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List of works by Lars Zender

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

scientific article published on September 2017

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

scientific article

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

scientific article

A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage

scientific journal article

A microRNA component of the p53 tumour suppressor network

scientific article

Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer

scientific article

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

scientific article

C-arm computed tomography parenchymal blood volume measurement in evaluation of hepatocellular carcinoma before transarterial chemoembolization with drug eluting beads

scientific article

Caspase 8 small interfering RNA prevents acute liver failure in mice

scientific article

Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma

scientific article

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma

scientific article

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

scientific article

Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo

scientific article

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

scientific article published on October 2016

Doxycycline regulation in a single retroviral vector by an autoregulatory loop facilitates controlled gene expression in liver cells

scientific article published on 13 February 2004

EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma

scientific article

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model

scientific article

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

scientific article published on 19 October 2008

IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models

scientific article published on 7 September 2016

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

scientific article

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening ⬇️

scientific article published on March 8, 2011

Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development

scientific article published on May 2012

Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies ⬇️

scientific article published on 02 April 2012

Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

scientific article published on 23 January 2012

Initial experience from a combination of systemic and regional chemotherapy in the treatment of patients with nonresectable cholangiocellular carcinoma in the liver

scientific article

Innate immune system favors emergency monopoiesis at the expense of DC-differentiation to control systemic bacterial infection in mice

scientific article

Integrative analyses for omics data: a Bayesian mixture model to assess the concordance of ChIP-chip and ChIP-seq measurements

scientific article

Integrative oncogenomic approaches for accelerated cancer-gene discovery

scientific article published on January 2008

Keeping your senescent cells under control

scientific article published on 6 May 2009

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

scientific article

MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression

scientific article

Molecular pathogenesis and targeted therapy of hepatocellular carcinoma

scientific article published on 09 September 2008

Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens

scholarly article

NFkappaB-mediated upregulation of bcl-xl restrains TRAIL-mediated apoptosis in murine viral hepatitis.

scientific article published on February 2005

Protein transduction domains fused to virus receptors improve cellular virus uptake and enhance oncolysis by tumor-specific replicating vectors

scientific article

Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma

scientific article

Reconstitution of Mice with Modified Liver Stem Cells

scientific article published on July 2015

Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma

scientific article published on 22 June 2013

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer

scientific article

Selectivity of oncolytic viral replication prevents antiviral immune response and toxicity, but does not improve antitumoral immunity

scientific article

Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

scientific article published on November 2004

Snapshot: genetic mouse models of cancer

scientific article

Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development

scientific article published on 26 February 2014

Targeting of p53-transcriptional dysfunction by conditionally replicating adenovirus is not limited by p53-homologues

scientific article

Telomerase-dependent virotherapy overcomes resistance of hepatocellular carcinomas against chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand by elimination of Mcl-1.

scientific article published on August 2005

The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation

scientific article published on 27 March 2011

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

scientific article published on 31 January 2017

Tissue-specific and reversible RNA interference in transgenic mice

scientific article

Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival.

scientific article

Tumor-specific adenoviral gene therapy: transcriptional repression of gene expression by utilizing p53-signal transduction pathways

scientific article published on January 2004

Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice ⬇️

scientific article published on June 6, 2011

Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

scientific article

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

scientific article

p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication

scientific article

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