List of works - James L. Riley

A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-term growth of CD4 T lymphocytes

scientific article published on December 2002

Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells

scientific article published on 10 October 2007

Adoptive immunotherapy: good habits instilled at youth have long-term benefits.

scientific article published on January 2008

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients ⬇️

scientific article published on May 16, 2012

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

scientific article

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

scientific article published on 21 April 2009

Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.

scientific article

Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.

scientific article

Clinical perspectives for regulatory T cells in transplantation tolerance ⬇️

scientific article published on 05 August 2011

Combination Checkpoint Blockade — Taking Melanoma Immunotherapy to the Next Level ⬇️

scientific article published on June 2, 2013

Constitutive cell surface association between CD4 and CCR5.

scientific article

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

scientific article published on 9 November 2008

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

scholarly article

Cutaneous T cell lymphoma expresses immunosuppressive CD80 (B7-1) cell surface protein in a STAT5-dependent manner

scientific article published on 12 February 2014

Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28

scientific journal article

DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.

scientific article published on January 2003

Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

scientific article

Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells

scientific article

Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells

scientific article

Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo

scientific article published on 31 August 2020

Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease–Targeted Disruption of the HIV Co-receptor CCR5 ⬇️

scientific article published on March 6, 2013

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

scientific article

Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules.

scientific article published on 20 March 2007

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

scientific article (publication date: July 2008)

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

scientific article published on February 2002

Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor

scientific article published on 24 May 2011

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

scientific article

FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease.

scientific article

Folate receptor alpha and caveolae are not required for Ebola virus glycoprotein-mediated viral infection

scientific article published on December 2003

Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

scientific article published on 12 May 2011

HIV sequence variation associated with env antisense adoptive T-cell therapy in the hNSG mouse model

scientific article

HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells

article

Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation

scientific article

Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells

scientific article published on August 2013

Kruppel-like factor 2 modulates CCR5 expression and susceptibility to HIV-1 infection

scientific article

Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule.

scientific article

Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction

scientific article published on November 1994

Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors

scientific article

Productive infection of neonatal CD8+ T lymphocytes by HIV-1.

scientific article

Prostaglandin E2 impairs CD4+ T cell activation by inhibition of lck: implications in Hodgkin's lymphoma

scientific article published in January 2006

RNA fingerprints provide direct evidence for the inhibitory role of TGF and PD-1 on CD4+ T cells in Hodgkin lymphoma

article

Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

scientific article

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

scientific article published on 14 August 2011

Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells

scientific article (publication date: 6 January 2011)

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.

scientific article published on 25 October 2013

Stabilized human TRIM5α protects human T cells from HIV-1 infection

scientific article

Steric shielding of surface epitopes and impaired immune recognition induced by the ebola virus glycoprotein

scientific article

Strength of PD-1 signaling differentially affects T-cell effector functions.

scientific article published on 22 April 2013

Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed gp41-derived fusion inhibitor

scientific article published on April 2005

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor.

scientific article published on 12 October 2017

TCR affinity and specificity requirements for human regulatory T-cell function ⬇️

scientific article published on February 7, 2012

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.

scientific article published on 7 September 2004

The CD28 signaling pathway regulates glucose metabolism

scientific article

The PDL1-PD1 Axis Converts Human T H 1 Cells into Regulatory T Cells ⬇️

scientific article published on November 30, 2011

The battle over mTOR: an emerging theatre in host-pathogen immunity

scientific article

The human CD8β M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties

scientific article

The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.

scientific article

The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation

scientific article published in August 2008

The potent oncogene NPM-ALK mediates malignant transformation of normal human CD4(+) T lymphocytes

scientific article

The road to recovery: translating PD-1 biology into clinical benefit

scientific article published on 22 December 2006

The role of co-stimulation in regulation of chemokine receptor expression and HIV-1 infection in primary T lymphocytes

scientific article published in June 1998

Topoisomerase inhibitors modulate expression of melanocytic antigens and enhance T cell recognition of tumor cells

scientific article

Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation

scientific article

cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas

scientific article

List of works by James L. Riley

A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-term growth of CD4 T lymphocytes

Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells

Adoptive immunotherapy: good habits instilled at youth have long-term benefits.

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients ⬇️

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.

Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.

Clinical perspectives for regulatory T cells in transplantation tolerance ⬇️

Combination Checkpoint Blockade — Taking Melanoma Immunotherapy to the Next Level ⬇️

Constitutive cell surface association between CD4 and CCR5.

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

Cutaneous T cell lymphoma expresses immunosuppressive CD80 (B7-1) cell surface protein in a STAT5-dependent manner

Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28

DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.

Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells

Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells

Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo

Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease–Targeted Disruption of the HIV Co-receptor CCR5 ⬇️

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules.

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease.

Folate receptor alpha and caveolae are not required for Ebola virus glycoprotein-mediated viral infection

Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

HIV sequence variation associated with env antisense adoptive T-cell therapy in the hNSG mouse model

HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells

Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation

Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells

Kruppel-like factor 2 modulates CCR5 expression and susceptibility to HIV-1 infection

Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule.

Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction

Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors

Productive infection of neonatal CD8+ T lymphocytes by HIV-1.

Prostaglandin E2 impairs CD4+ T cell activation by inhibition of lck: implications in Hodgkin's lymphoma

RNA fingerprints provide direct evidence for the inhibitory role of TGF and PD-1 on CD4+ T cells in Hodgkin lymphoma

Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.

Stabilized human TRIM5α protects human T cells from HIV-1 infection

Steric shielding of surface epitopes and impaired immune recognition induced by the ebola virus glycoprotein

Strength of PD-1 signaling differentially affects T-cell effector functions.

Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed gp41-derived fusion inhibitor

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor.

TCR affinity and specificity requirements for human regulatory T-cell function ⬇️

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.

The CD28 signaling pathway regulates glucose metabolism

The PDL1-PD1 Axis Converts Human T H 1 Cells into Regulatory T Cells ⬇️

The battle over mTOR: an emerging theatre in host-pathogen immunity

The human CD8β M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties

The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.

The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation

The potent oncogene NPM-ALK mediates malignant transformation of normal human CD4(+) T lymphocytes

The road to recovery: translating PD-1 biology into clinical benefit

The role of co-stimulation in regulation of chemokine receptor expression and HIV-1 infection in primary T lymphocytes

Topoisomerase inhibitors modulate expression of melanocytic antigens and enhance T cell recognition of tumor cells

Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation

cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas