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List of works by Gregers Wegener

'Let food be thy medicine, and medicine be thy food': Hippocrates revisited

scientific article published in February 2014

3D analysis of synaptic vesicle density and distribution after acute foot-shock stress by using serial section transmission electron microscopy.

scientific article

5-HT1A receptors in lithium-induced conditioned taste aversion

scientific article published on 01 September 1997

A Critical Role of Mitochondria in BDNF-Associated Synaptic Plasticity After One-Week Vortioxetine Treatment.

scientific article published on 5 March 2018

A Preclinical Study of Casein Glycomacropeptide as a Dietary Intervention for Acute Mania.

scientific article

A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats.

scientific article published on 12 December 2016

A gene-environment study of cytoglobin in the human and rat hippocampus

scientific article

A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression.

scientific article published on 2 October 2010

A new efficient method for synaptic vesicle quantification reveals differences between medial prefrontal cortex perforated and nonperforated synapses.

scientific article

A single dose of vortioxetine, but not ketamine or fluoxetine, increases plasticity-related gene expression in the rat frontal cortex

scientific article published on 25 May 2016

Acta Neuropsychiatrica 4.0.

scientific article published on 01 June 2011

Acta Neuropsychiatrica and Scandinavian College of Neuropsychopharmacology (SCNP).

scientific article published on 01 October 2011

Acta Neuropsychiatrica and social media

scientific article

Acta Neuropsychiatrica: 'A new beginning'.

scientific article published on February 2013

Acute Inescapable Stress Rapidly Increases Synaptic Energy Metabolism in Prefrontal Cortex and Alters Working Memory Performance

scientific article published on 16 March 2019

Acute stress rapidly increases the readily releasable pool of glutamate vesicles in prefrontal and frontal cortex through non-genomic action of corticosterone.

scientific article published in April 2014

Altered fecal microbiota composition in the Flinders sensitive line rat model of depression

scientific article published on 23 November 2018

An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats

scientific article

Animal models of depression and anxiety: What do they tell us about human condition?

scientific article published on December 2010

Antidepressant efficacy of high and low frequency transcranial magnetic stimulation in the FSL/FRL genetic rat model of depression.

scientific article published on 26 July 2016

Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression

scientific journal article

Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice

scientific article published in March 2003

Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation

scientific article published on 17 September 2019

Antidepressant-like effect of agmatine is not mediated by serotonin

scientific article published on 24 November 2007

Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene.

scientific article

Antidepressant-like effects induced by NMDA receptor blockade and NO synthesis inhibition in the ventral medial prefrontal cortex of rats exposed to the forced swim test

scientific article

Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation.

scientific article

Atypical Neurotransmitters and the Neurobiology of Depression.

scientific article published on 09 September 2015

Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase.

scientific article

Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression

scientific article published on 06 February 2019

Behavioral and systemic consequences of long-term inflammatory challenge

scientific article published on 28 August 2015

Brain proteome changes in female Brd1 mice unmask dendritic spine pathology and show enrichment for schizophrenia risk

scientific article published on 24 December 2018

Brain volumetric alterations accompanied with loss of striatal medium-sized spiny neurons and cortical parvalbumin expressing interneurons in Brd1 mice

scientific article published in Scientific Reports

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex

scientific article published on 04 June 2018

Central functions of neuropeptide Y in mood and anxiety disorders ⬇️

scientific article published on November 1, 2011

Changes in rat hippocampal CA1 synapses following imipramine treatment

scientific article published on 01 January 2008

Chronic desipramine prevents acute stress-induced reorganization of medial prefrontal cortex architecture by blocking glutamate vesicle accumulation and excitatory synapse increase

scientific article published on 13 December 2014

Chronic exposure to low doses of lipopolysaccharide and high-fat feeding increases body mass without affecting glucose tolerance in female rats

scientific article

Chronic lipopolysaccharide infusion fails to induce depressive-like behaviour in adult male rats

scientific article

Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner.

