List of works - Alba Naudí

A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans.

scientific article published on 24 March 2016

Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy

scientific article published on 01 August 2018

Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.

scientific article

Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q₁₀.

scientific article

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.

scientific article

Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study

scientific article published on 01 October 2019

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

scientific article

Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.

scientific article published on 25 June 2011

Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart

article

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

scientific article published on 15 March 2015

Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease

scientific article

Dietary Protein Restriction Decreases Oxidative Protein Damage, Peroxidizability Index, and Mitochondrial Complex I Content in Rat Liver

scientific article published on 01 April 2007

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

scientific article

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.

scientific article published on 28 November 2008

Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver

scientific article published on 08 May 2007

Effect of every other day feeding on mitochondrial free radical production and oxidative stress in mouse liver

scientific article published in June 2008

Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart.

scientific article

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

scientific article published on 13 May 2012

Effects of increased iron intake during the neonatal period on the brain of adult AbetaPP/PS1 transgenic mice.

scientific article published in January 2010

Estudio de la vulnerabilidad neuronal selectiva en el sistema nervioso central humano

scientific article published on 05 September 2013

Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage.

scientific article published on 25 February 2012

Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.

scientific article published on 30 April 2010

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver.

scientific article

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart

scientific article published on 18 October 2011

Glycation of mitochondrial proteins, oxidative stress and aging

scientific article published on 26 March 2010

Human Aging Is a Metabolome-related Matter of Gender.

scientific article published on 26 May 2015

Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.

scientific article published on 12 April 2014

Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease

scientific article published on 23 July 2008

Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.

scientific article published on 8 December 2013

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

scientific article

Lipidomics of human brain aging and Alzheimer's disease pathology.

scientific article published on 19 June 2015

Long lifespans have evolved with long and monounsaturated fatty acids in birds

scientific article published on 21 August 2015

Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance

scientific article published on 5 October 2017

Membrane lipid unsaturation as physiological adaptation to animal longevity.

scientific article published on 17 December 2013

Metabolomics of human brain aging and age-related neurodegenerative diseases

scientific article

Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease.

scientific article published in April 2011

Modification of brain lipids but not phenotype in alpha-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids

scientific article published on 12 November 2009

Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau

scientific article published on 10 September 2015

Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions.

scientific article published on 5 February 2013

Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy

scientific article

Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy

scientific article

Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype.

scientific article

Plasma long-chain free fatty acids predict mammalian longevity.

scientific article

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.

scientific article published on 4 August 2016

Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system.

scientific article published on 6 February 2017

Sixty years old is the breakpoint of human frontal cortex aging

scientific article published on 12 December 2016

Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex

scientific article published on 08 December 2016

Specific lipidome signatures in central nervous system from methionine-restricted mice.

scientific article published on 30 April 2013

Stanozolol treatment decreases the mitochondrial ROS generation and oxidative stress induced by acute exercise in rat skeletal muscle

scientific article published on 16 December 2010

Target of rapamycin activation predicts lifespan in fruit flies.

scientific article

The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.

scientific article published on 6 September 2010

Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage

scientific article published in December 2008

Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy

scientific article published on 23 February 2010

List of works by Alba Naudí

A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans.

Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy

Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.

Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q₁₀.

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.

Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.

Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease

Dietary Protein Restriction Decreases Oxidative Protein Damage, Peroxidizability Index, and Mitochondrial Complex I Content in Rat Liver

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.

Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver

Effect of every other day feeding on mitochondrial free radical production and oxidative stress in mouse liver

Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart.

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

Effects of increased iron intake during the neonatal period on the brain of adult AbetaPP/PS1 transgenic mice.

Estudio de la vulnerabilidad neuronal selectiva en el sistema nervioso central humano

Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage.

Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver.

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart

Glycation of mitochondrial proteins, oxidative stress and aging

Human Aging Is a Metabolome-related Matter of Gender.

Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.

Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease

Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

Lipidomics of human brain aging and Alzheimer's disease pathology.

Long lifespans have evolved with long and monounsaturated fatty acids in birds

Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance

Membrane lipid unsaturation as physiological adaptation to animal longevity.

Metabolomics of human brain aging and age-related neurodegenerative diseases

Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease.

Modification of brain lipids but not phenotype in alpha-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids

Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau

Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions.

Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy

Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy

Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype.

Plasma long-chain free fatty acids predict mammalian longevity.

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.

Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system.

Sixty years old is the breakpoint of human frontal cortex aging

Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex

Specific lipidome signatures in central nervous system from methionine-restricted mice.

Stanozolol treatment decreases the mitochondrial ROS generation and oxidative stress induced by acute exercise in rat skeletal muscle

Target of rapamycin activation predicts lifespan in fruit flies.

The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.

Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage

Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy