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List of works by Edward M. Sellers

3alpha-reduced neuroactive steroids and their precursors during pregnancy and the postpartum period

scientific article published in November 2005

5-HT and alcohol abuse

scientific article published on February 1, 1992

A Multiple-Dose, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group QT/QTc Study to Evaluate the Electrophysiologic Effects of THC/CBD Spray

scientific article

A comparative pharmacokinetic and dynamic evaluation of alprazolam sustained-release, bromazepam, and lorazepam

scientific article published in December 2000

A controlled trial of ondansetron, a 5-HT3 antagonist, in benzodiazepine discontinuation

scientific article published in April 1998

A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo

scientific article

A randomized, double-blind, placebo-controlled, crossover study to evaluate the subjective abuse potential and cognitive effects of nabiximols oromucosal spray in subjects with a history of recreational cannabis use

scientific article published on 01 April 2011

Absorption of oral and intramuscular chlordiazepoxide

scientific article published on 01 June 1978

Abuse Potential and Pharmacodynamic Characteristics of Oral and Intranasal Eluxadoline, a Mixed μ- and κ-Opioid Receptor Agonist and δ-Opioid Receptor Antagonist

scientific article

Abuse Potential of Lasmiditan: A Phase 1 Randomized, Placebo- and Alprazolam-Controlled Crossover Study

scientific article published on 20 November 2019

Abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered crushed oxycodone HCl abuse-deterrent controlled-release tablets in recreational opioid users

scientific article

Acute and chronic drug abuse emergencies in Metropolitan Toronto

scientific article published on February 1981

Addictive Drugs: Disposition, Tolerance, and Dependence Interrelationships ⬇️

scientific article published on January 1, 1978

Age- and gender-related differences in diazepam pharmacokinetics

scientific article published in January 1979

Age- and sex-related differences in patterns of drug overdose and abuse

scientific article published in November 1981

Alcohol withdrawal severity is decreased by symptom-orientated adjusted bolus therapy in the ICU.

scientific article published on 14 October 2003

Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction

scientific article published in January 1983

An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles

scientific article published in January 2002

Antagonist-precipitated opioid withdrawal in rats: evidence for dissociations between physical and motivational signs

scientific article

Anxiolytics and sedative/hypnotics dependence

scientific article published in December 1991

Assessing abuse liability during drug development: changing standards and expectations.

scientific article published on 23 January 2008

Assessing subjective and physiologic effects following intranasal administration of a new formulation of immediate release oxycodone HCl (Oxecta™) tablets in nondependent recreational opioid users

scientific article

Assessment of Pharmacokinetic and Pharmacodynamic Interactions Between Albumin-Fused Mutated Butyrylcholinesterase and Intravenously Administered Cocaine in Recreational Cocaine Users

scientific article

Assessment of pharmacokinetics and pharmacodynamic effects related to abuse potential of a unique oral osmotic-controlled extended-release methylphenidate formulation in humans

scientific article published on 25 October 2007

Assessment of the Abuse Potential of the Orexin Receptor Antagonist, Suvorexant, Compared With Zolpidem in a Randomized Crossover Study

scientific article published on 31 May 2016

Assessment of the abuse liability of a dual orexin receptor antagonist: a crossover study of almorexant and zolpidem in recreational drug users

scientific article published in April 2014

Association between CYP3A4 genotype and risk of endometrial cancer following tamoxifen use

scientific article published on 13 April 2007

Attractiveness of reformulated OxyContin(R) tablets: assessing comparative preferences and tampering potential

scientific article published on 19 June 2013

Binding of diazoxide and other benzothiadiazines to human albumin

scientific article published in February 1974

Binding of drugs to ion-exchange resins in simulated gastric fluid

scientific article published on September 1978

Blockade of morphine place conditioning by the CCKA receptor antagonist devazepide

scientific article published in May 1991

Brain Network Activation (BNA) reveals scopolamine-induced impairment of visual working memory

scientific article published on 18 February 2014

CYP2A6 genetic variation and potential consequences

scientific article (publication date: 18 November 2002)

CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking.

scientific article published in October 2006

CYP2D6 inhibition in patients treated with sertraline

scientific article published in April 1997

CYP2D6 phenotype and genotype in a Canadian Native Indian population

scientific article published in April 1997

CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone

scientific article published in November 1993

CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence

scientific article published in June 2003

Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies*

article

Categorization of Abuse Potential-Related Adverse Events

scientific article published on 11 October 2017

Challenges in the development of prescription opioid abuse-deterrent formulations

scientific article published on October 2007

Characteristics of dependent and nondependent regular users of codeine.

scientific article published in August 1999

Characterization of DSM-III-R criteria for uncomplicated alcohol withdrawal provides an empirical basis for DSM-IV.

scientific article published in May 1991

Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics

scientific article published on 28 April 2006

Claudio A. Naranjo, MD (1945-2014).

scientific article published on 25 November 2014

Clinical Pharmacokinetics of Chlordiazepoxide

scientific article published on September 1, 1978

Clinical detection and assessment of drug induced neurotoxicity

scientific article published on 01 January 1981

Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence

scientific article published in August 1994

Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".

scientific article published in November 2003

Comparative Drug Adsorption by Activated Charcoal

scientific article published on 01 November 1977

Comparative abuse liability and pharmacological effects of meprobamate, triazolam, and butabarbital

scientific article

Comparative abuse liability of intravenously administered remifentanil and fentanyl

scientific article published in December 2000

Comparative abuse liability of sertraline, alprazolam, and dextroamphetamine in humans

scientific article published in April 1995

Comparative metabolism of chloral hydrate and triclofos

scientific article published in October 1978

Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians

scientific article

Compliance among heavy alcohol users in clinical drug trials

scientific article published on 01 January 1988

Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations

scientific article

Cytochrome P450 2D6 and treatment of codeine dependence

scientific article

Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates.

scientific article

Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations

scientific article

Deconstructing Designer Drugs

scientific article published on 26 August 2016

Decreasing smoking behaviour and risk through CYP2A6 inhibition.

scientific article

Defining Rational Prescribing of Psychoactive Drugs*

scientific article published on 01 January 1988

Designer drugs that are potent inhibitors of CYP2D6

scientific article (publication date: June 2002)

Determinants of interindividual variability and extent of CYP2D6 and CYP1A2 inhibition by paroxetine and fluvoxamine in vivo

scientific article published in June 1998

Determination of free propylthiouracil clearance and single sample prediction of steady state

scientific article published on 01 January 1982

Diazepam actions and plasma concentrations following ethanol ingestion

scientific article published in January 1977

Diazepam and N-desmethyldiazepam in saliva of hospital inpatients

scientific article published in February 1980

Differences in the in vitro and in vivo pharmacokinetic profiles of once-daily modified-release methylphenidate formulations in Canada: examination of current bioequivalence criteria

scientific article published on 17 April 2012

Difficulties in assessing adverse drug reactions in clinical trials

scientific article published on 01 January 1982

Discussion on How and When Can This Approach Be Applied and Initial Reactions

Disposition of intravenous diazepam in young men and women

scientific article published in January 1981

Do Formulation Differences Alter Abuse Liability of Methylphenidate?

scientific article published on 01 October 2007

Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration

scientific article

Drug deprivation and reinforcement by diazepam in a dependent population

scientific article published in January 1987

Drug kinetics and alcohol ingestion

scientific article

Drug metabolism and interactions in abuse liability assessment.

scientific article published on December 1991

Drug metabolism in the elderly: confounding of age, smoking, and ethanol effects

scientific article published on January 1983

EMD 281014, a specific and potent 5HT2 antagonist in humans: a dose-finding PET study

scientific article published on September 2004

Effect of 5-HT3 receptor antagonists on the discriminative stimulus properties of morphine in rats

scientific article published in January 1993

Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail

scientific article

Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans

scientific article published on 01 January 1990

Effect of dexfenfluramine on saccharin drinking: behavioural and pharmacological studies

scientific article published in February 1994

Effect of drugs influencing 5-HT function on ethanol drinking and feeding behaviour in rats: studies using a drinkometer system

scientific article published in January 1992

Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers

scientific article published on 18 June 2010

Effect of metabolic blockade on the psychoactive effects of dextromethorphan

scientific article published in January 2010

Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker

scientific article published in August 2002

Effect of the 5-HT3 antagonist ondansetron on voluntary ethanol intake in rats and mice maintained on a limited access procedure

scientific article published in February 1995

Effect of the 5-HT3 receptor antagonists, MDL72222 and ondansetron on morphine place conditioning

scientific article published on January 1992

Effects of 5-HT3 receptor antagonists on behavioural measures of naloxone-precipitated opioid withdrawal

scientific article

Effects of 5-HT3, D1 and D2 receptor antagonists on ethanol- and cocaine-induced locomotion

scientific article published in May 1997

Effects of Low-Dose Opioids on Cognitive Dysfunction

scientific article published on 03 October 2011

Enalapril effects on alcohol intake and other consummatory behaviors in alcoholics

scientific article published in July 1991

Ethanol effects on drug release from Verapamil Meltrex, an innovative melt extruded formulation

scientific article

Ethanol-induced inhibition of hepatic uptake of propranolol in perfused rat liver and in man

scientific article published on 01 January 1984

Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

scientific article published in September 2004

Evaluating the safety and efficacy of dextromethorphan/quinidine in the treatment of pseudobulbar affect

scientific article

Evaluation of the abuse potential of extended release hydromorphone versus immediate release hydromorphone

scientific article published on February 2010

Evaluation of the abuse potential of lorcaserin, a serotonin 2C (5-HT2C) receptor agonist, in recreational polydrug users

scientific article published on 16 March 2011

Evaluation of zopiclone physical dependence liability in normal volunteers

scientific article published in January 1983

Evidence for the contribution of CCKB receptor mechanisms to individual differences in amphetamine-induced locomotion

scientific article (publication date: August 1994)

From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists

scientific article

Further studies to examine the nature of dexfenfluramine-induced suppression of heroin self-administration

scientific article published in July 1995

Gender differences in tobacco smoking: higher relative exposure to smoke than nicotine in women

scientific article published in March 2002

Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior

scientific article (publication date: February 2002)

Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence

scientific article published in October 1997

High-performance Liquid Chromatographic Determination of Plasma Propylthiouracil

scientific article published on 01 November 1979

Human abuse liability evaluation of CNS stimulant drugs

scientific article published on 30 April 2014

Human abuse liability of the smoking cessation drug varenicline in smokers and nonsmokers

scientific article

Human abuse potential and cognitive effects of taranabant, a cannabinoid 1 receptor inverse agonist: a randomized, double-blind, placebo- and active-controlled, crossover study in recreational polydrug users

scientific article published in August 2012

IN VITRO QUANTITATION OF BENZODIAZEPINE LIPOPHILICITY: RELATION TO IN VIVO DISTRIBUTION

scientific article published on 01 October 1983

INFLUENCE OF INTRAVENOUS INJECTION RATE ON PROTEIN BINDING AND VASCULAR ACTIVITY OF DIAZOXIDE

scientific article published on 01 November 1973

Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence.

scientific article

Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain

scientific article

Influence of 5-HT3 receptor antagonists and the indirect 5-HT agonist, dexfenfluramine, on heroin self-administration in rats

scientific article published in May 1994

Inhibition by fluoxetine of cytochrome P450 2D6 activity.

scientific article

Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking

scientific article published on 01 July 2000

Inhibition of cytochromes P450 by antifungal imidazole derivatives

scientific article published in March 2002

Inhibition of nicotine metabolism by methoxysalen: Pharmacokinetic and pharmacological studies in mice.

