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List of works by Kamil Musílek

(-)-CHANA, a fluorogenic probe for detecting amyloid binding alcohol dehydrogenase HSD10 activity in living cells

scientific article

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.

scientific article published in December 2018

6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: synthesis and antimicrobial activity

scientific article published on 28 September 2014

7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.

scientific article

7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies.

scientific article published on 20 February 2013

A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication

scientific article published on 25 May 2016

A Direct interaction between mitochondrial proteins and amyloid-β peptide and its significance for the progression and treatment of Alzheimer`s disease.

scientific article

A comparison of neuroprotective efficacy of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in tabun-poisoned rats.

scientific article

A comparison of neuroprotective efficacy of the oxime K203 and its fluorinated analogue (KR-22836) with obidoxime in Tabun-poisoned rats

scientific article published on November 2010

A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice

scientific article published on 10 December 2010

A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice

scientific article published in June 2009

A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice

scientific article published in August 2010

A comparison of the ability of newly-developed bispyridinium oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) to counteract the acute neurotoxicity of soman in rats

scientific article published on October 2010

A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice

scientific article published on 17 November 2011

A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats

scientific article published on March 2009

A comparison of the neuroprotective efficacy of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.

scientific article

A comparison of the potency of newly developed oximes (K347, K628) and currently available oximes (obidoxime, HI-6) to counteract acute neurotoxic effects of Tabun in rats.

scientific article published on January 2010

A comparison of the reactivating and therapeutic efficacy of newly developed bispyridinium oximes (K250, K251) with commonly used oximes against tabun in rats and mice.

scientific article published in August 2009

A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice

scientific article published in July 2010

A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice.

scientific article published on 24 October 2014

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.

scientific article published in March 2015

A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice

scientific article published on 01 December 2008

A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice

scientific article published on 01 January 2008

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

scientific article published on 21 February 2018

A resurrection of 7-MEOTA: a comparison with tacrine.

scientific article published in October 2013

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy

scientific article published on 30 May 2020

An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice

scientific article published in January 2009

An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice

scientific article published on 26 October 2007

An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning

scientific article published on 01 March 2012

Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties

scientific article published on 14 August 2014

Benzothiazoles - scaffold of interest for CNS targeted drugs.

scientific article

Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer's Disease Treatment

scientific article published on 17 March 2020

Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods.

scientific article

Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes

scientific article

Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators

scientific article published on 22 June 2010

Cholinergic antagonist 3-quinuclidinyl benzilate - Impact on learning and memory in Wistar rats

scientific article published on 13 March 2014

Comparative determination of the efficacy of bispyridinium oximes in paraoxon poisoning

scientific article published in June 2015

Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).

scientific article published on 9 October 2007

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.

scientific article published on 2 October 2015

Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides.

scientific article published on 21 December 2009

Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment

scientific article published on 30 May 2016

Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review.

scientific article

Development and validation of a FIA/UV-vis method for pK(a) determination of oxime based acetylcholinesterase reactivators

scientific article published on 11 September 2015

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy

scientific article published on 01 December 2019

Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy

scientific article

Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats.

scientific article published on June 2009

Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats

scientific article published on 14 November 2008

Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain

scientific article

Effective bisquaternary reactivators of tabun-inhibited AChE.

scientific article published in November 2005

Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime.

scientific article

Efficient preparation of organic substrate-RNA conjugates via in vitro transcription.

scientific article published in June 2005

Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity.

scientific article published on October 2008

Evaluation of aflatoxin B1--acetylcholinesterase dissociation kinetic using the amperometric biosensor technology: prospect for toxicity mechanism

scientific article published on 01 March 2010

Evaluation of oxime k203 as antidote in tabun poisoning

scientific article published on 01 March 2009

Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX).

scientific article published in January 2007

Evaluation of the neuroprotective efficacy of newly developed oximes (K206, K269) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats

scientific article published on 25 December 2008

Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment

scientific article published on 03 November 2015

Fluctuation in the ergosterol and deoxynivalenol content in barley and malt during malting process

scientific article published on 12 March 2010

Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent

scientific article published on 25 July 2009

Friend or enemy? Review of 17β-HSD10 and its role in human health or disease

scientific article published on 19 April 2020

From pyridinium-based to centrally active acetylcholinesterase reactivators

scientific article published on January 2014

In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication

scientific article published on 19 July 2017

In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties

scientific article

In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators

scientific article published in September 2013

In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase ⬇️

scientific article published on 23 March 2011

In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning - a new hope or a blind alley?

scientific article published on 11 January 2018

In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity

scientific article published on 30 December 2010

In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate

scientific article

In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases

scientific article published in February 2007

In vivo evaluation of cholinesterase activity, oxidative stress markers, cyto- and genotoxicity of K048 oxime–a promising antidote against organophosphate poisoning

scientific article published on 01 April 2014

Intended pharmacotherapeutical approaches of Alzheimer's disease therapy

scientific article published in February 2012

Interaction of cholinesterase modulators with DNA and their cytotoxic activity.

scientific article published in December 2013

Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase

scientific article

LC-MS/MS approaches for the assay of bis-quaternary pyridinium oximes used as AChE reactivators in biological matrices

scientific article

Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase.

scientific article published on 25 December 2014

Methylacridinium and its cholinergic properties.

scientific article published on 30 June 2009

Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS)

scientific article published on 25 September 2018

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase

scientific article published on 27 January 2021

Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site of human acetylcholinesterase

scientific article published on 02 November 2018

Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.

