List of works - Gary B. Evans

(4aR,6aS,10aR,10bS)-7,7,10a-Trimethyl-1,4,4a,5,6,6a,7,8,9,10,10a,10b-dodecahydro-2H-naphtho-[2,1-c]pyran (Pyamber). ⬇️

scientific article published on 8 October 2011

3-Bromo-7-methoxy-2-(tetrahydropyran-2-yl)pyrazolo[4,3-d]pyrimidine

7-(5-Methyl-sulfanyl-β-d-erythrofuran-osyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-amine monohydrate (MT-tubercidin·H(2)O).

scientific article published on 18 June 2010

8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases

scientific article

A Designed Approach to Enantiodivergent Enamine Catalysis

scientific article

A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori

scientific article

A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol

scientific article published on 20 July 2007

A single point mutation converts a glutaryl-7-aminocephalosporanic acid acylase into an N-acyl-homoserine lactone acylase

scientific article published on 23 April 2021

Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase

scientific article published on 3 July 2003

Acyclic Ribooxacarbenium Ion Mimics as Transition State Analogues of Human and Malarial Purine Nucleoside Phosphorylases

scientific article published on 11 May 2007

Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

scientific article published on 5 March 2013

Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins.

scientific article published in August 2001

Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase

scientific article published on June 2009

Association of HPA axis-related genetic variation with stress reactivity and aggressive behaviour in pigs

scientific article

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase

scientific article

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases

scientific article published on 6 February 2008

Bifunctional chiral auxiliaries 6: Alkylations of enolates derived from 1,3-diacylimidazolidine- 2-thiones and 1,3-diacylimidazolidin-2-ones

Biofilm Inhibition via Delivery of Novel Methylthioadenosine Nucleosidase Inhibitors from PVA-Tyramine Hydrogels while Supporting Mesenchymal Stromal Cell Viability

scientific article published on 10 January 2019

Bis[(1S)-1,4-azanediyl-1-(9-deazaadenin-9-yl)-1,4-dideoxy-5-methylsulfanyl-D-ribitol] tetrakis(hydrochloride) monohydrate: structure, DFT energy and ligand docking results of a potent methylthioadenosine phosphorylase inhibitor found in different mo

scientific article published on 8 October 2010

Book Review of Antisense Drug Technology: Principles, Strategies, and Applications. Second Edition Antisense Drug Technology: Principles, Strategies, and Applications. Second Edition. Edited by Stanley T. Crooke. CRC Press and Taylor & Francis Group

scientific article published in March 2008

Concomitant bromination and lactolisation of unsaturated diols with sodium bromite in aqueous acetic acid

Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues

scientific article

Corrigendum to “Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes”

scholarly article published in Carbohydrate Research

Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase

scientific article published on September 2010

Differential mRNA expression of genes in the porcine adrenal gland associated with psychosocial stress.

scientific article

Distortional binding of transition state analogs to human purine nucleoside phosphorylase probed by magic angle spinning solid-state NMR.

scientific article published on 16 September 2013

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

scientific article published on 31 July 2018

Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.

scientific article published on 16 June 2005

Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.

scientific article published on 7 November 2011

Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.

scientific article

Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy.

scientific article

Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli

scientific article published on 04 March 2005

Four generations of transition-state analogues for human purine nucleoside phosphorylase.

scientific article

Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.

scientific article

Imino-C-nucleoside synthesis: heteroaryl lithium carbanion additions to a carbohydrate cyclic imine and nitrone

scientific article published in March 2004

Iminoribitol Transition State Analogue Inhibitors of Protozoan Nucleoside Hydrolases†

article

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

scientific article (publication date: December 2015)

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

scientific article

Immucillins in Infectious Diseases

scientific article

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

scientific article

Inhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †

scientific article

Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state.

scientific article

Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states

scientific article

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues

scientific article published on 13 November 2020

Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases

scientific article published in May 2003

Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

scientific article published on 05 July 2020

Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states

scientific article

New Antibiotic Candidates against Helicobacter pylori

scientific article

Oligonucleotide transition state analogues of saporin L3.

scientific article

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

scientific article (publication date: 27 May 2003)

Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases

scientific article

Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A

scientific article

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model

scientific article (publication date: 2011)

Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function

scientific article published on 23 February 2004

Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes

scholarly article by K Nicolson published in October 1999

Primordial-like enzymes from bacteria with reduced genomes

scientific article

Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase

scientific article published on 12 November 2001

Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems

scientific article (publication date: 15 December 2016)

Salmonella enterica MTAN at 1.36 Å Resolution: A Structure-Based Design of Tailored Transition State Analogs

scientific article

Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase

scientific article published on July 2005

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

scientific article published on 28 March 2019

Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

scientific article published on 03 March 2005

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae

scientific article published on October 2006

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases

scientific article published on 26 January 2006

Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes

scientific article

Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases

Synthesis of a Transition State Analogue Inhibitor of Purine Nucleoside Phosphorylase via the Mannich Reaction

scientific article published on 01 October 2003

Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase

scientific article published on 27 November 2017

Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase

scientific article published in November 2003

Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins

scientific article (publication date: 11 March 2005)

Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase

scientific article

The Immucillins: Design, Synthesis and Application of Transition- State Analogues.

scientific article published on 20 August 2015

The Synthesis ofN-Ribosyl Transferase Inhibitors Based on a Transition State Blueprint

