List of works - David Tai Leong

3-D DNA nanodevices for on-site sensitive detection of antibiotic residues in food

scientific article published on 22 September 2020

A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness

scientific article published on 08 September 2021

A bio-inspired platform to modulate myogenic differentiation of human mesenchymal stem cells through focal adhesion regulation.

scientific article published in October 2012

A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation.

scientific article published on 19 April 2013

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

scientific article (publication date: 6 October 2011)

ATF5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells

scientific article published on 01 August 2012

Absolute quantification of gene expression in biomaterials research using real-time PCR.

scientific article published on 10 October 2006

Angiopoietin-1 accelerates restoration of endothelial cell barrier integrity from nanoparticle-induced leakiness

scientific article published on 19 February 2019

Antimicrobial Cluster Bombs: Silver Nanoclusters Packed with Daptomycin.

scientific article

Antimicrobial Gold Nanoclusters.

scientific article published on 8 June 2017

Assembling Defined DNA Nanostructure with Nitrogen-Enriched Carbon Dots for Theranostic Cancer Applications

scientific article published on 17 April 2020

Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells.

scientific article

Balancing the rate of cluster growth and etching for gram-scale synthesis of thiolate-protected Au(25) nanoclusters with atomic precision.

scientific article published on 24 March 2014

Bio-inspired micropatterned platform to steer stem cell differentiation.

scientific article

Biochemical studies of the lagunamides, potent cytotoxic cyclic depsipeptides from the marine cyanobacterium Lyngbya majuscula.

scientific article

Biomimicry 3D gastrointestinal spheroid platform for the assessment of toxicity and inflammatory effects of zinc oxide nanoparticles

scientific article published on 20 October 2014

Biophysical responses upon the interaction of nanomaterials with cellular interfaces

scientific article

Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route

scientific article published in 2022

Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility ⬇️

scientific article

Cell-microsphere constructs formed with human adipose-derived stem cells and gelatin microspheres promotes stemness, differentiation, and controlled pro-angiogenic potential.

scientific article published in July 2014

Cellular processing and destinies of artificial DNA nanostructures

scientific article published on 27 April 2016

Characterization of Osteogenically Induced Adipose Tissue-Derived Precursor Cells in 2-Dimensional and 3-Dimensional Environments

scientific article published on 01 January 2006

Clinically Relevant Detection of Streptococcus pneumoniae with DNA-Antibody Nanostructures.

scientific article published on 26 May 2017

Coexpressing shRNA with fluorescence tags for quantification of cell migration studies

scientific article

Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles

scientific article published on 7 January 2016

Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts

scientific article published on 28 August 2012

DNA Nanostructures Carrying Stoichiometrically Definable Antibodies

scientific article published on 29 August 2016

Decoupling the Direct and Indirect Biological Effects of ZnO Nanoparticles Using a Communicative Dual Cell-Type Tissue Construct.

scientific article published on 15 December 2015

Defect engineered bioactive transition metals dichalcogenides quantum dots

scientific article published in Nature Communications

Defect‐Rich Molybdenum Sulfide Quantum Dots for Amplified Photoluminescence and Photonics‐Driven Reactive Oxygen Species Generation

scientific article published in 2022

Direct laser machining-induced topographic pattern promotes up-regulation of myogenic markers in human mesenchymal stem cells.

scientific article

Directing Assembly and Disassembly of 2D MoS2 Nanosheets with DNA for Drug Delivery.

scientific article

Editorial: Nanomedicine's Multi-pronged Approach in Tackling Cancer

scientific article published on 01 January 2018

Effect of zinc oxide nanomaterials-induced oxidative stress on the p53 pathway

scientific article published on October 2013

Exploiting cancer's antioxidative weakness through p53 with nanotoxicology.

scientific article published in April 2014

Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes

From aggregation-induced emission of Au(I)-thiolate complexes to ultrabright Au(0)@Au(I)-thiolate core-shell nanoclusters

scientific article published on 01 October 2012

Glutathione-protected silver nanoclusters as cysteine-selective fluorometric and colorimetric probe

scientific article published on 11 January 2013

Gold Nanoparticles Induced Endothelial Leakiness Depends on Particle Size and Endothelial Cell Origin.

scientific article

Highlights from the latest articles in technical and technological advancements in nanotherapeutics.

scientific article published in January 2015

Highly Luminescent Thiolated Gold Nanoclusters Impregnated in Nanogel

scientific article published on 27 May 2016

Identification of a highly luminescent Au22(SG)18 nanocluster.

scientific article published on 14 January 2014

Increasing the Potential Interacting Area of Nanomedicine Enhances Its Homotypic Cancer Targeting Efficacy

scientific article published on 21 February 2020

Inorganic Nanomaterials as Highly Efficient Inhibitors of Cellular Hepatic Fibrosis

scientific article published on 11 September 2018

Inorganic nanoparticles as tubulin binding agents for cancer therapy

scientific article published on 01 July 2014

Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells

scientific article

Intramuscular nerve damage in lacerated skeletal muscles may direct the inflammatory cytokine response during recovery

scientific article published in July 2012

Investigating the effects of preinduction on human adipose-derived precursor cells in an athymic rat model

scientific article published in December 2006

In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer.

scientific article

Isolating bone marrow stem cells using sieve technology

scientific article published on 01 January 2004

Layered MoS2 defect-driven in situ synthesis of plasmonic gold nanocrystals visualizes the planar size and interfacial diversity

scientific article published on 27 May 2020

Lighting up thiolated Au@Ag nanoclusters via aggregation-induced emission.

scientific article published on 11 November 2013

Low-Dimensional Transition Metal Dichalcogenide Nanostructures Based Sensors

article published in 2016

Mechanistic Investigation of the Biological Effects of SiO₂, TiO₂, and ZnO Nanoparticles on Intestinal Cells

scientific article published on 22 April 2015

Mechanoregulation of stem cell fate via micro-/nano-scale manipulation for regenerative medicine

scientific article published on April 2013

Mesoporous Silica Nanoparticles as an Antitumoral-Angiogenesis Strategy

scientific article

MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

scientific article published on 29 May 2013

Micropatterned matrix directs differentiation of human mesenchymal stem cells towards myocardial lineage

scientific article published on 13 February 2010

Molecular design and medicinal applications of nano-nitric oxide delivery systems

scientific article published on 7 April 2017

Nano-TiO2 Drives Epithelial-Mesenchymal Transition in Intestinal Epithelial Cancer Cells

scientific article published on 02 July 2018

Nano-hydroxyapatite and nano-titanium dioxide exhibit different subcellular distribution and apoptotic profile in human oral epithelium.

scientific article published on 29 April 2014

Nanoarchitectonics beyond Self-Assembly: Challenges to Create Bio-Like Hierarchic Organization

scientific article published on 14 March 2020

Nanomedicine for the treatment of triple-negative breast cancer

scientific article published in April 2014

Nanoparticle Density: A Critical Biophysical Regulator of Endothelial Permeability.

scientific article

Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness

scientific article published on 28 January 2019

Nanoparticles strengthen intracellular tension and retard cellular migration.

scientific article published on 18 December 2013

Nanoparticles' interactions with vasculature in diseases

scientific article published on 01 October 2019

Nanotheranostics - application and further development of nanomedicine strategies for advanced theranostics

scientific article

Nature-inspired DNA nanosensor for real-time in situ detection of mRNA in living cells

scientific article published on 28 April 2015

Novel theranostic DNA nanoscaffolds for the simultaneous detection and killing of Escherichia coli and Staphylococcus aureus

scientific article published on 18 June 2014

Osteo-maturation of adipose-derived stem cells required the combined action of vitamin D3, beta-glycerophosphate, and ascorbic acid

scientific article published in August 2007

Oxidative stress by inorganic nanoparticles

scientific article published on 10 September 2015

Phage based green chemistry for gold ion reduction and gold retrieval.

scientific article published on 2 January 2014

Phototherapy with layered materials derived quantum dots

scientific article published on 04 December 2019

Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer.

scientific article published on 24 July 2009

Pro-inflammatory responses of RAW264.7 macrophages when treated with ultralow concentrations of silver, titanium dioxide, and zinc oxide nanoparticles.

scientific article published on 30 April 2015

Probing the relevance of 3D cancer models in nanomedicine research.

scientific article published on July 2014

Retooling Cancer Nanotherapeutics' Entry into Tumors to Alleviate Tumoral Hypoxia

scientific article published on 16 August 2020

Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1).

scientific article published on December 2009

Soft Material Approach to Induce Oxidative Stress in Mesenchymal Stem Cells for Functional Tissue Repair.

scientific article published on 9 September 2016

Storage of gold nanoclusters in muscle leads to their biphasic in vivo clearance.

scientific article

Sugar-Grafted Cyclodextrin Nanocarrier as a "Trojan Horse" for Potentiating Antibiotic Activity

scientific article published on 20 January 2016

The challenge to measure cell proliferation in two and three dimensions.

scientific article published in January 2005

The gap between endothelial cells: key to the quick escape of nanomaterials?

scientific article published in August 2014

The influence of lysosomal stability of silver nanomaterials on their toxicity to human cells.

scientific article published on 28 May 2014

The osteogenic differentiation of adipose tissue-derived precursor cells in a 3D scaffold/matrix environment

scientific article published on 01 December 2008

The reduction of anti-cancer drug antagonism by the spatial protection of drugs with PLA-TPGS nanoparticles.

scientific article published on 15 January 2014

The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles

scientific article

Titanium Dioxide Nanoparticles Enhance Leakiness and Drug Permeability in Primary Human Hepatic Sinusoidal Endothelial Cells ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2019

Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE-cadherin.

scientific article

Toward understanding the growth mechanism: tracing all stable intermediate species from reduction of Au(I)-thiolate complexes to evolution of Au₂₅ nanoclusters

scientific article published on 21 July 2014

Toxicity of Two-Dimensional Layered Materials and Their Heterostructures

scientific article published on 19 August 2019

Toxicity profiling of water contextual zinc oxide, silver, and titanium dioxide nanoparticles in human oral and gastrointestinal cell systems

scientific article

Tuning Endothelial Permeability with Functionalized Nanodiamonds.

scientific article published on 7 December 2015

Tuning the activity of platinum(IV) anticancer complexes through asymmetric acylation

scientific article published on 24 August 2012

Ultrabright organic dots with aggregation-induced emission characteristics for cell tracking

scientific article

Ultrasensitive IgG quantification using DNA nano-pyramids

scholarly article by Liang Yuan et al published July 2014 in NPG Asia materials

Ultrasmall Au(10-12)(SG)(10-12) nanomolecules for high tumor specificity and cancer radiotherapy

scientific article published on 11 May 2014

Ultrasmall glutathione-protected gold nanoclusters as next generation radiotherapy sensitizers with high tumor uptake and high renal clearance.

scientific article

Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood.

scientific article published on 04 August 2015

Viability and adipogenic potential of human adipose tissue processed cell population obtained from pump-assisted and syringe-assisted liposuction.

scientific article

List of works by David Tai Leong

3-D DNA nanodevices for on-site sensitive detection of antibiotic residues in food

A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness

A bio-inspired platform to modulate myogenic differentiation of human mesenchymal stem cells through focal adhesion regulation.

A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation.

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

ATF5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells

Absolute quantification of gene expression in biomaterials research using real-time PCR.

Angiopoietin-1 accelerates restoration of endothelial cell barrier integrity from nanoparticle-induced leakiness

Antimicrobial Cluster Bombs: Silver Nanoclusters Packed with Daptomycin.

Antimicrobial Gold Nanoclusters.

Assembling Defined DNA Nanostructure with Nitrogen-Enriched Carbon Dots for Theranostic Cancer Applications

Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells.

Balancing the rate of cluster growth and etching for gram-scale synthesis of thiolate-protected Au(25) nanoclusters with atomic precision.

Bio-inspired micropatterned platform to steer stem cell differentiation.

Biochemical studies of the lagunamides, potent cytotoxic cyclic depsipeptides from the marine cyanobacterium Lyngbya majuscula.

Biomimicry 3D gastrointestinal spheroid platform for the assessment of toxicity and inflammatory effects of zinc oxide nanoparticles

Biophysical responses upon the interaction of nanomaterials with cellular interfaces

Brain Accumulation and Toxicity Profiles of Silica Nanoparticles: The Influence of Size and Exposure Route

Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility ⬇️

Cell-microsphere constructs formed with human adipose-derived stem cells and gelatin microspheres promotes stemness, differentiation, and controlled pro-angiogenic potential.

Cellular processing and destinies of artificial DNA nanostructures

Characterization of Osteogenically Induced Adipose Tissue-Derived Precursor Cells in 2-Dimensional and 3-Dimensional Environments

Clinically Relevant Detection of Streptococcus pneumoniae with DNA-Antibody Nanostructures.

Coexpressing shRNA with fluorescence tags for quantification of cell migration studies

Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles

Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts

DNA Nanostructures Carrying Stoichiometrically Definable Antibodies

Decoupling the Direct and Indirect Biological Effects of ZnO Nanoparticles Using a Communicative Dual Cell-Type Tissue Construct.

Defect engineered bioactive transition metals dichalcogenides quantum dots

Defect‐Rich Molybdenum Sulfide Quantum Dots for Amplified Photoluminescence and Photonics‐Driven Reactive Oxygen Species Generation

Direct laser machining-induced topographic pattern promotes up-regulation of myogenic markers in human mesenchymal stem cells.

Directing Assembly and Disassembly of 2D MoS2 Nanosheets with DNA for Drug Delivery.

Editorial: Nanomedicine's Multi-pronged Approach in Tackling Cancer

Effect of zinc oxide nanomaterials-induced oxidative stress on the p53 pathway

Exploiting cancer's antioxidative weakness through p53 with nanotoxicology.

Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes

From aggregation-induced emission of Au(I)-thiolate complexes to ultrabright Au(0)@Au(I)-thiolate core-shell nanoclusters

Glutathione-protected silver nanoclusters as cysteine-selective fluorometric and colorimetric probe

Gold Nanoparticles Induced Endothelial Leakiness Depends on Particle Size and Endothelial Cell Origin.

Highlights from the latest articles in technical and technological advancements in nanotherapeutics.

Highly Luminescent Thiolated Gold Nanoclusters Impregnated in Nanogel

Identification of a highly luminescent Au22(SG)18 nanocluster.

Increasing the Potential Interacting Area of Nanomedicine Enhances Its Homotypic Cancer Targeting Efficacy

Inorganic Nanomaterials as Highly Efficient Inhibitors of Cellular Hepatic Fibrosis

Inorganic nanoparticles as tubulin binding agents for cancer therapy

Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells

Intramuscular nerve damage in lacerated skeletal muscles may direct the inflammatory cytokine response during recovery

Investigating the effects of preinduction on human adipose-derived precursor cells in an athymic rat model

In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer.

Isolating bone marrow stem cells using sieve technology

Layered MoS2 defect-driven in situ synthesis of plasmonic gold nanocrystals visualizes the planar size and interfacial diversity

Lighting up thiolated Au@Ag nanoclusters via aggregation-induced emission.

Low-Dimensional Transition Metal Dichalcogenide Nanostructures Based Sensors

Mechanistic Investigation of the Biological Effects of SiO₂, TiO₂, and ZnO Nanoparticles on Intestinal Cells

Mechanoregulation of stem cell fate via micro-/nano-scale manipulation for regenerative medicine

Mesoporous Silica Nanoparticles as an Antitumoral-Angiogenesis Strategy

MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

Micropatterned matrix directs differentiation of human mesenchymal stem cells towards myocardial lineage

Molecular design and medicinal applications of nano-nitric oxide delivery systems

Nano-TiO2 Drives Epithelial-Mesenchymal Transition in Intestinal Epithelial Cancer Cells

Nano-hydroxyapatite and nano-titanium dioxide exhibit different subcellular distribution and apoptotic profile in human oral epithelium.

Nanoarchitectonics beyond Self-Assembly: Challenges to Create Bio-Like Hierarchic Organization

Nanomedicine for the treatment of triple-negative breast cancer

Nanoparticle Density: A Critical Biophysical Regulator of Endothelial Permeability.

Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness

Nanoparticles strengthen intracellular tension and retard cellular migration.

Nanoparticles' interactions with vasculature in diseases

Nanotheranostics - application and further development of nanomedicine strategies for advanced theranostics

Nature-inspired DNA nanosensor for real-time in situ detection of mRNA in living cells

Novel theranostic DNA nanoscaffolds for the simultaneous detection and killing of Escherichia coli and Staphylococcus aureus

Osteo-maturation of adipose-derived stem cells required the combined action of vitamin D3, beta-glycerophosphate, and ascorbic acid

Oxidative stress by inorganic nanoparticles

Phage based green chemistry for gold ion reduction and gold retrieval.

Phototherapy with layered materials derived quantum dots

Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer.

Pro-inflammatory responses of RAW264.7 macrophages when treated with ultralow concentrations of silver, titanium dioxide, and zinc oxide nanoparticles.

Probing the relevance of 3D cancer models in nanomedicine research.

Retooling Cancer Nanotherapeutics' Entry into Tumors to Alleviate Tumoral Hypoxia

Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1).