scientific article

Inhibitors of cytochrome P450 differentially modify discriminative-stimulus and antinociceptive effects of hydrocodone and hydromorphone in rhesus monkeys

scientific article published in May 1999

Interactions of amphetamine analogs with human liver CYP2D6 ⬇️

scientific article (publication date: June 1997)

Intravascular factors affecting diazepam binding to human serum albumin

scientific article published on November 1979

Intravenous diazepam and oral ethanol interaction

scientific article published in November 1980

Kinetic and dynamic interactions of oral viqualine and ethanol in man.

scientific article published in January 1989

Kinetics and clinical importance of displacement of warfarin from albumin by acidic drugs.

scientific article

Lack of Interaction of Buprenorphine With Flunitrazepam Metabolism

scientific article published on 01 July 2000

Lack of effect of cimetidine on cigarette smoking

scientific article published on 01 January 1993

Lack of weight-based dose dependency and intraindividual variability of omeprazole for CYP2C19 phenotyping

scientific article

Letter: Propranolol-decreased noradrenaline excretion and alcohol withdrawal

scientific article

Long-term benzodiazepine therapy does not result in brain abnormalities.

scientific article

Measurement issues in postpartum depression part 1: Anxiety as a feature of postpartum depression

scientific article published on 01 February 2003

Measurement issues in postpartum depression part 2: assessment of somatic symptoms using the Hamilton Rating Scale for Depression

scientific article published in February 2003

Median and dorsal raphe injections of the 5-HT1A agonist, 8-OH-DPAT, and the GABAA agonist, muscimol, increase voluntary ethanol intake in Wistar rats

scientific article

Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19.

scientific article

Mitigating the risk of opioid abuse through a balanced undergraduate pain medicine curriculum

scientific article published on 04 December 2013

Mood changes during pregnancy and the postpartum period: development of a biopsychosocial model

scientific article published in June 2004

Morphine place conditioning is differentially affected by CCKA and CCKB receptor antagonists

scientific article published in February 1992

Multiple Drug Use and Psychiatric Comorbidity in Patients Admitted to the Hospital With Severe Benzodiazepine Dependence

scientific article published on 01 February 1996

NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations

scientific article

New CYP2A6 gene deletion and conversion variants in a population of Black African descent.

scientific article published on February 2010

Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking.

scientific article published on 8 December 2006

Nicotine metabolism defect reduces smoking

scientific article published in June 1998

Nicotine physical dependence and tolerance in the mouse following chronic oral administration.

scientific article

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.

scientific article

Objective determination of benzodiazepine use and abuse in alcoholics

scientific article

Oral Human Abuse Potential of Oxycodone DETERx® (Xtampza® ER).

scientific article published on 27 September 2016

Oral ketamine as a positive control in human abuse potential studies

scientific article

PROTEIN-BINDING OF DRUGS

scientific article published in The Lancet

Paroxetine Steady-State Plasma Concentration in Relation to CYP2D6 Genotype in Extensive Metabolizers

scientific article published on 01 October 1999

Partial agonist properties and toxicity of oral oxilorphan

scientific article published on April 1976

Patterns of benzodiazepine abuse and dependence

scientific article published in February 1986

Pharmacodynamic and pharmacokinetic drug interactions with coumarin anticoagulants

scientific article published on January 1976

Pharmacogenetics and Ethnoracial Differences in Smoking ⬇️

scientific article published on July 8, 1998

Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers

scientific article published in October 2004

Pharmacologic effects and abuse liability of bretazenil, diazepam, and alprazolam in humans

scientific article

Pharmacological control of alcohol consumption: tactics for the identification and testing of new drugs