The synthesis and antibacterial activity of totarol derivatives. Part 1: modifications of ring-C and pro-drugs

scientific article

The synthesis and antibacterial activity of totarol derivatives. Part 2: Modifications at C-12 and O-13.

scientific article published in July 2000

The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B.

scientific article

The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

The transition to magic bullets – transition state analogue drug design

scientific article published on 28 August 2018

Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase

scientific article published on 8 November 2013

Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase

scientific article published on February 2009

Tight binding enantiomers of pre-clinical drug candidates

scientific article

Transcriptional responses of PBMC in psychosocially stressed animals indicate an alerting of the immune system in female but not in castrated male pigs.

scientific article

Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

scientific article published on 24 August 2017

Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases

scientific article published on 11 February 2020

Transition state analogue discrimination by related purine nucleoside phosphorylases

scientific article

Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes

scientific article published in January 2007

Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics

scientific article

Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum

scientific article published on 13 November 2001

Transition state analogues in quorum sensing and SAM recycling

scientific article published on January 2008

Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases

scientific article published on 24 October 2013

Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein

scientific article published in October 2009

Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase

scientific article published on 19 October 2018

Two-step Ligand Binding in a (βα)8 Barrel Enzyme: SUBSTRATE-BOUND STRUCTURES SHED NEW LIGHT ON THE CATALYTIC CYCLE OF HisA

scientific article (publication date: 20 August 2015)

l -Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside Phosphorylase

scientific article

List of works by Gary B. Evans

(4aR,6aS,10aR,10bS)-7,7,10a-Trimethyl-1,4,4a,5,6,6a,7,8,9,10,10a,10b-dodecahydro-2H-naphtho-[2,1-c]pyran (Pyamber). ⬇️

3-Bromo-7-methoxy-2-(tetrahydropyran-2-yl)pyrazolo[4,3-d]pyrimidine

7-(5-Methyl-sulfanyl-β-d-erythrofuran-osyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-amine monohydrate (MT-tubercidin·H(2)O).

8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases

A Designed Approach to Enantiodivergent Enamine Catalysis

A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori

A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol

A single point mutation converts a glutaryl-7-aminocephalosporanic acid acylase into an N-acyl-homoserine lactone acylase

Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase

Acyclic Ribooxacarbenium Ion Mimics as Transition State Analogues of Human and Malarial Purine Nucleoside Phosphorylases

Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins.

Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase

Association of HPA axis-related genetic variation with stress reactivity and aggressive behaviour in pigs

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases

Bifunctional chiral auxiliaries 6: Alkylations of enolates derived from 1,3-diacylimidazolidine- 2-thiones and 1,3-diacylimidazolidin-2-ones

Biofilm Inhibition via Delivery of Novel Methylthioadenosine Nucleosidase Inhibitors from PVA-Tyramine Hydrogels while Supporting Mesenchymal Stromal Cell Viability

Bis[(1S)-1,4-azanediyl-1-(9-deazaadenin-9-yl)-1,4-dideoxy-5-methylsulfanyl-D-ribitol] tetrakis(hydrochloride) monohydrate: structure, DFT energy and ligand docking results of a potent methylthioadenosine phosphorylase inhibitor found in different mo

Book Review of Antisense Drug Technology: Principles, Strategies, and Applications. Second Edition Antisense Drug Technology: Principles, Strategies, and Applications. Second Edition. Edited by Stanley T. Crooke. CRC Press and Taylor & Francis Group

Concomitant bromination and lactolisation of unsaturated diols with sodium bromite in aqueous acetic acid

Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues

Corrigendum to “Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes”

Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase

Differential mRNA expression of genes in the porcine adrenal gland associated with psychosocial stress.

Distortional binding of transition state analogs to human purine nucleoside phosphorylase probed by magic angle spinning solid-state NMR.

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.

Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.

Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.

Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy.

Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli

Four generations of transition-state analogues for human purine nucleoside phosphorylase.

Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.

Imino-C-nucleoside synthesis: heteroaryl lithium carbanion additions to a carbohydrate cyclic imine and nitrone

Iminoribitol Transition State Analogue Inhibitors of Protozoan Nucleoside Hydrolases†

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

Immucillins in Infectious Diseases

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

Inhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †

Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state.

Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues

Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases

Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states

New Antibiotic Candidates against Helicobacter pylori

Oligonucleotide transition state analogues of saporin L3.

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases

Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model

Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function

Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes

Primordial-like enzymes from bacteria with reduced genomes

Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase

Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems

Salmonella enterica MTAN at 1.36 Å Resolution: A Structure-Based Design of Tailored Transition State Analogs

Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases

Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes

Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases

Synthesis of a Transition State Analogue Inhibitor of Purine Nucleoside Phosphorylase via the Mannich Reaction

Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase

Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase

Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins

Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase

The Immucillins: Design, Synthesis and Application of Transition- State Analogues.

The Synthesis ofN-Ribosyl Transferase Inhibitors Based on a Transition State Blueprint

The synthesis and antibacterial activity of totarol derivatives. Part 1: modifications of ring-C and pro-drugs

The synthesis and antibacterial activity of totarol derivatives. Part 2: Modifications at C-12 and O-13.

The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B.

The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

The transition to magic bullets – transition state analogue drug design

Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase