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List of works by Ian R. Baxendale

A Base-Catalysed One-Pot Three-Component Coupling Reaction Leading to Nitrosubstituted Pyrroles

A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B Antagonist

A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

scientific article published on 26 May 2011

A New Focused Microwave Approach to the Synthesis of Amino-Substituted Pyrroloisoquinolines and Pyrroloquinolines via a Sequential Multi-Component Coupling Process

article published in 2008

A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives

scientific article published on 05 May 2020

A Total Synthesis of Millingtonine A

scientific article published on 19 January 2012

A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor

scientific article

A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic.

scientific article published on 29 November 2017

A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist

scientific article published on November 2010

A continuous flow synthesis and derivatization of 1,2,4-thiadiazoles

scientific article published on 23 January 2017

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

scientific article published on 24 March 2006

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

scientific article published on 01 December 2006

A flow-based synthesis of imatinib: the API of Gleevec

scientific article published on 5 March 2010

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

scientific article published on 31 January 2011

A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1.

scientific article published on 16 April 2013

A modular flow reactor for performing Curtius rearrangements as a continuous flow process

scientific article published on 12 March 2008

A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

scientific article published on 01 February 2015

A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis

scientific article published on 27 July 2005

A solid-supported arylboronic acid catalyst for direct amidation

scientific article published on 01 March 2019

A “Catch–React–Release” Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

scientific article published on 19 July 2012

Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 Continuous Manufacturing Symposium

scientific article

An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

scientific article published on 18 December 2012

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals ⬇️

scientific article

An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

scientific article

Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions

scientific article published on 12 March 2008

Batch and Flow Synthesis of Pyrrolo[1,2-a]-quinolines via an Allene-Based Reaction Cascade

scientific article published on 28 October 2015

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2.

scientific article published on 20 January 2015

Catalytic Chan-Lam coupling using a 'tube-in-tube' reactor to deliver molecular oxygen as an oxidant

scientific article

Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters

scientific article published on 20 May 2009

Continuous flow reaction monitoring using an on-line miniature mass spectrometer

scientific article published on 01 September 2012

Continuous-Flow Hofmann Rearrangement Using Trichloroisocyanuric Acid for the Preparation of 2-Benzoxazolinone

scientific article published in 2022

Continuous-Flow Synthesis of 2H-Azirines and Their Diastereoselective Transformation to Aziridines

Copper-Mediated Nitrosation: 2-Nitrosophenolato Complexes and Their Use in the Synthesis of Heterocycles

scientific article published on 16 November 2019

Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly

scientific article published on 23 February 2011

Diastereoselective Synthesis and Diversification of Highly Functionalized Cyclopentanones

Diastereoselective Trifluoroacetylation of Highly Substituted Pyrrolidines by a Dakin-West Process.

scientific article published on 17 November 2016

Enzymatic Oxidative Cyclisation Reactions Leading to Dibenzoazocanes

Establishing a Flow Process to Coumarin-8-Carbaldehydes as Important Synthetic Scaffolds

scientific article published on 10 July 2012

Ethyl 2-hydroxy-2-phenyl-2-(thiazol-2-yl)acetate

Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole-2-carboxylate

Exploring Flow Procedures for Diazonium Formation

scientific article published on 14 July 2016

Flow Hydrodediazoniation of Aromatic Heterocycles.

scientific article published on 24 May 2019

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

scientific article

Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines

scientific article published on 19 July 2007

Flow carbonylation of sterically hindered ortho-substituted iodoarenes

scientific article published on 19 July 2016

Flow ozonolysis using a semipermeable Teflon AF-2400 membrane to effect gas-liquid contact.

scientific article

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

scientific article published on 06 March 2015

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

article

Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating

scientific article published in May 2005

Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.

scientific article

Indium- and Zinc-Mediated Acyloxyallylation of Protected and Unprotected Aldotetroses-Revealing a Pronounced Diastereodivergence and a Fundamental Difference in the Performance of the Mediating Metal.

scientific article published on 25 January 2018

KMnO4-Mediated Oxidation as a Continuous Flow Process

scientific article published on 01 August 2010

Large-Scale Synthesis of Crystalline 1,2,3,4,6,7-Hexa-O-acetyl-l-glycero-α-d-manno-heptopyranose

scientific article published on 10 March 2015

Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing

scientific article published on 17 November 2018

Microwave and flow syntheses of Pseudomonasquinolone signal (PQS) and analogues

article

Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines

scientific article

Microwave reactions under continuous flow conditions

scientific article published on December 2007

Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations

scientific article

Molybdenum(II)- and Tungsten(II)-Catalyzed Allylic Substitution

scientific article published on 01 April 1999

Molybdenum(II)-Catalyzed Allylation of Electron-Rich Aromatics and Heteroaromatics

scientific article published on 01 April 1999

Molybdenum(II)-catalyzed allylic substitution

Multi-Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C

scientific article published on 01 May 2004

Multi-step synthesis by using modular flow reactors: the preparation of yne--ones and their use in heterocycle synthesis

scientific article published on 01 January 2010

Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles.

scientific article published in January 2009

New tools and concepts for modern organic synthesis

scientific article

Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modes

scientific article published on 11 August 2005

Organic synthesis in a changing world

scientific article

Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Pharmaceutical strategy and innovation: an academics perspective

scientific article published on June 2007

Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil

article

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

scientific article published on 27 September 2010

Preparation of the Neolignan Natural Product Grossamide by a Continuous-Flow Process

Protein domain-based prediction of drug/compound-target interactions and experimental validation on LIM kinases

scientific article published on 29 November 2021

Rearrangement of 3-Hydroxyazetidines into 2-Oxazolines

scientific article published on 05 May 2020

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

scientific article published on 16 December 2010

Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

Solid supported reagents in multi-step flow synthesis

article

Solid-supported reagents for multi-step organic synthesis: preparation and application.

scientific article

Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

Sustainable Synthesis of Thioimidazoles via Carbohydrate-Based Multicomponent Reactions

scientific article published on 21 November 2014

Syn-Ethyl 1-hydroxy-7-methoxy-2,3-dihydro-1H-pyrrolo[3,4-b]quinolone-3-carboxylate HCl Salt

Syngas-Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes

Synthesis of (-)-Hennoxazole A: Integrating Batch and Flow Chemistry Methods

Synthesis of 1,3,6-Trisubstituted Azulenes

scientific article published on 11 November 2015

Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions Using a Modular Flow Reactor

Synthesis of Alkaloid Natural Products Using Solid-Supported Reagents and Scavengers

article published in 2005

Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

scientific article published on 08 July 2014

Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods

scientific article

Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates

scientific article published on 28 September 2009

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

scientific article published on 16 April 2007

Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

scientific article published on 22 December 2010

The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

scientific article published on 21 September 2011

The Synthesis and Utility of Metal-Nitrosophenolato Compounds-Highlighting the Baudisch Reaction

scientific article published on 06 November 2019

The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor

article

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

scientific article published on 8 December 2011

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors.

scientific article published in April 2010

The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

scientific article published on 10 February 2010

The flow synthesis of heterocycles for natural product and medicinal chemistry applications ⬇️

scientific article published on October 20, 2010

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

scientific article

The rapid generation of isothiocyanates in flow

scientific article published on 8 August 2013

The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib

scientific article published on 18 December 2012

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

scientific article

The synthesis of neurotensin antagonist SR 48692 for prostate cancer research.

scientific article published on 6 May 2013

Thiazole formation through a modified Gewald reaction

scientific article

Total syntheses of natural products containing spirocarbocycles

scientific article published on 10 September 2015

Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents

article by Ian R. Baxendale et al published August 2002 in Tetrahedron

Unprecedented Alkene Transposition in Phthalate–Amino Acid Adducts

[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

article

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