scientific article published on 7 June 2017

Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine

scientific article published on 01 February 2019

Chronic restraint stress affects serotonin transporter uptake kinetics but not binding sites in the rat hippocampus

scientific article

Chronic restraint stress increases the protein expression of VEGF and its receptor VEGFR-2 in the prefrontal cortex

scientific article published on 19 February 2015

Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats.

scientific article published on 23 February 2012

Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli

scientific article published on 28 February 2019

Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression.

scientific article published in August 2012

Decoding the Mechanism of Action of Rapid-Acting Antidepressant Treatment Strategies: Does Gender Matter?

scientific article published on 22 February 2019

Decreased in vivo α2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression

scientific article published on 7 January 2015

Depression and BMI influences the serum vascular endothelial growth factor level

scientific article published on 17 March 2014

Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level.

scientific article published on 6 June 2012

Detection of brain-derived neurotrophic factor (BDNF) in rat blood and brain preparations using ELISA: pitfalls and solutions

scientific article published on 5 January 2010

Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice

scientific article published on 16 March 2015

Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour

scientific article published on 18 February 2015

Differential brain, but not serum VEGF levels in a genetic rat model of depression

scientific article published in March 2010

Differential expression of postsynaptic NMDA and AMPA receptor subunits in the hippocampus and prefrontal cortex of the flinders sensitive line rat model of depression

scientific article published on 4 June 2016

Differential expression of synaptic proteins after chronic restraint stress in rat prefrontal cortex and hippocampus

scientific article published on 24 February 2011

Differential expression of synaptic vesicle proteins after repeated electroconvulsive seizures in rat frontal cortex and hippocampus.

scientific article published in September 2008

Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression

scientific article published on 28 May 2016

Diffusion-Weighted MRI and Quantitative Biophysical Modeling of Hippocampal Neurite Loss in Chronic Stress ⬇️

scientific article published on January 1, 2011

Discovery versus implementation research on mental disorders in low- and middle-income countries

scientific article

Drugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression-like behavior.

scientific article

Dual effect of nickel on L-arginine/nitric oxide system in RAW 264.7 macrophages

scientific article published on 15 February 2013

Effect of ischemic lesions in medial prefrontal cortex and nucleus accumbens on affective behavior in rats

scientific article published on 12 September 2019

Effects of anesthesia and species on the uptake or binding of radioligands in vivo in the Göttingen minipig

scientific article published on 08 September 2013

Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat

scientific journal article

Electroconvulsive seizures stimulate the vegf pathway via mTORC1 ⬇️

scientific article published on December 29, 2011

Electroconvulsive shocks decrease α2-adrenoceptor binding in the Flinders rat model of depression

scientific article published on 23 December 2014

Electroconvulsive stimulation differentially affects [11C]MDL100,907 binding to cortical and subcortical 5HT2A receptors in porcine brain

scientific article published on 19 March 2019

Elevated dopamine D1 receptor availability in striatum of Göttingen minipigs after electroconvulsive therapy

scientific article published in January 2017

Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression

scientific article published on 16 August 2016

Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals-relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats.

scientific article published on 28 July 2017

Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression

scientific article published on 01 October 2019

Evaluation of the relationship between hyperinsulinaemia and myocardial ischaemia/reperfusion injury in a rat model of depression.

scientific article

Expression of inflammatory markers in a genetic rodent model of depression

scientific article

Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour

scientific article published on 08 November 2021

Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism

scientific article published on 19 May 2016

GLP-1 receptor agonists have a sustained stimulatory effect on corticosterone release after chronic treatment

scientific article

Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: Effect of ketamine

scientific article

Gestational chronic mild stress: effects on acoustic startle in male offspring of rats

scientific article published on 26 January 2011

Grandmaternal high-fat diet primed anxiety-like behaviour in the second-generation female offspring

Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression

scientific article published on 01 February 2019

Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression

scientific article published in December 2010

Increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: role of 5HT 2A/C-receptors

scientific article published on 22 July 2006

Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression

scientific article

Inflammation, insulin resistance and neuroprogression in depression

scientific article published on 12 June 2019

Influence of diurnal phase on startle response in adult rats exposed to dexamethasone in utero

scientific article published on 21 December 2010

Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats

scientific article published on 20 July 2015

Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression

scientific article published on 2 October 2009

Investigating the role of protein kinase-G in the antidepressant-like response of sildenafil in combination with muscarinic acetylcholine receptor antagonism

scientific article published on 29 January 2010

Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma

scientific article published in July 2005

Isolation-induced behavioural changes in a genetic animal model of depression

scientific article published on 2 February 2012

Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats.

scientific article published on 22 September 2017

Ketamine regulates the presynaptic release machinery in the hippocampus

scientific article published on 30 March 2013

Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites

scientific article published on 25 June 2019

Latent toxoplasmosis aggravates anxiety- and depressive-like behaviour and suggest a role of gene-environment interactions in the behavioural response to the parasite

scientific article published on 12 February 2019

Latent toxoplasmosis and psychiatric symptoms – A role of tryptophan metabolism?

scientific article published on 17 December 2018

Local, but not systemic, administration of serotonergic antidepressants decreases hippocampal nitric oxide synthase activity

scientific article published on January 2003

Maternal High-fat Diet Programs Offspring Emotional Behavior in Adulthood

scientific article published on 17 July 2018

Maternal protein restriction before pregnancy reduces offspring early body mass and affects glucose metabolism in C57BL/6JBom mice

scientific article published in October 2012

Methylene blue inhibits hippocampal nitric oxide synthase activity in vivo

scientific article published in May 1999

Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia

scientific article published on 21 March 2017

MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro

scientific article published on 09 August 2016

Mitochondria are critical for BDNF-mediated Synaptic and Vascular plasticity of Hippocampus following Repeated Electroconvulsive Seizures.

scientific article published on 8 December 2017

Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment

scientific article published on 27 November 2012

Neonatal domoic acid alters in vivo binding of [(11)C]yohimbine to α2-adrenoceptors in adult rat brain.

scientific article published on 25 August 2016

Neurochemical differences in two rat strains exposed to social isolation rearing.

scientific article published on 01 October 2012

Neuropeptide S alters anxiety, but not depression-like behaviour in Flinders Sensitive Line rats: a genetic animal model of depression.

scientific article published on 9 May 2011

Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine

scientific journal article

Neurovascular plasticity of the hippocampus one week after a single dose of ketamine in genetic rat model of depression

scientific article

Nitric Oxide Synthase Inhibitors as Antidepressants

scientific article published on 20 January 2010

Nitric oxide as inflammatory mediator in post-traumatic stress disorder (PTSD): evidence from an animal model.

scientific article

Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression.

scientific article published on 10 December 2014

Nitric oxide is involved in the regulation of marble-burying behavior.

scientific article published on 8 June 2010

Nitric oxide modulates lithium-induced conditioned taste aversion.

scientific article

Nitric oxide signalling and antidepressant action revisited

scientific article published on 16 January 2019

Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder.

scientific article

Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review

scientific article

Potential roles for Homer1 and Spinophilin in the preventive effect of electroconvulsive seizures on stress-induced CA3c dendritic retraction in the hippocampus

scientific article published on 18 April 2015

Prelimbic neuronal nitric oxide synthase inhibition exerts antidepressant-like effects independently of BDNF signalling cascades

scientific article published on 20 March 2019

Prenatal and adult stress interplay--behavioral implications

scientific article published on 11 January 2010

Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats

scientific article

Probiotic treatment reduces depressive-like behaviour in rats independently of diet

scientific article published on 16 February 2017

Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression

scientific article published on 17 February 2018

Probiotics reduce risk-taking behavior in the Elevated Plus Maze in the Flinders Sensitive Line rat model of depression

scientific article published on 28 August 2018

Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat

scientific article published on 20 May 2019

Quantitative hippocampal structural changes following electroconvulsive seizure treatment in a rat model of depression

