List of works - Matthew N. Rasband

A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination

scientific article

A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.

scientific article

A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier

scientific article

Age-related molecular reorganization at the node of Ranvier

scientific article published on April 2006

Alterations in Intrinsic Membrane Properties and the Axon Initial Segment in a Mouse Model of Angelman Syndrome ⬇️

scientific article published on November 30, 2011

Amyloid-β plaques disrupt axon initial segments

scientific article published on 21 April 2016

An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier

scientific article

An αII Spectrin-Based Cytoskeleton Protects Large-Diameter Myelinated Axons from Degeneration

scientific article published on 16 October 2017

AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity.

scientific article published on 10 November 2008

Anti-GM1 antibodies cause complement-mediated disruption of sodium channel clusters in peripheral motor nerve fibers

scientific article published in April 2007

Axon initial segment-associated microglia.

scientific article published in February 2015

Axon initial segments: diverse and dynamic neuronal compartments

scientific article

Axon initial segments: structure, function, and disease

scientific article published on 11 May 2018

BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells

scientific article published on May 2015

BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier ⬇️

scientific article published on 01 August 2004

BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments

scientific article

Blast Wave Exposure Impairs Memory and Decreases Axon Initial Segment Length ⬇️

scientific article published on 06 February 2013

CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS.

scientific article

Clustered K+ channel complexes in axons ⬇️

scientific article published on September 17, 2010

Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.

scientific article

Composition, assembly, and maintenance of excitable membrane domains in myelinated axons.

scientific article

Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors

scientific article

Converging on the origins of axonal ion channel clustering

scientific article

Cytoskeletal control of axon domain assembly and function

scientific article published on 17 May 2016

Cytoskeleton: Axons Earn Their Stripes ⬇️

scientific article published on 01 March 2013

Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS

scientific article

Di-rectifying Tau.

scientific article

Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury

scientific article

Distinct potassium channels on pain-sensing neurons

scientific article

Does paranode formation and maintenance require partitioning of neurofascin 155 into lipid rafts?

scientific article published in March 2004

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia

scientific article

Dysfunction of nodes of Ranvier: A mechanism for anti-ganglioside antibody-mediated neuropathies ⬇️

scientific article published on December 8, 2011

Dysfunction of the β2-spectrin-based pathway in human heart failure

scientific article published on 22 April 2016

Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination

scientific article published in August 2003

Early events in node of Ranvier formation during myelination and remyelination in the PNS

scientific article

Editorial

scientific article published on 01 November 2009

Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestation.

scientific article

Endogenously expressed Ranbp2 is not at the axon initial segment

scientific article published on 11 March 2021

Excitable domains of myelinated nerves: axon initial segments and nodes of Ranvier.

scientific article published in January 2013

Galveston Brain Injury Conference 2010: clinical and experimental aspects of blast injury

scientific article published in August 2012

Genetic Reduction of the α1 Subunit of Na/K-ATPase Corrects Multiple Hippocampal Phenotypes in Angelman Syndrome ⬇️

scientific article published on August 15, 2013

Glial Contributions to Neural Function and Disease

scientific article published on 4 September 2015

Glial ankyrins facilitate paranodal axoglial junction assembly

scientific article

Glial βII Spectrin Contributes to Paranode Formation and Maintenance

scientific article published on 31 May 2018

Intrinsic and extrinsic determinants of ion channel localization in neurons

scientific article published on 19 June 2006

IκBα is not required for axon initial segment assembly

scientific article

Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals

scientific article

Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.

scientific article

Maintenance of neuronal polarity ⬇️

scientific article published on June 1, 2011

Mapping axon initial segment structure and function by multiplexed proximity biotinylation

scientific article published on 03 January 2020

Mechanisms of hearing loss after blast injury to the ear.

scientific article

Mechanisms of node of Ranvier assembly

scientific article published on 25 November 2020

Membrane domain organization of myelinated axons requires βII spectrin

scientific article

Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation.

scientific article published in November 2006

Molecular mechanisms of node of Ranvier formation.

scientific article

Na+ channels get anchored...with a little help

scientific article published on December 2008

Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse

scientific article

Neural ECM molecules in axonal and synaptic homeostatic plasticity

scientific article

Neurofascin as a novel target for autoantibody-mediated axonal injury

scientific article

Neurofascin as a target for autoantibodies in peripheral neuropathies

scientific article published on 24 October 2012

Nodal β spectrins are required to maintain Na+ channel clustering and axon integrity

scientific article published on 13 February 2020

Novel forms of neurofascin 155 in the central nervous system: alterations in paranodal disruption models and multiple sclerosis

scientific article

Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly.

scientific article

Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons

scientific article published in November 2003

Postnatal development of synaptic structure proteins in pyramidal neuron axon initial segments in monkey prefrontal cortex

scientific article published on June 2009

Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2.

scientific article published on May 2008

Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography.

scientific article

Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins.

scientific article

Proteomic mapping provides powerful insights into functional myelin biology.

scholarly article

Reassembly of Excitable Domains after CNS Axon Regeneration.

scientific article published on August 2016

Remodeling of the axon initial segment after focal cortical and white matter stroke.

scientific article published on 11 December 2012

Remyelination alters the pattern of myelin in the cerebral cortex

scientific article published on 27 May 2020

Schwann cell spectrins modulate peripheral nerve myelination

scientific article

Serotonin modulates spike probability in the axon initial segment through HCN channels

scientific article

Short- and long-term plasticity at the axon initial segment

scientific article published on November 2011

Spectrin and ankyrin-based cytoskeletons at polarized domains in myelinated axons.

scientific article published on April 2008

Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton

scientific journal article

Subcellular patterning: axonal domains with specialized structure and function.

scientific article

Submembranous cytoskeletons stabilize nodes of Ranvier

scientific article

The Nodes of Ranvier: Molecular Assembly and Maintenance

scientific article published on 09 September 2015

The Polarity Protein Pals1 Regulates Radial Sorting of Axons

scientific article published in July 2015

The axon initial segment and the maintenance of neuronal polarity.

scientific article published on 14 July 2010

The axon initial segment in nervous system disease and injury ⬇️

scientific article published on November 1, 2011

The functional organization and assembly of the axon initial segment.

scientific article published on June 2008

The ins and outs of polarized axonal domains.

scientific article

The myelin-axolemmal complex: biochemical dissection and the role of galactosphingolipids

scientific article published in November 2003

The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier

scientific article published on 30 January 2017

Three mechanisms assemble central nervous system nodes of Ranvier

scientific article published on May 2013

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination

scientific journal article

Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.

scientific article

alphaII-spectrin is essential for assembly of the nodes of Ranvier in myelinated axons.

scientific article published in March 2007

betaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG.

scientific article

αII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function

scientific article published on 16 October 2017

β spectrin-dependent and domain specific mechanisms for Na+ channel clustering

scientific article published on 19 May 2020

List of works by Matthew N. Rasband

A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination

A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.

A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier

Age-related molecular reorganization at the node of Ranvier

Alterations in Intrinsic Membrane Properties and the Axon Initial Segment in a Mouse Model of Angelman Syndrome ⬇️

Amyloid-β plaques disrupt axon initial segments

An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier

An αII Spectrin-Based Cytoskeleton Protects Large-Diameter Myelinated Axons from Degeneration

AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity.

Anti-GM1 antibodies cause complement-mediated disruption of sodium channel clusters in peripheral motor nerve fibers

Axon initial segment-associated microglia.

Axon initial segments: diverse and dynamic neuronal compartments

Axon initial segments: structure, function, and disease

BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells

BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier ⬇️

BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments

Blast Wave Exposure Impairs Memory and Decreases Axon Initial Segment Length ⬇️

CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS.

Clustered K+ channel complexes in axons ⬇️

Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.

Composition, assembly, and maintenance of excitable membrane domains in myelinated axons.

Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors

Converging on the origins of axonal ion channel clustering

Cytoskeletal control of axon domain assembly and function

Cytoskeleton: Axons Earn Their Stripes ⬇️

Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS

Di-rectifying Tau.

Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury

Distinct potassium channels on pain-sensing neurons

Does paranode formation and maintenance require partitioning of neurofascin 155 into lipid rafts?

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia

Dysfunction of nodes of Ranvier: A mechanism for anti-ganglioside antibody-mediated neuropathies ⬇️

Dysfunction of the β2-spectrin-based pathway in human heart failure

Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination

Early events in node of Ranvier formation during myelination and remyelination in the PNS

Editorial

Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestation.

Endogenously expressed Ranbp2 is not at the axon initial segment

Excitable domains of myelinated nerves: axon initial segments and nodes of Ranvier.

Galveston Brain Injury Conference 2010: clinical and experimental aspects of blast injury

Genetic Reduction of the α1 Subunit of Na/K-ATPase Corrects Multiple Hippocampal Phenotypes in Angelman Syndrome ⬇️

Glial Contributions to Neural Function and Disease

Glial ankyrins facilitate paranodal axoglial junction assembly

Glial βII Spectrin Contributes to Paranode Formation and Maintenance

Intrinsic and extrinsic determinants of ion channel localization in neurons

IκBα is not required for axon initial segment assembly

Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals

Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.

Maintenance of neuronal polarity ⬇️

Mapping axon initial segment structure and function by multiplexed proximity biotinylation

Mechanisms of hearing loss after blast injury to the ear.

Mechanisms of node of Ranvier assembly

Membrane domain organization of myelinated axons requires βII spectrin

Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation.

Molecular mechanisms of node of Ranvier formation.

Na+ channels get anchored...with a little help

Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse

Neural ECM molecules in axonal and synaptic homeostatic plasticity

Neurofascin as a novel target for autoantibody-mediated axonal injury

Neurofascin as a target for autoantibodies in peripheral neuropathies

Nodal β spectrins are required to maintain Na+ channel clustering and axon integrity

Novel forms of neurofascin 155 in the central nervous system: alterations in paranodal disruption models and multiple sclerosis

Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly.

Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons

Postnatal development of synaptic structure proteins in pyramidal neuron axon initial segments in monkey prefrontal cortex

Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2.

Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography.

Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins.

Proteomic mapping provides powerful insights into functional myelin biology.

Reassembly of Excitable Domains after CNS Axon Regeneration.

Remodeling of the axon initial segment after focal cortical and white matter stroke.

Remyelination alters the pattern of myelin in the cerebral cortex

Schwann cell spectrins modulate peripheral nerve myelination

Serotonin modulates spike probability in the axon initial segment through HCN channels

Short- and long-term plasticity at the axon initial segment

Spectrin and ankyrin-based cytoskeletons at polarized domains in myelinated axons.

Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton

Subcellular patterning: axonal domains with specialized structure and function.

Submembranous cytoskeletons stabilize nodes of Ranvier