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List of works by Roch-Philippe Charles

4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation

scientific article published on 13 May 2015

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.

scientific article

Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis

scientific article

Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake

scientific article

Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance

scientific article

Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo.

scientific article

Conditional gene targeting of the ENaC subunit genes Scnn1b and Scnn1g

scientific article published on 26 November 2008

E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor

scientific article published on 18 April 2012

MEK Inhibition Induces Therapeutic Iodine Uptake in a Murine Model of Anaplastic Thyroid Cancer

scientific article published on 21 November 2018

Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse

scientific article

Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method

scientific article published on 12 October 2015

Overview of Genetically Engineered Mouse Models of Papillary and Anaplastic Thyroid Cancers: Enabling Translational Biology for Patient Care Improvement

scientific article published on June 2015

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. ⬇️

scientific article

PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models

scientific article

PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors

scientific article published on 11 October 2017

Postnatal requirement of the epithelial sodium channel for maintenance of epidermal barrier function

scientific article published on 26 November 2007

Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis

scientific article published on 31 October 2017

The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer.

scientific article published on 16 May 2019

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

scientific article published on 21 September 2018

The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.

scientific article

The epidermal barrier function is dependent on the serine protease CAP1/Prss8

scientific article

The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes.

scientific article published on 27 February 2013

Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import

scientific article

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