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List of works by Kaylene J. Simpson

A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens

scientific article published in January 2018

A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4.

scientific article published on 17 November 2017

A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization

scientific article

A functional genetic screen defines the AKT-induced senescence signaling network

scientific article published on 08 July 2019

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.

scientific article published on 24 January 2014

A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation.

scientific article published on 17 September 2013

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity.

scientific article published on 12 February 2016

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

article

A high-throughput, multiplex cell death assay using an RNAi screening approach

scientific article

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

scientific article published on 14 December 2020

An interactive web-based application for Comprehensive Analysis of RNAi-screen Data

scientific article

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

scientific article published on 6 December 2010

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species

scientific article

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

scientific article published on 5 June 2017

Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.

scientific article published on August 2004

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

scientific article published in Nature Communications

Colloquium: SBI(2) HCS/HCA Informatics and Data Analysis--Best Practices and Unmet Needs September 15, 2015.

scientific article

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.

scientific article published in September 2016

Comparative high-throughput RNAi screening methodologies in C. elegans and mammalian cells.

scientific article published on 28 January 2012

Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

scientific article published on 21 March 2016

Developmentally-regulated expression of a putative protease inhibitor gene in the lactating mammary gland of the tammar wallaby, Macropus eugenii

scientific article published in July 1998

Differential expression of the whey acidic protein gene during lactation in the brushtail possum (Trichosurus vulpecula).

scientific article published in December 2001

Discovering cancer vulnerabilities using high-throughput micro-RNA screening

scientific article published on 16 November 2017

Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion.

scientific article

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

scientific article published on 7 April 2015

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

scientific article published in 2022

Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice

article

FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

scientific article published on 29 June 2009

Functional analysis of genes in regions commonly amplified in high-grade serous and endometrioid ovarian cancer

scientific article published on 29 January 2013

Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma

scientific article

Functional genomics down under: RNAi screening in the Victorian Centre for Functional Genomics

scientific article published on May 2014

Generation of a functional mammary gland from a single stem cell

scientific article (publication date: 5 January 2006)

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling.

scientific article published on 3 October 2017

Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat

scientific article

Genome-wide siRNA Screening at Biosafety Level 4 Reveals a Crucial Role for Fibrillarin in Henipavirus Infection

scientific article

High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids

scientific article published on 11 June 2021

High-content assay for measuring intracellular growth of Leishmania in human macrophages

scientific article

High-throughput approaches to measuring cell death

scientific article

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

scientific article published on 26 March 2018

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

scientific article

Knocking down the obstacles to functional genomics data sharing

scientific article

MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development

scientific article published in September 2004

Maternal regulation of milk composition, milk production, and pouch young development during lactation in the tammar wallaby (Macropus eugenii ).

scientific article

Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour

scientific article published in December 2016

Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

scientific article published on 14 May 2020

MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer.

scientific article

Molecular characterisation and hormone-dependent expression of the porcine whey acidic protein gene

scientific article published in February 1998

Optimized PCR conditions and increased shRNA fold representation improve reproducibility of pooled shRNA screens

scientific article

Phosphorylation of NS5A Serine-235 is essential to hepatitis C virus RNA replication and normal replication compartment formation

scientific article published on 10 February 2016

Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR.

scientific article published in November 2008

Psidin, a conserved protein that regulates protrusion dynamics and cell migration

scientific article

Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma

scientific article published on 22 May 2006

Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1

scientific article

SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium

scientific article published in January 2017

Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus.

scientific article published on 5 July 2017

Society of Biomolecular Imaging and Informatics Special Issue

scientific article

Society of Biomolecular Imaging and Informatics Special Issue

scientific article published on 01 September 2016

Society of Biomolecular Imaging and Informatics Special Issue

scientific article published on 14 August 2015

Society of Biomolecular Imaging and Informatics Special Issue

scientific article published on 01 January 2019

Society of Biomolecular Imaging and Informatics Special Issue

scientific article published on 01 August 2018

Society of Biomolecular Imaging and Informatics Special Issue, November 2015

scientific article published on 01 November 2015

Society of Biomolecular Imaging and Informatics Special Issue, October 2016

scientific article published on 23 September 2016

Strategies and challenges for systematically mapping biologically significant molecular pathways regulating carcinoma epithelial-mesenchymal transition.

scientific article published on 14 June 2013

Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells

scientific article published on 16 March 2015

Synthetic lethality between CCNE1 amplification and loss of BRCA1.

scientific article

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

scientific article published on 10 April 2015

Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology

scientific article

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

scientific article published on 11 November 2020

The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo

scientific article published on December 2005

The comparative biology of whey proteins

scientific article

Whole-genome multiparametric screening to identify modulators of epithelial-to-mesenchymal transition

scientific article published on September 2014

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