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List of works by Christoph Wittmann

A Precise Temperature-Responsive Bistable Switch Controlling Yersinia Virulence

scientific article

A bio-based route to the carbon-5 chemical glutaric acid and to bionylon-6,5 using metabolically engineered Corynebacterium glutamicum

A common approach for absolute quantification of short chain CoA thioesters in prokaryotic and eukaryotic microbes

scientific article published on 10 August 2020

A field of dreams: Lignin valorization into chemicals, materials, fuels, and health-care products

scientific article published on 06 April 2019

A roadmap for interpreting (13)C metabolite labeling patterns from cells

scientific article

Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains

scientific article published on January 2006

Acetate Dissimilation and Assimilation in Mycobacterium tuberculosis Depend on Carbon Availability

scientific article published on 27 July 2015

Adaptation of Bacillus subtilis carbon core metabolism to simultaneous nutrient limitation and osmotic challenge: a multi-omics perspective

scientific article published on 31 March 2014

Advanced biotechnology: metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products

scientific article published on 11 February 2015

Amplified expression of fructose 1,6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources

scientific article published on December 2005

Analysis and engineering of metabolic pathway fluxes in Corynebacterium glutamicum

scientific article published in January 2010

Analysis of 13C labeling enrichment in microbial culture applying metabolic tracer experiments using gas chromatography-combustion-isotope ratio mass spectrometry

scientific article published on 17 June 2008

Anodic Electro-Fermentation: Anaerobic production of L-Lysine by recombinant Corynebacterium glutamicum

scientific article published on 10 February 2018

Application of MALDI-TOF MS to lysine-producing Corynebacterium glutamicum: a novel approach for metabolic flux analysis

scientific article

Application of cation-exchange membranes for characterisation and imaging ammonia-oxidising bacteria in soils

scientific article published in 2005

Appropriate sampling for intracellular amino acid analysis in five phylogenetically different yeasts

article

Areal activities and stratification of hydrolytic enzymes involved in the biochemical cycles of carbon, nitrogen, sulphur and phosphorus in podsolized boreal forest soils

Bio-based production of chemicals, materials and fuels -Corynebacterium glutamicum as versatile cell factory

scientific article

Bio-based production of the platform chemical 1,5-diaminopentane

scientific article published on 15 July 2011

Bio-based succinate from sucrose: High-resolution 13C metabolic flux analysis and metabolic engineering of the rumen bacterium Basfia succiniciproducens.

scientific article

Biotechnological Production of Organic Acids from Renewable Resources.

scientific article published on 7 March 2017

Biotechnology of riboflavin

scientific article

Characterization and application of an optical sensor for quantification of dissolved O2 in shake-flasks

scientific article published in March 2003

Characterization and control of fungal morphology for improved production performance in biotechnology

scientific article published on 04 July 2012

Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis

scientific article

Comparative metabolic flux analysis of an Ashbya gossypii wild type strain and a high riboflavin-producing mutant strain

scientific article published on 14 August 2014

Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose.

scientific article published on January 2004

Comparative study on central metabolic fluxes of Bacillus megaterium strains in continuous culture using 13C labelled substrates

scientific article published on 4 November 2006

Complete genome sequence of the myxobacterium Sorangium cellulosum

scientific article

Consequences of phosphoenolpyruvate:sugar phosphotranferase system and pyruvate kinase isozymes inactivation in central carbon metabolism flux distribution in Escherichia coli

scientific article published on 13 September 2012

Contextual Flexibility in Pseudomonas aeruginosa Central Carbon Metabolism during Growth in Single Carbon Sources

scientific article published on 17 March 2020

Convergent evolution of zoonotic Brucella species toward the selective use of the pentose phosphate pathway

scientific article published on 05 October 2020

Core fluxome and metafluxome of lactic acid bacteria under simulated cocoa pulp fermentation conditions

scientific article published on 12 July 2013

Correcting mass isotopomer distributions for naturally occurring isotopes

scientific article published in November 2002

Corynebacterium glutamicum for Sustainable Bioproduction: From Metabolic Physiology to Systems Metabolic Engineering

scientific article published on 22 November 2016

Customization of Aspergillus niger morphology through addition of talc micro particles

scientific article

Debottlenecking recombinant protein production in Bacillus megaterium under large-scale conditions--targeted precursor feeding designed from metabolomics

scientific article published on 31 January 2012

Derivatization of small biomolecules for optimized matrix-assisted laser desorption/ionization mass spectrometry

scientific article

Design maßgeschneiderter Zellfabriken für die nachhaltige Produktion

Dynamic calibration and dissolved gas analysis using membrane inlet mass spectrometry for the quantification of cell respiration

scientific article published in January 2003

Dynamics of intracellular metabolites of glycolysis and TCA cycle during cell-cycle-related oscillation in Saccharomyces cerevisiae

scientific article published in March 2005

Dynamische Untersuchungen zum Aminosäure-Stoffwechsel von Bacillus megaterium mittels stabiler Isotope

ECOTOXICOLOGICAL ASSESSMENT OF A RECIPIENT LAKE SEDIMENT OF BLEACHED-KRAFT PULPING DISCHARGES

article

Ecotoxicological assessment of a recipient lake sediment of bleached-kraft pulping discharges

article

Ectoine production byAlkalibacillus haloalkaliphilus-Bioprocess development using response surface methodology and model-driven strategies

article

Editorial overview: Chemical biotechnology

scientific article published on 14 November 2016

Editorial: how multiplexed tools and approaches speed up the progress of metabolic engineering

scientific article published in May 2013

Effect of different carbon sources on central metabolic fluxes and the recombinant production of a hydrolase from Thermobifida fusca in Bacillus megaterium

scientific article published on 7 August 2007

Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116.

scientific article

Erratum to: Oxygen supply in disposable shake-flasks: prediction of oxygen transfer rate, oxygen saturation and maximum cell concentration during aerobic growth

scholarly article published in Biotechnology Letters

Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella

scientific article

Evaluation of ecological disturbance and intrinsic bioremediation potential of pulp mill-contaminated lake sediment using key enzymes as probes

scientific article published in February 2000

Exploring metabolic pathways in genome-scale networks via generating flux modes

scientific article published in 2010

Fermentation of plant-based milk alternatives for improved flavour and nutritional value

scientific article published on 04 November 2019

Fermentative Herstellung von Bernsteinsäure mit Basfia succiniciproducens DD1 in Serumflaschen

Filamentous fungi in good shape: Microparticles for tailor-made fungal morphology and enhanced enzyme production

article

Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties

scientific article

Fluxome analysis using GC-MS.

scientific article published on 7 February 2007

Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae

scientific article published in April 2003

From gene to product

scientific article published on January 20, 2013

From lignin to nylon: Cascaded chemical and biochemical conversion using metabolically engineered Pseudomonas putida

scientific article published on 13 March 2018

From systems biology to metabolically engineered cells — an omics perspective on the development of industrial microbes

article

From zero to hero - production of bio-based nylon from renewable resources using engineered Corynebacterium glutamicum

scientific article

From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production

article

Functionalization of magnetic nanoparticles with high-binding capacity for affinity separation of therapeutic proteins

GC-MS-Based 13C Metabolic Flux Analysis

Gene regulatory and metabolic adaptation processes of Dinoroseobacter shibae DFL12T during oxygen depletion

scientific article

Genealogy profiling through strain improvement by using metabolic network analysis: metabolic flux genealogy of several generations of lysine-producing corynebacteria

scientific article

Getting the big beast to work--systems biotechnology of Bacillus megaterium for novel high-value proteins

scientific article published on 28 June 2012

Green pathways: Metabolic network analysis of plant systems

scientific article published on 15 December 2015

Growth inhibition by ammonia and use of a pH-controlled feeding strategy for the effective cultivation of Mycobacterium chlorophenolicum

scientific article published in December 1995

Growth inhibition by ammonia and use of a pH-controlled feeding strategy for the effective cultivation of Mycobacterium chlorophenolicum

scientific article published in 1995

High yield production of extracellular recombinant levansucrase by Bacillus megaterium

scientific article published on 23 November 2012

Identification and elimination of the competing N-acetyldiaminopentane pathway for improved production of diaminopentane by Corynebacterium glutamicum

scientific article (publication date: August 2010)

Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria

scientific article published in April 2004

Improved assessment of aggregate size in Taxus plant cell suspension cultures using laser diffraction

article

Improved enzyme production by bio-pellets of Aspergillus niger: targeted morphology engineering using titanate microparticles

scientific article published on 2 September 2011

Improved riboflavin production with Ashbya gossypii from vegetable oil based on 13C metabolic network analysis with combined labeling analysis by GC/MS, LC/MS, 1D, and 2D NMR.

scientific article published on 11 April 2018

Improving 2-phenylethanol and 6-pentyl-α-pyrone production with fungi by microparticle-enhanced cultivation (MPEC).

scientific article

In silico metabolic network analysis of Arabidopsis leaves

scientific article

In vivo analysis of intracellular amino acid labelings by GC/MS

article

In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum

scientific article published in May 2005

In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome

scientific article published on March 2004

In-silico-driven metabolic engineering of Pseudomonas putida for enhanced production of poly-hydroxyalkanoates

scientific article published on 17 November 2012

Increased lysine production by flux coupling of the tricarboxylic acid cycle and the lysine biosynthetic pathway--metabolic engineering of the availability of succinyl-CoA in Corynebacterium glutamicum

scientific article published on 2 August 2012

Industrial biotechnology of Pseudomonas putida and related species

scientific article published on 18 February 2012

Industrial biotechnology of Pseudomonas putida: advances and prospects

scientific article published on 13 August 2020

Integrated analysis of gene expression and metabolic fluxes in PHA-producing Pseudomonas putida grown on glycerol

scientific article published on 3 May 2016

Integrated optical sensing of dissolved oxygen in microtiter plates: A novel tool for microbial cultivation

article

Integration of in vivo and in silico metabolic fluxes for improvement of recombinant protein production

scientific article published on 20 November 2011

Investigation of the central carbon metabolism of Sorangium cellulosum: metabolic network reconstruction and quantification of pathway fluxes.

scientific article published in January 2009

Large-Scale 13C flux profiling reveals conservation of the Entner-Doudoroff pathway as a glycolytic strategy among marine bacteria that use glucose

scientific article

Limited life cycle and cost assessment for the bioconversion of lignin-derived aromatics into adipic acid

scientific article published on 05 February 2020

Lysine production from the sugar alcohol mannitol: Design of the cell factory Corynebacterium glutamicum SEA-3 through integrated analysis and engineering of metabolic pathway fluxes

scientific article published on 27 April 2018

MALDI-TOF MS for quantification of substrates and products in cultivations ofCorynebacterium glutamicum

Mass spectrometry for metabolic flux analysis

scientific article published on 01 March 1999

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for metabolic flux analyses using isotope-labeled ethanol

scientific article

Measurement of isotopic enrichments in 13C-labelled molecules by 1D selective Zero-Quantum Filtered TOCSY NMR experiments

Membrane Inlet Mass Spectrometry for the on-line Measurement of Metabolic Fluxes: Case Lysine-Production byCorynebacterium glutamicum

Membrane fluidity of halophilic ectoine-secreting bacteria related to osmotic and thermal treatment

scientific article published on 8 May 2013

Membraneinlass-Massenspektrometrie zur prozessnahen metabolischen Flussanalyse am Beispiel der Lysin-Produktion vonCorynebacterium glutamicum

Metabolic Engineering of Corynebacterium glutamicum for High-Level Ectoine Production: Design, Combinatorial Assembly, and Implementation of a Transcriptionally Balanced Heterologous Ectoine Pathway

scientific article published on 03 July 2019

Metabolic Flux Analysis

article from 2013

Metabolic engineering of Corynebacterium glutamicum for production of 1,5-diaminopentane from hemicellulose

scientific article published on 7 February 2011

Metabolic engineering of Corynebacterium glutamicum for the production of cis, cis-muconic acid from lignin

scientific article published in 2018

Metabolic engineering of cellular transport for overproduction of the platform chemical 1,5-diaminopentane in Corynebacterium glutamicum

article by Stefanie Kind et al published September 2011 in Metabolic Engineering

Metabolic engineering of industrial platform microorganisms for biorefinery applications--optimization of substrate spectrum and process robustness by rational and evolutive strategies

scientific article

Metabolic engineering of the tricarboxylic acid cycle for improved lysine production by Corynebacterium glutamicum

scientific article published on 9 October 2009

Metabolic flux analysis in Ashbya gossypii using C-labeled yeast extract: industrial riboflavin production under complex nutrient conditions

article

Metabolic flux engineering of L-lysine production in Corynebacterium glutamicum--over expression and modification of G6P dehydrogenase

scientific article published on 6 June 2007

Metabolic flux pattern of glucose utilization by Xanthomonas campestris pv. campestris: prevalent role of the Entner-Doudoroff pathway and minor fluxes through the pentose phosphate pathway and glycolysis

scientific article

Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function

scientific article

Metabolic fluxes and beyond-systems biology understanding and engineering of microbial metabolism

scientific article published on 07 September 2010

Metabolic fluxes in Corynebacterium glutamicum during lysine production with sucrose as carbon source

scientific article published on December 2004

Metabolic fluxes in the central carbon metabolism of Dinoroseobacter shibae and Phaeobacter gallaeciensis, two members of the marine Roseobacter clade

scientific article published on 29 September 2009

Metabolic network analysis of lysine producing Corynebacterium glutamicum at a miniaturized scale

scientific article

Metabolic network simulation using logical loop algorithm and Jacobian matrix

scientific article published in October 2004

Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum

scientific article published on 18 April 2006

Metabolic physiology of Pseudomonas putida for heterologous production of myxochromide

article

Metabolic physiology of aroma-producing Kluyveromyces marxianus

scientific article published in November 2002

Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum

scientific article published on 13 March 2008

Metabolic screening of Saccharomyces cerevisiae single knockout strains reveals unexpected mobilization of metabolic potential

scientific article published in 2006

Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening

scientific article published on 30 January 2009

Microbial production of the drugs violacein and deoxyviolacein: analytical development and strain comparison.

scientific article

Microparticle based morphology engineering of filamentous microorganisms for industrial bio-production

scientific article published on 11 July 2012

Microplates with integrated oxygen sensing for medium optimization in animal cell culture

scientific article

Mineralization of detritus and oxidation of methane in acid boreal coniferous forest soils: seasonal and vertical distribution and effects of clear-cut

Minibioreactors

scientific article published on January 2004

Minimal nutrient requirement for growth ofMycobacterium chlorophenolicum

Modeling and experimental design for metabolic flux analysis of lysine-producing Corynebacteria by mass spectrometry

scientific article published in April 2001

Morphology and rheology in filamentous cultivations

scientific article published on January 2010

Morphology engineering of Aspergillus niger for improved enzyme production

scientific article published in April 2010

Novel Approach for High-Throughput Metabolic Screening of Whole Plants by Stable Isotopes

scientific article published on 10 March 2016

OpenFLUX: efficient modelling software for 13C-based metabolic flux analysis

scientific article published on May 2009

Optimized bioprocess for production of fructofuranosidase by recombinant Aspergillus niger

scientific article published on 26 May 2010

Oxygen supply in disposable shake-flasks: prediction of oxygen transfer rate, oxygen saturation and maximum cell concentration during aerobic growth

scientific article

Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR.