scientific article

Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus

scientific article published on 14 January 2017

Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner

scientific article published on 20 January 2020

Receptor occupancy of mirtazapine determined by PET in healthy volunteers

scientific article

Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice

scientific article published on 17 July 2020

Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model

scientific article published on 21 October 2019

Reduced mobility but unaffected startle response in female rats exposed to prenatal dexamethasone: different sides to a phenotype

scientific article published on 10 July 2010

Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats

scientific article published in August 2002

Reference genes for normalization: a study of rat brain tissue

scientific article published in April 2008

Repeated electroconvulsive seizures increase the total number of synapses in adult male rat hippocampus

scientific article published on 26 January 2009

Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues

scientific article published on 10 August 2010

S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression

scientific article published in January 2017

S-Ketamine Rapidly Reverses Synaptic and Vascular Deficits of Hippocampus in Genetic Animal Model of Depression.

scientific article

S-Ketamine Reverses Hippocampal Dendritic Spine Deficits in Flinders Sensitive Line Rats Within 1 h of Administration

scientific article published on 29 April 2019

Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity.

scientific article published on March 2015

Serotonergic modulation of receptor occupancy in rats treated with L-DOPA after unilateral 6-OHDA lesioning

scientific article

Sex-dependent behavior, neuropeptide profile and antidepressant response in rat model of depression

scientific article published on 29 May 2018

Stress and corticosterone increase the readily releasable pool of glutamate vesicles in synaptic terminals of prefrontal and frontal cortex.

scientific article published on 18 February 2014

Stress and re-stress increases conditioned taste aversion learning in rats: possible frontal cortical and hippocampal muscarinic receptor involvement

scientific article

Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus

scientific article

Sustained overexpression of neuropeptide S in the amygdala reduces anxiety-like behavior in rats

scientific article published on 23 March 2019

Syringe-feeding as a novel delivery method for accurate individual dosing of probiotics in rats

scientific article

Systematic evaluation of skeletal fractures caused by induction of electroconvulsive seizures in rat state a need for attention and refinement of the procedure

scientific article published on 5 April 2017

Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium

scientific article

Temporal Dynamics of Acute Stress-Induced Dendritic Remodeling in Medial Prefrontal Cortex and the Protective Effect of Desipramine.

scientific article published on November 2015

The Flinders Sensitive Line Rat Model of Depression—25 Years and Still Producing ⬇️

scientific article published on January 10, 2013

The Schizophrenia and Bipolar Disorder associated BRD1 gene is regulated upon chronic restraint stress

scientific journal article

The antidepressant action of imipramine and venlafaxine involves suppression of nitric oxide synthesis.

scientific article published on 18 November 2010

The antidepressant-like effect of probiotics and their faecal abundance may be modulated by the cohabiting gut microbiota in rats

scientific article published on 02 November 2018

The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration

scientific article

The current development of CNS drug research

scientific article

The effect of acute citalopram on extracellular 5-HT levels is not augmented by lithium: an in vivo microdialysis study

scientific article published on 01 July 2000

The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex

scientific article published on 24 November 2016

The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour.

scientific article published on 7 November 2017

Transcriptional regulation in the rat prefrontal cortex and hippocampus after a single administration of psilocybin

scientific article published on 04 November 2020

Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats

scientific article

Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain

scientific article published on 28 January 2020

Understanding in vivo modelling of depression in non-human animals: a systematic review protocol

article

Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus

scientific article published on 11 December 2015

Welcome home

scientific article published on 01 December 2012

Wistar rats subjected to chronic restraint stress display increased hippocampal spine density paralleled by increased expression levels of synaptic scaffolding proteins

scientific journal article

ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals.

scientific article

[11C]Mirtazapine binding in depressed antidepressant nonresponders studied by PET neuroimaging

scientific article published on 18 June 2009

α2-adrenoceptor binding in Flinders-sensitive line compared with Flinders-resistant line and Sprague-Dawley rats

scientific article published on 23 April 2015

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