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List of works by Manuela Battaglia

A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome

scientific article published on May 2007

Abnormalities of the Exocrine Pancreas in Type 1 Diabetes

scientific article

All in (IL-) 1?

scientific article published in November 2015

Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplant

scientific article

Autoimmune diabetic patients undergoing allogeneic islet transplantation: are we ready for a regulatory T-cell therapy?

scientific article published on 28 July 2009

CXCR1/2 inhibition blocks and reverses type 1 diabetes in mice

scientific article

Calcineurin inhibitor-free immunosuppressive regimen in type 1 diabetes patients receiving islet transplantation: single-group phase 1/2 trial

scientific article published on December 2014

Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice

scientific article

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.

scientific article

Combination of an Antigen-Specific Therapy and an Immunomodulatory Treatment to Simultaneous Block Recurrent Autoimmunity and Alloreactivity in Non-Obese Diabetic Mice

scientific article published on 16 June 2015

Comment on M. Guillot-Delost et al. (2008;10:834-846): Clinical-grade preparation of human natural regulatory T cells encoding the thymidine kinase suicide gene as a safety gene

scientific article published in February 2009

Concise Review: Cell-Based Therapies and Other Non-Traditional Approaches for Type 1 Diabetes

scientific article

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

scientific article

Evidence for preferred MHC class II-TCR recognition independent of the source of bound peptide

scientific article published on 01 August 2002

Expanding human T regulatory cells with the mTOR-inhibitor rapamycin

scientific article published in January 2012

Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes

scientific article

Experiments by nature: lessons on type 1 diabetes.

scientific article published on January 2014

Generation of Donor-specific T Regulatory Type 1 Cells From Patients on Dialysis for Cell Therapy After Kidney Transplantation

scientific article published in August 2015

Heterogeneous CD3 expression levels in differing T cell subsets correlate with the in vivo anti-CD3-mediated T cell modulation

scientific article published on 2 February 2015

Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.

scientific article

Hurdles in therapy with regulatory T cells

scientific article published on September 2015

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo

scientific article published on 21 December 2016

Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice

scientific article

Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice

scientific article published on 23 July 2009

Immune intervention with T regulatory cells: past lessons and future perspectives for type 1 diabetes.

scientific article published on June 2011

Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells

scientific article published in June 2006

Induction of transplantation tolerance via regulatory T cells.

scientific article published on September 2006

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

scientific article

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

scientific article published on 21 November 2019

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

scientific article published in February 2018

Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice.

scientific article published on 7 March 2015

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

scientific article published in January 2017

Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes

scientific article published on January 2010

Neutrophils and type 1 autoimmune diabetes

scientific article published on January 2014

Neutrophils and type 1 diabetes: current knowledge and suggested future directions

scientific article published on 01 August 2019

Overlap of direct and indirect alloreactive T-cell repertoires when MHC polymorphism is limited to the peptide binding groove

scientific article published in February 2002

PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner.

scientific article published on 13 December 2014

Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412.

scientific article published on 19 September 2011

Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance.

scientific article published in January 2006

Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation

scientific article (publication date: 2011)

Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation.

scientific article published on 11 February 2010

Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells

scientific article published on 16 June 2008

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

scientific article published on 3 March 2005

Reduction of circulating neutrophils precedes and accompanies type 1 diabetes

scientific article published on 24 January 2013

Regulatory T cells: prospective for clinical application in hematopoietic stem cell transplantation.

scientific article

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.

scientific article published on August 2007

Relevance of hyperglycemia on the timing of functional loss of allogeneic islet transplants: implication for mouse model

scientific article published in January 2007

Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity.

scientific article published on 21 October 2013

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

scientific article published on 12 February 2008

Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors.

scientific article published on 4 June 2014

Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells

scientific article

Standardization in flow cytometry: correct sample handling as a priority

scientific article published on 16 November 2012

Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice

scientific article

Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner

scientific article

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

scientific article published on 01 December 2018

The Tregs' world according to GARP.

scientific article published in December 2009

The fate of human Treg cells.

scientific article

The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cells.

scientific article published on 10 May 2007

The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization

scientific article published on 01 October 2014

The puzzling world of murine T regulatory cells.

scientific article

The role of interleukin 10 in the control of autoimmunity.

scientific article

The streetlight effect in type 1 diabetes

scientific article

Towards an Earlier and Timely Diagnosis of Type 1 Diabetes: Is it Time to Change Criteria to Define Disease Onset?

scientific article published on December 2015

Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.

scientific article published on January 2014

Tr1 cells: from discovery to their clinical application.

scientific article

Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen

scientific article published on 8 July 2013

Type 1 regulatory T (Tr1) cells: from the bench to the bedside

scientific article published on 28 November 2012

WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells

scientific article published on 12 February 2007

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