scientific article published in January 1981

Pharmacotherapy of alcohol and drug problems

scientific article published on 01 January 1991

Phencyclidine Ingestion: Drug Abuse and Psychosis

scientific article published on 01 May 1981

Plasma Protein Displacement Interactions Are Rarely of Clinical Significance

scientific article published on 01 January 1979

Plasma protein binding of diazepam and tolbutamide in chronic alcoholics

scientific article published in July 1976

Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study

scientific article published on 3 May 2006

Preliminary findings with the indirect 5-HT agonist dexfenfluramine on heroin discrimination and self-administration in rats

scientific article published in August 1993

Preventing and managing aberrant drug-related behavior in primary care: systematic review of outcomes evidence

scientific article published on March 2014

Propranolol and Chlordiazepoxide Effects on Cardiac Arrhythmias During Alcohol Withdrawal

scientific article published on 01 October 1980

Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study.

scientific article

Quantitation of phencyclidine in biological fluids and application to human overdose

scientific article

Randomized Open-Label Drug-Drug Interaction Trial of Dextromethorphan/Quinidine and Paroxetine in Healthy Volunteers

scientific article published on 01 March 2012

Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism

scientific article published on 15 May 2003

Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro.

scientific article

Research design strategies to evaluate the impact of formulations on abuse liability

scientific article published on 22 March 2006

Risk management and post-marketing surveillance for the abuse of medications acting on the central nervous system: expert panel report

scientific article

Socioeconomic and drug use determinants of smoking status in an urban adult population of Black African descent

scientific article

Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users

scientific article

Subjective effects and safety of whole and tampered morphine sulfate and naltrexone hydrochloride (ALO-01) extended-release capsules versus morphine solution and placebo in experienced non-dependent opioid users: a randomized, double-blind, placebo-

scientific article published in January 2009

Survival after massive procainamide ingestion

scientific article published on 01 October 1973

The CCKA receptor antagonist devazepide does not modify opioid self-administration or drug discrimination: comparison with the dopamine antagonist haloperidol

scientific article

The Effect of Multiple Doses of Peginterferon alfa-2b on the Steady-State Pharmacokinetics of Methadone in Patients With Chronic Hepatitis C Undergoing Methadone Maintenance Therapy

scientific article published on 30 March 2007

The NMDA antagonist dizocilpine (MK801) attenuates motivational as well as somatic aspects of naloxone precipitated opioid withdrawal

scientific article published in January 1992

The ambiguity of adverse drug reactions

scientific article published on 01 January 1977

The disulfiram and calcium carbimide acetaldehyde-mediated ethanol reactions

scientific article published on January 1981

The effect of an abuse-deterrent opioid formulation (OxyContin) on opioid abuse-related outcomes in the postmarketing setting.

scientific article published on 12 May 2016

The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo

scientific article

The effect of propranolol on normal physiologic tremor

scientific article

The extent and determinants of changes in CYP2D6 and CYP1A2 activities with therapeutic doses of sertraline.

scientific article

The nature and etiology of normal and alcohol withdrawal tremor

scientific article published on January 1, 1979

The quantitative assessment of physical dependence on opiates

scientific article published in November 1978

The role of adverse events and related safety data in the pre-market evaluation of drug abuse potential

scientific article

The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo

scientific article published in April 2003

The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence.

scientific article

Treatment of codeine dependence with inhibitors of cytochrome P450 2D6

scientific article (publication date: June 2002)

Update on tamper-resistant drug formulations ⬇️

scientific article published on February 13, 2013

Use of Remifentanil in a Novel Clinical Paradigm to Characterize Onset and Duration of Opioid Blockade by Samidorphan, a Potent μ-Receptor Antagonist

scientific article published on June 2015

Use of hair analysis for confirmation of self-reported cocaine use in users with negative urine tests

scientific article published in January 2001

Use of omeprazole as a CYP3A probe drug: effect of sex and menstrual cycle phase on CYP3A activity in healthy Caucasian adults

scientific article published in March 2006

Variability in heparin effect on serum drug binding

scientific article published in October 1980

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