scientific article published on 16 December 2010

Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase

scientific article published on 01 January 2016

Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.

scientific article published on 10 August 2007

Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies.

scientific article published in February 2010

Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase

scientific article published on 20 July 2008

New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin

scientific article published in October 2006

Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study

scientific article published on 07 September 2018

Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon

scientific article published in December 2009

Novel cholinesterase modulators and their ability to interact with DNA.

scientific article published on 17 June 2013

Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

scientific article published on 13 March 2007

Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase.

scientific article published in August 2010

Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase

scientific article published on 21 April 2016

Passive diffusion of acetylcholinesterase oxime reactivators through the blood-brain barrier: influence of molecular structure

scientific article published on 26 May 2010

Penetration of polar organic compounds through the blood-brain barrier

scientific article

Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs.

scientific article published on 23 March 2017

Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – Implications for early Myasthenia gravis treatment

scientific article published in February 2011

Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.

scientific article published on 20 January 2010

Preparation of benzalkonium salts differing in the length of a side alkyl chain

scientific article published on 24 October 2007

Preparation of quinolinium salts differing in the length of the alkyl side chain.

scientific article published on 25 May 2012

Preparation of the pyridinium salts differing in the length of the N-alkyl substituent

scientific article published on 19 March 2010

Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.

scientific article published on 31 October 2013

Preparation, in vitro screening and molecular modelling of monoquaternary compounds related to the selective acetylcholinesterase inhibitor BW284c51

scientific article published on 01 January 2014

Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.

scientific article published on 16 November 2010

Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment

scientific article published on 21 February 2011

Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016).

scientific article published on June 2017

Prophylaxis and post-exposure treatment of intoxications caused by nerve agents and organophosphorus pesticides

scientific article published in December 2013

Pyridinium oximes with ortho-positioned chlorine moiety exhibit improved physicochemical properties and efficient reactivation of human acetylcholinesterase inhibited by several nerve agents

scientific article published on 20 November 2018

QSAR Study of N-Myristoyltransferase Inhibitors of Antimalarial Agents

scientific article published on 13 September 2018

Quantification through TLC-Densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves

scientific article published on 15 September 2017

RNase T1 Refolding Assay for Determining Mitochondrial Cyclophilin D Activity: A Novel In Vitro Method Applicable in Drug Research and Discovery

scientific article published on 10 April 2020

RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker

scientific article published on 28 March 2008

Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase

scientific article published on 11 June 2014

Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase

scientific article published on 22 March 2012

Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker.

scientific article published on 17 March 2010

Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127.

scientific article published on 15 May 2009

Reactivation potency of the acetylcholinesterase reactivator obidoxime is limited.

scientific article published in December 2009

Recent advances with 5-HT3 modulators for neuropsychiatric and gastrointestinal disorders

scientific article published on 01 March 2020

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

scientific article published on 07 September 2015

Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography

scientific article published on 5 April 2013

SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides.

scientific article

Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity

scientific article published on 8 December 2015

Structural modifications of dicationic acetylcholinesterase reactivators studied under ion-pairing mechanism in reversed-phase liquid chromatography

scientific article

Structural requirements of acetylcholinesterase reactivators.

scientific article

Structure-Activity Relationship for the Reactivators of Acetylcholinesterase Inhibited by Nerve Agent VX

scientific article published in June 2013

Structure-activity relationship of quaternary acetylcholinesterase inhibitors - outlook for early myasthenia gravis treatment.

scientific article published on January 2010

Study on medicinal chemistry of K203 in wistar rats and beagle dogs.

scientific article published in January 2013

Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase

scientific article published on 14 May 2019

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment

scientific article published on 27 December 2016

Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine—new tacrine derivate with cholinergic properties

scientific article published on 22 August 2011

Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.

scientific article published on 2 December 2010

Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.

scientific article published on 16 August 2010

Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.

scientific article

Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

scientific article published in August 2007

Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.

scientific article published on 24 August 2006

Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase

scientific article published in January 2008

Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos

scientific article published in May 2006

Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.

scientific article

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

scientific article published on 07 May 2018

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

scientific article published on 01 December 2020

Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator.

scientific article published on 20 August 2007

The development of new oximes and the evaluation of their reactivating, therapeutic and neuroprotective efficacy against tabun.

scientific article published on October 2008

The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder

scientific article

The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K456, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

scientific article published on 18 October 2012

The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

scientific article published in March 2014

The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor

scientific article published on 26 August 2014

The preparation,in vitroscreening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage

scientific article published on 15 March 2011

The present approaches to the development of prophylactic and therapeutic antidotes against nerve agents

scientific article published on June 2008

The progress in the cholinesterase quantification methods.

scientific article published on 26 September 2012

Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor

scientific article

Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system

scientific article

Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings.

scientific article published on January 2012

Two step synthesis of a non-symmetric acetylcholinesterase reactivator

scientific article published on 7 August 2007

Two-Step Mechanism of Cellular Uptake of Cationic Gold Nanoparticles Modified by (16-Mercaptohexadecyl)trimethylammonium Bromide

scientific article

Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE

scientific article published on 01 January 2015

Vector Control and Insecticidal Resistance in the African Malaria Mosquito Anopheles gambiae

scholarly article by Monika Schmidt et al published 16 July 2018 in Chemical Research in Toxicology

[Mitochondrial enzyme ABAD and its role in the development and treatment of Alzheimer's disease].

scientific article published in August 2012

[Tacrine and its derivatives in the therapy of Alzheimers disease].

scientific article published in October 2012

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