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List of works by Thorsten Hoppe

A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress

scientific article published on 4 October 2005

A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation

scientific article published on 7 April 2006

A novel interaction between aging and ER overload in a protein conformational dementia

scientific article published on 18 January 2013

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

scientific article

A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans

scientific article

Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.

scientific article

Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo

scientific article

Analysis of ubiquitin-dependent proteolysis in Caenorhabditis elegans

scientific article published on January 2012

Author Correction: Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling

scientific article published on 01 January 2020

Author Correction: The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients

scientific article published on 17 February 2020

C. elegans, a model for aging with high-throughput capacity

article

CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication

scientific article

CHIPped balance of proteostasis and longevity

scientific article published on 27 October 2017

Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication

scientific article

Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans

scientific article published on 6 November 2014

Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity

scientific article published on 5 September 2017

Chaperoning myosin assembly in muscle formation and aging

scientific article published on 17 July 2013

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

scientific article published on 4 February 2016

Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD).

scientific article published on 21 August 2017

Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP

scientific article

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

scientific article published on 25 August 2013

Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome

scientific article

Double-edged alliance: mitochondrial surveillance by the UPS and autophagy

scientific article published on 04 September 2015

E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

scientific article published on 26 September 2016

ERADicate Tumor Progression with Metformin

scholarly article by Lena-Sophie Dreher published in August 2018

Erratum: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

scientific article published on 17 May 2016

Faculty of 1000 evaluation for A conserved ubiquitination pathway determines longevity in response to diet restriction

Faculty of 1000 evaluation for A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

Faculty of 1000 evaluation for AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP

Faculty of 1000 evaluation for AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics

Faculty of 1000 evaluation for ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation

Faculty of 1000 evaluation for ATPase-dependent quality control of DNA replication origin licensing

Faculty of 1000 evaluation for Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint

Faculty of 1000 evaluation for Autophagy mediates degradation of nuclear lamina

Faculty of 1000 evaluation for C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway

Faculty of 1000 evaluation for C. elegans mutant identification with a one-step whole-genome-sequencing and SNP mapping strategy

Faculty of 1000 evaluation for Cdc48/p97 mediates UV-dependent turnover of RNA Pol II

Faculty of 1000 evaluation for Chk1 is required for spindle checkpoint function

Faculty of 1000 evaluation for Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

Faculty of 1000 evaluation for Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function

Faculty of 1000 evaluation for HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

Faculty of 1000 evaluation for Loss of autophagy in the central nervous system causes neurodegeneration in mice

Faculty of 1000 evaluation for NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway

Faculty of 1000 evaluation for Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins

Faculty of 1000 evaluation for Non-transcriptional control of DNA replication by c-Myc

Faculty of 1000 evaluation for Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum

Faculty of 1000 evaluation for Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions

Faculty of 1000 evaluation for Protein quality control at the inner nuclear membrane

Faculty of 1000 evaluation for RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination

Faculty of 1000 evaluation for Reduced insulin/IGF-1 signaling restores germ cell immortality to caenorhabditis elegans Piwi mutants

Faculty of 1000 evaluation for Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril

Faculty of 1000 evaluation for Single-copy insertion of transgenes in Caenorhabditis elegans

Faculty of 1000 evaluation for Two neurons mediate diet-restriction-induced longevity in C. elegans

Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin ⬇️

scientific article published on July 19, 2012

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Hepatic ERAD takes control of the organism

scientific article published on 02 November 2018

Hexosamine pathway metabolites enhance protein quality control and prolong life.

scientific article published in March 2014

It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin

scientific article published on 25 May 2016

Less is more: how protein degradation regulates muscle development

article

Life and destruction: ubiquitin-mediated proteolysis in aging and longevity ⬇️

scientific article published on November 11, 2010

Limited proteolysis: DisRUPting proteasomal inhibition

scientific article published in August 2014

Membrane-bound transcription factors: regulated release by RIP or RUP.

scientific article

MicroRNAs meet calcium: joint venture in ER proteostasis

scientific article

Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone

scientific article

Multiubiquitylation by E4 enzymes: 'one size' doesn't fit all.

scientific article

Organismal Protein Homeostasis Mechanisms

scientific article published on 01 August 2020

Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system

scientific article published on April 2014

Protein quality control gets muscle into shape

scientific article published on 19 May 2008

Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly

scientific article published on 06 February 2020

Regulation of the DNA damage response by ubiquitin conjugation

scientific article

Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans

scientific article published in August 2004

Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis

scientific article

Reversible 26S proteasome disassembly upon mitochondrial stress

scholarly article by Nurit Livnat-Levanon published in September 2015

Reversible 26S proteasome disassembly upon mitochondrial stress.

scientific article

Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin

scientific article

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

scientific article

Stefan Jentsch (1955-2016)-Maestro of the ubiquitin family

scientific article

Stressed Out: Mitohormesis Is Crossing Borders

scientific article published on 28 March 2018

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

scientific article

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

scientific article published on 13 February 2011

The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans

scientific article

The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans

scientific article

The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover

scientific article

The Ubiquitin Proteasome System and Muscle Development

The Ubiquitin Proteasome System and Muscle Development

article

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

scientific article published on 11 December 2019

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients

scientific article published in Nature Communications

The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy

scientific article published on 18 March 2007

The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication

scientific article published on 06 January 2009

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.

scientific article

Think locally: control of ubiquitin-dependent protein degradation in neurons

scientific article published on 12 December 2008

Too salty for worms: hypertonic stress challenges proteostasis networks. Focus on “Hypertonic stress induces rapid and widespread protein damage in C. elegans” ⬇️

scientific article published on June 29, 2011

Ub and Down: Ubiquitin Exercise for the Elderly

Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA.

scientific article published on 14 March 2013

Ubiquitin sets the timer: impacts on aging and longevity.

scientific article published on April 2014

Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis

article published in 2018

Western blot analysis of the autophagosomal membrane protein LGG-1/LC3 in Caenorhabditis elegans

scientific article published on 04 February 2019

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