scientific article

Physiology of the yeast Kluyveromyces marxianus during batch and chemostat cultures with glucose as the sole carbon source

scientific article published on 18 January 2007

Production of medium chain length polyhydroxyalkanoate in metabolic flux optimized Pseudomonas putida

scientific article

Production of non-proteinogenic amino acids from α-keto acid precursors with recombinant Corynebacterium glutamicum

scientific article published on 4 June 2013

Proteome and carbon flux analysis of Pseudomonas aeruginosa clinical isolates from different infection sites

scientific article published on 09 March 2016

Pyrazine Biosynthesis in Corynebacterium glutamicum

Quantification of S-adenosyl methionine in microbial cell extracts

scientific article published in January 2006

Quantification of intracellular amino acids in batch cultures of Saccharomyces cerevisiae

scientific article

Reconciling in vivo and in silico key biological parameters of Pseudomonas putida KT2440 during growth on glucose under carbon-limited condition

scientific article

Respirometric 13C flux analysis, Part I: design, construction and validation of a novel multiple reactor system using on-line membrane inlet mass spectrometry

scientific article published on 17 July 2006

Respirometric 13C flux analysis--Part II: in vivo flux estimation of lysine-producing Corynebacterium glutamicum

scientific article published on 28 April 2006

Response of fluxome and metabolome to temperature-induced recombinant protein synthesis in Escherichia coli

scientific article published on 10 July 2007

Response of the central metabolism of Escherichia coli to modified expression of the gene encoding the glucose-6-phosphate dehydrogenase.

scientific article published on 3 July 2007

Robustness and plasticity of metabolic pathway flux among uropathogenic isolates of Pseudomonas aeruginosa

scientific article

Sampling for metabolome analysis of microorganisms.

scientific article published on 6 April 2007

Sampling of intracellular metabolites for stationary and non-stationary (13)C metabolic flux analysis in Escherichia coli.

scientific article

Software tool for automated processing of 13C labeling data from mass spectrometric spectra.

scientific article

Standard reporting requirements for biological samples in metabolomics experiments: microbial and in vitro biology experiments.

scientific article

Systems Metabolic Engineering Approaches for Rewiring Cells

scientific article published on 01 September 2019

Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development

scientific article published on 13 January 2012

Systems biology of recombinant protein production using Bacillus megaterium

scientific article published in January 2011

Systems level engineering of Corynebacterium glutamicum - Reprogramming translational efficiency for superior production

article

Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine

scientific article published on 15 November 2013

Systems metabolic engineering of Corynebacterium glutamicum for the production of the carbon-5 platform chemicals 5-aminovalerate and glutarate

scientific article

Systems metabolic engineering of Escherichia coli for gram scale production of the antitumor drug deoxyviolacein from glycerol.

scientific article published on 25 August 2014

Systems metabolic engineering of Escherichia coli for production of the antitumor drugs violacein and deoxyviolacein

scientific article published on 29 August 2013

Systems metabolic engineering of Escherichia coli for the heterologous production of high value molecules-a veteran at new shores

scientific article

Systems metabolic engineering of xylose-utilizingCorynebacterium glutamicumfor production of 1,5-diaminopentane

article

Systems-wide analysis and engineering of metabolic pathway fluxes in bio-succinate producing Basfia succiniciproducens

scientific article published on 9 July 2013

Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane

scientific article published on 8 April 2010

The key to acetate: metabolic fluxes of acetic acid bacteria under cocoa pulp fermentation-simulating conditions

scientific article published on August 2014

The pyruvate-tricarboxylic acid cycle node: a focal point of virulence control in the enteric pathogen Yersinia pseudotuberculosis

scientific article

The yeast Kluyveromyces marxianus and its biotechnological potential

scientific article published on 22 April 2008

Theoretical aspects of 13C metabolic flux analysis with sole quantification of carbon dioxide labeling

scientific article published in April 2005

Top value platform chemicals: bio-based production of organic acids

scientific article published on 04 September 2015

Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation

scientific article published on 22 November 2006

Transposon mutagenesis identified chromosomal and plasmid genes essential for adaptation of the marine bacterium Dinoroseobacter shibae to anaerobic conditions

scientific article

Use of Single-Frequency Impedance Spectroscopy to Characterize the Growth Dynamics of Biofilm Formation in Pseudomonas aeruginosa

scientific article published on 12 July 2017

Viability characterization of Taxus chinensis plant cell suspension cultures by rapid colorimetric- and image analysis-based techniques

scientific article published in September 2014