigens among the HLA peptidomes of glioblastoma tumors and plasma

scientific article published on 01 June 2019

[Clinically isolated syndrome].

scientific article

[Treatment of brain tumor patients: hyperthermia, hyperbaric oxygenation, electric fields or nanoparticles].

scientific article

[Treatment of the glioma microenvironment].

scientific article

[Treatment-associated neurological symptoms of cancer patients and their treatment]

scientific article published on 01 June 2019

cMyc and ERK activity are associated with resistance to ALK inhibitory treatment in glioblastoma

scientific article published on 28 November 2019

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy

scientific article

Paulina is supported by:

About Paulina

Help