List of works - Nico Scheer

A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity

scientific article published on 07 September 2015

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

scientific article published on September 2008

A quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish

scientific article published in March 2002

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

scientific article published on 01 March 2009

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.

scientific article

An instructive function for Notch in promoting gliogenesis in the zebrafish retina.

scientific article

Asymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio

scientific article published in April 2006

Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling

scientific article

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

scientific article published on 5 February 2015

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

scientific article published on 11 August 2015

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

scientific article published on 30 May 2019

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

scientific article published on 26 March 2014

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins

scientific article published on 22 May 2014

Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model

scientific article published on 18 February 2016

Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

scientific article published on 23 August 2012

Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines

scientific article published on 23 August 2012

Generation and utility of genetically humanized mouse models.

scientific article

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

scientific article published on 19 April 2010

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism

scientific article published on 04 February 2019

Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion

scientific article

In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice

scientific article published on 30 March 2010

Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines

scientific article published on 11 October 2011

Notch signaling is required for arterial-venous differentiation during embryonic vascular development.

scientific article

Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms

scientific article

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors

scientific article published on April 2014

Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line

scientific article published on 31 May 2011

The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice

scientific article published on 02 May 2018

The pharmacokinetics and metabolism of lumiracoxib in chimeric humanized and murinized FRG mice

scientific article published on 25 March 2017

Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins

scientific article published on September 2000

Use of the Gal4-UAS technique for targeted gene expression in the zebrafish

scientific article published in February 1999

Xenobiotic receptor humanized mice and their utility ⬇️

scientific article published on November 23, 2012

List of works by Nico Scheer

A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

A quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.

An instructive function for Notch in promoting gliogenesis in the zebrafish retina.

Asymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio

Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins

Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model

Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines

Generation and utility of genetically humanized mouse models.

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism

Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion

In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice

Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines

Notch signaling is required for arterial-venous differentiation during embryonic vascular development.

Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors

Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line

The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice

The pharmacokinetics and metabolism of lumiracoxib in chimeric humanized and murinized FRG mice

Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins

Use of the Gal4-UAS technique for targeted gene expression in the zebrafish

Xenobiotic receptor humanized mice and their utility ⬇️