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List of works by Lawreen Connors

A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics

scientific article published on 21 July 2018

A new era of amyloidosis: the trends at a major US referral centre

scientific article published on 15 July 2019

A new lysozyme tyr54asn mutation causing amyloidosis in a family of Swedish ancestry with gastrointestinal symptoms

scientific article published on 14 September 2012

A rare transthyretin mutation (Asp18Glu) associated with cardiomyopathy

scientific article

A simple screening test for variant transthyretins associated with familial transthyretin amyloidosis using isoelectric focusing

scientific article published in September 1998

AL-Base: a visual platform analysis tool for the study of amyloidogenic immunoglobulin light chain sequences

scientific article published on March 2009

Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue.

scientific article

Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway.

scientific article

Association of acquired von Willebrand syndrome with AL amyloidosis

scientific article published on 01 May 2007

Biophysical analysis of normal transthyretin: implications for fibril formation in senile systemic amyloidosis

scientific article published in June 2001

Blood Proteomic Profiling in Inherited (ATTRm) and Acquired (ATTRwt) Forms of Transthyretin-Associated Cardiac Amyloidosis.

scientific article published on 14 February 2017

Cellular response of cardiac fibroblasts to amyloidogenic light chains

scientific article published on January 2005

Characterization of transthyretin mutants from serum using immunoprecipitation, HPLC/electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry.

scientific article

Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysis

scientific article

Clinical features and survival in senile systemic amyloidosis: comparison to familial transthyretin cardiomyopathy

scientific article published on June 2011

Cooperative stabilization of transthyretin by clusterin and diflunisal.

scientific article

Detailed Structural Analysis of Amyloidogenic Wild-Type Transthyretin Using a Novel Purification Strategy and Mass Spectrometry

article

Detection of high-molecular-weight amyloid serum protein complexes using biological on-line tracer sedimentation.

scientific article

Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis

scientific article published on 12 October 2011

Dysregulation of miRNAs in AL amyloidosis

scientific article published on 11 August 2011

Effect of diflunisal on clusterin levels in ATTRwt amyloidosis

scientific article published on 01 January 2019

Evidence for a functional role of the molecular chaperone clusterin in amyloidotic cardiomyopathy.

scientific article

Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin

scientific article

Familial wild-type transthyretin cardiomyopathy

scientific article published on 01 March 2017

Features of atrial fibrillation in wild-type transthyretin cardiac amyloidosis: a systematic review and clinical experience

scientific article published on 19 June 2018

Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt).

scientific article

Heart Failure Resulting From Age-Related Cardiac Amyloid Disease Associated With Wild-Type Transthyretin: A Prospective, Observational Cohort Study.

scientific article

Hereditary Renal Amyloidosis Associated With a Novel Apolipoprotein A-II Variant.

scientific article published on 29 July 2017

Heterogeneity in primary structure, post-translational modifications, and germline gene usage of nine full-length amyloidogenic kappa1 immunoglobulin light chains

scientific article

High-dose melphalan and autologous stem cell transplantation for AL amyloidosis: recent trends in treatment-related mortality and 1-year survival at a single institution

scientific article published on June 2011

Homozygosity for the V122I mutation in transthyretin is associated with earlier onset of cardiac amyloidosis in the African American population in the seventh decade of life.

scientific article published on 30 October 2013

Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress

scientific article published on 25 March 2004

Identification of S-sulfonation and S-thiolation of a novel transthyretin Phe33Cys variant from a patient diagnosed with familial transthyretin amyloidosis

scientific article

Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model

scientific article published on 08 February 2017

Immunoglobulin heavy light chain test quantifies clonal disease in patients with AL amyloidosis and normal serum free light chain ratio

scientific article published on 28 September 2016

In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis

scientific article published on 20 June 2017

Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis.

scientific article published on 31 October 2013

Isolation and characterization of a kappa amyloid fibril protein

scientific article published on 01 September 1985

Lowered prealbumin levels in patients with familial amyloid polyneuropathy (FAP) and their non-affected but at risk relatives

scientific article

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity

scientific article published on 01 May 2015

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity.

scientific article

Metabolic phenotype in an AL amyloidosis transgenic mouse model.

scientific article published on June 2011

Monoclonal gammopathy of undetermined significance in systemic transthyretin amyloidosis (ATTR).

scientific article published on 9 February 2018

Nephelometric measurement of human serum prealbumin and correlation with acute-phase proteins CRP and SAA: results in familial amyloid polyneuropathy

scientific article published on 01 October 1984

Oxidative Post-Translational Modifications of an Amyloidogenic Immunoglobulin Light Chain Protein

scientific article published on 8 November 2016

Preclinical development of siRNA therapeutics for AL amyloidosis.

scientific article published on 12 May 2011

Predictors of Mortality in Light Chain Cardiac Amyloidosis with Heart Failure.

scientific article published on 12 June 2019

Prescription rates of protective co-therapy for NSAID users at high GI risk and results of attempts to improve adherence to guidelines

scientific article

Prevalence of mutant ATTR cardiac amyloidosis in elderly African Americans with heart failure

scientific article published on 20 October 2017

Quantitative serum free light chain assay in the diagnostic evaluation of AL amyloidosis

scientific article

Race/ethnicity in systemic AL amyloidosis: perspectives on disease and outcome disparities

scientific article published on 10 November 2020

Retinol binding protein 4 (RBP4) concentration identifies V122I transthyretin cardiac amyloidosis.

scientific article published in March 2017

Role of endocytic inhibitory drugs on internalization of amyloidogenic light chains by cardiac fibroblasts

scientific article

Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils

scientific article

Selective binding of nifedipine to amyloid fibrils

Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis.

scientific article

Sequence Communication: Tabulation of transthyretin (TTR) variants as of 1/1/2000

scientific article published on 01 March 2000

Serum Proteomic Variability Associated with Clinical Phenotype in Familial Transthyretin Amyloidosis (ATTRm).

scientific article published on 18 September 2017

Serum transthyretin levels in senile systemic amyloidosis: effects of age, gender and ethnicity

scientific article published on December 2008

Soft tissue, joint, and bone manifestations of AL amyloidosis: clinical presentation, molecular features, and survival

scientific article published on 01 November 2007

Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity

scientific article

Structural studies of serum clusterin in ATTRwt amyloidosis

scientific article published on 01 January 2019

Tabulation of human transthyretin (TTR) variants, 2003

article

The Critical Role of the Constant Region in Thermal Stability and Aggregation of Amyloidogenic Immunoglobulin Light Chain ⬇️

scientific article published on October 20, 2010

The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation

scientific article

The pathogenesis and biochemistry of amyloidosis

scientific article

Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma

scientific article

Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils

scientific article

Transthyretin amyloidosis associated with a novel variant (Trp41Leu) presenting with vitreous opacities

scientific article

Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease

scientific article published on 25 June 2018

Use of Serum Transthyretin as a Prognostic Indicator and Predictor of Outcome in Cardiac Amyloid Disease Associated With Wild-Type Transthyretin.

scientific article published in February 2018

Use of Ventilatory Efficiency Slope as a Marker for Increased Mortality in Wild-Type Transthyretin Cardiac Amyloidosis

scientific article published on 09 April 2019

Vertebral compression fractures as the initial presentation of AL amyloidosis: case series and review of literature.

scientific article published on 24 June 2015

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