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List of works by Qingsong Liu

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

scientific article published on 6 March 2011

Clavukoellians A-F, Highly Rearranged Nardosinane Sesquiterpenoids with Antiangiogenic Activity from Clavularia koellikeri

scientific article published on 17 April 2019

Determining Cysteines Available for Covalent Inhibition Across the Human Kinome

scientific article

Developing Irreversible Inhibitors of the Protein Kinase Cysteinome ⬇️

scientific article published on February 21, 2013

Development of ATP-competitive mTOR inhibitors

scientific article published on January 2012

Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML)

scientific article published on 20 March 2019

Discovery of ( E)- N1-(3-Fluorophenyl)- N3-(3-(2-(pyridin-2-yl)vinyl)-1 H-indazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs)

scientific article published on 14 May 2019

Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.

scientific article published on 10 March 2017

Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmo

scientific article published on 12 November 2020

Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase

scientific article published on 28 September 2017

Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome

scientific article published on 31 January 2017

Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors

scientific article published on 28 June 2019

Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido[5,4- b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors.

scientific article

Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia

scientific article published on 08 January 2019

Discovery of a highly potent and selective Bruton's tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma

scientific article published on 14 September 2020

Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models

scientific article published on 23 December 2019

Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?

scientific article

Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase

scientific article published on 5 June 2015

Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma

scientific article published on 20 June 2013

Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition

scientific article published on 10 April 2019

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.

scientific article

Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis

article

Selective Akt Inhibitors Synergize with Tyrosine Kinase Inhibitors and Effectively Override Stroma-Associated Cytoprotection of Mutant FLT3-Positive AML Cells ⬇️

scientific article published on February 21, 2013

Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance

scientific article published on 27 February 2019

Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent

scientific article published on 3 February 2017

Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance

scientific article published on 12 April 2019

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